Zusammenfassung Einleitung Der konstante Anstieg der Lebenserwartung seit über 170 Jahren ist eine der größten Leistungen der modernen Gesellschaft. Die Wahrscheinlichkeit, dass ein 80-Jähriger 100 Jahre wird, hat sich in Deutschland seit 1950 verzwanzigfacht. Dieser Sachverhalt hat verschiedenste Implikationen für den klinischen Alltag und therapeutische Leitlinien. In der Hernienversorgung sollte neben quantitativen Faktoren (Komplikationen,...
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Abstract Objectives Our objective was to identify preconception and prenatal predictors of early experiences of co-occurring risk and protective factors to help target prevention efforts to the highest-need families prior to the birth of the child. Methods Data were from the Alaska Longitudinal Child Abuse and Neglect Linkage project and the 2012–2014 Alaska...
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IJERPH, Vol. 16, Pages 4181: Protective Effect of Breastfeeding on the Adverse Health Effects Induced by Air Pollution: Current Evidence and Possible Mechanisms International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214181 Authors: Zielinska Hamulka Air pollution is a major social, economic, and health problem around the world. Children are particularly susceptible to the negative effects of air pollution due to their immaturity and excessive growth...
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IJERPH, Vol. 16, Pages 4182: Food Safety Incident, Public Health Concern, and Risk Spillover Heterogeneity: Avian Influenza Shocks as Natural Experiments in China’s Consumer Markets International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214182 Authors: Yi Tao Zhu Tan Qi Background: Food safety incidents have aroused widespread public health concern, causing food price risk. However, the causal paths remain largely unexplored in previous...
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IJERPH, Vol. 16, Pages 4180: Conveying Safety Messages on Agricultural Machinery: The Comprehension of Safety Pictorials in a Group of Migrant Farmworkers in Italy International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214180 Authors: Bagagiolo Vigoroso Caffaro Cremasco Cavallo The comprehension of safety signs affixed to agricultural machinery is fundamental to warning users about the residual risks which cannot be eliminated with machinery...
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IJERPH, Vol. 16, Pages 4179: Interaction Among Influenza Viruses A/H1N1, A/H3N2, and B in Japan International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214179 Authors: Ayako Suzuki Kenji Mizumoto Andrei R. Akhmetzhanov Hiroshi Nishiura Seasonal influenza epidemics occur each winter season in temperate zones, involving up to 650,000 deaths each year globally. A published study demonstrated that the circulation of one influenza virus type during...
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IJERPH, Vol. 16, Pages 4178: Associations between the Home Physical Environment and Children’s Home-Based Physical Activity and Sitting International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214178 Authors: Sheldrick Maitland Mackintosh Rosenberg Griffiths Fry Stratton It is important to understand the correlates of children’s physical activity (PA) and sitting at home, where children spend significant time. The home...
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IJERPH, Vol. 16, Pages 4176: Modelling Economic Growth, Carbon Emissions, and Fossil Fuel Consumption in China: Cointegration and Multivariate Causality International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214176 Authors: Lv Chu McAleer Wong Most authors apply the Granger causality-VECM (vector error correction model), and Toda–Yamamoto procedures to investigate the relationships among fossil fuel consumption, CO2 emissions, and...
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IJERPH, Vol. 16, Pages 4177: Social Media, Thin-Ideal, Body Dissatisfaction and Disordered Eating Attitudes: An Exploratory Analysis International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214177 Authors: Aparicio-Martinez Perea-Moreno Martinez-Jimenez Redel-Macías Pagliari Vaquero-Abellan Disordered eating attitudes are rapidly increasing, especially among young women in their twenties. These disordered behaviours result from the interaction...
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IJERPH, Vol. 16, Pages 4175: Are Karst Rocky Desertification Areas Affected by Increasing Human Activity in Southern China? An Empirical Analysis from Nighttime Light Data International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214175 Authors: Shi Yang Li Due to remarkable socioeconomic development, an increasing number of karst rocky desertification areas have been severely affected by human activities in southern China. Effectively analyzing...
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IJERPH, Vol. 16, Pages 4174: Perceptions of Mental Health and Wellbeing Following Residential Displacement and Damage from the 2018 St. John River Flood International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214174 Authors: Julia Woodhall-Melnik Caitlin Grogan Climate change has spurred an increase in the prevalence and severity of natural disasters. Damage from natural disasters can lead to residential instability, which negatively impacts mental health...
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IJERPH, Vol. 16, Pages 4172: Effect of Ambient Oxygen Content, Safety Shoe Type, and Lifting Frequency on Subject’s MAWL and Physiological Responses International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214172 Authors: Atef M. Ghaleb Mohamed Z. Ramadan Ahmed Badwelan Khalid Saad Aljaloud Objective: The purpose of this study was to evaluate the lifting capabilities of individuals in hypoxia when they wear different types of safety shoes and to...
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IJERPH, Vol. 16, Pages 4173: Assessment of Anxiety and Depression in Polish Primary Parental Caregivers of Children with Cerebral Palsy Compared to a Control Group, as well as Identification of Selected Predictors International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214173 Authors: Barbara Gugała Beata Penar-Zadarko Danuta Pięciak-Kotlarz Katarzyna Wardak Aneta Lewicka-Chomont Magdalena Futyma-Ziaja Józef Opara Background: Taking care...
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IJERPH, Vol. 16, Pages 4171: Food Security and Obesity among Mexican Agricultural Migrant Workers International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214171 Authors: José Castañeda Graciela Caire-Juvera Sergio Sandoval Pedro Alejandro Castañeda Alma Delia Contreras Gloria Elena Portillo María Isabel Ortega-Vélez Mexican migrant farm workers are one of the poorest and most marginalized social groups within the country. They face the...
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IJERPH, Vol. 16, Pages 4170: An Increased Risk of Stunting among Newborns in Poorer Rural Settings: A Cross-Sectional Pilot Study among Pregnant Women at Selected Sites in Rural Cambodia International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214170 Authors: Margit Steinholt Sam Ol Ha Chandy Houy Jon Øyvind Odland Maria Lisa Odland We conducted an observational study of 194 pregnant women from two different study sites in rural Cambodia. Socioeconomic...
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IJERPH, Vol. 16, Pages 4168: Regarding the Yin and Yang of Precision Cancer- Screening and Treatment: Are We Creating a Neglected Majority? International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16214168 Authors: Colleen M. McBride Yue Guan Jennifer L. Hay In this commentary, we submit that the current emphasis of precision cancer screening and treatment (PCST) has been to provide and interpret the implications of “positive” screening...
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The website used Suffolk's links to Ed Sheeran and Harry Potter in a bid to dupe people.
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A man who has fathered up to 110 children says it is impossible for sperm donors to be anonymous.
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A grandmother, 72, says social services gave her no option but to take in a relative's six children.
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Abstract Purpose To investigate changes in bone mineral density (BMD) following denosumab after previous bisphosphonate therapy and the impact of chronic kidney disease (CKD) on response. Methods A retrospective study of 134 patients (11 M, 123 F) aged [mean (SD)] 72 [11] years on denosumab was undertaken. Ninety-five patients had previously been on oral...
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A new vaccine is the first that prevents people with a dormant tuberculosis infection from developing active disease
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I have this vision of how travel will be done in the future based on this idea: Take a pair of entangled electrons X and Y and let X fall into a large mass (the sun). While Y rests in place, it should grow in mass as X descends towards the sun. The increase in mass would be due to the increase in the velocity of X. The faster X goes the heavier both X and Y would get. I think this would solve a few problems in the current understanding of the early universe and how complexity would emerge from the...
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Abstract Mealybugs (Hemiptera, Coccomorpha: Pseudococcidae) are plant sap-sucking insects which require close association with nutritional microorganisms for their proper development and reproduction. Here, we present the results of histological, ultrastructural, and molecular analyses of symbiotic systems of six mealybugs belonging to the Phenacoccinae subfamily: Phenacoccus aceris, Rhodania porifera, Coccura comari, Mirococcus clarus, Peliococcus calluneti, and Ceroputo pilosellae....
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Abstract Earwigs (Dermaptera) use different strategies to increase their reproductive success. Most species lay eggs; however, viviparity of the matrotrophic type has been reported in two groups: Hemimeridae and Arixeniidae. In Arixeniidae, offspring develop in two separate places: inside an ovary (the intraovarian phase) and within a uterus (the intrauterine phase). Both morphological and physiological aspects of viviparity in Arixeniidae have begun to be unraveled only recently....
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Abstract It is widely accepted that allelopathy among mosses and lichens do exist due to its similar ecological needs, though it is rarely documented. With an aim to test whether there is an effect of allelochemicals to mosses, we grow axenically two moss species (namely Physcomitrella patens and Pohlia drummondii) in controlled conditions and use them to test the effect of lichen Pseudevernia furfuracea acetone extracts containing active compounds: atranorin, chloratranorin,...
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Abstract Spermatogenesis and spermatozoa ultrastructure of the amphibian leech Batracobdella algira Moquin-Tandon, 1846 (Hirudinida: Glossiphoniidae) have been investigated by means of electron and fluorescent microscopy. In B. algira, there are seven pairs of testisacs (testes) that are located latero-ventrally throughout the body. Each testis contains numerous cysts with developing germ cells. The germ cells in a given cyst are in the same developmental stage (i.e., there are...
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Abstract Indium sulfide thin films were prepared by chemical bath deposition method on glass substrates for about 40 min as deposition time and 60 °C as deposition temperature. The films were post-annealed at different temperatures such as 100 °C, 200 °C, 300 °C and 400 °C, for about 1 h. Structural and optical properties of In2S3 thin films after post-annealing process have been investigated. The crystallinity and nanostructures of the films were studied by using X-ray diffraction,...
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Abstract The higher order of nonlinear partial differential equations in mathematical physics is studied. We used the analytical mathematical methods of the nonlinear (3+1)-dimensional extended Zakharov–Kuznetsov dynamical, modified KdV–Zakharov–Kuznetsov and generalized shallow water wave equations to demonstrate the efficiency and validity of the proposed powerful technique. The shallow water wave models have been applied in tidal waves and weather simulation. Exact wave...
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Contributor : Wang shouhuaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe hypothesized that the circRNA will play an important role in the progresion of gallbladder cancer. To test this hypothesis, we collect the gallbladder cancer and matched normal tissue from 4 different patients and examined the circRNA expression in these 8 sampels through next generation sequencing.
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Contributors : Chenggang Wang ; Xiaoen Huang ; Yanping Zhang ; Jian L Li ; Zhonglin MouSeries Type : Expression profiling by arrayOrganism : Arabidopsis thalianaThe goal of the microarray was to compare the bacterial pathogen Pseudomonas syringae pv. maculicola ES4326 (Psm)-induced transcriptome changes in the systemic leaves of the wild-type Col-0, lecrk-VI.2-2, and bak1-5 plants. Results showed that local Psm inoculation induced dramatic transcriptional changes in Col-0, with 564 and 151 genes...
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Contributors : Antoinette F van Ouwerkerk ; Vincent M ChristoffelsSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensExpression analysis of whole tissue and cardiomyocytes of fetal and adult atrial free wall
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Contributors : Nathan P Palmer ; I S Kohane ; Jocelyn A SilvesterSeries Type : Expression profiling by arrayOrganism : Homo sapiensPresenting features of inflammatory bowel disease (IBD) are non-specific. We hypothesized that mRNA profiles could (1) identify genes and pathways involved in disease pathogenesis; (2) identify a molecular signature that differentiates IBD from other conditions; (3) provide insight into systemic and colon-specific dysregulation through study of the concordance of the...
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Contributors : Ji Wu ; Jian Wang ; Zhuxia ZhengSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculuswe employed RNA-Seq to examine transcriptome profiles of male and female mouse gonads at 12.5dpc, 13.5dpc, 16.5dpc and 6dpp.Methods: Gonadal mRNA profiles of 12.5dpc,13.5dpc, 16.5dpc and 6dpp mice were generated by deep sequencing, in triplicate, using Illumina Hiseq 2500. The cDNA library was constructed with a SMARTer® Ultra Low Input RNA for lllumina® Sequencing...
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Contributors : Reka Toth ; Heiko Schiffmann ; Claudia Hube-Magg ; Franziska Büscheck ; Doris Höflmayer ; Sören Weidemann ; Patrick Lebok ; Christoph Fraune ; Sarah Minner ; Guido Sauter ; Christoph Plass ; Yassen Assenov ; Ronald Simon ; Jan Meiners ; Clarissa GerhäuserSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensThe clinical course of prostate cancer (PCa) is highly variable, demanding an individualized approach to therapy and robust prognostic...
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Contributors : Shuqin Zeng ; Jochen Bick ; Susanne E Ulbrich ; Stefan BauersachsSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofathe aim of this present study was to characterize the complex transcriptome changes in different endometrial cell types during the preimplantation period for improving our understanding of localization of endometrial gene expression regulation in context of recognition of pregnancy. To do this analysis in a transcriptome-wide manner,...
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Contributors : Craig T Werner ; Jennifer A Martin ; Andrew F Stewart ; Ian Maze ; David M DietzSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Rattus norvegicusNeuroadaptations in the nucleus accumbens (NAc) underlie cue-induced cocaine craving that intensifies (“incubates”) during withdrawal and contributes to persistent relapse vulnerability. Long-lasting gene changes govern perpetual behavioral abnormalities but the role of epigenetic plasticity in cocaine...
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Contributors : Seon-Kyu Kim ; Jeong-Hwan Kim ; Jin-Cheon Kim ; Seon-Young Kim ; Young-Sung KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe objective of this study is to identify a gene set to predict recurrence of colorectal cancer (CRC) patients. We generated RNA-seq data of 110 primary CRC samples and identified significant genes associated with recurrence of CRC. Through diverse statistical methods including generalized linear model likelihood...
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Contributor : S H YuebenSeries Type : OtherOrganism : Homo sapiensTo investigate the role of METTL3-mediated m6A modification, we performed m6A-sequencing to map the m6A modification in control or METTL3 knockdown BGC823 cells.
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Contributors : Wen Ni ; Su Yao ; Jianming LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAnalysis of RNA-seq-based differential expression after overexpression of GAS5 or knockdown of YAP revealed a highly significant overlap of common targets.
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Contributors : Kun Qiao ; Da PangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn the present study, Linc00673 displayed high expression in breast cancer tissues and was associated with poor prognosis of breast cancer patients. Importantly, Linc00673 depletion inhibited breast cancer cell proliferation by impairing cell cycle progression and apoptosis. Mechanically, RNA sequencing was performed to investigate the potential crosstalk between Linc00673 and...
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Contributor : Guruprasad MedigeshiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo identify the molecular pathways that are perturbed due to transient zinc chelationZinc is known to regulate the functions of about 10% of the human proteome and a large number of physiological processes that are zinc dependent have been identified and characterized under conditions of zinc deficiency and supplementation. As zinc homeostasis is closely linked to the normal functioning...
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Contributors : Dayle Johnston ; Bernadette Earley ; Matthew S McCabe ; Gordon Blackshields ; Kenneth Lemon ; Catherine Duffy ; Michael McMenamy ; S L Cosby ; JaeWoo Kim ; Jeremy F Taylor ; Sinead M WatersSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurusBovine respiratory disease (BRD) is the leading cause of morbidity and mortality in calves over one month of age. In a controlled challenge study in artificially-reared dairy calves, the influence of the host...
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Contributors : Wen Ni ; Su Yao ; Jianming LiSeries Type : OtherOrganism : Homo sapiensWe performed methylated RNA immunoprecipitation followed by sequencing (MeRIP–seq) combined with transcription sequencing to clarify the mechanism underlined YTHDF3 in CRC
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Contributors : Wen Ni ; Su YaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe analysis of the RNA-binding protein immunoprecipitation sequencing (RIP-seq) experiment is performed to identified YAP-specific binding lncRNAs.
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Contributors : Anna Sintsova ; Arwen Frick-Cheng ; Sara Smith ; Ali Pirani ; Evan Snitkin ; Harry MobleySeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coliUropathogenic Escherichia coli (UPEC) is the major causative agent of uncomplicated urinary tract infections (UTIs). A common virulence genotype of UPEC strains responsible for UTIs is yet to be defined, due to the large variation of virulence factors observed in UPEC strains. We hypothesized that studying...
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Contributors : Yoshihide Matsumoto ; Yuki Nakanishi ; Akihisa Fukuda ; Hiroshi SenoSeries Type : Expression profiling by arrayOrganism : Mus musculusThe EP4 receptor is known to mediate the protective effect of prostaglandin (PG) E2 in the gastrointestinal tract; however, the exact role of epithelial EP4 in intestinal pathophysiology remains unknown. We investigated the role of epithelial EP4 in maintaining colonic homeostasis by characterizing the intestinal epithelial cell-specific EP4 knockout...
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Contributors : Guohong Hu ; Min CongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe conduct transcriptome comparison of control and Mtss1-overexpressed Py8119 cells to gain genomic insights on the biological processes that Mtss1 is involved in breast cancer cells. Through unsupervised cluster analysis of differentially expressed genes (DEGs), we found 1661 genes were significantly changed in Mtss1 cells. Single Site Analysis and Gene Set Enrichment Analysis...
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Contributors : Yue-Hua Jiang ; Ling-Yu Jiang ; Xiao LiSeries Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Homo sapiensWe have employed transcriptome microarray expression profiling as a discovery platform to figure out the pharmacological mechanisms of quercetin against endothelial senescence induced by ox-LDL in vitro. Expression of RCHY1, EIF4E1B, IGFBP3, SERPINE1, BRAF, SLC5A11 from this signature was quantified in the same kind of samples by real-time...
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Contributors : Markus Germann ; Nadine Zangger ; Freddy RadtkeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHigh T cell infiltration in colorectal cancer (CRC) correlates with a better disease outcome and immunotherapy response. This is observed in only a small subset of CRC patients. A better understanding of the factors influencing tumor T cell responses in CRC could inspire novel therapeutic approaches to achieve broader immunotherapy responsiveness....
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