Introduction: The vestibular implant could become a clinically useful device in the near future. This study investigated the feasibility of restoring the high-frequency dynamic visual acuity (DVA) with a vestibular implant, using the functional Head Impulse Test (fHIT). Methods: A 72-year-old female, with bilateral vestibulopathy and fitted with a modified cochlear implant incorporating three vestibular electrodes (MED-EL, Innsbruck, Austria), was available for this study. Electrical stimulation...
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Background and Objectives: Hereditary hearing loss (HL) can originate from mutations in one of many genes involved in the complex process of hearing. CABP2 mutations have been reported to cause moderate HL. Here, we report the whole exome sequencing (WES) of a proband presenting with prelingual, severe HL in an Iranian family. Methods: A comprehensive family history was obtained, and clinical evaluations and pedigree analysis were performed in the family with 2 affected members. After excluding mutations...
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Background: The most common complaint of patients affected by chemotherapy-induced hearing loss is difficulty understanding speech in noisy environments despite the use of hearing aids. Cochlear dead regions, those areas with damaged or absent inner hair cells and dendrites, may account for this type of hearing loss. However, it is unknown whether this condition is associated with cisplatin agents. Objective: The aim of this study was to determine whether cisplatin is associated with hearing loss...
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Objective: Our aim was to determine the effect of acute changes in cochlear place of stimulation on cochlear implant (CI) sound quality. Design: In Experiment 1, 5 single-sided deaf (SSD) listeners fitted with a long (28-mm) electrode array were tested. Basal shifts in place of stimulation were implemented by turning off the most apical electrodes and reassigning the filters to more basal electrodes. In Experiment 2, 2 SSD patients fitted with a shorter (16.5-mm) electrode array were tested. Both...
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Abstract Background Cognitive and mood disorders negatively impact daily life in patients with multiple sclerosis (MS). Pharmacological treatments did not demonstrate any effect on cognition compared with cognitive rehabilitation (CR). However, if CR programs offer promising results on cognition, they are less consistent concerning mood and quality of life (QoL). In this context, we designed a randomized controlled trial to evaluate...
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Abstract Early life adversity is a risk factor for psychiatric disorders, yet the mechanisms by which adversity increases this risk are still being delineated. Here we used a limited bedding and nesting (LBN) manipulation in rats that models a low resource environment to examine effects on growth, developmental milestones, and endocrine endpoints. In LBN, dams and pups, from pups’ postnatal days 2–9, are exposed to a limited resource environment where dams lack proper materials to build a nest....
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Abstract Cross‐frequency phase‐phase coupling (PPC) has been suggested to play a role in cognitive processing and, in particular, in memory consolidation during sleep. Controversial results have been reported regarding the existence of spontaneous phase‐phase coupling in the hippocampus. Here, we investigated this phenomenon in intracranial EEG recordings from the human hippocampus acquired during waking state and different sleep stages. We estimated the strength of interactions between different...
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Acute T-cell lymphoblastic leukaemia (T-ALL) is an aggressive disorder derived from immature thymocytes. The variability observed in clinical responses on this type of tumours to treatments, the high toxicity ... (Source: BMC Cancer)
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Non-small cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) mutations often develop brain metastases. Treatment with EGFR-tyrosine kinase inhibitors (TKIs) has shown the effec... (Source: BMC Cancer)
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The survival rate of patients with advanced oesophageal cancer is very low and can vary significantly, even among patients with the same TNM stage. It is important to look for indicators that are economical an... (Source: BMC Cancer)
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Updated!An earlier version of this article was published on 29 October 2010.A few years ago I found myself in Brentwood, Essex, UK, and in need of a bite to eat, so I popped into the Crown Street Café, which is in, er, Crown Street.I was struck by this notice at the bottom of the menu: menu-fast+food, by Terry Freedman What a difference from the thinking...
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Oct 29, 2019 The tagline: "Create an app from a Google Sheet in five minutes, for free. Glide turns spreadsheets into beautiful, easy-to-use apps." It does what it promises. You'll use Google Sheets for your data, and Glide will build the interface that allows you to load and manipulate data from your smart phone. There are 'Pro Components' you can buy for your app, including file upload, buy button, and geolocation. Here are sample Glide apps and video instructions...
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W3C, Oct 29, 2019 As the title suggests, this is a page with links to four tools to create Open Digital Rights Language (ODRL) licenses. The page is on the W3C Community and Business Groups (CGBG) website. Web: [Direct Link] [This Post]
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Abstract A novel carboxylesterase gene, named dlfae4, was discovered and sequenced from a soil metagenomic library. The dlfae4 gene was composed of 1017 base pairs encoding 338 amino acid residues with a predicted molecular mass of 37.2 kDa. DLFae4 exhibited strong hydrolytic activity towards methyl ferulate under optimum pH and temperature conditions (pH 8.6, 50 °C) and displayed remarkable thermostability, with residual activity as high as 50% after incubation for 3 h at 60 °C....
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Publication date: Available online 29 October 2019Source: Computer Speech & LanguageAuthor(s): Craig S. Greenberg, Lisa P. Mason, Seyed Omid Sadjadi, Douglas A. ReynoldsAbstractThe National Institute of Standards and Technology has been conducting Speaker Recognition Evaluations (SREs) for over 20 years. This article provides an overview of the practice of evaluating speaker recognition technology as it has evolved during this time. Focus is given to the current state of speaker recognition evaluation....
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Publication date: Available online 28 October 2019Source: Quaternary GeochronologyAuthor(s): Gonca Gençalioğlu-Kuşcu, Göksu Uslular, Martin Danišík, Anthony Koppers, Daniel P. Miggins, Bjarne Friedrichs, Axel K. SchmittAbstractKyra is an important tephra unit for Nisyros pre-caldera stage due to a number of subunits with various compositions (basaltic andesite to dacite) and distal dispersion on surrounding Greek islands (Tilos and Chalki) and Datça peninsula (Turkey). As for the most Nisyros tephra...
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Abstract Background Bladder cancer (BC) is a common urothelial malignancy, characterized by a high recurrence rate. The biology of bladder cancer is complex and needs to be deciphered. The latest evidence reveals the critical role of the non-coding RNAs, particularly microRNAs (miRNAs), as vital regulatory elements in cancer. Method We performed...
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Abstract Background Breast cancer (BC) is the most frequent malignant tumor in females and the 2nd most common cause of brain metastasis (BM), that are associated with a fatal prognosis. The increasing incidence from 10% up to 40% is due to more effective treatments of extracerebral sites with improved prognosis and increasing use of MRI in diagnostics. A frequently administered, potent chemotherapeutic group of drugs for BC treatment...
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Abstract Background BMP3 gene is often found hypermethylated and hence inactivated in several types of cancers including colorectal cancer (CRC), indicating that it has a suppressor role in carcinogenesis. Though BMP3 is a reliable biomarker for screening CRC, the molecular mechanism of BMP3 in carcinogenesis remains largely unknown. Methods ...
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Abstract Background Our previous work demonstrated that lncRNA-MALAT1 was overexpressed in recurrent colorectal cancer (CRC) and metastatic sites in post-surgical patients. However, the upstream regulatory mechanism of MALAT1 is not well-defined. Histone demethylase JMJD2C holds great potential of epigenetic regulating mechanism in tumor diseases, especially the moderating effect on the promoter activity of targeted genes associated...
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Abstract Along with iron and steel production, large amount of slag is generated. Proper management on the iron- and steelmaking slag is highly demanded due to the high cost of direct disposal of the slag to landfill, which is the most adopted management approach. In this article, the potential application of iron- and steelmaking slag has been reviewed, which included the slag utilization in construction as cement and sand, in water, soil, and gas treatment, as well as in value...
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Title: Halloween Can Be Frightful for Kids With Allergies, AsthmaCategory: Health NewsCreated: 10/26/2019 12:00:00 AMLast Editorial Review: 10/28/2019 12:00:00 AM (Source: MedicineNet Allergies General)
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Publication date: Available online 28 October 2019Source: The Journal of Emergency MedicineAuthor(s): Nadav Granat, Selma Gabrieli, Evan Avraham AlpertAbstractBackgroundColitis refers to an inflammatory process of the colon, composed of a variety of different etiologies including inflammatory bowel disease, infectious colitis, ischemic colitis, and allergic colitis. Usually, abdominal computed tomography (CT) is the gold standard in diagnosing the various forms of colitis. However, by the use of...
