Publication date: Available online 28 October 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Annalisa Ferino, Valentina Rapozzi, Luigi E. XodoAbstractIn highly proliferating cancer cells oncogenic mutations reprogram the metabolism and increase the production of reactive oxygen species (ROS). Cancer cells prevent ROS accumulation by upregulating antioxidant systems. Here we show that an increase of oxidative stress (ROS and singlet oxygen), generated by photoactivated...
Tue Oct 29, 2019 19:35
Publication date: Available online 28 October 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): J. Rajkumari, C. Maria Magdalane, B. Siddhardha, J. Madhavan, G. Ramalingam, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, A.K.M. Ghilan, V. Duraipandiayan, K. KaviyarasuAbstractTitanium dioxide nanoparticles (TiO2-NPs) were synthesized using the aqueous leaf extract of Aloe barbadensis as a reducing and fabricating agent. The biosynthesis of the TiO2-NPs was initially confirmed...
Tue Oct 29, 2019 19:35
In this report, using the solvothermal decomposition of Gadolinium (III) in the presence of Na3cit, monitored by surface modification with PEG and L-Cys. The synthesized nanoparticles were confirmed by the TEM, DLS and UV–Visible spectroscopy. The morphological results show normal distance across of the flawless Gd2O3-PEG-Cys-NPs show 7.9 ± 0.4 nm, discretely, with a thin size exchange. This infers the surface adjustment does not obviously alteration the center size of the Gd2O3-NPs when contrasted...
Tue Oct 29, 2019 19:35
Publication date: November 2019Source: Lingua, Volume 231Author(s): (Source: Lingua)
Mon Oct 28, 2019 00:14
Conclusions The evidence for verb treatments is predominantly of a low level. There are encouraging findings in terms of treatments being replicable; however, this is tempered by poor monitoring of treatment fidelity. The quality of verb treatment research would be improved by researchers reaching consensus regarding outcome measures (including generalization to, e.g., sentences and discourse) by manualizing treatment to facilitate implementation and exploring the opinions of participants. Finally,...
Thu Oct 24, 2019 00:00
Authors: Plante E PMID: 31653411 [PubMed - as supplied by publisher] (Source: Journal of Communication Disorders)
Thu Oct 17, 2019 00:00
Publication date: Available online 28 October 2019Source: Journal of Theoretical BiologyAuthor(s): Alberto Giaretta, Gianna Maria Toffolo, Timothy C. ElstonAbstractHigh risk forms of human papillomaviruses (HPVs) promote cancerous lesions and are implicated in almost all cervical cancer. Of particular relevance to cancer progression is regulation of the early promoter that controls gene expression in the initial phases of infection and can eventually lead to pre-cancer progression. Our goal was to...
Tue Oct 29, 2019 20:41
Publication date: Available online 29 October 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Gunjan Vasant Bonde, Gufran Ajmal, Sarita Kumari Yadav, Pooja Mittal, Juhi Singh, Bharati V. Bakde, Brahmeshwar MishraABSTRACTNanocolloids are considered ideal carriers for hydrophobic drugs owing to their core–shell structure. Lapatinib is a potential anti-cancer agent, but its clinical use is limited because of its poor aqueous solubility, thus requiring larger oral doses with the associated...
Tue Oct 29, 2019 20:35
ConclusionsOur quantitative approach provides a feasible clarification for the proliferation-to-invasion transition of in vitro tumor models (spheroids). Moreover, the transition time is a useful reference for the invasive potential of tumor cells.General significanceThis quantitative approach is potentially applicable to primary tumor cells, and thus has potential applications in the fields of cancer metastasis investigations and clinical diagnostics. (Source: Biochimica et Biophysica Acta (BBA)...
Tue Oct 29, 2019 20:35
Publication date: Available online 28 October 2019Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Dorota MatyszewskaAbstractThe interactions of two selected anthracyclines, daunorubicin (DNR) and idarubicin (IDA), with phospholipid monolayers used as simple models of cell membranes, were investigated. The results of Langmuir experiments together with Brewster angle microscopy showed that both drugs strongly affect cancer cell membranes composed of 1,2-dimyristoyl-sn-glycero-3-phospho-l-serine...
Tue Oct 29, 2019 20:35
Publication date: Available online 28 October 2019Source: Microchemical JournalAuthor(s): Xingzong Jiang, Zhen Lu, Mingqin Shangguan, Sili Yi, Xiaoyang Zeng, Yongle Zhang, Linxi HouAbstractHydrazine (N2H4) has been classified as an environmental contaminant and human carcinogen owing to its high toxicity. Being exposed to high levels of hydrazine can cause irreversible damage to human bodies. Hence, it is significant to explore an effective method to selectively recognize and detect it. In this work,...
Tue Oct 29, 2019 20:15
CONCLUSION: This model may enhance early-stage HCC detection and help to overcome insufficient sensitivity of AFP. PMID: 31648804 [PubMed - as supplied by publisher] (Source: Annals of Hepatology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Oct 29, 2019 20:15
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01977D, PaperXiang Zhou, Lingyu Wu, Min Pan, Yuqi Chen, Haiyan Huang, Xiaoe Zhang, Fuan Wang Benefit from high sequence specificity and structural simplicity of DNAzyme, a series of DNAzyme logic gates are rationally designed by using microRNAs as inputs. Through the introduction of a duplex... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Tue Oct 29, 2019 20:14
Publication date: Available online 29 October 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): Derik E. Haggard, Woodrow Setzer, Richard Judson, Katie Paul FriedmanAbstractSynthesis of 11 steroid hormones in human adrenocortical carcinoma cells (H295R) was measured in a high-throughput steroidogenesis assay (HT-H295R) for 656 chemicals in concentration-response as part of the US Environmental Protection Agency's ToxCast program. This work extends previous analysis of the HT-H295R dataset...
Tue Oct 29, 2019 20:08
CONCLUSIONS: DMFT, DMFS, Plaque and oral hygiene indices and S.mutans values were found significantly different in β-TM patients than healthy, control group patients, in this study. PMID: 31655829 [PubMed - as supplied by publisher] (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Tue Oct 29, 2019 19:54
CONCLUSIONS: It cannot be guaranteed that the use of mouthwash represents an independent risk factor for the development of head and neck cancer. However, the risk does increase when it occurs in association with other carcinogenic risk factors. PMID: 31655832 [PubMed - as supplied by publisher] (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Tue Oct 29, 2019 19:54
Authors: van der Waal I Abstract There is a distinct lack of uniformity in the definitions and clinical terminologies related to oral leukoplakia and leukoplakialike lesions and disorders. Proposals have been put forward to subclassify leukoplakia into a homogeneous and a non-homogeneous type based on color only, being either predominantly white or mixed whiteand-red, respectively, irrespective of the texture of the lesion. In this proposal there is no need anymore to regard the poorly...
Tue Oct 29, 2019 19:54
CONCLUSIONS: Socioeconomic factors may be related to the advanced clinical stage of oral cancer. PMID: 31655836 [PubMed - as supplied by publisher] (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Tue Oct 29, 2019 19:54
Barakat syndrome is an autosomal dominant rare genetic disease caused by haploinsufficiency of the GATA binding protein 3 (GATA3) gene. It is also known as HDR syndrome, and is characterized by varying degrees of... (Source: BMC Endocrine Disorders)
Mon Oct 28, 2019 01:00
Publication date: Available online 29 October 2019Source: Genes & DiseasesAuthor(s): Kuei-Ling Tung, Kai-Yuan Chen, Marcos Negrete, Tianyi Chen, Alexias Safi, Abed Alhalim Aljamal, Lingyun Song, Gregory E. Crawford, Shengli Ding, David S. Hsu, Xiling ShenAbstractColorectal cancer is a leading cause of cancer deaths. Most colorectal cancer patients eventually develop chemoresistance to the current standard-of-care therapies. Here, we used patient-derived colorectal cancer organoids to demonstrate...
Tue Oct 29, 2019 19:12
Publication date: Available online 28 October 2019Source: European UrologyAuthor(s): Aditya Bagrodia, Phillip Pierorazio, Nirmish Singla, Peter Albers (Source: European Urology)
Tue Oct 29, 2019 19:02
CONCLUSION: When neurological symptoms occur in patients receiving chemotherapy for gastrointestinal cancer, the measurement of thiamine serum levels may become a standard reference for treatment indication. PMID: 31657715 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Tue Oct 29, 2019 18:58
Conditions: Locally Advanced Cancer; Metastatic Cancer; Chronic Respiratory Failure; Chronic Heart Failure; Chronic Liver Failure; Chronic Renal Failure Intervention: Other: Screening for PC by means of two different screening tools Sponsor: Azienda Ospedaliera Città della Salute e della Scienza di Torino Completed (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Oct 29, 2019 17:00
Condition: Neuroendocrine Tumors Intervention: Drug: Octreotide Acetate Sponsor: National Cancer Institute, Naples Active, not recruiting (Source: ClinicalTrials.gov)
Wed Oct 16, 2019 18:00
Conditions: Eosinophilia; Angioedema Intervention: Biological: Nucala (mepolizumab) Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
Wed Oct 16, 2019 18:00
BACKGROUND: The incidence of fear of falling (FOF) is high among people with cancer. However, factors that are associated with FOF in people with cancer has not yet been investigated. Therefore, the objective of this study was to identify the associated fa... (Source: SafetyLit)
Tue Oct 29, 2019 18:41
ConclusionsOur study suggests that in cancer patients undergoing chemotherapy, leukopenia is not associated with morbidity or mortality and should not influence operative planning in either the elective or emergent setting. (Source: The American Journal of Surgery)
Tue Oct 29, 2019 18:17
ConclusionA neuroendocrine neoplasm of the gallbladder may closely resemble a benign paraganglion. If a NET is suspected, the clinician should be aware of the histopathologic mimicry of a paraganglion prior to initiating additional treatments. (Source: International Journal of Surgery Case Reports)
Tue Oct 29, 2019 18:17
ConclusionThis is a rare case of a mesenteric pseudocyst of small size presenting with lifelong abdominal pain secondary to its location near the root of the mesentery and inflammatory reaction secondary to infection. It is important to maintain a high index of suspicion for mesenteric cyst as many complications may result if misdiagnosed or without proper surgical management. (Source: International Journal of Surgery Case Reports)
Tue Oct 29, 2019 18:17
ConclusionComplete surgical resection may improve prognosis and extend survival in patients with this rare and aggressive form of gallbladder cancer. (Source: International Journal of Surgery Case Reports)
Tue Oct 29, 2019 18:17
CONCLUSIONWhen detecting a lytic spinal tumor in a patient who suffers from LS a SPB should be taken under consideration. (Source: International Journal of Surgery Case Reports)
Tue Oct 29, 2019 18:17
ConclusionLaparoscopic splenectomy for solitary splenic metastases seems safe and feasible with short recovery period even in patients with previous open surgery. More research in the area is needed. (Source: International Journal of Surgery Case Reports)
Tue Oct 29, 2019 18:17
ConclusionAs a model animal, rats not only provide a convenient resource for studying human diseases but also provide the possibility for exploring the molecular mechanism of exercise intervention in diseases. This review also aims to provide exercise intervention frameworks and optimal exercise dose recommendations for further human exercise intervention research.Graphical abstract (Source: Journal of Sport and Health Science)
Tue Oct 29, 2019 18:10
In conclusion, the Japanese version of the PEPPI-10 is a useful tool that can empower breast cancer outpatients during the course of their treatment. PMID: 31656242 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Tue Oct 29, 2019 18:00
Condition: Vestibular Disease Intervention: Behavioral: Heading direction adaptation Sponsors: University of Rochester; National Institute on Deafness and Other Communication Disorders (NIDCD) Not yet recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Tue Oct 29, 2019 17:00
Conditions: Hearing Loss, Sudden; Prednisone Acetate; Hyperbaric Oxygen; Somatic Stimulus Intervention: Combination Product: Drugs and Stimulation Sponsor: Dan Su Not yet recruiting (Source: ClinicalTrials.gov)
Thu Oct 17, 2019 18:00
Conditions: Cochlear Implant Surgery; Hearing Loss, Cochlear Intervention: Device: Cochlear Implant Surgery Sponsors: Ann& Robert H Lurie Children's Hospital of Chicago; Med-El Corporation Recruiting (Source: ClinicalTrials.gov)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Thu Oct 17, 2019 18:00
A woman who sued The University of Kansas Health System for a misdiagnosis of pancreatic cancer quietly settled her case last year, apparently for millions. The settlement was confidential, but KCUR reports that a Kansas agency that provides excess insurance coverage for providers paid out $1.8 million. Those excess insurance payments suggest that the overall settlement exceeded several million dollars, KCUR reports. A spokeswoman for the system sa id it would have no comment on the settlement....
Tue Oct 29, 2019 16:34
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