Abstract Purpose To investigate changes in bone mineral density (BMD) following denosumab after previous bisphosphonate therapy and the impact of chronic kidney disease (CKD) on response. Methods A retrospective study of 134 patients (11 M, 123 F) aged [mean (SD)] 72 [11] years on denosumab was undertaken. Ninety-five patients had previously been on oral...
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Abstract Indium sulfide thin films were prepared by chemical bath deposition method on glass substrates for about 40 min as deposition time and 60 °C as deposition temperature. The films were post-annealed at different temperatures such as 100 °C, 200 °C, 300 °C and 400 °C, for about 1 h. Structural and optical properties of In2S3 thin films after post-annealing process have been investigated. The crystallinity and nanostructures of the films were studied by using X-ray diffraction,...
Abstract The higher order of nonlinear partial differential equations in mathematical physics is studied. We used the analytical mathematical methods of the nonlinear (3+1)-dimensional extended Zakharov–Kuznetsov dynamical, modified KdV–Zakharov–Kuznetsov and generalized shallow water wave equations to demonstrate the efficiency and validity of the proposed powerful technique. The shallow water wave models have been applied in tidal waves and weather simulation. Exact wave...
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Abstract In recent years, large-scale mortalities are observed in tilapia due to infection with a novel orthomyxo-like virus named, tilapia lake virus (TiLV) which is marked to be a severe threat to universal tilapia industry. Currently, there are knowledge gaps relating to the antiviral peptide as well as there are no affordable vaccines or drugs available against TiLV yet. To understand the spreading of infection of TiLV in different organs of Oreochromis niloticus, RT-PCR analysis...
Abstract In this review, the basic concepts and applications of design of experiments (DoE) in recombinant protein biotechnology will be discussed. The production of recombinant proteins usually begins with the construction of an expression vector that is then introduced into a microbial host. The target protein is overexpressed in the host’s cells and subsequently, it is isolated using a suitable purification method, its activity is assessed using a biological assay, while its...
Abstract A novel carboxylesterase gene, named dlfae4, was discovered and sequenced from a soil metagenomic library. The dlfae4 gene was composed of 1017 base pairs encoding 338 amino acid residues with a predicted molecular mass of 37.2 kDa. DLFae4 exhibited strong hydrolytic activity towards methyl ferulate under optimum pH and temperature conditions (pH 8.6, 50 °C) and displayed remarkable thermostability, with residual activity as high as 50% after incubation for 3 h at 60 °C....
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AbstractThe Research to Accelerate Cures and Equity (RACE) for Children Act was enacted in 2017 to authorize the FDA to require pediatric studies for new cancer drugs that have a molecular target relevant to the growth or progression of a pediatric cancer. To assess the possible scope of this new policy, we examined all 78 adult cancer drugs approved by the FDA from 2007-2017. Only 17 (21.8%) drugs received any pediatric labeling information. Based on the FDA’s Pediatric Molecular Target List, we...
AbstractBackgroundRecent efforts of gene expression profiling analyses recognized at least 4 different triple-negative breast cancer (TNBC) molecular subtypes. However, little is known regarding their tumor microenvironment (TME) heterogeneity.MethodsHere, we investigated TME heterogeneity within each TNBC molecular subtype including immune infiltrate localization and composition together with expression of targetable immune pathways using publicly available transcriptomic and genomic datasets from...
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TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis
In this study, Yan et al. demonstrate that TIPE2, which is induced by tumor-derived ROS, promotes the functional polarization of protumoral myeloid-derived suppressor cells (MDSCs) during tumorigenesis by specifying the expression of MDSC signature genes such as Cebpb.
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Modern Pathology, Published online: 29 October 2019; doi:10.1038/s41379-019-0397-3Diagnosis of T-cell lymphoid proliferations of the skin: putting all the pieces together
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ObjectiveTo compare perinatal and maternal outcomes for Australian women with uncomplicated pregnancies according to planned place of birth, that is, in hospital labour wards, birth centres or at home. DesignA population-based retrospective design, linking and analysing routinely collected electronic data. Analysis comprised 2 tests and binary logistic regression for categorical data, yielding adjusted ORs. Continuous data were analysed using analysis of variance. SettingAll eight Australian states...
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Publication date: Available online 28 October 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Michel D. Landry, Joost van Wijchen, Djenana Jalovcic, Carina Boström, Anna Pettersson, Maria Nordheim Alme
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Publication date: Available online 28 October 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Alessandra Merlotti, Angelo Rosa, Daniel RemondiniAbstractGenome organization in eukaryotes during interphase stems from the delicate balance between non-random correlations present in the DNA polynucleotide linear sequence and the physico/chemical reactions which shape continuously the form and structure of DNA and chromatin inside the nucleus of the cell. It is now...
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Publication date: Available online 28 October 2019Source: Artificial Intelligence in MedicineAuthor(s): Xuechen Li, Linlin Shen, Xinpeng Xie, Shiyun Huang, Zhien Xie, Xian Hong, Juan YuAbstractLung cancer is the leading cause of cancer death worldwide. Early detection of lung cancer is helpful to provide the best possible clinical treatment for patients. Due to the limited number of radiologist and the huge number of chest x-ray radiographs (CXR) available for observation, a computer-aided detection...
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Spin transfer nano-oscillators (STNOs) are a new type of radio frequency (RF) oscillators that utilize the current-induced magnetization precession in a magnetic tunnel junction device to generate high frequency microwave signal. Since both the frequency and the amplitude of STNOs can be tuned by changing the current, they are potentially used for amplitude shift keying and frequency shift keying modulation without the need for an RF mixer, which leads to compact RF components. In this...
A high-performance supercapacitor electrode NiCo 2 S 4 (NCS) nanosheet on SiO 2 @C core-shell nanospheres (SiO 2 @C-NCS nanocomposite) is prepared via simple an effective solution-based method. Benefiting from compositional and structural advantages, the as-prepared SiO 2 @C-NCS nanocomposite exhibits a high specific capacitance (625 F g −1 at 1 mA cm −2 ) and a stable cycling performance. An asymmetric supercapacitor (ASC) assembled with SiO 2 @C-NCS nanocomposite as a positive electrode ...
We reveal the comparative relationship between small changes in quantum conductivity behavior for molecular junctions. We clarify the mechanisms of acquiring and losing additional thermal activation energy during average current flow in a gold-1,4 benzenediamine (BDA)-gold molecular junction and explain the quantum conductance modulation process. Small changes in working temperature lead to a change in quantum conductivity, which is reflected in random telegraph signal behavior. We demonstrate...
Prussian blue (PB) modified nanoporous gold (NPG) electrodes exhibit great potential for improving the detection sensitivity and stability for hydrogen peroxide monitoring. The NPG provides large surface-to-volume ratio as well as diffusion ‘highways’ to assist the transfer of the ions. In the present work, we optimized the deposition time for NPG fabrication and examine the electrochemical performance of the electrodes. A critical deposition time on the electrochemical performances including...
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Publication date: Available online 28 October 2019Source: Acta BiomaterialiaAuthor(s): Wenhui Wang, Hongliu Wu, Yu Sun, Jun Yan, Lei Zhang, Shaoxiang Zhang, Jiahua Ni, Yang Song, Xiaonong ZhangAbstractMg-based implants are used in biomedical applications predominantly because of their degradable property. In this paper, the effect of local misorientations (intragranular misorientation) on the corrosion behavior of high-purity Mg (HPM) was systematically investigated according to microstructure characterization...
Publication date: Available online 28 October 2019Source: Acta BiomaterialiaAuthor(s): Zhuqing Wan, Ping Zhang, Yunsong Liu, Longwei Lv, Yongsheng ZhouAbstractFour-dimensional (4D) bioprinting, in which the concept of time is integrated with three-dimensional (3D) bioprinting as the fourth dimension, is widely proposed as the next-generation of tissue engineering technology as it presents the possibility of constructing complex, functional structures. 4D bioprinting can be used to fabricate dynamic...
Publication date: Available online 28 October 2019Source: Acta BiomaterialiaAuthor(s): D. Cristea, S. Krishtul, P. Kuppusamy, L. Baruch, M. Machluf, A. BlankAbstractCell microencapsulation within biocompatible polymers is an established technology for immobilizing living cells that secrete therapeutic products. These can be transplanted into a desired site in the body for the controlled and continuous delivery of the therapeutic molecules. One of the most important properties of the material that...
