The three-body problem has vexed mathematicians and physicists for 300 years, but AI can find solutions far faster than any other method anyone has come up with
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Video game developer Ninja Theory has previously worked with scientists to portray psychosis and now plans to create games to aid mental health
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We’ve discovered brain cells help us judge the distance to an object, and they remain active even if we can no longer see the object suggesting a role in memory
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Once thought too abstract, category theory has become remarkably pervasive in science, says mathematician and pianist Eugenia Cheng
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Abstract In recent years, large-scale mortalities are observed in tilapia due to infection with a novel orthomyxo-like virus named, tilapia lake virus (TiLV) which is marked to be a severe threat to universal tilapia industry. Currently, there are knowledge gaps relating to the antiviral peptide as well as there are no affordable vaccines or drugs available against TiLV yet. To understand the spreading of infection of TiLV in different organs of Oreochromis niloticus, RT-PCR analysis...
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Abstract In this review, the basic concepts and applications of design of experiments (DoE) in recombinant protein biotechnology will be discussed. The production of recombinant proteins usually begins with the construction of an expression vector that is then introduced into a microbial host. The target protein is overexpressed in the host’s cells and subsequently, it is isolated using a suitable purification method, its activity is assessed using a biological assay, while its...
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Abstract A novel carboxylesterase gene, named dlfae4, was discovered and sequenced from a soil metagenomic library. The dlfae4 gene was composed of 1017 base pairs encoding 338 amino acid residues with a predicted molecular mass of 37.2 kDa. DLFae4 exhibited strong hydrolytic activity towards methyl ferulate under optimum pH and temperature conditions (pH 8.6, 50 °C) and displayed remarkable thermostability, with residual activity as high as 50% after incubation for 3 h at 60 °C....
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AbstractThe Research to Accelerate Cures and Equity (RACE) for Children Act was enacted in 2017 to authorize the FDA to require pediatric studies for new cancer drugs that have a molecular target relevant to the growth or progression of a pediatric cancer. To assess the possible scope of this new policy, we examined all 78 adult cancer drugs approved by the FDA from 2007-2017. Only 17 (21.8%) drugs received any pediatric labeling information. Based on the FDA’s Pediatric Molecular Target List, we...
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AbstractBackgroundRecent efforts of gene expression profiling analyses recognized at least 4 different triple-negative breast cancer (TNBC) molecular subtypes. However, little is known regarding their tumor microenvironment (TME) heterogeneity.MethodsHere, we investigated TME heterogeneity within each TNBC molecular subtype including immune infiltrate localization and composition together with expression of targetable immune pathways using publicly available transcriptomic and genomic datasets from...
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As an important means of communication, exosomes play an important role in the development of hepatocellular carcinoma (HCC). (Source: Molecular Cancer)
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TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis
In this study, Yan et al. demonstrate that TIPE2, which is induced by tumor-derived ROS, promotes the functional polarization of protumoral myeloid-derived suppressor cells (MDSCs) during tumorigenesis by specifying the expression of MDSC signature genes such as Cebpb.
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At present, the enhancement of China’s comprehensive national strength, stable currency policy, and the new round of opening-up strategy layout have provided opportunities for the financial development in border areas, especially for the RMB internationalization advancement in border areas, while the lagging financial system construction in current border areas also challenges its RMB internationalization. Based on Friedman’s monetary demand theory (1970), the thesis has combined the periodical characteristics...
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In order to further improve the complexity of chaotic system, a new four-dimensional chaotic system is constructed based on Sprott B chaotic system. By analyzing the system’s phase diagrams, symmetry, equilibrium points, and Lyapunov exponents, it is found that the system can generate not only both two-wing and four-wing attractors but also the attractors with symmetrical coexistence, and the dynamic characteristics of the new system constructed are more abundant. In addition, the system is simulated...
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The residual symmetry of a negative-order Korteweg–de Vries (nKdV) equation is derived through its Lax pair. Such residual symmetry can be localized, and the original nKdV equation is extended into an enlarged system by introducing four new variables. By using Lie’s first theorem, we obtain the finite transformation for the localized residual symmetry. Furthermore, we localize the linear superposition of multiple residual symmetries and construct n-th Bäcklund transformation for this nKdV equation...
