Abstract Cholesterol accumulation in late endosomes is a prevailing phenotype of Niemann-Pick type C1 (NPC1) mutant cells. Likewise, annexin A6 (AnxA6) overexpression induces a phenotype reminiscent of NPC1 mutant cells. Here, we demonstrate that this cellular cholesterol imbalance is due to AnxA6 promoting Rab7 inactivation via TBC1D15, a Rab7-GAP. In NPC1 mutant cells, AnxA6 depletion and eventual Rab7 activation was associated with peripheral distribution and increased mobility...
IJMS, Vol. 20, Pages 5390: Xeno-Free Propagation of Spermatogonial Stem Cells from Infant Boys International Journal of Molecular Sciences doi: 10.3390/ijms20215390 Authors: Dong Gul Hildorf Pors Kristensen Hoffmann Cortes Thorup Andersen Spermatogonial stem cell (SSC) transplantation therapy is a promising strategy to renew spermatogenesis for prepubertal boys whose fertility is compromised. However, propagation of SSCs is required due to a limited...
Publication date: Available online 29 October 2019Source: NeuroImageAuthor(s): Justin Campbell, Zirui Huang, Jun Zhang, Xuehai Wu, Pengmin Qin, Georg Northoff, George A. Mashour, Anthony G. HudetzAbstractDetermining the level of consciousness in patients with disorders of consciousness (DOC) remains challenging. To address this challenge, resting-state fMRI (rs-fMRI) has been widely used for detecting the local, regional, and network activity differences between DOC patients and healthy controls....
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM)Issue: Ahead of print
Abstract Flow, transport, mechanical, and fracture properties of porous media depend on their morphology and are usually estimated by experimental and/or computational methods. The precision of the computational approaches depends on the accuracy of the model that represents the morphology. If high accuracy is required, the computations and even experiments can be quite time-consuming. At the same time, linking the morphology directly to the permeability, as well as other important...
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01545K, PaperTobias Meyer, Roland Ackermann, Robert Kammel, Michael Schmitt, S. Nolte, Andreas Tünnermann, Juergen PoppDue to ageing populations the number of tumors is increasing worldwide. Successful surgical treatment requires complete resection of tumors to reduce recurrence rates. To reach this goal, novel methods combining...The content of this RSS Feed (c) The Royal Society of Chemistry
17m
Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01977D, PaperXiang Zhou, Lingyu Wu, Min Pan, Yuqi Chen, Haiyan Huang, Xiaoe Zhang, Fuan WangBenefit from high sequence specificity and structural simplicity of DNAzyme, a series of DNAzyme logic gates are rationally designed by using microRNAs as inputs. Through the introduction of a duplex...The content of this RSS Feed (c) The Royal Society of Chemistry
18m
Abstract Background Perioral dermatitis is a clinically distinctive reaction pattern of facial dermatitis, including redness, dryness, burning, pruritus and skin tightness. A gold standard treatment remains unclear. Objectives Our study evaluates the clinical value of a skin care cream with the transient receptor potential vanilloid type 1 inhibitor 4‐t‐butylcyclohexanol in POD patients over 8 weeks. Methods This open, unblinded 8‐week clinical trial included 48 patients. A skin care...
Abstract Background Discoid lupus erythematosus (DLE) is a most well‐known clinical variation of chronic cutaneous lupus erythematosus inside the spectrum of lupus erythematosus (LE). Cutaneous trauma remains a significant and peculiar causative factor for DLE. Aims We present a case wherein the patient demonstrated unilateral distribution of DLE on a clinically normal appearing occult facial scald of edible oil, representing Koebner phenomenon (KP) i.e. occurrence of a new skin disease...
Publication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Yuan-Yuan Fan, Wen Ding, Cheng Zhang, Lin Fu, De-Xiang Xu, Xi ChenAbstractLiver fibrosis results from sustained liver injury and is characterized by inflammation, hepatic stellate cell (HSC) activation, extracellular matrix (ECM) accumulation and liver structure destruction. The Farnesoid-X receptor (FXR) antagonizes toxic liver injury and fibrosis, yet the mechanism in liver fibrosis remains unclear. We...
Abstract The randomized controlled trial (RCT) in surgery may not always be ethical, feasible, or necessary to address a particular research question about the effect of a surgical intervention. If so, properly designed and conducted observational (non-randomized) studies may be valuable alternatives for an RCT and produce credible results. In this paper, we discus differences between RCTs and observational studies and differentiate between three types of comparisons of surgical...
Abstract Background Recent preclinical data suggest that androgen receptor (AR) signaling plays a significant role in subsets of breast cancer. Clinical trials testing AR-targeting therapies in breast cancer have been conducted. Assessment of AR-signal in breast cancer tissue maybe useful for treatment selections. Prostate specific antigen (PSA) is the product of an androgen-responsive gene. Serum PSA (sPSA) can be detected in women...
