Traditional folks in different parts of the world use Rumex crispus L. for the treatment of microbial infections, malaria, and sleeping sickness in the form of decoction or tincture. In the search for a natural alternative remedy, this study aimed to evaluate the antimicrobial, antitrypanosomal, and antiplasmodial efficacy and the toxicity of R. crispus extracts. Antimicrobial potency of the extracts was evaluated using the agar dilution method to determine the minimum inhibitory concentration (MIC)....
07:05
The hypoglycemic decoction (HD) is a traditional Chinese medicine (TCM) preparation for the treatment of diabetes mellitus (DM), with a remarkable therapeutic effect. However, its mechanism of action is still unclear at the metabolic level. In this study, the biochemical markers from type 2 DM (T2DM) rats, induced by a high-sugar and high-fat diet combined with streptozotocin (STZ), were detected. The metabolomics-based analysis using high-performance liquid chromatography coupled with tandem mass...
07:05
Objective. Postincision pain often occurs after surgery and is an emergency to be treated in clinic. Electroacupuncture (EA) is a Chinese traditional treatment widely used to cure acute or chronic pain, but its mechanism is not clear. Interleukin-10 (IL-10) is a powerful anti-inflammatory cytokine that shows neuroprotective effects in inflammation and injury in the CNS. The present study attempts to reveal that IL-10 is crucial for EA analgesia on postincision pain. Methods. A model of incision pain...
05:05
WALTHAM, Mass.--(BUSINESS WIRE)--Deciphera Pharmaceuticals, Inc. (Nasdaq:DCPH), a clinical-stage biopharmaceutical company addressing key mechanisms of tumor drug resistance, today announced the presentation of updated results from its ongoing Phase 1 study of ripretinib, a broad-spectrum KIT and PDGFRα inhibitor, in patients with second-line through fourth-line plus GIST, as well as its Phase 1 study of DCC-3014, an oral inhibitor of CSF1R, in patients with advanced solid tumors. The data are
Tue Oct 29, 2019 18:30
Abstract Objectives The lymphocyte‐to‐monocyte ratio (LMR) reflects the status of tumor‐infiltrating immune cells and host immunity. The LMR has been reported as a prognostic marker in various cancers. The present study evaluated the role of the LMR as a prognostic marker in patients with progressive radioiodine‐refractory (RAIR) differentiated thyroid carcinoma (DTC). Design Retrospective cohort study Patients Forty patients with progressive RAIR DTC who were treated by sorafenib...
Tue Oct 29, 2019 20:22
Radio-frequency identification (RFID) tag anticollision algorithm is a key technology that affects the performance of RFID systems. In dynamic arrival scenarios, when the tags arrive the reader’s interrogation zone, they cannot participate in the ongoing identification immediately, resulting in longer waiting time and tag miss. Focusing on solving this problem, based on blocking technology, dynamic frame-slotted ALOHA (DFSA) algorithm, and the first-come-first-serve (FCFS) idea, a fast RFID tag anticollision...
08:05
The electrochemical oxidation of the Rhodamine B dye (Rh-B) was carried out using dimensionally stable type anode (DSA, Ti/Ru0.3Ti0.7O2). The work was performed using the electrochemical flow cell system. The effect of several operating factors, such as supporting electrolytes, current density, electrolysis time, temperature, and initial concentration of Rh-B dye, were investigated. The UV-visible spectroscopy and chemical oxygen demand (COD) measurements were conducted to monitor the removal and...
08:05
The 8-bit RGB image of a cracked concrete surface, obtained with a high-resolution camera based on a close-distance photographing and using an optical microscope, is used to estimate the geometrical parameters of the crack. The parameters such as the crack’s width, depth, and morphology can be determined by the pixel intensity distribution of the image. For the estimation, the image is transformed into 16-bit gray scale to enhance the geometrical parameters of the crack and then a mathematical relationship...
08:05
In this paper, a practical PI-PD controller parameter tuning method is proposed, which uses the incenter of the triangle and the Fermat point of the convex polygon to optimize the PI-PD controller. Combined with the stability boundary locus method, the PI-PD controller parameters that can ensure stability for the unstable fractional-order system with time delay are obtained. Firstly, the parameters of the inner-loop PD controller are determined by the centre coordinates of the CSR in the plane....
08:05
The Chinese currency, RMB, is developing as an international currency. Therefore, the effective strategy for trading RMB exchange rates would be attractive to international investors and policymakers. In this paper, we have constructed hybrid EMD-MLP models to forecast RMB exchange rates and developed a trading strategy based on these models. Empirical results show that the proposed hybrid EMD-MLP model always performs best based on both NMSE and criteria when the forecasting period is greater than...
08:05
The complicated interaction patterns among heterogeneous individuals have a profound impact on the contagion process in the networks. In recent years, there has been increasing evidence for the emergence of many-body interactions between two or more nodes in a wide range of biological and social networks. To encode these multinode interactions explicitly, the simplicial complex is now a popular alternative to simple networks. Meanwhile, the time-varying network has been acknowledged as a key ingredient...