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An outbreak of African swine fever (ASF) occurred at a farm in central Namibia in March 2018. Fourteen pigs died out of a herd of 59 animals over a period of 16 days between the first and sixteenth of March 2018. The clinical signs observed included sternal recumbency, fever, weakness, pain and reluctance to move, hyperemia of the skin and anorexia, followed by death. Necropsy findings included large amounts of unclotted blood in the pleural and peritoneal cavities, diffuse carcass congestion, splenomegaly,...
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A disturbance observer-based hybrid sliding mode impedance control method is proposed in this paper, which is able to achieve robot end constant contact force-tracking control without force/torque sensors. The method requires only the values of joint torque, joint angle, and joint angular velocity, which are converted by robot servo motor signals, to implement the control. The control scheme consists of two parts: one is a disturbance observer and the other is a hybrid sliding mode impedance controller....
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Objective. To explore the incidence and significance of intra- and extra-osseous edema associated with benign tumors and tumor-like diseases. Methods. Magnetic resonance imaging (MRI) data from 300 benign osseous tumors and tumor-like diseases diagnosed by pathology were retrospectively reviewed. Borderline tumors, cases associated with pathological fractures, and skull lesions were excluded from the study. Bone marrow and soft tissue edema were defined on T2WI with fat suppression on MRI in all...
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In recent times, secure communication protocols over web such as HTTPS (Hypertext Transfer Protocol Secure) are being widely used instead of plain web communication protocols like HTTP (Hypertext Transfer Protocol). HTTPS provides end-to-end encryption between the user and service. Nowadays, organizations use network firewalls and/or intrusion detection and prevention systems (IDPS) to analyze the network traffic to detect and protect against attacks and vulnerabilities. Depending on the size of...
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Through well-designed counterfeit websites, phishing induces online users to visit forged web pages to obtain their private sensitive information, e.g., account number and password. Existing antiphishing approaches are mostly based on page-related features, which require to crawl content of web pages as well as accessing third-party search engines or DNS services. This not only leads to their low efficiency in detecting phishing but also makes them rely on network environment and third-party services...
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Squamous cell papilloma (SCP) is generally a human papillomavirus (HPV) induced exophytic or endophytic proliferation on the surface of the skin, oral cavity, larynx, esophagus, cervix, vagina, and anal canal. The endophytic type SCP can cause differential diagnostic difficulties with keratoacanthoma, inverted follicular keratosis, and squamous cell carcinoma; however, these lesions are not associated with HPV infection. The authors present a female patient who noticed an extremely rapidly growing...
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Background. The number of patients receiving direct oral anticoagulants (DOACs) is increasing, however, this treatment is associated with the risk of bleeding. More than 10 percent of patients on DOACs have to interrupt their anticoagulation for an invasive procedure every year. For this reason, the correct management of DOACs in the perioperative setting is mandatory. Case Presentation. An 81-year-old male patient, with known impaired renal function, presented to our emergency department with a...
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This article presents three cases of cranial nerve palsy following shoulder surgery with general anesthesia in the beach chair position. All patients underwent preoperative ultrasound-guided interscalene nerve block. Two cases of postoperative hypoglossal and one case of combined hypoglossal and recurrent laryngeal nerve palsies (Tapia’s syndrome) were identified. Through this case series, we provide a literature review identifying postoperative cranial nerve palsies in addition to the discussion...
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Aiming at the problems of complex structures, variable loads, and fluctuation of power outputs of multienergy networks, this paper proposes an optimal allocation strategy of multienergy networks based on the double-layer nondominated sorting genetic algorithm, which can optimize the allocation of distributed generation (DG) and then improve the system economy. In this strategy, the multiobjective nondominated sorting genetic algorithm is adopted in both layers, and the second-layer optimization is...
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Metal wear debris and released ions (CoCrMo), which are widely generated in metal-on-metal bearings of hip implants, are also found in patients with metal-on-polyethylene bearings due to the mechanically assisted crevice corrosion of modular taper junctions, including head-neck and neck-stem taper interfaces. The resulting adverse reactions to metal debris and metal ions frequently lead to early arthroplasty revision surgery. National guidelines have since been published where the blood metal ion...
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Direct analysis and identification of biological tissue is significant for clinical applications. In this study, porcine liver and kidney have been analyzed using laser ablation electrospray ionization time-of-flight mass spectrometry (LAESI-TOFMS). This method showed good reproducibility for the same types of tissue and is capable of distinguishing different tissue species. The margin assessment was also performed using porcine renal tissue, and the response time was less than 6 s. Furthermore,...
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Objectives. To review the evidence of acupuncture for acute and preventive treatment of migraine for further awareness of the effect of acupuncture for migraine. Design. An overview of systematic reviews and meta-analyses (SR/MAs) for randomized controlled trials. Material and Methods. We searched PubMed, Embase, the Cochrane Library, China Knowledge Resource Integrated Database, VIP Chinese Journal Full Text Database, WANFANG Data, and China Biology Medicine disc from their establishment to May...
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With the development of computer vision technology, more and more enterprises begin to use computer vision instead of manual inspection for steel surface defect detection. However, classical image processing methods often face great difficulties when dealing with images containing noise and distortions, which leads to low computational efficiency and poor accuracy of detection. In view of the particularity of hot round steel production, a computational intelligence method is proposed in this paper....
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Purpose. This study aimed to differentiate patients with bilateral disc cupping associated with suprasellar tumor from patients with open-angle glaucoma by analyzing differences in optical coherence tomography (OCT) of the optic nerve. Methods. In this retrospective cross-sectional study, we collected data from the eyes of 25 patients with suprasellar craniopharyngioma or pituitary macroadenomas (group 1) and 35 patients with primary open-angle glaucoma (POAG) (group 2), seen between 2001 and 2015,...
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Henoch-Schönlein nephritis or immunoglobulin A (IgA) vasculitis is characterized by purpura, arthralgia, abdominal pain, and glomerulonephritis with glomerular IgA deposition. Notably, the presence of purpura is essential to diagnose this disease. We report the case of a patient in whom proteinuria and haematuria were detected during screening tests and he was diagnosed with IgA nephropathy at 20 years of age. Corticosteroids were administered for 7 years and were subsequently tapered. At 35 years...
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Human malaria has arguably affected more of human history than any other pathogen. Pregnant women have a higher risk of developing severe malaria as well as the risk of severe complications. We present a case of severe malaria in a pregnant patient from sub-Saharan Africa who was treated successfully with artesunate. A 28-year-old Nigerian woman with a 20-week intrauterine pregnancy presented with a five-day history of fever and diffuse joint pains. Evaluation of peripheral thin blood smear demonstrated...
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Goose bone is traditionally used in the treatment of many ailments including in bone fracture. The aim of the present study was to evaluate the subacute toxicity of goose bone in a rat model by investigating some hematological and biochemical parameters in rats. Subsequently, a histopathological study was performed to confirm the presence of pathological lesions in the rat’s vital organs including the liver, kidney, heart, brain, pancreas, lung, spleen, and stomach. Adult Wistar rats were divided...
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In the past three decades, about 0.93% of people moved from rural areas to cities per year in China. Therefore, understanding of the relationships among urban physical environment (UPE), economic development, and population growth are significant for China to realize sustainable urban development. Based on the concept and connotation of UPE and ecocity, the UPE evaluation system was constructed containing 6 first-level of indicators (i.e., climate, quality of ambient air and atmosphere, freshwater,...
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Virus-like particles (VLPs) are being used for therapeutic developments such as vaccines and drug nanocarriers. Among these, plant virus capsids are gaining interest for the formation of VLPs because they can be safely handled and are noncytotoxic. A paradigm in virology, however, is that plant viruses cannot transfect and deliver directly their genetic material or other cargos into mammalian cells. In this work, we prepared VLPs with the CCMV capsid and the mRNA-EGFP as a cargo and reporter gene....
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Publication date: Available online 29 October 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Gunjan Vasant Bonde, Gufran Ajmal, Sarita Kumari Yadav, Pooja Mittal, Juhi Singh, Bharati V. Bakde, Brahmeshwar MishraABSTRACTNanocolloids are considered ideal carriers for hydrophobic drugs owing to their core–shell structure. Lapatinib is a potential anti-cancer agent, but its clinical use is limited because of its poor aqueous solubility, thus requiring larger oral doses with the associated...
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Abstract Sri Lanka has one of the highest incidences of human leptospirosis worldwide. Outbreaks of this zoonotic infection are related to the monsoons and flooding. The study investigates risk factors associated with environmental, animal and occupational exposure while acknowledging the potential bias due to hanta viral infections in the study samples. Data were obtained from structured interviews with 483 patients (276 cases and 207 controls). Risk exposures were studied for...
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The annual and seasonal changes in the tropical Pacific Walker circulation (PWC) during the Last Glacial Maximum (LGM) are investigated using all available numerical experiments from the Paleoclimate Modelling Intercomparison Project Phases 2 and 3. Compared to the preindustrial period, the annual mean of the PWC intensity weakened by an average of 0.96×1014 kg2 m−2 s−1 or 15%, and both the western edge and centre of the PWC cell shifted eastward by an average of 9° and 8°, respectively, as obtained...