25m
Abstract Background The prognostic value of programmed death-ligand 1 (PD-L1) and BRAF expression in nasopharyngeal carcinoma (NPC) is not well-defined. In this study we investigated alterations in PD-L1, BRAF and EGFR by using immunohistochemistry analysis in a cohort of consecutively enrolled NPC patients. Methods A retrospective review of...
25m
Abstract Background Nivolumab is an immune checkpoint inhibitor specific to the programmed death 1 (PD-1) receptor. Nivolumab has shown clinical responses in many malignancies. Although immune-related adverse events (irAEs) associated with nivolumab are largely tolerable, severe irAEs have occurred in some patients. However, the mechanisms underlying the development of irAEs are not fully clarified. ...
25m
Background Parasympathetic nerve hypersensitivity contributes to the severity of allergic rhinitis (AR), but the precise mechanism underlying neuroimmune regulation in patients with AR remains unclear. This study investigated the effect of cholinergic nerve inhibition on AR CD4+ T‐helper (Th)2‐cell polarization and the underlying regulatory mechanism in vitro. Methods An in‐vitro neuroimmune coculture model of D‐U87 cells and CD4+ T cells was established. D‐U87 cells with cholinergic neuron...
Abstract Purpose To investigate changes in bone mineral density (BMD) following denosumab after previous bisphosphonate therapy and the impact of chronic kidney disease (CKD) on response. Methods A retrospective study of 134 patients (11 M, 123 F) aged [mean (SD)] 72 [11] years on denosumab was undertaken. Ninety-five patients had previously been on oral...
Publication date: Available online 28 October 2019Source: Journal of Genetics and GenomicsAuthor(s): Shuangquan Chen, Juan Zhang, Dongming Zhang, Jianwei JiaoAbstractIdentifying approaches for treating neurodegeneration is a thorny task but is important for a growing number of patients. Researchers have focused on discovering the underlying molecular mechanisms of reprogramming and optimizing the technologies for acquiring neurons. Direct conversion is one of the most important processes for treating...
Chem. Commun., 2019, Accepted ManuscriptDOI: 10.1039/C9CC06934H, CommunicationPayel Dowari, Saurav Das, BAPAN PRAMANIK, Debapratim DasA new strategy to construct transient supramolecular peptide amphiphile (SPA) and its dissipative vesicular aggregates is displayed. The construction of the amphiphile is assisted by the ternary complexation of Cucurbit[8]uril...The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2019, Accepted ManuscriptDOI: 10.1039/C9CC05240B, Communication Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Christian Rank, Alexander Jones, Tatjana Wall, Patrick Di Martino-Fumo, Sarah Schroeck, Markus Gerhards, Frederic PatureauHighlypi-extended hetero-cyclic / aromatic skeletons are of great importance as they can be utilized in many organic material based technologies. Therefore, developing efficient, pre-activation-free, synthetic...
Chem. Commun., 2019, Accepted ManuscriptDOI: 10.1039/C9CC07862B, CommunicationWiyanti F. Simanulang, Hiroshi Itahara, Naoko Takahashi, Satoru Kosaka, Ken-ichi Shimizu, Shinya FurukawaNoble-metal-alternative Ni–Si catalysts more active than Pd in the hydrogen storage reaction was developed using a unique procedure, i.e., surface dealloying with hydrofluoric acid treatment. The combination of the structural...The content of this RSS Feed (c) The Royal Society of Chemistry
Osram, a German company best known for manufacturing LED lights, recently unveiled CHRONOGY Eyewear, a pair of glasses that can regulate and supplement the light that falls onto the photoreceptors in the eyes, helping to regulate our body clocks. The CHRONOGY Eyewear comes with a smartphone app that can be used to program the glasses. Intensity and timing can be set to achieve a variety of goals, whether it be to recover from jet lag faster, to get better sleep, or maybe even to improve...
Recent fluorescence imaging technology applications of indocyanine green in general thoracic surgery
Abstract Thoracic surgeons perform a wide variety of cancer operations, which are often associated with high morbidity and mortality. Thus, thoracic surgery involves many special challenges that require innovative solutions. The increased utilization of minimally invasive practices, poor overall cancer survival, and significant morbidity of critical operations remain key obstacles to overcome. Fluorescence imaging technology (FIT), involving the implementation of fluorescent dyes...
Introduction: The vestibular implant could become a clinically useful device in the near future. This study investigated the feasibility of restoring the high-frequency dynamic visual acuity (DVA) with a vestibular implant, using the functional Head Impulse Test (fHIT). Methods: A 72-year-old female, with bilateral vestibulopathy and fitted with a modified cochlear implant incorporating three vestibular electrodes (MED-EL, Innsbruck, Austria), was available for this study. Electrical stimulation...