Publication date: Available online 28 October 2019Source: Acta BiomaterialiaAuthor(s): Tien-Chun Yang, Chia-Yu Chang, Aliaksandr A. Yarmishyn, Yen-Shiang Mao, Yi-Ping Yang, Mong-Lien Wang, Chih-Chien Hsu, Hsin- Yu Yang, De-Kuang Hwang, Shih-Jen Chen, Ming-Long Tsai, Yun-Hsien Lai, Yonhua Tzeng, Chia-Ching Chang, Shih-Hwa ChiouAbstractNanodiamonds (NDs) are considered to be relatively safe carbon nanomaterials used for the transmission of DNA, proteins and drugs. The feasibility of utilizing the NDs...
Publication date: Available online 28 October 2019Source: Acta BiomaterialiaAuthor(s): Ying Li, Yu Cao, Lai Wei, Jinjie Wang, Min Zhang, Xuexia Yang, Wenshuo Wang, Guang YangAbstractProtein-templated gold nanoclusters have attracted attention in fluorescence imaging due to their simple synthesis and good biocompatibility. However, limitations still exist such as poor colloid stability and undesirable fluorescence intensity. Here we describe the self-assembly of keratin-templated gold nanoclusters...
Publication date: Available online 28 October 2019Source: Acta BiomaterialiaAuthor(s): Y. Li, P. Pavanram, J. Zhou, K. Lietaert, P. Taheri, W. Li, H. San, M.A. Leeflang, J.M.C. Mol, H. Jahr, A.A. ZadpoorAbstractAdditively manufacturing (AM) opens up the possibility for biodegradable metals to possess uniquely combined characteristics that are desired for bone substitution, including bone-mimicking mechanical properties, topologically ordered porous structure, pore interconnectivity and biodegradability....
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Publication date: Available online 28 October 2019Source: Materials & DesignAuthor(s): Yaofeng Luo, Yunlai Deng, Liqun Guan, Lingying Ye, Xiaobin GuoAbstractIn this study, the microstructure and corrosion resistance of Mg-6Gd-2Y-χNd-0.2Zr (χ = 0, 0.5, 1 and 1.5 wt%) alloys in extrusion condition are investigated using the correlative microscopic observations, immersion tests and electrochemical measurements. Results show that the addition of Nd can affect the grain size, crystal orientation and...
Publication date: Available online 28 October 2019Source: Materials & DesignAuthor(s): Jianglong Gu, Shouliang Yang, Minjie Gao, Jing Bai, Yuchun Zhai, Jialuo DingAbstractThe application of wire + arc additively manufactured (WAAM) aluminum alloys has been restricted by the porosity defect, which is generally detrimental to the mechanical properties. Suppressing of micropores in the WAAM components has attracted considerable attention in recent years. Inter-layer rolling was introduced to eliminate...
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Abstract Oral dapagliflozin (Edistride®, Forxiga®) is approved in the EU at a dosage of 5 mg/day as an adjunct to insulin in adults with type 1 diabetes (T1D) and a body mass index (BMI) of ≥ 27 kg/m2, when insulin alone does not provide adequate glycaemic control despite optimal insulin therapy. As a highly selective SGLT2 inhibitor, dapagliflozin decreases plasma glucose levels independently of insulin action and enables glycaemic control improvement without increasing the risks...
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Publication date: Available online 29 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): C. Paterson, M.C. Thomson, B. Caldwell, R. Young, A. McLean, S. Porteous, S. Clark, C.M. Messow, S. Kean, D. Grose, C. Lamb, M. Rizwannullah, A. James, S. Schipani, C. Wilson, R. Rulach, R. JonesAbstractRadiotherapy-induced xerostomia (RIX) is a common and untreatable side effect of radiotherapy to the head and neck. Visco-ease™ mouth spray (Lamellar Biomedical Ltd), a new product...
