Τετάρτη 30 Οκτωβρίου 2019


Definition of a Good Death, Attitudes Toward Death, and Feelings of Interconnectedness Among People Taking Care of Terminally ill Patients With Cancer: An Exploratory Study.
Authors: Bovero A, Gottardo F, Botto R, Tosi C, Selvatico M, Torta R Abstract The concept of a good death is crucial in palliative care, but its relationship with attitudes toward death and feelings of interconnectedness needs to be further deepened. The first aim of this study was to explore the concept of good death, attitudes toward death, and feelings of interconnectedness among family caregivers (FCs) and health-care providers (HCPs) of terminally ill patients with cancer. The second...
MedWorm Palliative Care Research
Thu Oct 24, 2019 00:00
To resect or not to resect? Risks and benefits of surgery in older patients with glioblastoma
ConclusionsGTR may provide a better OS even in GBM patients with advanced age. STR still shows a benefit over SB for OS in older patients <75 years. For older individuals, SB presents a safer option with regards to the risk of postoperative morbidity and should be favored in cases, when the surgical alternative is limited to STR. (Source: Journal of Geriatric Oncology)
MedWorm Cancer & Oncology Research
03:42
Effectiveness of Multi-Prognostic Index in older patients with advanced malignancies treated with immunotherapy
ConclusionsMPI score is an effective tool for the stratification of older patients with cancer eligible for immunotherapy with checkpoint inhibitors. Further studies are required to achieve conclusive remarks on MPI usefulness in different underlying tumor types. (Source: Journal of Geriatric Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps...
MedWorm Cancer & Oncology Research
03:42
Captaining the PIDD ship
As the review in this issue of the Annals makes clear, patients with common variable immunodeficiency (CVID) may exhibit one or more of a multiplicity of autoimmune diatheses involving any body system.1 The association of primary immunodeficiency diseases (PIDD) and autoimmunity is not restricted, however, to CVID.2 Similar associations between immunodeficiency and malignancy have been extensively reported as well.3 Our immunodeficiency patients are not merely subject to an increased incidence of...
MedWorm Cancer & Oncology Research
03:11
Serous BMP8A has clinical significance in ultrasonic diagnosis of thyroid cancer and promotes thyroid cancer cell progression.
CONCLUSION: In summary, we identified a novel biomarker for early diagnosis in addition to Ultrasound of thyroid cancer, which was subjected to TCF7L1 regulation. PMID: 31656161 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
MedWorm Cancer & Oncology Research
03:04
MicroRNA-186-5p Inhibits Proliferation And Metastasis Of Esophageal Cancer By Mediating HOXA9
(Source: OncoTargets and Therapy)
MedWorm Cancer & Oncology Research
02:26
Clinicopathological Characteristics And EGFR-TKIs Efficacies In Lung Squamous Cell Carcinoma Patients Harboring An EGFR Sensitizing Mutation
(Source: OncoTargets and Therapy)
MedWorm Cancer & Oncology Research
02:23
TIMP1 Is A Potential Key Gene Associated With The Pathogenesis And Prognosis Of Ulcerative Colitis-Associated Colorectal Cancer
(Source: OncoTargets and Therapy)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
02:16
Coexistence Of A Huge Venous Thromboembolism And Bleeding Tendency In Cytokine Release Syndrome During CAR-T Therapy
(Source: OncoTargets and Therapy)
MedWorm Cancer & Oncology Research
02:10
EFEMP2 Inhibits Breast Cancer Invasion And Metastasis In Vitro And In Vivo
(Source: OncoTargets and Therapy)
MedWorm Cancer & Oncology Research
02:00
Mechanism and therapeutic prospect of resveratrol combined with TRAIL in the treatment of renal cell carcinoma
Cancer Gene Therapy, Published online: 30 October 2019; doi:10.1038/s41417-019-0150-6Mechanism and therapeutic prospect of resveratrol combined with TRAIL in the treatment of renal cell carcinoma (Source: Cancer Gene Therapy)
MedWorm Cancer & Oncology Research
00:00
Induction of Tolerance and Immunity by Dendritic Cells: Mechanisms and Clinical Applications
Dendritic cells (DCs) are key regulators of immune responses that operate at the interface between innate and adaptive immunity, and defects in DC functions contribute to the pathogenesis of a variety of disorders. For instance, cancer evolves in the context of limited DC activity, and some autoimmune diseases are initiated by DC-dependent antigen presentation. Thus, correcting aberrant DC functions stands out as a promising therapeutic paradigm for a variety of diseases, as demonstrated by an abundant...
MedWorm Cancer & Oncology Research
00:00
Retraction Note: Enhanced suppression of tumor growth using a combination of NK4 plasmid DNA-PEG engrafted cationized dextran complex and ultrasound irradiation
Cancer Gene Therapy, Published online: 30 October 2019; doi:10.1038/s41417-019-0148-0Retraction Note: Enhanced suppression of tumor growth using a combination of NK4 plasmid DNA-PEG engrafted cationized dextran complex and ultrasound irradiation (Source: Cancer Gene Therapy)
MedWorm Cancer & Oncology Research
00:00
A Qualitative Analysis of Barriers to Colorectal Cancer Screening among Korean Americans
AbstractColorectal cancer (CRC) is the second most-commonly diagnosed cancer among Korean Americans after breast cancer, with incidence rates exceeding that of lung, prostate, and stomach cancers. However, CRC screening rates are lower among Korean Americans than the general U.S. population. To understand barriers to screening in this population, we conducted 11 focus groups with 51 Korean Americans ages 40+ in the Washington, DC, metropolitan area between 2011 and 2016. Our analysis used the Health...
MedWorm Cancer & Oncology Research
00:00
Oncology Patients Increasingly Ask About Diet: What to Say? Oncology Patients Increasingly Ask About Diet: What to Say?
The oncology team must be prepared to help sort myths from facts when patients ask about the ketogenic diet, the alkaline diet, and fasting.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology News
01:24
Smoldering Multiple Myeloma Can Be Slowed by Lenalidomide
Early treatment with lenalidomide can stave off multiple myeloma and provide longer progression-free survival (PFS) than just monitoring alone. (Source: CancerNetwork)
MedWorm Cancer & Oncology News
Tue Oct 29, 2019 05:00
Can Machine Learning Help Anticipate Death from Cancer?
A new machine-learning computer model helped predict which patients of cancer may die soon. (Source: CancerNetwork)
MedWorm Cancer & Oncology News
Tue Oct 29, 2019 05:00
Selumetinib Clinically Improves NF1-Associated Neurofibromas
The MEK inhibitor selumetinib showed clinical responses in the plexiform neurofibromas of adult patients with neurofibromatosis type 1. (Source: CancerNetwork)
MedWorm Cancer & Oncology News
Tue Oct 29, 2019 05:00
Palliative Care Still Underutilized in Hematologic Malignancies Palliative Care Still Underutilized in Hematologic Malignancies
The use of palliative in hematologic malignancies has been rising, but use is still low and occurs late.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm: Cancer &amp; Oncology
Tue Oct 29, 2019 16:57
Health Tip: Cold, Flu or Allergy?
-- Determining if you have a cold, the flu or an allergy can be difficult when you're having common symptoms, such as sneezing or a sore throat. The common symptoms reflect that each condition affects your respiratory system, says the National... (Source: Drugs.com - Daily MedNews)
MedWorm Allergy & Immunology Top 20
Tue Oct 29, 2019 08:00
Recent advances in genetic predisposition to pediatric acute lymphoblastic leukemia.
Authors: Bloom M, Maciaszek JL, Clark ME, Pui CH, Nichols KE Abstract INTRODUCTION: Historically, the majority of childhood cancers, including acute lymphoblastic leukemia (ALL), were not thought to have a hereditary basis. However, recent germline genomic studies have revealed that at least 5 - 10% of children with cancer (and approximately 3 - 4% of children with ALL) develop the disease due to an underlying genetic predisposition. Areas covered: This review discusses several recently...