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Publication date: Available online 28 October 2019Source: The Journal of Emergency MedicineAuthor(s): Daniel Popa, Ian Grover, Stephen Hayden, Peter WituckiAbstractBackgroundArterial gas embolus (AGE) is a rare complication of esophagoduodenoscopy (EGD) that has been described in only a few case reports in the literature. The exact etiology remains unknown, but many of the cases share some common characteristics.Case ReportWe report the case of a 52-year-old otherwise healthy man who underwent outpatient...
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Leptitox Review Losing Weight In Just, Easily And Your Program A means to get some exercise when accomplishing an essential task is to clean the house daily. The attempt of cleansing burns a house, in addition to a lot of calories, which Leptitox Review will help you attain your weight-loss objectives. If you play a few songs and put on some headphones, the job goes. Should you get those feet tapping to the beat of their music, you may burn calories. Exercise every day, even when you just have the...
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Objective. To explore the incidence and significance of intra- and extra-osseous edema associated with benign tumors and tumor-like diseases. Methods. Magnetic resonance imaging (MRI) data from 300 benign osseous tumors and tumor-like diseases diagnosed by pathology were retrospectively reviewed. Borderline tumors, cases associated with pathological fractures, and skull lesions were excluded from the study. Bone marrow and soft tissue edema were defined on T2WI with fat suppression on MRI in all...
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Metal wear debris and released ions (CoCrMo), which are widely generated in metal-on-metal bearings of hip implants, are also found in patients with metal-on-polyethylene bearings due to the mechanically assisted crevice corrosion of modular taper junctions, including head-neck and neck-stem taper interfaces. The resulting adverse reactions to metal debris and metal ions frequently lead to early arthroplasty revision surgery. National guidelines have since been published where the blood metal ion...
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Virus-like particles (VLPs) are being used for therapeutic developments such as vaccines and drug nanocarriers. Among these, plant virus capsids are gaining interest for the formation of VLPs because they can be safely handled and are noncytotoxic. A paradigm in virology, however, is that plant viruses cannot transfect and deliver directly their genetic material or other cargos into mammalian cells. In this work, we prepared VLPs with the CCMV capsid and the mRNA-EGFP as a cargo and reporter gene....
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Histones, the major protein components of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and subsequently mediate organ failure. Extracellular histones can promote endothelial damage and platelet aggregation, which can be suppressed by administration of recombinant thrombomodulin (rTM). The present study aimed to clarify whether histones can activate neutrophils to induce NET formation and whether rTM can prevent histone-induced NET formation....
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Compared to the innate immune system, the contribution of the adaptive immune response during obesity and insulin resistance is still not completely understood. Here we demonstrate that high fat diet (HFD) increases the frequencies of activated CD4+ and CD8+ T cells and frequencies of T cells positive for IFN-γ and IL-17 in the adipose tissue. The adipocyte-derived soluble factor adiponectin reduces IFN-γ and IL-17 positive CD4+ T cells from HFD mice and dampens the differentiation of naïve T cells...
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Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disease (PTLD) is a life-threatening complication of T-lymphocyte deplete allogeneic hematopoietic stem cell transplantation (allo-HSCT). For patients with PTLD refractory to Rituximab, donor lymphocyte infusion (DLI) is established as a successful option for salvage therapy. However, although in vivo lymphocyte expansion has been correlated with good clinical outcome following DLI, the specificity and functional characteristics...
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Microbial metabolites have a profound effect on the development of type 1 diabetes (T1D). The cross-talk between the gut microbiota, the nervous system, and immune system is necessary to establish and maintain immune and gut tolerance. As quoted by Hippocrates, “All disease begins in the gut.” Although this has been recognized for 2,000 years, the connection between the gut and autoimmune T1D is not yet well-understood. Here, we outline new advances supported by our research and others that have...
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Conventional foot-and-mouth disease (FMD) vaccines exhibit several limitations, such as the slow induction of antibodies, short-term persistence of antibody titers, as well as low vaccine efficacy and safety, in pigs. Despite the importance of cellular immune response in host defense at the early stages of foot-and-mouth disease virus (FMDV) infection, most FMD vaccines focus on humoral immune response. Antibody response alone is insufficient to provide full protection against FMDV infection; cellular...
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Autoinflammatory diseases include disorders with a monogenic cause and also complex conditions associated to polygenic or multifactorial factors. An increased number of both monogenic and polygenic autoinflammatory conditions have been identified during the last years. Although skin manifestations are often predominant in monogenic autoinflammatory diseases, clinical and histopathological information regarding their dermatological involvement is still scarce. Monogenic autoinflammatory diseases with...
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Sleep deprivation negatively influences all aspects of health. Oxidative stress and inflammatory responses induced by sleep deprivation participate in its adverse effects but the regulatory mechanisms to counteract them remain poorly understood. In mice subjected to sleep deprivation for 7 days, we found activation of microglia and astrocyte accompanied by down-regulation of α7 nicotinic acetylcholine receptor (α7-nAChR) and reduced activation of downstream PI3K/AKT/GSK-3β. These changes occurred...
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Vibrio cholerae is a Gram-negative enteropathogen causing potentially life-threatening cholera disease outbreaks, for which the World Health Organization currently registers 2–4 million cases and ~100.000 cholera-associated deaths annually worldwide. Genomic Vibrio cholerae research revealed that the strains causing this ongoing cholera pandemic are members of the El Tor biotype, which fully replaced the Classical biotype that caused former cholera pandemics. While both of these biotypes express...
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Wnt ligands interact with the transmembrane cell surface receptors Frizzled and ROR/RYK to initiate complex signaling cascades that are crucial for cell physiology and the proper functioning of the immune system. Wnt signaling is instrumental in maintaining immune surveillance and during infections by pathogenic microbes helps mount host resistance to infection. Some pathogens, however, utilize Wnt signaling to build a niche for their survival. The goal of this review is to summarize current and...
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(Source: Journal of Allergy and Clinical Immunology)
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(Source: Journal of Clinical Immunology)
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This study could open new avenues for the improvement of therapeutic efficacy of Sorafenib treated HCC patients by using Tau in combination. PMID: 31653148 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Play Polska Liga Mobilna – tak nazywa się liga dla grających na urządzeniach mobilnych, która właśnie startuje. Organizuje ją marka Play wraz z Fantasyexpo, agencją organizującą w Polsce rozgrywki sportów elektronicznych. Wsparcie rozgrywkom zapewnia LifeTube – sieć partnerska YouTube zrzeszająca ponad 800 influencerów. Liga obejmie jedne z najpopularniejszych tytułów mobilnej rozrywki na całym świecie: Brawl Stars (100 milionów pobrań), Clash Royale (100 milionów pobrań), World of […] Artykuł Startuje...
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Brak miejsc parkingowych to jedna z największych bolączek komunikacyjnych wszystkich większych miast. W Polsce setki tysięcy kierowców codziennie boryka się z problemem parkowania, często nawet kilka razy dziennie. Zarządcy dróg od lat próbują znaleźć sposób, który jednocześnie zaspokoi potrzeby kierowców oraz wpasuje się w możliwości urbanistyczne. Okazuje się, że takie rozwiązanie już istnieje i jest powszechnie dostępne. Miasta próbują niwelować problem zatłoczonych ulic oraz parkowania na wiele...
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Od kilku lat mobile uznawany jest za jeden z najlepszych kanałów do marketingowej komunikacji z klientami. Mnogość platform społecznościowych, personalizacja, bezpośrednia i dwukierunkowa komunikacja, uznawane są za największe zalety urządzeń mobilnych. Branżowa organizacja Mobile Marketing Association, zrzeszająca największych graczy rynku mobile, przygotowała ciekawy raport „The State of the Industry: Mobile Marketing in EMEA 2019”, który opisuje, jaki naprawdę jest dzisiejszy mobile. Raport został...
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Zgadzam się z grafikiem, który projektował dla nas nową wersję serwisu, że dotychczasowy layout uległ przedawnieniu. Trendy w projektowaniu stron WWW ulegają z roku na rok przeobrażeniom. Mody zmieniają się, dlatego GoMobi.pl zostało gruntownie odświeżone. Zniknęły z niego także nieaktualizowane działy. W wersji desktopowej odeszliśmy od chowania wszystkich kategorii w hamburgerze, co jeszcze jakiś czas temu było standardem na rynku. Teraz wszystkie kategorie dostępne są bezpośrednio na stronie […]...
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bmj;367/oct29_16/l6266/FAF1faAfter a couple of false starts—one as a senior house officer in Belfast and another in a maternity ward in Birmingham—Hugh Adair Courtney decided that as one of his main...
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If, as Kar suggests,1 you look at the four hour target—which says that 95% of patients attending emergency departments should be admitted, transferred, or discharged within four hours—as purely a...
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bmj;367/oct29_15/l6263/FAF1faStephanie Michelle Clarke (“Steph”) was a bright and talented young doctor with a stellar career ahead of her. After qualification she had a very happy and successful FY1...
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bmj;367/oct29_11/l6262/FAF1faTurabali M H Chakera (“Turab”) was born in Dar Es Salaam, Tanganyika (now Tanzania, Africa), the middle child in a family of five children. After initial education in...
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As mentioned by Kar,1 four hour targets—where 95% of patients attending emergency departments should be admitted, transferred, or discharged within four hours—are now being used as measures of...
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In their article on prognostic models for predicting outcome in patients with chronic obstructive pulmonary disease (COPD), Bellou and colleagues mention the dearth of prognostic models from Asia.1...
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bmj;367/oct29_9/l6259/FAF1faNeville Woolf was a respected pathologist and a dedicated educator and mentor, who made important research contributions to our understanding of the pathogenesis of...
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bmj;367/oct29_8/l6220/FAF1faIn 1983, after a pay award to doctors that was far greater than that for non-medical NHS workers, Eric Beck was the senior author of a letter in the Times decrying the...
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It happens to us all . . .True, but research by the independent think tank the Resolution Foundation has found that some parts of the UK are ageing faster than others.1Ah, like Oldham and...
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Clinical academia is very difficult because you have to be simultaneously good at two different things, says Emma Crosbie, professor of gynaecological oncology at the University of...
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I’ve recently been considering whether quality improvement is as accessible as it’s often made out to be. There’s a pervading sense that anyone can attend a course and then have a go. But people...
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“Don’t get old, doctor,” my patients often advise me. However, we always end up agreeing that the alternative is worse. When patients in their 90s complain that they can no longer manage the two mile...
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Patterns of violence over the past 20 years have followed a sustained downward trend according to routine police and hospital data, as well as findings from the Crime Survey for England and Wales.1...
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A template letter for patients who have been “refused” hormone replacement therapy to send to their GP warning of “litigation” has been criticised for being confrontational and inappropriate.The GP...
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Senior NHS leaders have called for the UK’s largest group of registered homoeopaths to have its accreditation revoked amid concerns that some practitioners are spreading misinformation about...
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Abstract Background Infertility continues to be an enigmatic and emerging problem. Although in vitro fertilization has proved to be revolutionary and immensely beneficial to many people, it is far from perfect, and many women experience recurrent in vitro fertilization failures. There can be a multitude of factors involved in recurrent in vitro fertilization failures. The aim of this report was to explore the role of hysteroscopy...
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Abstract Background Klebsiella pneumoniae-induced pyogenic liver abscess (KP-PLA) has emerged as a life-threatening disease worldwide. However, to date, a limited number of scholars have attempted to systematically elucidate the characteristics of KP-PLA. The aim of the present study was to analyze clinical, microbiological, and molecular epidemiological characteristics of KP-PLA patients in Southeastern China. ...
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Abstract Background Hand hygiene is a critical component of infection control. Much of the focus on improving hand hygiene in healthcare settings has been directed towards healthcare worker compliance but its importance for patients, including those in long-term care facilities (LTCFs), is increasingly being recognised. Alcohol-based hand rub (ABHR) can lead to improved compliance. We aimed to determine acceptability and tolerability...
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Abstract Background Cardiac metastasis from renal cell carcinoma is an exceptional event, particularly when there is lack of inferior vena cava involvement. Only a few cases have been reported worldwide so far. Case presentation We presented a case of a 58-year-old man diagnosed with isolated right ventricular metastasis of renal cell carcinoma...
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Abstract Background Internal hemorrhoids are the most common anal diseases. Aluminum potassium sulfate and tannic acid (ALTA) injection is a new sclerosing therapy for the treatment of internal hemorrhoids. Although ALTA injection has been widely used, there are no previous reports of rectal cancer patients who underwent robot-assisted low anterior resection (Rob-LAR) after ALTA injection to treat internal hemorrhoids. ...
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Abstract Background Systemic lupus erythematosus (SLE), an autoimmune disease characterized by systemic inflammatory lesions, is often associated with obesity. Obesity aggravates symptoms of SLE; however, these symptoms can be improved by weight loss through diet therapy and bariatric surgery. However, there are only a few reports regarding the effectiveness of bariatric surgery in obese patients with SLE. Herein, we discuss the...
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A Houston-based pharmaceutical company targeting epigenetic — or, non-genetic — causes of cancer has new capital to develop its cancer drug. Houston-based Salarius Pharmaceuticals Inc. (Nasdaq: SLRX) entered into a $10.9 million common stock purchase agreement with Chicago-based institutional investor Aspire Capital Fund LLC, according to an Oct. 28 pre ss release. The agreement allows for Aspire Capital to purchase up to $10.9 million in common stock over a 30-month period through 2022, per…...
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Zusammenfassung Einleitung Der konstante Anstieg der Lebenserwartung seit über 170 Jahren ist eine der größten Leistungen der modernen Gesellschaft. Die Wahrscheinlichkeit, dass ein 80-Jähriger 100 Jahre wird, hat sich in Deutschland seit 1950 verzwanzigfacht. Dieser Sachverhalt hat verschiedenste Implikationen für den klinischen Alltag und therapeutische Leitlinien. In der Hernienversorgung sollte neben quantitativen Faktoren (Komplikationen,...
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Abstract Here we show a seven-step chemical synthesis of a DNA-encoded macrocycle library (DEML) on DNA. Inspired by polyketide and mixed peptide-polyketide natural products, the library was designed to incorporate rich backbone diversity. Achieving this diversity, however, comes at the cost of the custom synthesis of bifunctional building block libraries. This study outlines the importance of careful retrosynthetic design in DNA-encoded libraries, while revealing areas where new DNA synthetic methods...
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Cyclic oligochalcogenides (COCs) are emerging as promising systems to penetrate cells. Clearly better than and different to the reported diselenolanes and epidithiodiketopiperazines, we introduce the benzopolysulfanes (BPS), which show efficient delivery, insensitivity to inhibitors of endocytosis, and compatibility with substrates as large as proteins. This high activity coincides with high reactivity, selectively toward thiols, exceeding exchange rates of disulfides under tension. The result is...
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Publication date: Available online 28 October 2019Source: Cancer Treatment ReviewsAuthor(s): Hiroyuki Arai, Francesca Battaglin, Jingyuan Wang, Jae Ho Lo, Shivani Soni, Wu Zhang, Heinz-Josef LenzAbstractRegorafenib is a multi-targeting kinase inhibitor approved for the treatment of metastatic colorectal cancer patients in refractory to standard chemotherapy. Similarly to sorafenib, this agent was originally developed as a RAF1 inhibitor. However, the kinase inhibitory profile is distinct from sorafenib....
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The Editor-in-Chief is retracting this article [1] because the authors have not been able to provide documentary evidence that they obtained consent to publish from the patient whose details are described in this case report
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Publication date: Available online 29 October 2019Source: Journal of Rural StudiesAuthor(s): Danielle Galliano, Amélie Gonçalves, Pierre TribouletAbstractA growing literature highlights the development of specific innovative patterns in peripheral areas and the need to better understand how and why firms can innovate despite the absence of agglomeration effects. These peripheral areas can, among other things, offer local resources (material and immaterial) for developing environmental innovations....
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Publication date: Available online 28 October 2019Source: Toxicology LettersAuthor(s): Yongwei Wang, Luying Lai, Wenjing Guo, Shenghui Peng, Ruimeng Liu, Pu Hong, Guanshan Wei, Fengxian Li, Shan Jiang, Pei Wang, Ji Li, Hongyi Lei, Wei Zhao, Shiyuan XuAbstractBackgroundBupivacaine (BP) is commonly used as a local anaesthetic(LA) in the clinic, but it can also cause neurotoxicity, especially in patients with diabetes. Previous studies have found that high-glucose environments can aggravate BP-induced...
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Abstract Background Advanced practice physiotherapists (APP) have helped improve accessibility to orthopaedic outpatient care. Several studies have validated the APP practice model in orthopaedic care, demonstrating high agreement between APPs and orthopaedic surgeons (OS) regarding diagnosis and management. However, as APPs tend to be experienced senior physiotherapists, such a study involving physiotherapy students (PS) has not...
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