Abstract Background Aesthetic porcelain veneers proved to be a long-term reliable prosthetic solution, ensuring minimal invasiveness. The use of veneers requires an adhesive cementation technique, so maintaining as much enamel as possible is to ensure lasting success. A diagnostic mock-up is a key tool that allows a preview of the outcome of the aesthetic restoration: it is obtainable both in an analog and digital way. With the recent...
02:00
Publication date: Available online 28 October 2019Source: Auris Nasus LarynxAuthor(s): Dong-Hyun Kim, Kyungil Jang, Seulah Lee, Hyun Jin LeeAbstractPain after tonsil surgery is troublesome because it causes discomfort. In addition, handling patients with postoperative pain is challenging to otolaryngologists. Many laboratory studies have assessed the use of analgesics and surgical techniques to discover methods for effective control of postoperative pain associated with tonsil surgery. In this review...
14:11
Publication date: Available online 28 October 2019Source: Revista Española de Medicina Nuclear e Imagen MolecularAuthor(s): Z. Hasbek, H. Ozer, S.A. Erturk, E. Erdiş, B. Yucel, E. Çiftçi, A. ÇakmakcilarResumenObjetivoEl factor inducible para hipoxia (HIF-1) tiene un papel crítico en la homeostasis del oxígeno y es un activador transcripcional de angiogénesis, eritropoyesis, hierro y metabolismo de glucosa. La tasa de metabolismo de glucosa aumenta en algunos tumores a través de HIF-1α. Nuestro objetivo...
14:07
Abstract Professor Hugh A. Sampson, MD is a Canadian‐ born American clinician and translational researcher, whose evidence‐based approach validated food allergy as a legitimate allergic disorder. He single‐handedly transformed the management of patients with food allergies and initiated investigations that led to novel diagnostic tests and therapies giving hope to millions of individuals and their families worldwide. Hugh Sampson's immense impact on the rapidly developing field of food allergy makes...
10:39
The active site of the essential, eukaryotic CDK1 kinase is generated by core structural elements, among which the PSTAIRE motif in the critical C-helix, is universally conserved in metazoans. The CDK2 kinase, sharing the PSTAIRE, arose early in metazoan evolution and permitted subdivision of tasks along the S-M-phase axis. The marine chordate, Oikopleura dioica, is the only metazoan known to possess more than a single CDK1 ortholog, and all of its 5 paralogs show sequence divergences in the PSTAIRE....
02:00
Increasing our understanding of how various evolutionary processes drive the genomic landscape of variation is fundamental to a better understanding of the genomic consequences of speciation. However, the genome-wide patterns of within- and between- species variation have not been fully investigated in most forest tree species despite their global ecological and economic importance. Here, we use whole-genome resequencing data from four Populus species spanning the speciation continuum to reconstruct...
02:00
The diversity and biology of unicellular relatives of animals has strongly informed our understanding of the transition from single-celled organisms to the multicellular Metazoa. Here we analyse the cellular structures and complex life cycles of the novel unicellular holozoans Pigoraptor and Syssomonas (Opisthokonta). Both lineages are characterized by complex life cycles with a variety of cell types, the formation of multicellular aggregations and syncytium-like structures, and an unusual diet for...
02:00
The active site of the essential, eukaryotic CDK1 kinase is generated by core structural elements, among which the PSTAIRE motif in the critical alpha C-helix, is universally conserved in metazoans. The CDK2 kinase, sharing the PSTAIRE, arose early in metazoan evolution and permitted subdivision of tasks along the S-M-phase axis. The marine chordate, Oikopleura dioica, is the only metazoan known to possess more than a single CDK1 ortholog, and all of its 5 paralogs show sequence divergences in the...
02:00
The evolution of mate preferences may depend on natural selection acting on the mating cues and on the underlying genetic architecture. While the evolution of assortative mating acting on locally adapted traits has been well-characterized, the evolution of disassortative mating is poorly characterized. Here we aim at understanding the evolution of disassortative mating for traits under strong local selection, by focusing on polymorphic mimicry as an illustrative example. Positive frequency-dependent...
02:00
Sex-specific selection pressures can generate different phenotypic optima for males and females in response to the current environment. Less widely appreciated is the possibility of sex-specific transgenerational plasticity (TGP): mothers and fathers may exert different effects on offspring traits and parental cues may persist selectively across generations via only daughters or sons. Here, we demonstrate that maternal and paternal exposure to predation risk has largely distinct effects on offspring...
02:00
Maize landraces are well adapted to their local environments and present valuable sources of genetic diversity for breeding and conservation. But the maintenance of open-pollinated landraces in ex-situ programs is challenging, as regeneration of seed can often lead to inbreeding depression and the loss of diversity due to genetic drift. Recent reports suggest that the production of doubled-haploid (DH) lines from landraces may serve as a convenient means to preserve genetic diversity in a homozygous...
02:00
Early research on orthologous protein sequence comparisons by Margoliash in 1963 discovered the astonishing phenomenon of genetic equidistance, which has inspired the ad hoc interpretation known as the molecular clock. Kimura then developed the neutral theory and claimed the molecular clock as its best evidence. However, subsequent studies over the years have largely invalidated the universal molecular clock. Yet, a watered down version of the molecular clock and the neutral theory still reigns as...
02:00
Why proteins evolve at different rates is an open question in evolutionary biology. Here, we reveal the importance of a mutation's collateral fitness effects, which we define as effects that do not derive from changes in the protein's ability to perform its physiological function. We comprehensively measured the collateral fitness effects of missense mutations in the E. coli TEM-1 antibiotic resistance gene using growth competition experiments in the absence of antibiotic. At least 42% of missense...
02:00
Publication date: Available online 29 October 2019Source: CortexAuthor(s): Patrice Revol, Nathalie Toutounji, Laurence Havé, Gilles Rode, Sophie Jacquin-Courtois, Yves RossettiAbstractNeglect manifestations are typically explored in the visual modality. Although they are less commonly investigated tactile deficits also exist, and the aim of this study was to explore neglect in this modality. A haptic object discrimination task was designed to assess whether or not shape perception is impaired in...
13:56
Duchenne/Becker muscular dystrophy (DMD/BMD) is the most common genetic neuromuscular disease in children, resulting from a defect in the DMD gene located on Xp21.2. The new emerging treatment using exon skipping...
Mon Oct 28, 2019 02:00
To evaluate the availability of information regarding patient access to investigational treatments through clinical trials and non-trial pre-approval access pathways from a sample of patient advocacy organizat...
Mon Oct 28, 2019 02:00
Publication date: November 2019Source: Journal of Phonetics, Volume 77Author(s): Anders HøjenAbstractSecond-language acquisition has been shown to be influenced by age of learning (AOL), years of second-language experience and degree of second-language use. This study examined native and second-language speaking rates in a speeded sentence production task; speaking rate was expected to reflect the speed with which processes underlying speech production can be executed. Sixty Spanish-English bilingual...
13:51
Publication date: Available online 29 October 2019Source: Medical HypothesesAuthor(s): Leslie M. KlevayAbstractSecondary analyses of data from the Age-Related Eye Disease Study (AREDS) revealed that higher calcium intakes were associated with slower progression to age-related macular degeneration (AMD). Earlier, primary analyses had revealed that a supplement containing copper reduced the odds of developing AMD while lengthening life. Because ocular lesions are being reported increasingly in neuropathy...
13:43
Publication date: Available online 28 October 2019Source: Medical HypothesesAuthor(s): Merve Açikoğlu, Seda Arslan TuncerAbstractThe present study developed a feature selection (FS)-based decision support system using the electroencephalography (EEG) signals recorded from neonates with and without seizures. The study employed 10 different FS algorithms to reduce the classification cost by using fewer features and to improve the classification performance of the model by removing the irrelevant features....