MedWorm Cancer & Oncology Research
02:15
Extracellular biosynthesis of cobalt ferrite nanoparticles by Monascus purpureus and their antioxidant, anticancer and antimicrobial activities: Yield enhancement by gamma irradiation
Publication date: February 2020Source: Materials Science and Engineering: C, Volume 107Author(s): El-Sayed R. El-Sayed, Heba K. Abdelhakim, Zainab ZakariaAbstractCobalt ferrite nanoparticles were successfully synthesized using the fungus Monascus purpureus ATCC16436 as a potentially low-cost, eco-friendly and easy to produce method. Fourier transform infrared spectroscopy confirmed the functional groups present in the prepared samples. X-ray diffraction pattern of the synthesized nanoparticles revealed...
MedWorm Cancer & Oncology Research
02:08
Hypofractionation in Prostate Cancer Using Proton Beam.
Authors: Quinn TJ, Hamstra D PMID: 31655657 [PubMed - in process] (Source: Health Physics)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
01:53
Updates and advancements in the management of hepatocellular carcinoma patients after hepatectomy.
Authors: Lu SD, Li L, Liang XM, Chen W, Chen FL, Fan LL, Ahir BK, Zhang WG, Zhong JH Abstract Introduction: The 5-year recurrence rate of hepatocellular carcinoma (HCC) after hepatic resection or local ablation is up to 70%. Adjuvant therapies to prevent HCC recurrence have been reported but are not currently recommended by EASL or AASLD guidelines. This review examined evidence from randomized controlled trials, meta-analyses and systematic reviews on the safety and efficacy of adjuvant...
MedWorm Cancer & Oncology Research
01:22
Inflammatory bowel disease: long-term therapeutic challenges.
Authors: Ashton JJ, Green Z, Kolimarala V, Beattie RM Abstract Introduction- Long-term, sustained, remission is the ultimate goal of contemporary inflammatory bowel disease therapy. Avoiding complications, surgery and malignancy, alongside minimising the side effects of medications are vital. However, the reality of treatment involves patients losing response to therapy, or developing complications requiring cessation of medication. The reasons for this are numerous and include medication...
MedWorm Cancer & Oncology Research
01:22
Retrospective comparison of different percutaneous approaches to manage occluded primary uncovered self-expandable metal stents in patients with unresectable malignant hilar biliary obstruction.
Conclusion: Uncovered SEMS could provide a longer duration to reintervention compared to the catheter drainages to manage occluded primary SEMS in patients with unresectable MHBO. PMID: 31656114 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
MedWorm Cancer & Oncology Research
01:18
1,2,3-Triazolyl ester of ketorolac (15K), a potent PAK1 blocker, inhibits both growth and metastasis of orthotopic human pancreatic cancer xenografts in mice.
Authors: Hennig R, Albawardi A, Almarzooqi S, Haneefa S, Imbaraj E, Zaaba NE, Nemmar A, Subramanya S, Maruta H, Adrian TE Abstract More than 90% of human pancreatic cancers carry the oncogenic mutant of Ki-RAS and their growth depends on its downstream kinase PAK1, mainly because PAK1 blocks the apoptosis of cancer cells selectively. We developed a highly cell-permeable PAK1-blocker called 15K from an old pain-killer (ketorolac), that is shown here to inhibit the growth of three pancreatic...
MedWorm Cancer & Oncology Research
00:29
Sensitive determination of the human epidermal growth factor receptor 2 (HER2) by immuno-polymerase chain reaction with inductively coupled plasma-mass spectrometry detection.
Authors: Asensio AF, Sierra LM, Montes-Bayón M, Blanco-González E Abstract Sensitive and selective analytical methods are necessary for the determination of clinical biomarkers of breast cancer. The human epidermal growth factor receptor 2 (HER2) is an important breast cancer biomarker since tumors with HER2 protein overexpression (HER2-positive tumors) turn out to be more aggressive and likely to recur. Therefore, accurate determination of serum HER2 values is critical to optimize clinical...
MedWorm Cancer & Oncology Research
Tue Oct 29, 2019 23:56
Hemicyanine-based near-infrared fluorescent probe for the ultrasensitive detection of hNQO1 activity and discrimination of  human cancer cells.
Hemicyanine-based near-infrared fluorescent probe for the ultrasensitive detection of hNQO1 activity and discrimination of human cancer cells. Anal Chim Acta. 2019 Dec 20;1090:125-132 Authors: Zheng Y, Pan D, Zhang Y, Zhang Y, Shen Y Abstract NAD(P)H: Quinone Oxidoreductase 1 (hNQO1) is a cytosolic flavin two-electron reductase involved in many physiological and pathological processes that is overexpressed in many cancers and recognized as a potential cancer biomarker. However,...
MedWorm Cancer & Oncology Research
Tue Oct 29, 2019 23:56
Molecularly imprinted photoelectrochemical sensor for carcinoembryonic antigen based on polymerized ionic liquid hydrogel and hollow gold nanoballs/MoSe2 nanosheets.
Authors: Wang C, Wang Y, Zhang H, Deng H, Xiong X, Li C, Li W Abstract Using carcinoembryonic antigen (CEA) imprinted polymerized ionic liquid hydrogel as a recognition element and hollow gold nanoballs/MoSe2 nanosheets as a photoactive element, a photoelectrochemical (PEC) sensing platform was successfully fabricated. To accomplish the imprinted process under room temperature to maintain the biological activity and the configuration of CEA, and thus to improve the sensing performances,...
MedWorm Cancer & Oncology Research
Tue Oct 29, 2019 23:56
Multi-resolution Convolutional Networks for Chest X-Ray Radiograph Based Lung Nodule Detection
Publication date: Available online 28 October 2019Source: Artificial Intelligence in MedicineAuthor(s): Xuechen Li, Linlin Shen, Xinpeng Xie, Shiyun Huang, Zhien Xie, Xian Hong, Juan YuAbstractLung cancer is the leading cause of cancer death worldwide. Early detection of lung cancer is helpful to provide the best possible clinical treatment for patients. Due to the limited number of radiologist and the huge number of chest x-ray radiographs (CXR) available for observation, a computer-aided detection...
MedWorm Cancer & Oncology Research
Tue Oct 29, 2019 23:02
BAP1 promotes stalled fork restart and cell survival via INO80 in response to replication stress.
Authors: Lee HS, Seo HR, Lee SA, Choi S, Kang D, Kwon J Abstract The recovery from replication stress by restarting stalled forks to continue DNA synthesis is crucial for maintaining genome stability and thereby preventing diseases such as cancer. We previously showed that BRCA1-associated protein 1 (BAP1), a nuclear deubiquitinase with tumor suppressor activity, promotes replication fork progression by stabilizing the INO80 chromatin remodeler via deubiquitination and recruiting it to...
MedWorm Cancer & Oncology Research
Tue Oct 29, 2019 22:59
Publisher's Correction: The Great Escape: How phosphatidylinositol 4-kinases and PI4P promote vesicle exit from the Golgi (and drive cancer).
Authors: PMID: 31657444 [PubMed - in process] (Source: The Biochemical Journal)
MedWorm Cancer & Oncology Research
Tue Oct 29, 2019 22:59
Effectiveness of Rehabilitation Approaches Proposed to Children With Severe-to-Profound Prelinguistic Deafness on the Development of Auditory, Speech, and Language Skills: A Systematic Review.
Conclusion More robust studies are needed to decide on the approach to prioritize with severe-to-profound deaf children. PMID: 31652408 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)
MedWorm Audiology Research
Fri Oct 25, 2019 00:00
An easy method for preventing the flu
Thanks to Lori, this morning I read a very interesting article in Forbes magazine about how to (help) prevent getting the flu AND how to lower hospital infections. Such a simple, easy thing we can all do… Have a look: http://bit.ly/31RP6QT Very very interesting…makes sense, too! (Source: Margaret's Corner)
MedWorm Cancer & Oncology Blogs
Mon Oct 28, 2019 09:03
Analysis of the long-term beneficial effects of menopausal hormone therapy on sleep quality and menopausal symptoms.
Authors: Li C, Wang L, Sun X, Yang X Abstract A large number of menopausal women report sleep disturbances along with psychological, somatic and urogenital menopausal symptoms. The aim of this study was to evaluate the efficacy of menopausal hormonal therapy (MHT) in improving subjective sleep quality and the severity of menopausal symptoms. An institutional ethics committee approved this retrospective chart review of 342 women treated with MHT for menopausal symptoms. Standard 28-day MHT...
MedWorm Cancer & Oncology Research
Tue Oct 29, 2019 22:45

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