Atmosphere, Vol. 10, Pages 660: Investigating the Influence of the Implementation of an Energy Development Plan on Air Quality Using WRF-CAMx Modeling Tools: A Case Study of Shandong Province in China Atmosphere doi: 10.3390/atmos10110660 Authors: Luo He Yu He Zhang Ma In this paper, the Weather Research Forecast (WRF) Comprehensive Air Quality Model with Extensions (CAMx) modeling system with the particulate source apportionment technology (PSAT) module was used...
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»Deutsche Staatschefs und deutsche Botschafter in Moskau kamen und gingen - aber Gustav Hilger blieb.« - Mit diesen Worten umschrieb Stalin jenen Mann, dessen Biografie im Mittelpunkt von Jörn Happels Studie steht. Als Experte, Diplomat und Dolmetscher war der gebürtige Moskauer von 1918 bis 1941 aus den deutsch-sowjetischen Beziehungen nicht wegzudenken. Er beriet zahlreiche Politiker und Wirtschaftsvertreter und übersetzte für Stalin und Molotov, Hitler und Ribbentrop. Ab 1941 arbeitete Hilger...
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The tetratopic ligands 1,4-bis(2-ethylbutoxy)-2,5-bis(3,2':6',3''-terpyridin-4'-yl)benzene ( 1 ) and 1,4-bis(3-methylbutoxy)-2,5-bis(3,2':6',3''-terpyridin-4'-yl)benzene ( 2 ) have been prepared and characterized by 1 H and 13 C{ 1 H} NMR, IR, and absorption spectroscopies and mass spectrometry. Reactions of 1 and 2 with cobalt(II) thiocyanate under conditions of crystal growth at room temperature result in the formation of [{Co( 1 )(NCS) 2 }·MeOH·3CHCl 3 ] n and [{Co( 2 )(NCS) 2 }·0.8MeOH·1.8CHCl...
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Background Parasympathetic nerve hypersensitivity contributes to the severity of allergic rhinitis (AR), but the precise mechanism underlying neuroimmune regulation in patients with AR remains unclear. This study investigated the effect of cholinergic nerve inhibition on AR CD4+ T‐helper (Th)2‐cell polarization and the underlying regulatory mechanism in vitro. Methods An in‐vitro neuroimmune coculture model of D‐U87 cells and CD4+ T cells was established. D‐U87 cells with cholinergic neuron...
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Abstract Purpose To investigate changes in bone mineral density (BMD) following denosumab after previous bisphosphonate therapy and the impact of chronic kidney disease (CKD) on response. Methods A retrospective study of 134 patients (11 M, 123 F) aged [mean (SD)] 72 [11] years on denosumab was undertaken. Ninety-five patients had previously been on oral...
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Abstract Background Pituitary metastasis is a rare condition with a poor prognosis. Very few patients with pituitary metastasis are symptomatic. It is often associated with presence of co-existing metastases to other organs. Isolated pituitary metastasis as the first presentation of primary malignancy is uncommon. Case presentation A 72-year-old...
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Abstract Intracranial abscess is a rare but life‐threatening disease. There have been no reports on intracranial abscess induced by the residual primary tooth and the impacted successive permanent tooth with infection. We report on an interesting case of a 29‐year‐old man suffering from an epidural abscess, potentially caused by an infection of the residual primary maxillary right canine and the impacted permanent maxillary right canine. The patient recovered completely after prolonged antibiotic...
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The Underlying Biochemical Principles of Treatment ← Older revision Revision as of 08:02, 29 October 2019 (One intermediate revision by the same user not shown)Line 16: Line 16: The fundamental principles behind these extra therapies are as follows: The fundamental principles behind these extra therapies are as follows:−#starve the cancer of its food supply;+#starve the cancer of its food supply ie sugar and starch- do the PK diet;−#get rid of growth promoters;+#get rid of growth promoters...
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An association between maternal diabetes, its medication and childhood cancer has not been previously explored in a registry‐based setting. With a case‐control design, we aimed to explore whether maternal diabetes is associated with an increased risk of childhood cancer in the offspring. Combining data from population‐based registries, we analyzed a total of 2,029 cases, i.e. persons with childhood cancer diagnosed under the age of 20 years between years 1996‐2014 and a total of 10,103 matched population...
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Abstract The Amazon represents one of the most complex biomes in the world; however, the temporal variations in parasite community structure of fishes inhabiting this region remain poorly understood. Therefore, processes generating such variations are still unknown. The present study evaluated the long-term temporal variation of community structure of metazoan parasites of Pimelodus blochii collected in Iaco River, State of Acre (Southwestern Brazilian Amazon). A total of 196 parasites...