13:43
Publication date: Available online 28 October 2019Source: Medical HypothesesAuthor(s): Jeremy D.W. Clifton, Eric S. KimAbstractAaron Beck’s insight—that beliefs about one’s self, future, and environment shape behavior—had major implications for health psychology research and practice. Yet, beliefs about one’s environment have remained relatively understudied. A recent comprehensive empirically-driven effort has led to the identification of 26 primal world beliefs, or primals, (e.g., the world is:...
13:43
Nature Communications, Published online: 29 October 2019; doi:10.1038/s41467-019-12683-8Alzheimer’s disease is characterised by the deposition of Aβ amyloid fibrils and tau protein neurofibrillary tangles. Here the authors use cryo-EM to structurally characterise brain derived Aβ amyloid fibrils and find that they are polymorphic and right-hand twisted, which differs from in vitro generated Aβ fibrils.
02:00
Nature Communications, Published online: 29 October 2019; doi:10.1038/s41467-019-13016-5Author Correction: Unifying scrambling, thermalization and entanglement through measurement of fidelity out-of-time-order correlators in the Dicke model
02:00
Nature Communications, Published online: 29 October 2019; doi:10.1038/s41467-019-12895-yImpulsive behaviour is common in various neuropsychiatric disorders. Here, the authors identify a pathway from the lateral hypothalamus to the ventral hippocampus and the role of melanin-concentrating hormone signaling in these neurons in specifically regulating impulsivity.
02:00
Nature Communications, Published online: 29 October 2019; doi:10.1038/s41467-019-12883-2The loss of anomalous sulfur isotope compositions from sedimentary rocks has been considered a symptom of permanent atmospheric oxygenation. Here the authors show sulfur and oxygen isotope evidence from
02:00
Nature Communications, Published online: 29 October 2019; doi:10.1038/s41467-019-12902-2Recombinant MHC class II molecules are instrumental in antigen-specific T-cell identification assays and showed efficacy as experimental medicines. Here, the authors engineer MHC class II molecules with species-specific knob-into-hole heteromerization domains, enabling a translatable purification process with improved stability, yields, and biological potency.
02:00
Nature Communications, Published online: 29 October 2019; doi:10.1038/s41467-019-12763-9Familial cortical myoclonic tremor with epilepsy (FAME) is a slowly progressing cortical tremor mapping to various genomic loci, including intronic expansions in SAMD12 for FAME1. Here, Florian et al. describe mixed intronic TTTTA/TTTCA expansions of various lengths in the first intron of MARCH6 as a cause of FAME3.
02:00
Nature Communications, Published online: 29 October 2019; doi:10.1038/s41467-019-12671-yFamilial cortical myoclonic tremor (FAME) has so far been mapped to regions on chromosome 2, 3, 5 and 8 and pentameric repeat expansions in SAMD12 were identified as cause of FAME1. Here, Corbett et al. identify ATTTT/ATTTC repeat expansions in intron 1 of STARD7 in individuals with FAME2.”
02:00
Nature Communications, Published online: 29 October 2019; doi:10.1038/s41467-019-12735-zAML1-ETO is a fusion protein in which acetylation of lysine-43 is critical to leukemogenesis. Here, they show that TAF1 is required for AML1-ETO mediated gene expression such that it binds to acetylated AML1-ETO to facilitate the association of AML1-ETO with chromatin, and consequently, promotes leukemic self-renewal.
02:00
02:00
02:00
Publication date: Available online 28 October 2019Source: Allergology InternationalAuthor(s): Michihiro Hide, Atsushi Fukunaga, Junichi Maehara, Kazunori Eto, James Hao, Moshe Vardi, Yuji NomotoAbstractBackgroundHereditary angioedema (HAE) is a genetic disease characterized by recurrent swelling episodes affecting the skin, gastrointestinal mucosa, and upper respiratory tract.MethodsA phase 3, single-arm, open-label study was performed to evaluate a selective bradykinin B2 receptor antagonist, icatibant,...
13:41
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου