Abstract Objectives Prospective practice‐based clinical evaluation of chairside fabricated monolithic partial crowns composed of zirconia‐containing lithium silicate (ZLS) ceramic material. Materials and Methods Between October 2013 and September 2014, 71 patients were restored with 92 partial crowns on vital or sufficiently endodontically treated teeth. The monolithic restorations were fabricated chairside (Cerec SW 4.2/Cerec MC XL) from a glaze‐fired ZLS ceramic material (Celtra Duo,...
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Research has shown that utilizing medical interpreters in language discordant patient-provider encounters improves outcomes. There is limited research evaluating the views of medical interpreters on best interpreter practices when they are utilized to break bad news or participate in end of life conversations.
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Objectives: Given the relative novelty of stereotactic body radiation therapy as a treatment modality low-risk and intermediate-risk prostate cancer, little data exist evaluating dosimetry and its impact on patient-reported quality of life (PR-QOL) metrics. Herein, we present an interim analysis of a phase II clinical trial of PR-QOL and dosimetric correlates. Methods: Patients with biopsy-proven low-risk or intermediate-risk prostate cancer, prostate volume ≤100 cm3, and life expectancy...
Objectives: To investigate local control and functional outcome following state-of-the-art fractionated stereotactic radiotherapy (FSRT) for paragangliomas of the head and neck. Methods: In total, 40 consecutive patients with paragangliomas of the head and neck received conventionally FSRT from 2003 to 2016 at the Department of Radiation Oncology of the University Hospital Erlangen. Local control, toxicities, and functional outcome were examined during follow-up. In total, 148 magnetic resonance...
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Objectives: Thick melanomas, defined as ≥4 mm in thickness, represent ~5% of new melanoma diagnoses and have been associated with poor overall survival (OS). Ultrathick melanomas, those lesions ≥8 mm in thickness, have been associated with worse survival. We sought to compare prognostic factors for thick and ultrathick melanoma. Methods: Retrospective analysis of a prospective database of all patients receiving an operation for melanoma, June 2005 to December 2016 was performed. Multivariate...
Objectives: Cancer patients with comorbid diabetes have a 50% increased risk of all-cause mortality compared with cancer patients without diabetes. Less attention to diabetes management (glucose control, medication adherence, and diabetes self-management behaviors) during active cancer treatment is hypothesized as an explanation for worse outcomes among diabetic cancer patients. The objective of this systematic review is to determine and quantify how a cancer diagnosis impacts diabetes management. ...
Objectives: Although adolescents and young adults (AYA) suffer disproportionately from cutaneous melanoma (CM), little is known regarding the burden of CM leading to hospitalization in AYA. The objective of this study was to elucidate sociodemographic/hospitalization characteristics of AYA CM inpatients, determine which factors lead to the greater length of stay (LOS) and cost of care for AYA CM inpatients, and evaluate trends in the prevalence, LOS, and cost of care for AYA CM hospitalizations. ...
Objectives: In endometrial cancer, the appropriate sequence of adjuvant chemotherapy (aCT) and adjuvant radiation therapy (aRT) is unclear. We aim evaluated whether early chemotherapy is associated with improved overall survival (OS) and cancer-specific survival (CSS). Methods: Endometrial cancer patients that received aCT and aRT were selected from the SEER-Medicare database. Early chemotherapy was defined as receiving aCT before aRT, with or without additional aCT (“sandwich” regimens)....
Objectives: Current National Comprehensive Cancer Network (NCCN) guidelines support systemic therapy based on mutational status in stage IV non–small cell lung cancer (NSCLC), with stereotactic body radiation therapy (SBRT) reserved for oligoprogression. We aimed to evaluate the cost-effectiveness of the routine addition of SBRT to upfront therapy in stage IV NSCLC by mutational subgroup. Materials and Methods: A Markov state transition model was constructed to perform a cost-effectiveness...
Objectives: Insulin-like growth factor-methotrexate (IGF-MTX) is a conjugate of methotrexate and 765IGF, a variant of IGF-1 with high affinity for insulin-like growth factor type 1 receptor. The study aim was to determine the maximum tolerated dose of IGF-MTX in refractory solid organ and hematologic malignancies expressing insulin-like growth factor type 1 receptor. Materials and Methods: This phase I trial used a modified toxicity probability interval design with 5 cohort dose levels, and...
Objectives: The discovery of tyrosine kinase inhibitors (TKI) has remarkably improved the clinical course of patients with non–small cell lung cancer driven by Epidermal Growth Factor Receptor (EGFR) mutations. However, virtually in all cases, the disease resurfaces in a TKI-resistant form that is mainly linked to an acquired EGFR-T790M mutation, a MET amplification, or small cell lung cancer (SCLC) transformation. Third-generation TKIs are able to block tumor growth through an irreversible binding...
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Background: Although lobectomy is the standard of care in stage I non–small cell lung cancer (NSCLC), medical comorbidities increase surgical risk in elderly patients. No population-based studies compare short-term mortality (STM) for surgery (STM-S), radiation (STM-R), and observation (STM-O) in elderly patients with stage I NSCLC. Methods: A total of 60,466 biopsy-proven stage I NSCLC cases diagnosed between 2004 and 2012 were retrieved from the Surveillance, Epidemiology, and End Results...
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Abstract Purpose To evaluate the effect of protective coatings on the surface roughness, contact angle, and Candida albicans (C. albicans) adhesion to polymethyl methacrylate (PMMA) denture base materials. Material and methods A total of 560 rectangular heat‐ and auto‐polymerized acrylic resin specimens were fabricated and divided into 5 groups (n = 14/group) according to coating agent. Uncoated specimens were used as control. Coating materials were: nano‐coat, Optiglaze, nano‐silica, or...
Abstract Purpose : To report the rate of technical complications and prosthesis survival in a cohort of edentulous patients treated with implant‐supported fixed complete dental prostheses (IFCDPs) after a mean observation period of at least 1 year. Materials and Methods : The single‐visit examination included clinical and radiographic assessment, occlusal analysis, photographs and questionnaire assessing patient satisfaction in a cohort of 52 patients rehabilitated with 71 IFCDPs (supported...
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Related ArticlesMandibular dental changes following serial and late extraction of mandibular second premolars. Angle Orthod. 2019 Oct 24;: Authors: Mintenko R, Kennedy DB, Aleksejuniene J, Hannam AG, Yen EH Abstract OBJECTIVES: To determine changes in occlusal curves and dental tipping occurring from mandibular second premolar serial extraction, early extraction of deciduous mandibular second molars with missing second premolars, and late second premolar...
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The recommended treatment for cutaneous squamous cell cancer (CuSCC) of the head and neck is Mohs surgical excision or wide local excision. Excision is recommended to a gross surgical margin of 4–6 mm however ...
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The recommended treatment for cutaneous squamous cell cancer (CuSCC) of the head and neck is Mohs surgical excision or wide local excision. Excision is recommended to a gross surgical margin of 4–6 mm however ...
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Publication date: Available online 25 October 2019Source: Diagnostic Microbiology and Infectious DiseaseAuthor(s): Jennifer H. Ku, Gregory Ranches, Sarah A.R. Siegel, Kevin L. WinthropAbstractPulmonary nontuberculous mycobacterial (NTM) disease occurs frequently in older women, and phenotypes of men with NTM disease are largely undescribed. We conducted a case–control study of 34 men with non-cystic fibrosis pulmonary NTM disease(cases), and three male and female control groups with or without NTM...
Publication date: Available online 25 October 2019Source: Diagnostic Microbiology and Infectious DiseaseAuthor(s): Delphine Girlich, Souad Ouzani, Isabelle Langlois, Christine Begasse, Nicolas Arangia, Nicolas Fortineau, Thierry Naas, Laurent DortetAbstractAn OXA-181 producing Escherichia coli isolate that went recurrently undetected directly from rectal swab sample using Xpert® Carba-R, was successfully detected using ertapenem supplemented broth enrichment followed by culture-based method. Our...
Publication date: Available online 24 October 2019Source: Diagnostic Microbiology and Infectious DiseaseAuthor(s): Mustafa Sadek, Laurent Poirel, Patrice NordmannAbstractThis study compared the impact of different approaches, namely non-enrichment, non-selective enrichment, and selective (antibiotic-containing) enrichment steps, for detecting extended-spectrum ß-lactamase producing Enterobacterales (ESBL-E), carbapenemase-producing Enterobacterales (CPE), polymyxin-resistant Enterobacterales (PMR-E),...
Publication date: Available online 24 October 2019Source: Diagnostic Microbiology and Infectious DiseaseAuthor(s): Matthew Bonaparte, James Huleatt, Shekema Hodge, Lingyi Zheng, Yaniv Lustig, Carlos A. DiazGranados, Yasemin Ataman-Önal, Stephen SavarinoAbstractWe assessed a dengue IgG rapid diagnostic test (RDT) and IgG ELISA to determine their suitability for dengue pre-vaccination screening. Each exhibited ≥99% specificity. The RDT demonstrated no Zika cross-reactivity, while the ELISA displayed...
Publication date: Available online 24 October 2019Source: Diagnostic Microbiology and Infectious DiseaseAuthor(s): Mayur Shukla, Yongcheng Sun, Joshua McCormick, Andre Hopkins, Lara Pereira, Anne Gaynor, Ellen Kersh, Yetunde FakileAbstractThe Centers for Disease Control and Prevention’s (CDC) Division of STD Prevention, in collaboration with the Association of Public Health Laboratories (APHL), is developing a nationally available syphilis serum repository for research of Food and Drug Administration...
Publication date: Available online 24 October 2019Source: Diagnostic Microbiology and Infectious DiseaseAuthor(s): Vaigundan Dhayabaran, Divya Chidambaram, Patnam R. KrishnaswamyAbstractLeptospirosis is a recurring global disease of severe illness involving pulmonary and renal involvement in cattle and humans; that needs attention to cure. The major challenge in treating leptospirosis disease is the diagnosis of the disease. The culturing of an organism is a gold standard for confirmation of the...
Publication date: Available online 24 October 2019Source: Diagnostic Microbiology and Infectious DiseaseAuthor(s): JaffarA. Al-Tawfiq, Mohammad BabikerAbstractClostridium difficile infection manifests as intestinal infections, namely pseudomembranous colitis. The occurrence of extra-intestinal disease is thought to be rare with a rate of 1.08% of 2034 isolates of C. difficile and an incidence of 4/100,000 admissions. C. difficile had been rarely associated with osteomyelitis. Here, we report the...
Publication date: Available online 24 October 2019Source: Diagnostic Microbiology and Infectious DiseaseAuthor(s): Preeti Pancholi, Steve Young, R. Widen, Suzane Silbert, B. Schmitt, R. Dunn, A. Drain, S.A. WeissfeldAbstractWe evaluated the performance of the Luminex ARIES® C. difficile Assay on 984 stool specimens prospectively collected from patients being tested for CDI at four clinical laboratories in the United States. Results were compared to direct and enriched toxigenic culture. Positive...
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Abstract Purpose This study aimed to identify a safe, rapid, and accessible method of estimating muscle volume of key lower limb muscle groups to reduce the time-demand of acquiring this measurement and potentially facilitate its application as a clinical monitoring tool. Methods Unilateral MRI images were acquired from the 12th thoracic vertebrae to the...
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Abstract This article presents a theory for constructing hierarchical networks in such a way that the networks are guaranteed to be provably scale covariant. We first present a general sufficiency argument for obtaining scale covariance, which holds for a wide class of networks defined from linear and nonlinear differential expressions expressed in terms of scale-normalized scale-space derivatives. Then, we present a more detailed development of one example of such a network constructed...
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Summary Background Preclinical studies suggested synergistic anti-tumor activity when pairing mTOR inhibitors with histone deacetylase (HDAC) inhibitors. We completed a phase I, dose-finding trial for the mTOR inhibitor everolimus combined with the HDAC inhibitor panobinostat in advanced clear cell renal cell carcinoma (ccRCC) patients. We additionally investigated expression of microRNA 605 (miR-605) in serum samples obtained from trial participants. Patients and Methods Twenty-one...
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I wanted to take a second to show you around the farm, but also tell you about Team Trees. We're going to plant 20 million trees by Jan 1, 2020. If we work together, and everyone gives a little, we can make it happen! I Like To Make Stuff is pledging to donate $1000 to plant 1000 trees, and we're asking you to join us in any way that you can. Maybe you donate $1, or $1 for each person in your family... skip a latte and donate that $5. Join us at Team Trees by going to http://teamtrees.org or...
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As New Study Shows Smog’s Deadly Effects, Court Orders EPA to Protect Public Breathing smog can be as bad for you as smoking. The good news is, a court rejected EPA’s plan to let the air stay dirty. A haze of smog covers the Port of Houston. James Dillard Emphysema is commonly known as a “smoker’s disease.” Yet a recent study shows that...
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Abstract The dipeptidyl peptidase-4 inhibitor (DPP-4i) alogliptin is an oral, antidiabetic treatment that is approved in many countries to treat patients with type 2 diabetes mellitus (T2DM), including the USA, Europe, and Japan. Alogliptin is efficacious both as monotherapy and as add-on/combination therapy with other commonly prescribed T2DM treatments, such as metformin and pioglitazone. Overall, alogliptin is well-tolerated in patients with T2DM, including older patients, those...
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Abstract Objective The recommended treatment for cutaneous squamous cell cancer (CuSCC) of the head and neck is Mohs surgical excision or wide local excision. Excision is recommended to a gross surgical margin of 4–6 mm however this is based on limited evidence and specify a goal histologic margin. The objective of this study was therefore to examine the reported histological margin distance following WLE of advanced CuSCC and its...
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We report FDG PET/CT images of a 63-year-old woman referred for characterization of osteolytic lesions of the cervical spine. This patient with chronic renal failure had a history of follicular thyroid carcinoma with undifferentiated cells, treated by a total thyroidectomy, completed by radioactive iodine in 2017. Because of cancer history, a FDG PET/CT was performed and showed multiple moderately hypermetabolic osteolytic lesions of the spine from C3 to T1, with joint erosion on CT. A laminectomy...
A 72-year-old man with a history of T1cN0M0 prostate adenocarcinoma and rising prostate-specific antigen underwent a fluciclovine PET/CT scan that showed high uptake in several para-aortic nodes, suspicious for prostate cancer. A right upper lobe single pulmonary nodule (SPN), demonstrated only mild uptake, which raised the suspicion for a lung primary. Subsequent FDG PET/CT showed high uptake in the SPN, revealing poorly differentiated adenocarcinoma at biopsy, but with no abnormal uptake in the...
18F-FDG PET/CT for a 74-year-old man with elevated serum soluble interleukin 2 receptor showed multiple intense uptake in the liver, spleen, and bone. A surgical biopsy from 2 of liver tumors confirmed hepatosplenic αβ T-cell lymphoma. One and a half months after biopsy, FDG PET scan was performed again for staging before starting chemotherapy, and it showed the complete disappearance of all of the lesions. The excisional biopsy could be a possible trigger of his spontaneous regression. Received...
Breast cancer is the most common cancer in women with rising incidence worldwide. 18F-FDG PET/CT imaging has already established itself as a pivotal modality for staging, restating and response assessment in patients with carcinoma breast. The complex biology of this cancer is increasingly being decoded and various molecular targets have been identified and exploited for guiding the treatment at various time points during the course of the disease. We here depict a series of various metabolic and...
Metastatic involvement of the larynx is rare due to the absence of vessels within the cartilaginous tissue. The probability of metastatic spread increases with aging as a result of larynx ossification. The secondary involvement of larynx is more frequently associated with melanoma and renal cell carcinoma. Few observations have been reported also in prostate cancer patients, usually associated with advanced disease and diffuse metastatic bone involvement. We report a case of an 83-year-old man with...
Extraocular muscles show physiologic radiotracer uptake on 18F-FDG PET/CT as is encountered in most routine scans. Certain pathologies can cause palsy of one or more of the extraocular muscles, leading to hypometabolism on 18F-FDG PET/CT. We present a case with a classical finding of unilateral hypometabolism of the lateral rectus muscle, disrupting the “V” sign formed due to physiologic uptake. The patient had presented with the complaint of diplopia and was being evaluated further to rule out the...
A 65-year-old man underwent FDG PET/CT for evaluation of vertebral lesions, radiologically suspected to be metastases. The scan showed hypermetabolism in D8 to D9 vertebrae, retroperitoneal lymph nodes, and both the lobes of prostate. Transrectal ultrasound-guided biopsy of prostate was performed with suspicion of prostate malignancy. The biopsy revealed caseating granulomatous lesions in prostate suggestive of tuberculosis. Post antitubercular treatment patient showed excellent clinical response....
Brown tumors are rare skeletal anomalies occurring in patients with hyperparathyroidism and exposing patients to pathological fractures. We report the case of a 26-year-old woman with severe primary hyperparathyroidism (calcemia, 2.9 mmol/L; parathyroid hormone, 59 pmol/L) who underwent 18F-fluorocholine (FCH) PET/CT before parathyroidectomy. FCH PET localized the hyperfunctioning parathyroid gland and showed multiple foci in correspondence with bone lytic lesions on CT. Those lesions were not visible...
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Publication date: Available online 24 October 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): David Z. Allen, Noah Worobetz, Jordan Lukens, Cameron Sheehan, Amanda Onwuka, Ryan M. Dopirak, Tendy Chiang, Charles ElmaraghyAbstractIntroductionAdenotonsillectomy (AT) is the most common surgical procedure for the treatment of sleep related breathing issues in children. While overnight observation in the hospital setting is utilized frequently in children after a AT, ICU setting...
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The authors report a rare case of intraosseous hemangioma of the mandible in a 14-year-old male. Surgical intervention with embolization is as important as histological and radiological examination to reduce the bleeding complication. Magnetic resonance angiography is paramount of importance in these lesions to detect the supplier arteries. Address correspondence and reprint requests to Mustafa Yalcin, DDS, PhD, Department of the Oral and Maxillofacial Surgery, Faculty of Dentistry, Gaziantep University,...
Craniosynostosis is a congenital cranial malformation involving premature fusion of cranial sutures. Indications for surgical repair of craniosynostosis include elevation of intracranial pressure, which can result in impaired vision and mental disability, as well as correction of abnormal skull shape. Resorbable plating systems have become the preferred technique for bony fixation in the repair of craniosynostosis. Multiple studies demonstrate the safety and low complication rate of resorbable plating...
Background: The impact of metopic craniosynostosis on intracranial volume (ICV) and ICV growth is unclear. In addition, the relationship between head circumference (HC) and ICV in these patients is not previously described. Methods: A retrospective review of 72 patients with metopic craniosynostosis was performed. The ICVs were calculated from manually segmented preoperative computed tomography scans. Magnetic resonance imaging data for 270 healthy children were available. The ICVs were calculated...
In nasal reconstruction, it is necessary to replace all anatomic layers in order to reinstate correct aesthetics. The most apt donor site to use in order to cover the nose has been recognized as forehead skin. Traditionally 2 phases are required to reconstruct the forehead flap; however, an intermediate third phase was described by Millard which is between transfer of the flap and division of the pedicle. These methods will be compared in this study with regard to both complication rates and aesthetic...
Nasal bone stabilization, in the setting of comminuted nasal fracture or surgical osteotomy, represents a challenging surgical experience. Postoperative shifting of osseous fragments may result in compromised outcomes in an otherwise well-performed procedure. Although prior studies have reported nasal bone fixation with implementation of wires, plates, or halos, these techniques are often difficult to employ routinely. Herein, the authors describe a novel and facile technique for the maintenance...
Objective: Complex secondary deformities of cleft lip include nasal and labial deformities, alveolar cleft, oronasal fistula, and so on. In this report, the authors present a method to simultaneously repair the above complex deformities with autogenous costal cartilage and rib grafts. Methods: The surgical procedure of simultaneous correction includes filling the alveolar cleft with autologous rib;repairing the oronasal fistula with a local mucosal flap;correcting the nasal deformity with...
Purpose: The aim of this study was to evaluate the efficacy, feasibility, and safety of the endoscopic optic canal and orbital apex decompression for patients with traumatic orbital apex syndrome. Design: Retrospective, noncomparative case series. Method: Thirty-one patients (31 eyes) with traumatic orbital apex syndrome underwent endoscopic transethmosphenoid optic canal and orbital apex decompression at the Eye Hospital of Wenzhou Medical University from May 1st, 2012 to May 1st, 2018....
Cutaneous lymphangioma circumscriptum (CLC) is an uncommon congenital lymphatic malformation. Its dermoscopic features have been reported, however, if blood has infiltrated the lacunas, a pink hue overwhelms the lacunar structures, rendering dermoscopic features indistinguishable. In addition, dermoscopy cannot assess the subcutaneous extent of the lesion before surgery. The high-frequency array transducer Sonography with a high-frequency transducer is excellent in its resolution to evaluate skin...
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This article reviews current technologies in nursing education and the impact of technology on learning. The integration of technology into nursing curricula is thought to improve efficiency and enhance student experiences through active learning and interactive learning designs. The following focused questions are explored: (1) What are the current technologies used by university students and faculty in nursing programs? (2) How does that technology influence student learning? The primary themes...
The handoff or handover is the exchange of pertinent medical information from one provider to another. Inadequate handoff communication between healthcare providers can negatively impact patient outcomes. In an effort to improve handoff communication, many studies have developed and evaluated the use of a handoff tool such as a handoff checklist or handoff form to facilitate handoff communication. Recently, the use of the IPASS handoff form, based on the mnemonic for the process, has been associated...
The aim of this study was to identify nurse managers' daily tasks during the rescheduling of sudden nursing staff absences by comparing two techniques: a paper-based system as phone calls and emails or information technology–based staffing systems. In addition, it is intended to evaluate the usability of information technology–based staffing solutions and evaluate estimated cost savings by using hospital permanent staff to cover sudden absences. A quasi-experimental pretest and posttest one-group...
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Abstract Objective The objective of this systematic review was to evaluate the effectiveness of an osteopathic treatment on the autonomic nervous system (ANS). For this purpose, published primary studies were analysed and critically evaluated. Method To generate this review, 15 electronic databases were systematically searched for studies. Randomized...
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Pharmacogenomics, Ahead of Print.
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Abstract Background and objective The ideal delivery of radiation to the surgical cavity of brain metastases (BMs) remains the subject of debate. Risks of local failure (LF) and radiation necrosis (RN) have prompted a reappraisal of the timing and/or modality of this critical component of BM management. IORT delivered at the time of resection for BMs requiring surgery offers the potential for improved local control (LC) afforded by the...
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Abstract Background Human herpesvirus‐6B (HHV‐6B) infection after allogenic hematopoietic stem cell transplantation (allo‐HSCT) is known to be associated with post‐transplant limbic encephalitis in adults. Meanwhile, the association between HHV‐6B infection and central nervous system complications remains unclear in pediatric allo‐HSCT patients. Methods In this study, HHV‐6B infection was monitored for more than 50 days after HSCT using virus isolation and real‐time PCR. Clinical information...
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Abstract Objectives To validate the Hospital Anxiety and Depression Scale (HADS) and the 10‐item Perceived Stress Scale (PSS‐10) for use in patients with oral lichen planus (OLP) and to provide cross‐sectional analysis of anxiety, depressive and distress symptoms in patients with OLP. Methods Validity and reliability of both instruments were assessed in 260 participants with OLP in one tertiary Oral Medicine Centre through confirmatory factor analysis and calculation of reliability coefficients....
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Erratum zu: Somnologie 2019 https://doi.org/10.1007/s11818-019-00219-7 Im Editorial zum Themenheft „Die innere Uhr“ (Ausgabe 3/2019) bestehen unvollständige Angaben zu den Autoren des ebenfalls im Themenheft enthaltenen Beitrags „Effects of light on human circadian rhythms, sleep and mood“. Bitte …
Zusammenfassung Hintergrund Die obstruktive Schlafapnoe (OSA) ist ein wichtiger Risikofaktor für kardiovaskuläre, metabolische und neurologische Erkrankungen. Zudem gibt es Hinweise darauf, dass OSA durch intermittierende Hypoxie und Schlaffragmentierung Einfluss auf Genese, Progression und Metastasierung von Malignomen nimmt. Als mögliche Pathomechanismen werden oxidativer Stress, systemische Inflammation, Angiogenese durch HIF-1/2 und...
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Annals of Otology, Rhinology &Laryngology, Ahead of Print. Objectives:Diesel exhaust particles (DEP)s are notorious ambient pollutants composed of a complex mixture of a carbon core and diverse chemical irritants. Several studies have demonstrated significant relationships between DEP exposure and serious nasal inflammatory response in vitro, but available information regarding underlying networks in terms of gene expression changes has not sufficiently explained potential mechanisms of DEP-induced...
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