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Modern Pathology, Published online: 29 October 2019; doi:10.1038/s41379-019-0397-3Diagnosis of T-cell lymphoid proliferations of the skin: putting all the pieces together
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ObjectiveTo compare perinatal and maternal outcomes for Australian women with uncomplicated pregnancies according to planned place of birth, that is, in hospital labour wards, birth centres or at home. DesignA population-based retrospective design, linking and analysing routinely collected electronic data. Analysis comprised 2 tests and binary logistic regression for categorical data, yielding adjusted ORs. Continuous data were analysed using analysis of variance. SettingAll eight Australian states...
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Contributors : Chenggang Wang ; Xiaoen Huang ; Yanping Zhang ; Jian L Li ; Zhonglin MouSeries Type : Expression profiling by arrayOrganism : Arabidopsis thalianaThe goal of the microarray was to compare the bacterial pathogen Pseudomonas syringae pv. maculicola ES4326 (Psm)-induced transcriptome changes in the systemic leaves of the wild-type Col-0, lecrk-VI.2-2, and bak1-5 plants. Results showed that local Psm inoculation induced dramatic transcriptional changes in Col-0, with 564 and 151 genes...
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Contributors : Anna Sintsova ; Arwen Frick-Cheng ; Sara Smith ; Ali Pirani ; Evan Snitkin ; Harry MobleySeries Type : Expression profiling by high throughput sequencingOrganism : Escherichia coliUropathogenic Escherichia coli (UPEC) is the major causative agent of uncomplicated urinary tract infections (UTIs). A common virulence genotype of UPEC strains responsible for UTIs is yet to be defined, due to the large variation of virulence factors observed in UPEC strains. We hypothesized that studying...
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Contributors : Nathan P Palmer ; I S Kohane ; Jocelyn A SilvesterSeries Type : Expression profiling by arrayOrganism : Homo sapiensPresenting features of inflammatory bowel disease (IBD) are non-specific. We hypothesized that mRNA profiles could (1) identify genes and pathways involved in disease pathogenesis; (2) identify a molecular signature that differentiates IBD from other conditions; (3) provide insight into systemic and colon-specific dysregulation through study of the concordance of the...
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Contributors : Seon-Kyu Kim ; Jeong-Hwan Kim ; Jin-Cheon Kim ; Seon-Young Kim ; Young-Sung KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe objective of this study is to identify a gene set to predict recurrence of colorectal cancer (CRC) patients. We generated RNA-seq data of 110 primary CRC samples and identified significant genes associated with recurrence of CRC. Through diverse statistical methods including generalized linear model likelihood...
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Contributors : Kun Qiao ; Da PangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensIn the present study, Linc00673 displayed high expression in breast cancer tissues and was associated with poor prognosis of breast cancer patients. Importantly, Linc00673 depletion inhibited breast cancer cell proliferation by impairing cell cycle progression and apoptosis. Mechanically, RNA sequencing was performed to investigate the potential crosstalk between Linc00673 and...
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Contributors : Dayle Johnston ; Bernadette Earley ; Matthew S McCabe ; Gordon Blackshields ; Kenneth Lemon ; Catherine Duffy ; Michael McMenamy ; S L Cosby ; JaeWoo Kim ; Jeremy F Taylor ; Sinead M WatersSeries Type : Expression profiling by high throughput sequencingOrganism : Bos taurusBovine respiratory disease (BRD) is the leading cause of morbidity and mortality in calves over one month of age. In a controlled challenge study in artificially-reared dairy calves, the influence of the host...
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Contributors : Shuqin Zeng ; Jochen Bick ; Susanne E Ulbrich ; Stefan BauersachsSeries Type : Expression profiling by high throughput sequencingOrganism : Sus scrofathe aim of this present study was to characterize the complex transcriptome changes in different endometrial cell types during the preimplantation period for improving our understanding of localization of endometrial gene expression regulation in context of recognition of pregnancy. To do this analysis in a transcriptome-wide manner,...
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Contributor : Guruprasad MedigeshiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo identify the molecular pathways that are perturbed due to transient zinc chelationZinc is known to regulate the functions of about 10% of the human proteome and a large number of physiological processes that are zinc dependent have been identified and characterized under conditions of zinc deficiency and supplementation. As zinc homeostasis is closely linked to the normal functioning...