08:05
Background. HIV-associated neurocognitive disorders (HAND) represent a spectrum of cognitive abnormalities affecting attention, concentration, learning, memory, executive function, psychomotor speed, and/or dexterity. Our objectives in this analysis are to determine the prevalence of HAND and the covariates in a Kenyan population. Methods. We conducted a cross-sectional study in a convenient sample of people living with HIV on antiretroviral therapy (ART) attending routine care visits at the Kenyatta...
07:05
This paper proposes a novel PV-Trombe wall system combined with phase-change material, which is named as PV-PCM-Trombe system. The work mainly experimentally studies the effectiveness and characteristics of using phase change materials to improve the overheating problem of PV-Trombe wall in summer. Through experiments, the photoelectric performance of the system using phase-change board surfaces with and without a matte black paint lacquer are compared; moreover, the influence on thermal environment...
07:05
MicroRNAs (miRNAs) influence stem cell functions, including mobilization, proliferation, and differentiation. miR-150 is abundantly expressed in monocytes. Knockdown of miR-150 promotes bone marrow stem cell migration. The role of miR-150 in adipose-derived stem cells (ADSCs) is unclear. In this study, the effects of miR-150 on adipogenic differentiation and proliferation of ADSCs were investigated. ADSCs were isolated from the inguinal adipose tissue of wild-type (WT) and miR-150 knockout (KO) mice...
07:05
Seasonal Variations of Phosphorus Species in the Overlying and Pore Waters of the Tuohe River, China
Overlying sediment and pore waters were collected in summer and winter at upstream (Jintang) and downstream (Neijiang) sites of the Tuohe River, which is one of the five largest tributaries of the Yangtze River in China. Phosphorus species, including soluble reactive phosphorus (SRP), soluble unreactive phosphorus (SUP), and total dissolved phosphorus (TDP), and some diagenetic constituents including dissolved Fe(II), Mn(II), and sulfide in overlying and pore waters, were measured systematically....
07:05
Spatial joints with end-plate connections show significant spatial coupling effects under spatial loading. Mechanical behaviour and failure modes of these spatial joints differ from those of planar joints. This study involved experiments and finite element analyses with respect to planar joints with end-plate connections under static load. The numerical results agreed well with the experimental data, and this verified the adequacy of the finite element analyses. Then, finite element models of the...
07:05
The effectiveness of load transfer in the CFRP-adhesive-concrete system highly relies on the integrity of the interfacial bond between adhesive layer and concrete. In the present paper, the effects of water immersion on the mode I fracture energy of the adhesion between CFRP adhesive and concrete were investigated experimentally and numerically. Four-point bending test was conducted to measure the mode I fracture energy of the interfacial layer between adhesive and concrete. The moisture content...
07:05
Improper execution of modern code-designed structures in many developing countries have resulted in significant deficient building stock; low strength of concrete, reduced reinforcement, inappropriate detailing of beam-column members, and lack of lateral ties in joint panels. Observations based on earthquake-induced damages and experimental studies conducted on such buildings have revealed significant vulnerability of beam-column joints of bare moment-resisting frame structures. Shake table tests...
07:05
Background and Purpose. The thrombin-activatable fibrinolysis inhibitor (TAFI) is an important inhibitor of fibrinolysis and plays a critical role in the pathogenesis of arterial thrombosis; genetic polymorphisms of the TAFI gene affect its activity and increase the risk of thrombosis. Moreover, studies in young patients are still scarce. The aim was to examine the contribution of the Thr325Ile and Ala147Thr polymorphisms with ST acute myocardial infarction (STEMI) or idiopathic ischemic stroke (IIS)...
07:05
Pressure injury (PI) affects quality of life and results in economic and social burdens. Local transplantation of human adipose-derived stem cells (ASCs) is considered an effective treatment. However, ASC suspension alone is vulnerable to the immune system and results in a shortened cell survival. There is increasing evidence of a synergistic effect of platelet-rich plasma (PRP) combined with ASCs on wound healing. This study investigated the effectiveness, synergy, and mechanism of wound healing...
06:05
In the rock cutting process, conical pick wear is often encountered. In order to restrain this condition, a saw blades and conical pick combined cutting method was put forward. Saw blades were employed to slit the rock for increasing the free surface, and then the conical pick was used to break the rock. To research the cutting performance of the new cutting method, the corresponding experimental device and a three-dimensional finite element model are established. In order to obtain crack propagation...
06:05
In this paper, by means of the Hirota bilinear method, a dimensionally reduced nonlinear evolution equation is investigated. Through its bilinear form, lump solutions are obtained. We construct interaction solutions between lump solutions and one soliton solution by choosing quadratic functions and exponential function. Interaction solutions with the combinations of exponential functions and sine function are also given. Meanwhile, the figures of these solutions are plotted. The dynamical characteristics...
06:05
Action observation therapy has recently attracted increasing attention; however, the mechanisms through which action observation and execution (AOE) modulate neural activity in stroke patients remain unclear. This study was aimed at investigating the effects of action observation and two types of AOE on motor cortical activations after stroke using magnetoencephalography. Twenty patients with stroke and 20 healthy controls were recruited for the collection of data on the beta oscillatory activity...
05:05
Purpose. Ivabradine has emerged as a new antiarrhythmic agent that could compete with the traditional ones, such as beta-blockers. This experimental study aims to ascertain whether ivabradine directly interferes with the myocardial contractility in an in vitro environment. Methods. Myocardial tissues from the right atrial appendages of patients undergoing cardiac surgery were dissected to obtain 40 specimens from 20 patients (length: 3 mm), which were exposed to electrical impulses at a frequency...
05:05
Through bringing nutrient-rich subsurface water to the surface, the artificial upwelling technology is applied to increase the primary marine productivity which could be assessed by Chlorophyll a concentration. Chlorophyll a concentration may vary with different water physical properties. Therefore, it is necessary to study the relationship between Chlorophyll a concentration and other water physical parameters. To ensure the accuracy of predicting the concentration of Chlorophyll a, we develop several...
05:05
The aim of this study was to assess the oxidative stress status in eyes affected by synchysis scintillans and to compare it to vitreoretinal disorders without synchysis scintillans. Human aqueous and vitreous humors were obtained during vitrectomy from thirty-seven otherwise healthy patients that were randomly chosen among patients that had to undergo a 25-gauge pars plana vitrectomy from the central vitreous cavity, for either synchysis scintillans (n = 16) or vitreoretinal disorders without synchysis...
05:05
Aim. Type 2 diabetes increases the risk of cognitive decline which adversely impacts self-management of the disease. Evidence also supports a relationship between low serum 25(OH)D levels and poor cognition. The purpose of this trial was to assess vitamin D supplementation on cognitive executive functioning in persons living with type 2 diabetes. Methods. This was a double-blinded RCT where participants were randomized to receive either weekly vitamin D3 supplementation (50,000 IUs) or a matching...
05:05
The deposition of palladium nanoparticles (PdNPs) on the surface of n-Si (100) substrate by pulsed electrolysis in dimethyl sulfoxide (DMSO) solutions of Pd(NO3)2 was investigated. It has been shown that nonaqueous medium (DMSO) contributes the Pd (II) recovery at high cathode potential values avoiding side processes to occur. In combination with the pulse mode, this allows the deposition of spherical PdNPs with their uniform distribution on the silicon surface. We established that the main factors...
05:05
The aim of this study was to analyze the influence mechanism of aeolian sand on the mechanical property of concrete and establish the time-varying compressive strength model. Test studies on the development of concrete’s compressive strength with aeolian sand from the Mu Us Desert were carried out. Influence mechanism of aeolian sand on the strength of concrete was revealed by using the nuclear magnetic resonance (NMR) to analyze the pore ratio and structures of aeolian sand concrete (ASC) and using...
05:05
Spacer bars in the smart reversible lanes make periodically broadcast of messages to share their local observed traffic information with each other. This aims to help other spacer bars acquire the global traffic information and make consistent movement when separating the flows. However, radio interference and vehicles in the traffic may degrade the qualities of wireless communication links and cause frequent message losses in the broadcast. Existing solutions tend to use data forwarding to enhance...
05:05
In this study, an applicable and effective method, which is based on a least-squares residual power series method (LSRPSM), is proposed to solve the time-fractional differential equations. The least-squares residual power series method combines the residual power series method with the least-squares method. These calculations depend on the sense of Caputo. Firstly, using the classic residual power series method, the analytical solution can be solved. Secondly, the concept of fractional Wronskian...
05:05
Inhalation of diesel exhaust particulate (DEP) causes oxidative stress-induced lung inflammation. This study investigated the protective effects of TF-343, an antioxidant and anti-inflammatory agent, in mouse and cellular models of DEP-induced lung inflammation as well as the underlying molecular mechanisms. Mice were intratracheally instilled with DEP or vehicle (0.05% Tween 80 in saline). TF-343 was orally administered for 3 weeks. Cell counts and histological analysis of lung tissue showed that...
04:05
Purpose. To evaluate the efficacy of phakic posterior chamber intraocular lens with a central hole (ICL V4c) in treating patients with moderate to high myopia. Methods. PubMed, Embase, Cochrane Library, Clinical Trial, China Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), and China Science Periodical Database (CSPD) were searched online. The search included publications from the building of the library until December 2018. All randomized controlled trials containing...
04:05
Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent kidney malignancies. The tumor microenvironment (TME) is highly related to the oncogenesis, progress, and prognosis of ccRCC. The aim of this study was to infer the level of infiltrating stromal and immune cells and assess the prognostic value of them. The gene expression profile was obtained from TCGA and used for calculating the stromal and immune scores. Based on a cut-off value, patients were divided into low- and high-stromal/immune...
04:05
In recent years, the damaging effects of antimicrobial resistance relating to wound management and infections have driven the ongoing development of composite wound dressing mats containing natural compounds, such as plant extracts and their derivatives. The present research reports the fabrication of novel electrospun Polycaprolactone (PCL)/Polyvinyl Alcohol (PVA)/Chitosan (CS) fiber mats loaded with Eugenol (EUG), an essential oil, known for its therapeutic properties. The electrospun fiber mats...
02:05
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