Background and Objectives: Hereditary hearing loss (HL) can originate from mutations in one of many genes involved in the complex process of hearing. CABP2 mutations have been reported to cause moderate HL. Here, we report the whole exome sequencing (WES) of a proband presenting with prelingual, severe HL in an Iranian family. Methods: A comprehensive family history was obtained, and clinical evaluations and pedigree analysis were performed in the family with 2 affected members. After excluding mutations...
Background: The most common complaint of patients affected by chemotherapy-induced hearing loss is difficulty understanding speech in noisy environments despite the use of hearing aids. Cochlear dead regions, those areas with damaged or absent inner hair cells and dendrites, may account for this type of hearing loss. However, it is unknown whether this condition is associated with cisplatin agents. Objective: The aim of this study was to determine whether cisplatin is associated with hearing loss...
Objective: Our aim was to determine the effect of acute changes in cochlear place of stimulation on cochlear implant (CI) sound quality. Design: In Experiment 1, 5 single-sided deaf (SSD) listeners fitted with a long (28-mm) electrode array were tested. Basal shifts in place of stimulation were implemented by turning off the most apical electrodes and reassigning the filters to more basal electrodes. In Experiment 2, 2 SSD patients fitted with a shorter (16.5-mm) electrode array were tested. Both...
Analysis of the 56 million ePCR records in the NEMSIS national dataset shows days with the most traumatic pediatric cardiac arrests in 2013 and 2014
Zusammenfassung Einleitung Der konstante Anstieg der Lebenserwartung seit über 170 Jahren ist eine der größten Leistungen der modernen Gesellschaft. Die Wahrscheinlichkeit, dass ein 80-Jähriger 100 Jahre wird, hat sich in Deutschland seit 1950 verzwanzigfacht. Dieser Sachverhalt hat verschiedenste Implikationen für den klinischen Alltag und therapeutische Leitlinien. In der Hernienversorgung sollte neben quantitativen Faktoren (Komplikationen,...
ObjectiveTo compare perinatal and maternal outcomes for Australian women with uncomplicated pregnancies according to planned place of birth, that is, in hospital labour wards, birth centres or at home. DesignA population-based retrospective design, linking and analysing routinely collected electronic data. Analysis comprised 2 tests and binary logistic regression for categorical data, yielding adjusted ORs. Continuous data were analysed using analysis of variance. SettingAll eight Australian states...
Abstract Objectives Our objective was to identify preconception and prenatal predictors of early experiences of co-occurring risk and protective factors to help target prevention efforts to the highest-need families prior to the birth of the child. Methods Data were from the Alaska Longitudinal Child Abuse and Neglect Linkage project and the 2012–2014 Alaska...
In adults, back pain is a very commonplace complaint. If you polled the adults at your workplace or at a school event you would probably find that almost everyone has experienced back pain at some point over the last few years. But what happens when it is your young athlete? It is the middle of a busy sports season and your son or daughter comes home complaining of back pain. Surprisingly this complaint is much more common than you may think! In the adolescent age group, the prevalence of low...
Abstract Indium sulfide thin films were prepared by chemical bath deposition method on glass substrates for about 40 min as deposition time and 60 °C as deposition temperature. The films were post-annealed at different temperatures such as 100 °C, 200 °C, 300 °C and 400 °C, for about 1 h. Structural and optical properties of In2S3 thin films after post-annealing process have been investigated. The crystallinity and nanostructures of the films were studied by using X-ray diffraction,...
AbstractThe Research to Accelerate Cures and Equity (RACE) for Children Act was enacted in 2017 to authorize the FDA to require pediatric studies for new cancer drugs that have a molecular target relevant to the growth or progression of a pediatric cancer. To assess the possible scope of this new policy, we examined all 78 adult cancer drugs approved by the FDA from 2007-2017. Only 17 (21.8%) drugs received any pediatric labeling information. Based on the FDA’s Pediatric Molecular Target List, we...
AbstractBackgroundRecent efforts of gene expression profiling analyses recognized at least 4 different triple-negative breast cancer (TNBC) molecular subtypes. However, little is known regarding their tumor microenvironment (TME) heterogeneity.MethodsHere, we investigated TME heterogeneity within each TNBC molecular subtype including immune infiltrate localization and composition together with expression of targetable immune pathways using publicly available transcriptomic and genomic datasets from...
Modern Pathology, Published online: 29 October 2019; doi:10.1038/s41379-019-0397-3Diagnosis of T-cell lymphoid proliferations of the skin: putting all the pieces together
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου