Related ArticlesAssociation between TERT promoter mutations and clinical behaviors in differentiated thyroid carcinoma: a systematic review and meta-analysis. Endocrine. 2019 Oct 26;: Authors: Yang J, Gong Y, Yan S, Chen H, Qin S, Gong R Abstract BACKGROUND: The association between telomerase reverse transcriptase (TERT) promoter mutations and some clinical behaviors in thyroid cancer remains controversial and requires additional investigation. This...
Related ArticlesCharacteristics of ultrasonographic images of ductal carcinoma in situ with abnormalities of the ducts. J Med Ultrason (2001). 2019 Oct 26;: Authors: Ban K, Tsunoda H, Watanabe T, Kaoku S, Yamaguchi T, Ueno E, Hirokaga K, Tanaka K Abstract PURPOSE: Although the number of ductal carcinoma in situ (DCIS) cases has increased with the spread of breast cancer screening in Japan, there are very few reports that summarize ultrasound image features...
Related ArticlesGermline missense mutation of Deleted in malignant brain tumor 1 (DMBT1) in familial mediastinal neuroendocrine cancer and in vitro effects in thyroid cancer cells. Neuroendocrinology. 2019 Oct 28;: Authors: Qu N, Shi RL, Liao T, Huang SL, Wen D, Hu JQ, Zhang TT, Han LT, Ma B, Wang J, Wang YL, Wang Y, Ji QH Abstract BACKGROUND: Neuroendocrine tumor (NET) rarely occurs in the mediastinum and the etiology and pathogenesis are still unclear....
Related ArticlesOrphan nuclear receptor TR3/Nur77 biologics inhibit tumor growth by targeting angiogenesis and tumor cells. Microvasc Res. 2019 Oct 22;:103934 Authors: Chen C, Li Y, Hou S, Bourbon PM, Qin L, Zhao K, Ye T, Zhao D, Zeng H Abstract Pathological angiogenesis is a hallmark of many diseases. Previously, we reported that orphan nuclear receptor TR3/Nur77 was a critical mediator of angiogenesis to regulate tumor growth, sepsis and skin wound...
Related ArticlesFinancial burden of thyroid cancer in the United States: An estimate of economic and psychological hardship among thyroid cancer survivors. Surgery. 2019 Oct 22;: Authors: Barrows CE, Belle JM, Fleishman A, Lubitz CC, James BC Abstract BACKGROUND: Annual cancer-related healthcare expenditure in the United States is estimated to exceed $150 billion by 2020. As the prevalence of thyroid cancer increases worldwide, thyroid cancer survivorship...
Related ArticlesOccult carcinoma confirmed to be a diffuse sclerosing variant of papillary thyroid carcinoma with unusual immunohistochemical features: A pitfall of clinicopathological diagnosis. Auris Nasus Larynx. 2019 Oct 22;: Authors: Kubo T, Kikuchi N, Shiina S, Torigoe T, Iwaki H Abstract Immunocytochemistry in a 78-year-old man diagnosed as having systemic metastatic cancer of unknown primary origin revealed atypical cells positive for napsin...
Related ArticlesComprehensive Assessment of GPR68 Expression in Normal and Neoplastic Human Tissues Using a Novel Rabbit Monoclonal Antibody. Int J Mol Sci. 2019 Oct 23;20(21): Authors: Herzig M, Dasgupta P, Kaemmerer D, Sänger J, Evert K, Schulz S, Lupp A Abstract : GPR68 (OGR1) belongs to the proton-sensing G protein-coupled receptors that are involved in cellular adaptations to pH changes during tumour development. Although expression of GPR68 has...
Related ArticlesPredicted Basal Metabolic Rate and Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (Epic). Int J Cancer. 2019 Oct 25;: Authors: Kliemann N, Murphy N, Viallon V, Freisling H, Tsilidis KK, Rinaldi S, Mancini FR, Fagherazzi G, Boutron-Ruault MC, Boeing H, Schulze MB, Masala G, Krogh V, Sacerdote C, Santucci de Magistris M, Bueno-de-Mesquita B, Weiderpass E, Kühn T, Kaaks R, Jakszyn P, Redondo-Sánchez D, Amiano P, Chirlaque...
Related ArticlesActive surveillance in papillary thyroid microcarcinomas is feasible and safe: experience at one single Italian center. J Clin Endocrinol Metab. 2019 Oct 25;: Authors: Molinaro E, Campopiano MC, Pieruzzi L, Matrone A, Agate L, Bottici V, Viola D, Cappagli V, Valerio L, Giani C, Puleo L, Lorusso L, Piaggi P, Torregrossa L, Basolo F, Vitti P, Tuttle RM, Elisei R Abstract CONTEXT: The dramatic rise in the incidence of thyroid cancer over...
Related ArticlesThyroid function and life expectancy with and without noncommunicable diseases: A population-based study. PLoS Med. 2019 Oct;16(10):e1002957 Authors: Bano A, Chaker L, Mattace-Raso FUS, Terzikhan N, Kavousi M, Ikram MA, Peeters RP, Franco OH Abstract BACKGROUND: Variations in thyroid function within reference ranges are associated with increased risk of diseases and death. However, the impact of thyroid function on life expectancy (LE)...
Related ArticlesAsymptomatic Metastasis to Thyroid Cartilage Detected by 18F-Choline and 64Cu-PSMA PET/CT as a Single Site of Disease Relapse in a Patient With Castration-Resistant Prostate Carcinoma. Clin Nucl Med. 2019 Oct 17;: Authors: Annovazzi A, Faiella A, Pescarmona E, Sanguineti G, Sciuto R Abstract Metastatic involvement of the larynx is rare due to the absence of vessels within the cartilaginous tissue. The probability of metastatic spread...
Related ArticlesFDG PET/CT of Cervical Gout With Spinal Cord Compression. Clin Nucl Med. 2019 Oct 17;: Authors: Emsen B, Fitoussi A, Chalaye J, Adam C, Itti E Abstract We report FDG PET/CT images of a 63-year-old woman referred for characterization of osteolytic lesions of the cervical spine. This patient with chronic renal failure had a history of follicular thyroid carcinoma with undifferentiated cells, treated by a total thyroidectomy, completed by...
Related ArticlesOvarian cancer metastasis to the breast 18 years after the initial diagnosis: A case report. Medicine (Baltimore). 2019 Oct;98(43):e17577 Authors: Wang Z, Zhao D, Liu R, Zheng B Abstract RATIONALE: Ovarian cancer often metastasizes, but it is unusual to transfer to the breast as an isolated mass. In particular, it is rare for patients to have breast metastases after 18 years of diagnosis of ovarian cancer. Therefore, accurate identification...
Related ArticlesAssociations of telomerase reverse transcriptase rs10069690 and rs2736100 polymorphisms with papillary thyroid carcinoma. Eur J Cancer Prev. 2019 Oct 22;: Authors: Liu Y, Shi F Abstract Papillary thyroid carcinoma is one of the most common endocrine malignancies. Telomerase reverse transcriptase rs10069690 and rs2736100 polymorphisms have been studied in thyroid carcinomas with different ethnicity, but the results were inconsistent. Therefore,...
Related ArticlesIncidence of second primary malignancies in patients with thyroid cancer in the Turkish population Turk J Med Sci. 2019 Oct 24;49(5):1529-1533 Authors: Karaköse M, Çordan İ, Can M, Kocabaş M, Kulaksızoğlu M, Karakurt F Abstract Background/aim: Thyroid cancer is the most common endocrine malignancy. Recently the incidence has been increasing faster compared to other malignancies. Different studies have shown that the incidence...
Related ArticlesVps34 PI 3-kinase controls thyroid hormone production by regulating thyroglobulin iodination, lysosomal proteolysis and tissue homeostasis. Thyroid. 2019 Oct 25;: Authors: Grieco G, Wang T, Delcorte O, Spourquet C, Janssens V, Strickaert A, Gaide Chevronnay H, Liao XH, Bilanges B, Refetoff S, Vanhaesebroeck B, Maenhaut C, Courtoy PJ, Pierreux CE Abstract BACKGROUND: The production of thyroid hormones (T3, T4) depends on the organization...
Related ArticlesA Novel ALK Fusion in Pediatric Medullary Thyroid Carcinoma. Thyroid. 2019 Oct 25;: Authors: Hillier K, Hughes A, Shamberger R, Shusterman S, Perez-Atayde A, Wassner AJ, Iafrate AJ, Dubuc A, Janeway K, Rothenberg SM, Cox MC, Randolph GW, Wirth LJ, Tsai HK, Church AJ, DuBois S Abstract BACKGROUND: Medullary thyroid carcinoma (MTC) is most commonly associated with RET gene mutations. ALK fusions have rarely been described, though not previously...
Related ArticlesMetachronous rectal metastasis from pulmonary adenocarcinoma after 11 years of chemo-, immuno-, and radiotherapy for recurrent lesions: a case report. Surg Case Rep. 2019 Oct 24;5(1):151 Authors: Suzuki Y, Imasato M, Nakahara Y, Naito A, Mikamori M, Ohtsuka M, Furukawa K, Moon JH, Asaoka T, Kishi K, Yasuoka H, Komuta K, Akamatsu H Abstract BACKGROUND: Rectal metastasis from pulmonary adenocarcinoma is rare, and it has been regarded as...
Related ArticlesDynamics of serum antithyroglobulin antibodies in patients with differentiated thyroid cancer. Endocrine. 2019 Oct 24;: Authors: Bueno F, Falcone MGG, Peñaloza MA, Abelleira E, Pitoia F Abstract PURPOSE: Serum antithyroglobulin antibodies (sTgAb) affect the reliability of Tg measurement in patients with thyroid cancer. We compared the outcome of patients with detectable and undetectable sTgAb, stratified according to the initial risk...
Related ArticlesVitiligo Adverse Event Observed in a Patient With Durable Complete Response After Nivolumab for Metastatic Renal Cell Carcinoma. Front Oncol. 2019;9:1033 Authors: Billon E, Walz J, Brunelle S, Thomassin J, Salem N, Guerin M, Vicier C, Dermeche S, Albiges L, Tantot F, Nenan S, Pignot G, Gravis G Abstract Background: Renal cell carcinoma is the third most prevalent urological cancer worldwide and about 30% of patients present with metastatic...
Related ArticlesDeep Small RNA Sequencing of BRAF V600E Mutated Papillary Thyroid Carcinoma With Lymph Node Metastasis. Front Genet. 2019;10:941 Authors: Yusof AM, Jamal R, Saidin S, Muhammad R, Suhaimi SNA, Rose IM, Nazarie WFW, Fu FTY, Mutalib NA PMID: 31649724 [PubMed]
Related ArticlesNovel use of a CLIA-certified CDKN2C loss assay in sporadic medullary thyroid carcinoma. Surgery. 2019 Oct 21;: Authors: Maxwell JE, Gule-Monroe MK, Subbiah V, Hu M, Perrier ND, Cabanillas ME, Lee JE, Graham PH, Cote GJ, Busaidy NL, Grubbs EG Abstract BACKGROUND: The cyclin-dependent-kinase inhibitor/retinoblastoma pathway has been implicated in sporadic medullary thyroid carcinoma tumorigenesis. Somatic CDKN2C loss has been associated...
Related ArticlesHigh Expression of miR-206 Predicts Adverse Outcomes：A Potential Therapeutic Target for Esophageal Cancer. Comb Chem High Throughput Screen. 2019 Oct 18;: Authors: Du G, Zhou J, Cheng L, Ma X, Gui Y, Tan B Abstract BACKGROUND: MicroRNA-206 (miR-206) inhibits cell proliferation, invasion and migration in a variety of tumors, but the prognostic value of its Esophageal Cancer (EC) remains unclear. OBJECTIVE: To study the role of...
Related ArticlesConceptual interpretation of analysing and reporting of results on systematic review and meta-analysis of optimal extent of lateral neck dissection for well-differentiated thyroid carcinoma with metastatic lateral neck lymph nodes. Oral Oncol. 2019 02;89:153-154 Authors: Jayaraj R, Kumarasamy C PMID: 30612934 [PubMed - indexed for MEDLINE]
Related ArticlesRegional recurrence rate of lymph-node-positive thyroid carcinoma after selective or comprehensive neck dissection. Oral Oncol. 2019 03;90:147-149 Authors: Deng L, Cao Y, Lin J PMID: 30554855 [PubMed - indexed for MEDLINE]
Related ArticlesRisk Stratification of Thyroid Nodules Using the Thyroid Imaging Reporting and Data System (TIRADS): The Omission of Thyroid Scintigraphy Increases the Rate of Falsely Suspected Lesions. J Nucl Med. 2019 03;60(3):342-347 Authors: Schenke S, Seifert P, Zimny M, Winkens T, Binse I, Görges R Abstract Thyroid nodules are a common finding, especially in iodine-deficient regions. Ultrasonographic scoring systems such as the Thyroid Imaging...
Related ArticlesReliability of the ultrasound classification system of thyroid nodules in predicting malignancy. Med J Malaysia. 2018 02;73(1):9-15 Authors: Farihah AG, Nurismah MI, Husyairi H, Shahrun Niza AS, Radhika S Abstract AIM: This study aims to evaluate the reliability of the Ultrasound (U) Classification system in predicting thyroid malignancy by using pathology diagnosis as the reference standard. METHODS: It was a cross-sectional...
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Related ArticlesImproving self-efficacy for hearing aid self-management: the early delivery of a multimedia-based education programme in first-time hearing aid users. Int J Audiol. 2019 Oct 25;:1-10 Authors: Gomez R, Ferguson M Abstract Objectives: This study examined the effect of a multimedia educational programme for first-time hearing aid users (C2Hear reusable learning objects, RLOs), delivered at the hearing assessment on (1) self-efficacy for...
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Related ArticlesEvaluation of clinical criteria to determine the need for cervical spine imaging in victims of blunt assault. J Clin Neurosci. 2019 Oct 21;: Authors: Chaudry J, Swaminathan N, Gershon RK, Gordy DP, Allred L, Lirette ST, Khan MA Abstract The purpose of this study is to evaluate effectiveness of clinical criteria, specifically the NEXUS Criteria, in determining the need for cervical spine imaging in victims of blunt assault to head and...
Related ArticlesDiagnostic impact of preoperative corticosteroids in primary central nervous system lymphoma. J Clin Neurosci. 2019 Oct 21;: Authors: Bullis CL, Maldonado-Perez A, Bowden SG, Yaghi N, Munger D, Wood MD, Ambady P, Neuwelt EA, Han SJ Abstract PURPOSE: High dose corticosteroids are an effective tool for rapidly alleviating neurologic symptoms caused by intracranial mass lesions. However, there is concern that preoperative corticosteroids...
Related ArticlesDeep learning in the detection of high-grade glioma recurrence using multiple MRI sequences: A pilot study. J Clin Neurosci. 2019 Oct 21;: Authors: Bacchi S, Zerner T, Dongas J, Asahina AT, Abou-Hamden A, Otto S, Oakden-Rayner L, Patel S Abstract The identification of high-grade glioma (HGG) progression may pose a diagnostic dilemma due to similar appearances of treatment-related changes (TRC) (e.g. pseudoprogression or radionecrosis)....
Related ArticlesAMR monitoring in microvascular decompression for hemifacial spasm: 115 cases report. J Clin Neurosci. 2019 Oct 21;: Authors: Zhu W, Sun C, Zhang Y, Xu J, Wu S Abstract In MVD operations assisted by AMR monitoring, the reliability and validity of decompression can be evaluated by observing whether AMR disappears. Although intraoperative AMR monitoring has been used widely, debate exists over its reliability and positive contribution....
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Related Articles18F-Fluorocholine PET/CT Imaging of Brown Tumors in a Patient With Severe Primary Hyperparathyroidism. Clin Nucl Med. 2019 Oct 17;: Authors: Zhang-Yin J, Gaujoux S, Delbot T, Gauthé M, Talbot JN Abstract Brown tumors are rare skeletal anomalies occurring in patients with hyperparathyroidism and exposing patients to pathological fractures. We report the case of a 26-year-old woman with severe primary hyperparathyroidism (calcemia, 2.9...
Related ArticlesThe Great Mimicker-Tuberculosis Involving Prostate and Vertebrae Posing as Metastatic Prostate Carcinoma on FDG PET/CT. Clin Nucl Med. 2019 Oct 17;: Authors: Joshi PV, Shewalkar B, George T, Sahasrabudhe S, Joshi S, Kulkarni M Abstract A 65-year-old man underwent FDG PET/CT for evaluation of vertebral lesions, radiologically suspected to be metastases. The scan showed hypermetabolism in D8 to D9 vertebrae, retroperitoneal lymph nodes,...
Related ArticlesBreast Cancer Imaging With PET Based Radiopharmaceuticals Other Than 18F-FDG. Clin Nucl Med. 2019 Oct 17;: Authors: Vatsa R, Singh SS, Ashwathanarayana AG, Kumar R, Rana N, Shukla J, Mittal BR Abstract Breast cancer is the most common cancer in women with rising incidence worldwide. F-FDG PET/CT imaging has already established itself as a pivotal modality for staging, restating and response assessment in patients with carcinoma breast....
Related ArticlesComplete Spontaneous Regression of Hepatosplenic T-Cell Lymphoma After Surgical Biopsy. Clin Nucl Med. 2019 Oct 17;: Authors: Nakamoto R, Okuyama C, Oka S Abstract F-FDG PET/CT for a 74-year-old man with elevated serum soluble interleukin 2 receptor showed multiple intense uptake in the liver, spleen, and bone. A surgical biopsy from 2 of liver tumors confirmed hepatosplenic αβ T-cell lymphoma. One and a half months after biopsy, FDG...
Related ArticlesDifferential 18F-FDG and 18F-Fluciclovine Uptake Pattern in a Patient With Poorly Differentiated Adenocarcinoma of the Lung and Prostate Cancer Biochemical Recurrence. Clin Nucl Med. 2019 Oct 17;: Authors: Nguyen NC, Muthukrishnan A, Mountz JM Abstract A 72-year-old man with a history of T1cN0M0 prostate adenocarcinoma and rising prostate-specific antigen underwent a fluciclovine PET/CT scan that showed high uptake in several para-aortic...
Related ArticlesUnilateral Lateral Rectus Paralysis Showing Incomplete "V" Sign' on 18F-FDG PET/CT. Clin Nucl Med. 2019 Oct 17;: Authors: Parihar AS, Vadi SK, Kumar R, Singh H, Takkar A, Mittal BR, Lal V Abstract Extraocular muscles show physiologic radiotracer uptake on F-FDG PET/CT as is encountered in most routine scans. Certain pathologies can cause palsy of one or more of the extraocular muscles, leading to hypometabolism on F-FDG PET/CT. We present...
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Abstract Leonurine hydrochloride (LH) has been reported to exhibit a number of biological properties such as suppression of inflammation. This study aimed to examine whether the progression of osteoarthritis (OA) could be delayed by the administration of LH in an OA model. Rat chondrocytes were treated with LH under the condition of TNF-α-induced inflammation. After that, real-time PCR and Western blotting were conducted to evaluate relative gene/protein expression levels. For...
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Abstract Introduction This survey assessed the impact of rheumatoid arthritis (RA) on the lives of patients based on the perceptions of both patients and healthcare professionals (HCPs). Methods This is a cross-sectional survey of patients with RA. Data were collected from patients and HCPs who manage RA using a structured, closed-ended questionnaire in their...
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Abstract When considering incident investigations and security checks focused on energetic materials, there is an ongoing need for rapid, on-scene chemical identification. Currently applied methods are not capable of meeting all requirements, and hence, portable mass spectrometry is an interesting alternative although many instrumental challenges still exist. To be able to analyze explosives with mass spectrometry outside the traditional laboratory, suitable ambient ionization...
Abstract The identification of known (dereplication) or unknown nonribosomal peptides (NRPs) produced by microorganisms is a time consuming, expensive, and challenging task where mass spectrometry and nuclear magnetic resonance play a key role. The first step of the identification process always involves the establishment of a molecular formula. Unfortunately, the number of potential molecular formulae increases significantly with higher molecular masses and the lower precision...
Abstract The development of simple, low-cost, and specific detection method for mercury (Hg(II)) ions in aqueous media using matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) is a challenge due to matrix interferences and acidity that destroy weak interactions. Herein, a new binary matrix consists of mefenamic acid, and thymine (T) is applied for simple and specific detection of Hg(II) in aqueous solution and blood sample. Mass spectra show metal-to-ligand...
Abstract Ion trapping using radio-frequency (RF) devices has been widely used in mass spectrometry (MS). The pseudopotential well (PW) model enables the use of a pseudopotential depth, D, to evaluate the ion trapping capability of the RF devices in the pure electric field. It remains unclear how gas pressures regulate the ion trapping and D. Here, we calculated the D of a linear ion trap (LIT) from 1 mTorr to 2 Torr, a pressure range critical for the operation of the RF devices,...
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