Authors: Bovero A, Gottardo F, Botto R, Tosi C, Selvatico M, Torta R Abstract The concept of a good death is crucial in palliative care, but its relationship with attitudes toward death and feelings of interconnectedness needs to be further deepened. The first aim of this study was to explore the concept of good death, attitudes toward death, and feelings of interconnectedness among family caregivers (FCs) and health-care providers (HCPs) of terminally ill patients with cancer. The second...
Thu Oct 24, 2019 00:00
ConclusionsGTR may provide a better OS even in GBM patients with advanced age. STR still shows a benefit over SB for OS in older patients <75 years. For older individuals, SB presents a safer option with regards to the risk of postoperative morbidity and should be favored in cases, when the surgical alternative is limited to STR. (Source: Journal of Geriatric Oncology)
03:42
ConclusionsMPI score is an effective tool for the stratification of older patients with cancer eligible for immunotherapy with checkpoint inhibitors. Further studies are required to achieve conclusive remarks on MPI usefulness in different underlying tumor types. (Source: Journal of Geriatric Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps...
03:42
As the review in this issue of the Annals makes clear, patients with common variable immunodeficiency (CVID) may exhibit one or more of a multiplicity of autoimmune diatheses involving any body system.1 The association of primary immunodeficiency diseases (PIDD) and autoimmunity is not restricted, however, to CVID.2 Similar associations between immunodeficiency and malignancy have been extensively reported as well.3 Our immunodeficiency patients are not merely subject to an increased incidence of...
03:11
CONCLUSION: In summary, we identified a novel biomarker for early diagnosis in addition to Ultrasound of thyroid cancer, which was subjected to TCF7L1 regulation. PMID: 31656161 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
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(Source: OncoTargets and Therapy)
02:26
(Source: OncoTargets and Therapy)
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(Source: OncoTargets and Therapy)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
02:16
(Source: OncoTargets and Therapy)
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(Source: OncoTargets and Therapy)
02:00
Cancer Gene Therapy, Published online: 30 October 2019; doi:10.1038/s41417-019-0150-6Mechanism and therapeutic prospect of resveratrol combined with TRAIL in the treatment of renal cell carcinoma (Source: Cancer Gene Therapy)
00:00
Dendritic cells (DCs) are key regulators of immune responses that operate at the interface between innate and adaptive immunity, and defects in DC functions contribute to the pathogenesis of a variety of disorders. For instance, cancer evolves in the context of limited DC activity, and some autoimmune diseases are initiated by DC-dependent antigen presentation. Thus, correcting aberrant DC functions stands out as a promising therapeutic paradigm for a variety of diseases, as demonstrated by an abundant...
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Cancer Gene Therapy, Published online: 30 October 2019; doi:10.1038/s41417-019-0148-0Retraction Note: Enhanced suppression of tumor growth using a combination of NK4 plasmid DNA-PEG engrafted cationized dextran complex and ultrasound irradiation (Source: Cancer Gene Therapy)
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AbstractColorectal cancer (CRC) is the second most-commonly diagnosed cancer among Korean Americans after breast cancer, with incidence rates exceeding that of lung, prostate, and stomach cancers. However, CRC screening rates are lower among Korean Americans than the general U.S. population. To understand barriers to screening in this population, we conducted 11 focus groups with 51 Korean Americans ages 40+ in the Washington, DC, metropolitan area between 2011 and 2016. Our analysis used the Health...
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The oncology team must be prepared to help sort myths from facts when patients ask about the ketogenic diet, the alkaline diet, and fasting.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
01:24
Early treatment with lenalidomide can stave off multiple myeloma and provide longer progression-free survival (PFS) than just monitoring alone. (Source: CancerNetwork)
Tue Oct 29, 2019 05:00
A new machine-learning computer model helped predict which patients of cancer may die soon. (Source: CancerNetwork)
Tue Oct 29, 2019 05:00
The MEK inhibitor selumetinib showed clinical responses in the plexiform neurofibromas of adult patients with neurofibromatosis type 1. (Source: CancerNetwork)
Tue Oct 29, 2019 05:00
The use of palliative in hematologic malignancies has been rising, but use is still low and occurs late.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Tue Oct 29, 2019 16:57
-- Determining if you have a cold, the flu or an allergy can be difficult when you're having common symptoms, such as sneezing or a sore throat. The common symptoms reflect that each condition affects your respiratory system, says the National... (Source: Drugs.com - Daily MedNews)
Tue Oct 29, 2019 08:00
Authors: Bloom M, Maciaszek JL, Clark ME, Pui CH, Nichols KE Abstract INTRODUCTION: Historically, the majority of childhood cancers, including acute lymphoblastic leukemia (ALL), were not thought to have a hereditary basis. However, recent germline genomic studies have revealed that at least 5 - 10% of children with cancer (and approximately 3 - 4% of children with ALL) develop the disease due to an underlying genetic predisposition. Areas covered: This review discusses several recently...
02:15
Publication date: February 2020Source: Materials Science and Engineering: C, Volume 107Author(s): El-Sayed R. El-Sayed, Heba K. Abdelhakim, Zainab ZakariaAbstractCobalt ferrite nanoparticles were successfully synthesized using the fungus Monascus purpureus ATCC16436 as a potentially low-cost, eco-friendly and easy to produce method. Fourier transform infrared spectroscopy confirmed the functional groups present in the prepared samples. X-ray diffraction pattern of the synthesized nanoparticles revealed...
02:08
Authors: Quinn TJ, Hamstra D PMID: 31655657 [PubMed - in process] (Source: Health Physics)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
01:53
Authors: Lu SD, Li L, Liang XM, Chen W, Chen FL, Fan LL, Ahir BK, Zhang WG, Zhong JH Abstract Introduction: The 5-year recurrence rate of hepatocellular carcinoma (HCC) after hepatic resection or local ablation is up to 70%. Adjuvant therapies to prevent HCC recurrence have been reported but are not currently recommended by EASL or AASLD guidelines. This review examined evidence from randomized controlled trials, meta-analyses and systematic reviews on the safety and efficacy of adjuvant...
01:22
Authors: Ashton JJ, Green Z, Kolimarala V, Beattie RM Abstract Introduction- Long-term, sustained, remission is the ultimate goal of contemporary inflammatory bowel disease therapy. Avoiding complications, surgery and malignancy, alongside minimising the side effects of medications are vital. However, the reality of treatment involves patients losing response to therapy, or developing complications requiring cessation of medication. The reasons for this are numerous and include medication...
01:22
Conclusion: Uncovered SEMS could provide a longer duration to reintervention compared to the catheter drainages to manage occluded primary SEMS in patients with unresectable MHBO. PMID: 31656114 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
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Authors: Hennig R, Albawardi A, Almarzooqi S, Haneefa S, Imbaraj E, Zaaba NE, Nemmar A, Subramanya S, Maruta H, Adrian TE Abstract More than 90% of human pancreatic cancers carry the oncogenic mutant of Ki-RAS and their growth depends on its downstream kinase PAK1, mainly because PAK1 blocks the apoptosis of cancer cells selectively. We developed a highly cell-permeable PAK1-blocker called 15K from an old pain-killer (ketorolac), that is shown here to inhibit the growth of three pancreatic...
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Authors: Asensio AF, Sierra LM, Montes-Bayón M, Blanco-González E Abstract Sensitive and selective analytical methods are necessary for the determination of clinical biomarkers of breast cancer. The human epidermal growth factor receptor 2 (HER2) is an important breast cancer biomarker since tumors with HER2 protein overexpression (HER2-positive tumors) turn out to be more aggressive and likely to recur. Therefore, accurate determination of serum HER2 values is critical to optimize clinical...
Tue Oct 29, 2019 23:56
Hemicyanine-based near-infrared fluorescent probe for the ultrasensitive detection of hNQO1 activity and discrimination of human cancer cells. Anal Chim Acta. 2019 Dec 20;1090:125-132 Authors: Zheng Y, Pan D, Zhang Y, Zhang Y, Shen Y Abstract NAD(P)H: Quinone Oxidoreductase 1 (hNQO1) is a cytosolic flavin two-electron reductase involved in many physiological and pathological processes that is overexpressed in many cancers and recognized as a potential cancer biomarker. However,...
Tue Oct 29, 2019 23:56
Authors: Wang C, Wang Y, Zhang H, Deng H, Xiong X, Li C, Li W Abstract Using carcinoembryonic antigen (CEA) imprinted polymerized ionic liquid hydrogel as a recognition element and hollow gold nanoballs/MoSe2 nanosheets as a photoactive element, a photoelectrochemical (PEC) sensing platform was successfully fabricated. To accomplish the imprinted process under room temperature to maintain the biological activity and the configuration of CEA, and thus to improve the sensing performances,...
Tue Oct 29, 2019 23:56
Publication date: Available online 28 October 2019Source: Artificial Intelligence in MedicineAuthor(s): Xuechen Li, Linlin Shen, Xinpeng Xie, Shiyun Huang, Zhien Xie, Xian Hong, Juan YuAbstractLung cancer is the leading cause of cancer death worldwide. Early detection of lung cancer is helpful to provide the best possible clinical treatment for patients. Due to the limited number of radiologist and the huge number of chest x-ray radiographs (CXR) available for observation, a computer-aided detection...
Tue Oct 29, 2019 23:02
Authors: Lee HS, Seo HR, Lee SA, Choi S, Kang D, Kwon J Abstract The recovery from replication stress by restarting stalled forks to continue DNA synthesis is crucial for maintaining genome stability and thereby preventing diseases such as cancer. We previously showed that BRCA1-associated protein 1 (BAP1), a nuclear deubiquitinase with tumor suppressor activity, promotes replication fork progression by stabilizing the INO80 chromatin remodeler via deubiquitination and recruiting it to...
Tue Oct 29, 2019 22:59
Authors: PMID: 31657444 [PubMed - in process] (Source: The Biochemical Journal)
Tue Oct 29, 2019 22:59
Conclusion More robust studies are needed to decide on the approach to prioritize with severe-to-profound deaf children. PMID: 31652408 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)
Fri Oct 25, 2019 00:00
Thanks to Lori, this morning I read a very interesting article in Forbes magazine about how to (help) prevent getting the flu AND how to lower hospital infections. Such a simple, easy thing we can all do… Have a look: http://bit.ly/31RP6QT Very very interesting…makes sense, too! (Source: Margaret's Corner)
Mon Oct 28, 2019 09:03
Authors: Li C, Wang L, Sun X, Yang X Abstract A large number of menopausal women report sleep disturbances along with psychological, somatic and urogenital menopausal symptoms. The aim of this study was to evaluate the efficacy of menopausal hormonal therapy (MHT) in improving subjective sleep quality and the severity of menopausal symptoms. An institutional ethics committee approved this retrospective chart review of 342 women treated with MHT for menopausal symptoms. Standard 28-day MHT...
Tue Oct 29, 2019 22:45
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