Publication date: Available online 29 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Y. Jinno, K. Johansson, M. Stocchero, M. Toia, S. Galli, A. Stavropoulos, J.P. BecktorAbstractOur aim was to investigate the possible impact of contamination with saliva on osseointegration during placement of implants with simultaneous bone augmentation. Six hemispheric shape bone defects (8 mm in diameter × 4 mm deep) were prepared in each iliac bone of six sheep. A dental implant...
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Abstract Purpose To search the pattern of diagnoses in nonagenarians undergoing emergency abdominal surgery between January 2009 and December 2013 in two hospitals. To test the hypothesis that pre-hospital functional status is an effective criterion for predicting postoperative mortality in nonagenarians after emergency abdominal surgery. Methods The study...
Abstract Background To compare the mechanical strength of antegrade versus retrograde lag screw fixation of anterior column acetabular fractures. Methods Standardised anterior column fractures were created in synthetic pelvis models and stabilised by either antegrade (ANTE, n = 4) or retrograde (RETRO, n = 4) anterior column screw fixation. In a validated...
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Chem. Commun., 2019, Accepted ManuscriptDOI: 10.1039/C9CC07327B, CommunicationShaotao Bai, Sander Kluwer, Joost N. H. ReekIn this communication, we report rhodium DIMPhos complexes with an intergrated DIM-receptor that can bind carboxylate containing effectors and their application in the rhodium catalyzed hydroformylation reaction. The binding of...The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2019, Accepted ManuscriptDOI: 10.1039/C9CC06877E, CommunicationBohan Tang, Jiantao Zhao, Yang Jiao, Jiang-Fei Xu, Xi ZhangThe redox property of a ferrocene derivative, the catalyst of Fenton oxidation, is modulated by the host-guest complexation of cucurbit[7]uril. The supramolecularly modulated catalyst significantly accelerates the catalytic oxidation of...The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2019, Accepted ManuscriptDOI: 10.1039/C9CC06182G, CommunicationMiguel Angel Soler, Barbara Medagli, Marta Semrau, Paola Storici, Gregor Bajc, Ario de Marco, Alessandro Laio, Sara FortunaWe present an in silico mutagenetic protocol for improving the binding affinity of single domain antibodies (or nanobodies, VHHs). The method iteratively attempts random mutations in the interacting region of...The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2019, Accepted ManuscriptDOI: 10.1039/C9CC07510K, CommunicationYu-Bin Dong, Qun Guan, Le-Le Zhou, Yan-An LiWe demonstrate herein an effective cascade reaction for combined photodynamic and starvation therapy in treating breast tumors based on a photosensitizer and CO prodrug decorated NMOF. The PDT-induced ROS can...The content of this RSS Feed (c) The Royal Society of Chemistry
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AbstractMultivesicular bodies (MVBs) are membrane-bound organelles that belong to the endosomal pathway. They participate in the transport, sorting, storage, recycling, degradation, and release of multiple substances. They interchange cargo with other organelles and participate in their renovation and degradation. We have used focused ion beam milling and scanning electron microscopy (FIB-SEM) to obtain stacks of serial sections from the neuropil of the somatosensory cortex of the juvenile rat. Using...
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Publication date: Available online 28 October 2019Source: Neuroscience ResearchAuthor(s): Yoshikazu Ugawa, John C Rothwell, Walter PaulusAbstractA single pulse of TMS or direct electric stimulation over M1 causes repetitive synchronized firing of corticospinal tract (CST) neurons. Two mechanisms for the repetitive firing have been proposed: a cascade of synaptic inputs to the pyramidal neurons and a single reverberating circuit of interneurons. Here, we propose another possibility in which bursting...
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Cancers, Vol. 11, Pages 1685: Intra-Patient Heterogeneity of Circulating Tumor Cells and Circulating Tumor DNA in Blood of Melanoma Patients Cancers doi: 10.3390/cancers11111685 Authors: Katharina Gorges Lisa Wiltfang Tobias M. Gorges Alexander Sartori Lina Hildebrandt Laura Keller Beate Volkmer Sven Peine Anna Babayan Ingrid Moll Stefan W. Schneider Sören Twarock Peter Mohr Jens W. Fischer Klaus Pantel Despite remarkable progress in melanoma...
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