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Abstract Although esophageal cancers have poor survival outcomes, evidence suggests that preoperative chemoradiation followed by surgery have improved survival outcomes. Minimally invasive surgery has equivalent oncological outcomes with less complication compared with open surgery, but there is insufficient data available in South Indian population. Our aim was to analyze the perioperative outcome and survival between minimally invasive and open transhiatal esophagectomy group....
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CONCLUSION: The DRP showed a potential in predicting fulvestrant treatment but was not significant in the overall analysis. Use of older biopsies, long-term endocrine treatment and multiple therapies between biopsy used for analysis and fulvestrant treatment, probably affect the predictive accuracy. PMID: 31654283 [PubMed - as supplied by publisher] (Source: Breast Cancer)
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CONCLUSION: Breast density on mammography is a risk factor for breast cancer after adjustment for other risk factors. This risk is particularly high in postmenopausal women and those with a high BMI. PMID: 31650498 [PubMed - as supplied by publisher] (Source: Breast Cancer)
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Abstract Value of hepatitis C virus (HCV) core antigen (cAg) test has been controversy in patients with low HCV loads for its lower sensitivity. We assessed correlation between HCV-cAg and HCV RNA in serum samples with low viral loads and analyzed the performance of HCV-cAg assay in determining diagnosis and treatment outcomes in chronic hepatitis C patients. Both HCV RNA and HCV-cAg were detected for 2298 serum samples. Correlation analysis was performed between the two tests....
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Human malaria has arguably affected more of human history than any other pathogen. Pregnant women have a higher risk of developing severe malaria as well as the risk of severe complications. We present a case of severe malaria in a pregnant patient from sub-Saharan Africa who was treated successfully with artesunate. A 28-year-old Nigerian woman with a 20-week intrauterine pregnancy presented with a five-day history of fever and diffuse joint pains. Evaluation of peripheral thin blood smear demonstrated...
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Abstract Purpose Jejuno-ileal atresia remains the most common form of intestinal obstruction in the neonatal and infantile age group and has an incidence of 1:300 to 1:1500. Apple peel atresia (APA) is the rarest of the five described types. The morbidity and mortality of patients with APA managed at our institution are high, and we review our experience with this paper. We compared our outcomes with other developed and developing countries....
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Abstract Background CircMYO10 is a circular RNA generated by back-splicing of gene MYO10 and is upregulated in osteosarcoma cell lines, but its functional role in osteosarcoma is still unknown. This study aimed to clarify the mechanism of circMYO10 in osteosarcoma. Methods CircMYO10 expression in 10 paired osteosarcoma and chondroma tissues...
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Abstract Dermatomycoses, often caused by both dermatophytic and non dermatophytic fungi, affect the epidermis, nail, and hair. There is an increase in antifungal resistance against antimycotics of many dermatophytes and non-dermatophytes, and this has posed a serious global challenge. Therefore, the search for effective and easily consumable new substances with antimycotic activity is of great necessity. This study aims to isolate dermatomycotic agents from domestic animals and...
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Abstract Hepatitis E virus (HEV) infection has been recognised as an important cause of acute viral hepatitis of zoonotic importance globally. This study evaluated the haematological, serum biochemical and histopathological changes in HEV seropositive pigs. A total of 120 pigs were sourced from the Bodija Municipal abattoir, Ibadan, Nigeria, for this study. The haematology and serum biochemistry of the sampled pigs seropositive to HEV antibodies using the ID Screen® Hepatitis...
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Abstract Cutaneous horn (cornu cutaneum) is a circumscribed, conical, and hyperkeratotic epidermis projected from the skin surface. Cutaneous horn is described in domestic animals with unknown etiology in some of them. In this report, this lesion was observed on the apex of the ear in a female Pakistani goat. The size of the cutaneous horn was 12 cm length. It was removed under local anesthesia and fixed in 10% neutral buffered formalin. Histopathologic examination showed well-differentiated...
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Abstract Nocardia spp. are causing various infections in human and animals. Nocardia isolation and identification are hard and need of professional experts and equipped laboratory. Sometimes there are various bugs in the isolation, identification, antibiogram, etc. according to some articles. The purpose of this study is to survey comments and questions in letters to the editor that have been published in the journals about nocardial infections (nocardiosis) in human, and we...
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Abstract The aim of this study was to determine the haematological reference values of a population of dromedary camels (Camelus dromedarius) in northern Nigeria to provide data required during laboratory investigation of health. The haematological variables were determined with EDTA anti-coagulated blood samples collected from the jugular veins of 121 camels during antemortem sessions at the abattoir in Maiduguri (Borno State). Serum total protein, albumin and globulin concentrations...
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Abstract Anthropogenic impact and environmental threats can cause diseases to marine turtles and in severe cases death, contributing to population decline worldwide. The Gulf of Ulloa (GU) represents an important foraging habitat for loggerhead sea turtles and olive ridley turtles; it is also considered a highly productive area for fisheries and is known for the mortality of marine turtles, which has been associated to bycatch. However, there is little information in the area...
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Abstract A 3-year-old intact male mongrel dog was presented to the Referral Veterinary Polyclinic, ICAR-Indian Veterinary Research Institute, Izatnagar, with the history of inappetence, multiple subcutaneous swellings, and haematuria for the past 15 days. The dog had a history of mating with stray dogs, a few months ago. Physical examination revealed normal vital signs and generalized lymphadenopathy along with multiple subcutaneous hard masses of approximately 1–5 cm size was...
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The affiliation of Abolfazl Hajibemani in the original published version of this article was incorrect. Instead of Tabriz University, it should have been University of Tabriz.
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Abstract The aim of this study was to determine the normal hematological and biochemical parameters of the Thoroughbred Appaloosa horse breeds which reared in Tong and Issık-Kul regions of Kyrgyzstan. Fifty-six (n = 56) healthy horse breeds in different ages (0–12 months and 1–5 years) and gender (n = 29 male and n = 27 female) were clinically examined and blood samples were taken. Red blood cell (RBC) count, white blood cell (WBC) count, the count (#); the percentage (%) of...
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Abstract Anti-inflammatory, analgesic, and leukocyte mobilization activities of ciprofloxacin, lincomycin, and erythromycin were evaluated in this study. The study involved two sets of thirty-three adult female Wistar rats assigned into five treatments, grouped into eleven of three rats per group. For agar-induced paw edema, the first three groups were treated 10 mg/kg, 20 mg/kg, and 40 mg/kg of ciprofloxacin, next three groups same doses of lincomycin, next three groups same...
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Abstract In this project, red-backed salamanders, Plethodon cinereus, were collected from the heart of their range (Mountain Lake, Virginia, USA), in an effort to document the typical, or baseline, leukocyte profile of this species in its natural state. From microscopic examination of thin blood films, we determined relative proportions of all leukocyte types and determined the ratio of neutrophils to lymphocytes, which is a useful index of stress levels. In addition, individuals...
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Abstract The purpose of this study was to evaluate the potential effect of different levels of Gracilaria corticata (Gracilaria), Sargassum cristaefolium (Sargassum), Rhus coriaria (sumac), and Punica granatum (pomegranate) peel powdered on growth performance, carcass characteristics, and immune responses of Japanese quails against avian influenza and Newcastle disease killed vaccine virus. A total of 360 one-day-old Japanese quails were randomly distributed into nine dietary...
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Abstract The malignant ovine theileriosis due to Theileria lestoquardi is highly pathogenic in sheep. During an experimental study, clinical and pathological findings were investigated in sheep infected with T. lestoquardi. The common clinical signs were high fever, emaciation, enlarged lymph nodes, anemia, icterus, nasal discharge, cough, severe pneumonia, circling, opisthotonus, recumbency, and death. Schizonts of Theileria were detected in impression smears of the lymph nodes,...
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The π‐electron donor naphtho[1,2‐b:5,6‐b′]dithiophene and its corresponding bis(hydroxymethyl) derivative (yellow) can act as guests for the π‐electron accepting cyclophane cyclobis(paraquat‐p‐phenylene) host (blue) and appear as promising building blocks for further development of electroactive molecular machines based on cyclobis(paraquat‐p‐phenylene). The synthesis and characterization of 2,7‐bis(hydroxymethyl)naphtho[1,2‐b:5,6‐b′]dithiophene 1 is described. Electrochemical investigations...
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A series of perylenediimide (PDI)‐based multimers were synthesized using an original Suzuki‐Miyaura Coupling (SMC) reaction. The new approach considers the reaction between 1‐nitroPDI as the electrophilic reagent with a wide variety of boronic esters to reach PDI dimers, trimers and tetramers which are of particular interest as Non‐Fullerene Acceptors (NFAs) in organic photovoltaics. In this work, we compared the reactivity of 1‐bromoPDI and 1‐nitroPDI towards this pallado‐catalyzed cross‐coupling...
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1,4,5‐Trisubstituted 1,2,3‐triazoles and 1,2,3‐triazole‐fused isoindolines are synthesized by a sustainable Pd‐catalyzed direct arylation reaction performed under solvent‐free conditions and in the presence of a recyclable heterogeneous catalyst. Fully substituted triazoles are synthesized by a sustainable direct arylation reaction performed under solvent‐free conditions and in the presence of a recyclable Pd/C heterogeneous catalyst. Exclusion of air as well as anhydrous conditions are not...
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A first approach to 2‐iodocarbazoles by benzannulation of indole‐tethered propargyl alcohols has been developed at room temperature in an open‐flask reaction using iodine. This benzannulation protocol involves a regioselective 5‐endo‐spirocyclization followed by a selective 1,2‐alkenyl migration and aromatization cascade. Regioselective benzannulation reaction of indol‐3‐yl‐but‐3‐yn‐2‐ols to functionaly embellished 2‐iodocarbazoles is described for the first time using iodine at room temperature...
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Intracyclic labeling with various heterocycles with carbon‐11 has been performed directly using cyclotron‐produced [11C]CO2. Many heterocycles have been obtained through a de novo cyclization in only 10 min without a preliminary transformation of [11C]CO2 Labeling of heterocycles with carbon‐11 is generally performed through peripheral functionalizations and more scarcely inside heterocyclic core. Such less common approach usually requires preliminary multi‐step synthesis of reactive species. Herein,...
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C60 reacts under ambient light with o‐phthalaldehyde to afford an unanticipated C60‐phthalide derivative in 43 % yield. Alternatively, this hydrofullerene can be accessed via a novel tetrabutylammonium decatungstate photocatalyzed reaction of C60 with phthalides (4 examples). A new, simple, and rapid photochemical reaction of o‐phthalaldehyde with C60 has been disclosed. This reaction afforded exclusively the unanticipated C60‐phthalide derivative 11 in good yield. The formation of this product...
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Total, asymmetric synthesis of (+)‐Paroxetine and (+)‐Femoxetine is reported. The key step is organocatalytic Michael addition of aldehydes to trans‐nitroalkenes realized in bath or continues flow. High efficiency and selectivity in the Michael addition was achieved by application of Wang resin‐supported Hayashi–Jørgensen catalyst. Total, asymmetric synthesis of (+)‐Paroxetine and (+)‐Femoxetine, selective serotonin reuptake inhibitors, used for the treatment of depression, anxiety, and panic...
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New England Journal of Medicine, Ahead of Print.
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Pharmaceutics, Vol. 11, Pages 560: The Future of PSMA-Targeted Radionuclide Therapy: An Overview of Recent Preclinical Research Pharmaceutics doi: 10.3390/pharmaceutics11110560 Authors: Eline A.M. Ruigrok Wytske M. van Weerden Julie Nonnekens Marion de Jong Prostate specific membrane antigen (PSMA) has become a major focus point in the research and development of prostate cancer (PCa) imaging and therapeutic strategies using radiolabeled tracers. PSMA has shown to be an excellent...
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Abstract The kidney is frequently involved in adverse effects caused by exposure to foreign compounds, including drugs. An early prediction of those effects is crucial for allowing novel, safe drugs entering the market. Yet, in current pharmacotherapy, drug-induced nephrotoxicity accounts for up to 25% of the reported serious adverse effects, of which one-third is attributed to antimicrobials use. Adverse drug effects can be due to direct toxicity, for instance as a result of kidney-specific...
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Abstract High-content screening (HCS) technology combining automated microscopy and quantitative image analysis can address biological questions in academia and the pharmaceutical industry. Various HCS experimental applications have been utilized in the research field of in vitro toxicology. In this review, we describe several HCS application approaches used for studying the mechanism of compound toxicity, highlight some challenges faced in the toxicological community, and discuss...
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We wish to submit a corrigendum to the above-mentioned article. Thank you very much for consideration and publication.
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Genes, Vol. 10, Pages 856: Predominance of Dystrophinopathy Genotypes in Mexican Male Patients Presenting as Muscular Dystrophy with A Normal Multiplex Polymerase Chain Reaction DMD Gene Result: A Study Including Targeted Next-Generation Sequencing Genes doi: 10.3390/genes10110856 Authors: Miguel Angel Alcántara-Ortigoza Miriam Erandi Reyna-Fabián Ariadna González-del Angel Bernardette Estandia-Ortega Cesárea Bermúdez-López Gabriela Marisol Cruz-Miranda Matilde Ruíz-García...
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Abstract Conventional wheelchairs are used by people who can actuate their hand, but there are conditions that cause the user cannot operate the wheelchair, such as handicapped people and amputated arms. Hence, they need an assistant to operate the wheelchair, as we know those conditions are dependent on others. An intelligent wheelchair becomes a solution to this problem by tracking and following an assistant in front of a wheelchair; it uses a camera that has been embedded...
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Abstract This paper presents a novel approach to the occlusion handling problem in depth estimation using three views. A solution based on modification of similarity cost function is proposed. During the depth estimation via optimization algorithms, like Graph Cuts, the similarity metric is constantly updated so that only non-occluded fragments in the side views are considered. At each iteration of the algorithm, non-occluded fragments are detected based on side view virtual...
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Abstract Passive Global Navigation Satellite System (GNSS)-based Synthetic Aperture Radar (SAR), known as GNSS-SAR, is a recently developing SAR imaging system. Due to the restrictions of transmission power and long distance transmission between GNSS satellites and earth surface, the received signals can be very weak after reflections, in which a noisy GNSS-SAR image can be resulted in. In this study, a new imaging algorithm for GNSS-SAR objects signal detectability enhancement...
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Abstract User experience has become the most reliable and trustworthy source for service providers to assess system performance. To fulfill customer requirements, service providers require an efficient quality of experience (QoE) estimation model. QoE is a subjective metric that deals with user perception and can vary dramatically due to various factors such as emotions, the degree of annoyance, past experience, and aesthetics. Moreover, subjective QoE evaluation is expensive...
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Discriminative dictionary learning for retinal vessel segmentation using fusion of multiple features
Abstract In recent years, automated retinal vessel segmentation has become especially essential for the early detection of some ophthalmological and cardiovascular diseases. In this paper, we have presented a new retinal vessel segmentation method via discriminative dictionary learning using fusion of multiple features, which is able to capture both thick and thin vessel structures. In the training stage, we employ six different enhancement algorithms to obtain multiple complementary...
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Abstract Edges and flat areas in the sinogram of low-dose X-ray computed tomography are difficult to distinguish. This lack of distinction leads to excessive smoothing in the sinogram restoration. To address this problem, we propose a sinogram restoration algorithm using the regularized Perona–Malik (P–M) equation with intuitionistic fuzzy entropy. Firstly, considering the sinogram fuzziness, a novel edge indicator function is constructed using both the gradient magnitude and...
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Abstract The main problem to be addressed in this paper is on the high required computational powers of the existing fractional pixel location search algorithms. The current solution method is based on the computation of the phase shift of the power spectral densities of two consecutive frames of a video sequence. Since the probability density function of each frame of the video sequence is required for computing its power spectral density but it is unknown in the practical situation,...
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Abstract This paper proposes a method for generating inter-frame video images based on spatial continuity generative adversarial networks (SC-GANs) to smooth the playing of low-frame rate videos and to clarify blurry image edges caused by the use of traditional methods to improve the video frame rate. Firstly, the auto-encoder is used as a discriminator and Wasserstein distance is applied to represent the difference between the loss distribution of the real sample and the generated...
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Conclusion: The strategy proposed seemed safe and effective, resulting in radical treatment and persistence of regular menstrual period. Further studies are needed. PMID: 31650042 [PubMed] (Source: Clinical Colorectal Cancer)
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Discussion: MYB transcription factor is aberrantly overexpressed in a range of epithelial cancers, not limited to the above tumour types. Based on promising pre-clinical data of vaccine-induced tumour clearance and establishment of anti-tumour memory, we are embarking on this first-in-human trial. If successful, the results from this trial will allow progression to a Phase II trial and validation of this breakthrough immunotherapeutic approach, not only in CRC and AdCC, but other MYB over-expressing...
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Abstract Emissions from everyday consumer products have been associated with adverse effects on air quality and health. This study investigates volatile organic compounds (VOCs) emitted from 134 common consumer products, both fragranced and fragrance-free, including those with claims of green. Product types include personal care products, air fresheners, cleaning supplies, laundry products, and sunscreens. Using GC/MS headspace analysis, this study found 1538 VOC occurrences (individual...
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In this case study, we implicate the disease-modifying potential of interferon-β for relapsing Schilder disease.
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