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Contributors : Craig T Werner ; Jennifer A Martin ; Andrew F Stewart ; Ian Maze ; David M DietzSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Rattus norvegicusNeuroadaptations in the nucleus accumbens (NAc) underlie cue-induced cocaine craving that intensifies (“incubates”) during withdrawal and contributes to persistent relapse vulnerability. Long-lasting gene changes govern perpetual behavioral abnormalities but the role of epigenetic plasticity in cocaine...
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Contributors : Wen Ni ; Su Yao ; Jianming LiSeries Type : OtherOrganism : Homo sapiensWe performed methylated RNA immunoprecipitation followed by sequencing (MeRIP–seq) combined with transcription sequencing to clarify the mechanism underlined YTHDF3 in CRC
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Contributors : Wen Ni ; Su YaoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe analysis of the RNA-binding protein immunoprecipitation sequencing (RIP-seq) experiment is performed to identified YAP-specific binding lncRNAs.
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Contributors : Wen Ni ; Su Yao ; Jianming LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAnalysis of RNA-seq-based differential expression after overexpression of GAS5 or knockdown of YAP revealed a highly significant overlap of common targets.
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Contributors : Yoshihide Matsumoto ; Yuki Nakanishi ; Akihisa Fukuda ; Hiroshi SenoSeries Type : Expression profiling by arrayOrganism : Mus musculusThe EP4 receptor is known to mediate the protective effect of prostaglandin (PG) E2 in the gastrointestinal tract; however, the exact role of epithelial EP4 in intestinal pathophysiology remains unknown. We investigated the role of epithelial EP4 in maintaining colonic homeostasis by characterizing the intestinal epithelial cell-specific EP4 knockout...
2h
Contributors : Guohong Hu ; Min CongSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWe conduct transcriptome comparison of control and Mtss1-overexpressed Py8119 cells to gain genomic insights on the biological processes that Mtss1 is involved in breast cancer cells. Through unsupervised cluster analysis of differentially expressed genes (DEGs), we found 1661 genes were significantly changed in Mtss1 cells. Single Site Analysis and Gene Set Enrichment Analysis...
2h
Contributors : Yue-Hua Jiang ; Ling-Yu Jiang ; Xiao LiSeries Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Homo sapiensWe have employed transcriptome microarray expression profiling as a discovery platform to figure out the pharmacological mechanisms of quercetin against endothelial senescence induced by ox-LDL in vitro. Expression of RCHY1, EIF4E1B, IGFBP3, SERPINE1, BRAF, SLC5A11 from this signature was quantified in the same kind of samples by real-time...
5h
Contributors : Markus Germann ; Nadine Zangger ; Freddy RadtkeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHigh T cell infiltration in colorectal cancer (CRC) correlates with a better disease outcome and immunotherapy response. This is observed in only a small subset of CRC patients. A better understanding of the factors influencing tumor T cell responses in CRC could inspire novel therapeutic approaches to achieve broader immunotherapy responsiveness....
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Publication date: Available online 28 October 2019Source: Archives of Physical Medicine and RehabilitationAuthor(s): Michel D. Landry, Joost van Wijchen, Djenana Jalovcic, Carina Boström, Anna Pettersson, Maria Nordheim Alme
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Publication date: Available online 28 October 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Alessandra Merlotti, Angelo Rosa, Daniel RemondiniAbstractGenome organization in eukaryotes during interphase stems from the delicate balance between non-random correlations present in the DNA polynucleotide linear sequence and the physico/chemical reactions which shape continuously the form and structure of DNA and chromatin inside the nucleus of the cell. It is now...
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Publication date: Available online 28 October 2019Source: Artificial Intelligence in MedicineAuthor(s): Xuechen Li, Linlin Shen, Xinpeng Xie, Shiyun Huang, Zhien Xie, Xian Hong, Juan YuAbstractLung cancer is the leading cause of cancer death worldwide. Early detection of lung cancer is helpful to provide the best possible clinical treatment for patients. Due to the limited number of radiologist and the huge number of chest x-ray radiographs (CXR) available for observation, a computer-aided detection...
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An interactive spreadsheet for comparing data about children and young people across all local authorities in England.
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The Department for Education publishes official statistics on education and children.
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Information for academies, sixth-form colleges and non-diocesan Voluntary Aided (VA) schools about the Condition Improvement Fund (CIF).
2h
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