Τρίτη 29 Οκτωβρίου 2019


Preconception and Prenatal Predictors of Early Experiences of Risk and Protection Among Alaska Children
Abstract Objectives Our objective was to identify preconception and prenatal predictors of early experiences of co-occurring risk and protective factors to help target prevention efforts to the highest-need families prior to the birth of the child. Methods Data were from the Alaska Longitudinal Child Abuse and Neglect Linkage project and the 2012–2014 Alaska...
Latest Results for Maternal and Child Health Journal
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Back Pain in Young Athletes: Why It Happens and What to Do
In adults, back pain is a very commonplace complaint.  If you polled the adults at your workplace or at a school event you would probably find that almost everyone has experienced back pain at some point over the last few years. But what happens when it is your young athlete?  It is the middle of a busy sports season and your son or daughter comes home complaining of back pain.  Surprisingly this complaint is much more common than you may think!  In the adolescent age group, the prevalence of low...
ChildrensMD
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Early volume reduction of the hippocampus after whole-brain radiation therapy: an automated brain structure segmentation study
Abstract Purpose To assess atrophy differences among brain regions and time-dependent changes after whole-brain radiation therapy (WBRT). Materials and methods Twenty patients with lung cancer who underwent both WBRT and chemotherapy (WBRT group) and 18 patients with lung cancer who underwent only chemotherapy (control group) were recruited. Three-dimensional...
Latest Results for Japanese/ /Journal/ /of/ /Radiology
1h
High‐dose posaconazole for azole‐resistant aspergillosis and other difficult‐to‐treat mould infections
Abstract Background Oral follow‐up therapy is problematic in moulds with reduced azole‐susceptibility, such as azole‐resistant A. fumigatus infection. Currently only intravenous liposomal amphotericin B (L‐AmB) is advocated by guidelines for the treatment of azole‐resistant aspergillosis infections. Preclinical research indicates that high‐dose posaconazole (HD‐POS) might be a feasible option provided that high drug exposure (i.e. POS serum through levels >3 mg/L) can be achieved and is safe....
Mycoses
1h
Metachronous ovarian endometrioid carcinomas in a patient with a PTEN variant: case report of incidentally detected Cowden syndrome
Abstract Background Somatic PTEN mutation occurs in a proportion of ovarian endometrioid carcinomas. However, these cancers have seldom been reported in diseases associated with germline PTEN variants, such as Cowden syndrome (CS). Case presentation The present case was a 39-year-old woman with a left ovarian carcinoma who demonstrated a germline...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=12885&channel-name=BMC+Cancer
1h
The release of tryptase from mast cells promote tumor cell metastasis via exosomes
Abstract Background Cancer cells release exosomes and can be taken up by mast cells (MCs), but the potential functional effects of MCs on tumor metastasis remain unknown. Method Exosomes were isolated from the lung adenocarcinoma cell line A549, and the uptake of PKH26-labeled exosomes by bone marrow MCs was examined via flow cytometry and fluorescence...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=12885&channel-name=BMC+Cancer
1h
GX15–070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma
Abstract Background Neuroblastoma (NB) is a frequent pediatric tumor associated with poor prognosis. The disregulation of Bcl-2, an anti-apoptotic protein, is crucial for the tumoral development and chemoresistance. Autophagy is also implicated in tumor cell survival and chemoresistance. The aim of our study was to demonstrate therapeutic efficiency of GX 15–070, a pan-Bcl-2 family inhibitor, used alone and in combination with conventional...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=12885&channel-name=BMC+Cancer
3h
Dipeptidyl-peptidase-4 (DPP-4) inhibitor ameliorates 5-flurouracil induced intestinal mucositis
Abstract Background Chemotherapy-induced alimentary mucositis (AM) is difficult to prevent and treatment is rarely effective. Recent study have been showed that glucagon-like peptide (GLP)-1 and GLP-2 has protective in chemotherapy-induced AM. While the DPP-4 enzyme degrades this GLP-1, the DPP-4 inhibitor blocks the degradation process and raises the concentration of GLP-1. This study aimed to assess the role of DPP-4 inhibitor,...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=12885&channel-name=BMC+Cancer
3h
Furosemide use and survival in patients with esophageal or gastric cancer: a population-based cohort study
Abstract Background Pre-clinical studies have shown that furosemide slows cancer cell growth by acting on the Na-K-2Cl transporter, particularly for gastric cancer cells. However, epidemiological studies have not investigated furosemide use and mortality in gastroesophageal cancer patients. Consequently, we conducted a population-based study to investigate whether furosemide use is associated with reduced cancer-specific mortality...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=12885&channel-name=BMC+Cancer
3h
Serum gamma-glutamyltransferase and the overall survival of metastatic pancreatic cancer
Abstract Background Accumulating evidence suggests that Gamma-glutamyltransferase (GGT) may be involved in cancer occurrence and progression. However, the prognostic role of serum GGT in pancreatic cancer (PC) survival lacks adequate evaluation. In this study, we aimed to analyze the association between serum GGT measured at diagnosis and overall survival (OS) in patients with metastatic PC. ...
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=12885&channel-name=BMC+Cancer
3h
Exploring new potential role of DDB2 by host cell reactivation assay in human tumorigenic cells
Abstract Background The Host Cell Reactivation assay (HCR) allows studying the DNA repair capability in different types of human cells. This assay was carried out to assess the ability in removing UV-lesions from DNA, thus verifying NER efficiency. Previously we have shown that DDB2, a protein involved in the Global Genome Repair, interacts directly with PCNA and, in human cells, the loss of this interaction affects DNA repair machinery....
http://link.springer.com/search.rss?facet-content-type=Article&facet-journal-id=12885&channel-name=BMC+Cancer
5h
Gastrointestinal stromal tumors - summary of mutational status of the primary/secondary KIT/PDGFRA mutations, BRAF mutations and SDH defects: Mutational status of the primary/secondary KIT/PDGFRA mutations, BRAF mutations and SDH defects in GIST.
Publication date: Available online 29 October 2019Source: Pathology - Research and PracticeAuthor(s): Alena Kalfusova, Zdenek Linke, Marketa Kalinova, Lenka Krskova, Irena Hilska, Jana Szabova, Ales Vicha, Roman KodetABSTRACTThe most important findings revealing pathogenesis, molecular characteristics, genotyping and targeted therapy of gastrointestinal stromal tumors (GISTs) are activated oncogenic mutations in KIT and PDGFRA genes. Imatinib mesylate (IM), which inhibits both KIT and PDGFRA receptors,...
ScienceDirect Publication: Pathology - Research and Practice
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Breathing variability predicts the suggested need for corrective intervention due to the perceived severity of patient-ventilator asynchrony during NIV
Abstract Patient-ventilator asynchrony is associated with intolerance to noninvasive ventilation (NIV) and worsened outcomes. Our goal was to develop a tool to determine a patient needs for  intervention by a practitioner due to the presence of patient-ventilator asynchrony. We postulated that a clinician can determine when a patient needs corrective intervention due to the perceived severity of patient-ventilator asynchrony. We hypothesized a new measure, patient breathing variability,...
Latest Results for Journal of Clinical Monitoring and Computing
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Milled versus moulded mock-ups based on the superimposition of 3D meshes from digital oral impressions: a comparative in vitro study in the aesthetic area
Abstract Background Aesthetic porcelain veneers proved to be a long-term reliable prosthetic solution, ensuring minimal invasiveness. The use of veneers requires an adhesive cementation technique, so maintaining as much enamel as possible is to ensure lasting success. A diagnostic mock-up is a key tool that allows a preview of the outcome of the aesthetic restoration: it is obtainable both in an analog and digital way. With the recent...
Latest Results for BMC Oral Health
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Update review of pain control methods of tonsil surgery
Publication date: Available online 28 October 2019Source: Auris Nasus LarynxAuthor(s): Dong-Hyun Kim, Kyungil Jang, Seulah Lee, Hyun Jin LeeAbstractPain after tonsil surgery is troublesome because it causes discomfort. In addition, handling patients with postoperative pain is challenging to otolaryngologists. Many laboratory studies have assessed the use of analgesics and surgical techniques to discover methods for effective control of postoperative pain associated with tonsil surgery. In this review...
Auris Nasus Larynx
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Oxysterols and sterols: from lipidomics to food sciences
Publication date: Available online 28 October 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): M T Rodriguez-Estrada, V Cardenia, M Poirot, L Iuliano, G Lizard
ScienceDirect Publication: The Journal of Steroid Biochemistry and Molecular Biology
1h
Intratumoral immunoglobulin isotypes predict survival in lung adenocarcinoma subtypes
Abstract Background The role of tumor-infiltrating B-cells (TIBs) and intratumorally-produced antibodies in cancer-immunity interactions essentially remains terra incognita. In particular, it remains unexplored how driver mutations could be associated with distinct TIBs signatures and their role in tumor microenvironment. Methods Here we analyzed...
Latest Results for Journal for ImmunoTherapy of Cancer
1h
New tech allows SC fire, EMS to control traffic lights during emergencies
Once crews have gone through the light, the system will change back to its regular traffic cycle
EMS1 Product Articles
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Relaciones entre el factor-1α inducido por hipoxia y los parámetros de la PET/TC con <sup>18</sup>F-FDG en el cáncer colorrectal
Publication date: Available online 28 October 2019Source: Revista Española de Medicina Nuclear e Imagen MolecularAuthor(s): Z. Hasbek, H. Ozer, S.A. Erturk, E. Erdiş, B. Yucel, E. Çiftçi, A. ÇakmakcilarResumenObjetivoEl factor inducible para hipoxia (HIF-1) tiene un papel crítico en la homeostasis del oxígeno y es un activador transcripcional de angiogénesis, eritropoyesis, hierro y metabolismo de glucosa. La tasa de metabolismo de glucosa aumenta en algunos tumores a través de HIF-1α. Nuestro objetivo...
Revista Española de Medicina Nuclear e Imagen Molecular
1h
Legends of Allergy/Immunology: Hugh A. Sampson
Abstract Professor Hugh A. Sampson, MD is a Canadian‐ born American clinician and translational researcher, whose evidence‐based approach validated food allergy as a legitimate allergic disorder. He single‐handedly transformed the management of patients with food allergies and initiated investigations that led to novel diagnostic tests and therapies giving hope to millions of individuals and their families worldwide. Hugh Sampson's immense impact on the rapidly developing field of food allergy makes...
Allergy
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Cesarean delivery and risk of atopic dermatitis
Allergy
1h
Toxins, Vol. 11, Pages 627: Phytotoxic Metabolites Produced by Legume-Associated Ascochyta and Its Related Genera in the Dothideomycetes
Toxins, Vol. 11, Pages 627: Phytotoxic Metabolites Produced by Legume-Associated Ascochyta and Its Related Genera in the Dothideomycetes Toxins doi: 10.3390/toxins11110627 Authors: Wonyong Kim Weidong Chen Phytotoxins, secondary metabolites toxic to plants and produced by fungi, are believed to play an important role in disease development by targeting host cellular machineries and/or interfering with host immune responses. The Ascochyta blight diseases on different legume plants...
Toxins
2h
Toxins, Vol. 11, Pages 626: Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways
Toxins, Vol. 11, Pages 626: Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways Toxins doi: 10.3390/toxins11110626 Authors: Yashad Dongol Fernanda Caldas Cardoso Richard J Lewis Voltage-gated sodium channels (NaVs) are a key determinant of neuronal signalling. Neurotoxins from diverse taxa that selectively activate or inhibit NaV channels have helped unravel the role of NaV channels in diseases, including chronic pain. Spider...
Toxins
4h
Prisms adaptation improves haptic object discrimination in hemispatial neglect
Publication date: Available online 29 October 2019Source: CortexAuthor(s): Patrice Revol, Nathalie Toutounji, Laurence Havé, Gilles Rode, Sophie Jacquin-Courtois, Yves RossettiAbstractNeglect manifestations are typically explored in the visual modality. Although they are less commonly investigated tactile deficits also exist, and the aim of this study was to explore neglect in this modality. A haptic object discrimination task was designed to assess whether or not shape perception is impaired in...
Cortex
2h
The analysis of DMD gene deletions by multiplex PCR in Indonesian DMD/BMD patients: the era of personalized medicine
Duchenne/Becker muscular dystrophy (DMD/BMD) is the most common genetic neuromuscular disease in children, resulting from a defect in the DMD gene located on Xp21.2. The new emerging treatment using exon skipping...
BMC Research Notes
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Patient advocacy organizations’ information for patients on pre-approval access to investigational treatments
To evaluate the availability of information regarding patient access to investigational treatments through clinical trials and non-trial pre-approval access pathways from a sample of patient advocacy organizat...
BMC Research Notes
2h
Predictors of bilinguals’ speaking rates
Publication date: November 2019Source: Journal of Phonetics, Volume 77Author(s): Anders HøjenAbstractSecond-language acquisition has been shown to be influenced by age of learning (AOL), years of second-language experience and degree of second-language use. This study examined native and second-language speaking rates in a speeded sentence production task; speaking rate was expected to reflect the speed with which processes underlying speech production can be executed. Sixty Spanish-English bilingual...
Phonetics
2h
Calcium can delay age-related macular degeneration via enhanced copper metabolism
Publication date: Available online 29 October 2019Source: Medical HypothesesAuthor(s): Leslie M. KlevayAbstractSecondary analyses of data from the Age-Related Eye Disease Study (AREDS) revealed that higher calcium intakes were associated with slower progression to age-related macular degeneration (AMD). Earlier, primary analyses had revealed that a supplement containing copper reduced the odds of developing AMD while lengthening life. Because ocular lesions are being reported increasingly in neuropathy...
ScienceDirect Publication: Medical Hypotheses
2h
Incorporating Feature Selection Methods into a Machine Learning-Based Neonatal Seizure Diagnosis
Publication date: Available online 28 October 2019Source: Medical HypothesesAuthor(s): Merve Açikoğlu, Seda Arslan TuncerAbstractThe present study developed a feature selection (FS)-based decision support system using the electroencephalography (EEG) signals recorded from neonates with and without seizures. The study employed 10 different FS algorithms to reduce the classification cost by using fewer features and to improve the classification performance of the model by removing the irrelevant features....
ScienceDirect Publication: Medical Hypotheses
2h
Healthy in a Crummy World: Implications of Primal World Beliefs for Health Psychology
Publication date: Available online 28 October 2019Source: Medical HypothesesAuthor(s): Jeremy D.W. Clifton, Eric S. KimAbstractAaron Beck’s insight—that beliefs about one’s self, future, and environment shape behavior—had major implications for health psychology research and practice. Yet, beliefs about one’s environment have remained relatively understudied. A recent comprehensive empirically-driven effort has led to the identification of 26 primal world beliefs, or primals, (e.g., the world is:...
ScienceDirect Publication: Medical Hypotheses
2h
On-chip label-free determination of cell survival rate
Publication date: Available online 28 October 2019Source: Biosensors and BioelectronicsAuthor(s): Qiang Zi, Weiping Ding, Chunli Sun, Shibo Li, Dayong Gao, Liqun He, Jing Liu, Lei Xu, Bensheng QiuAbstractCell survival rate (CSR) is a very important parameter in biological and medical fields. Today, the routine method to determine this parameter is time-consuming; it also makes the labeled cells no longer usable for subsequent experiments. Here, we developed an on-chip label-free method for determining...
Biosensors and Bioelectronics
2h
Integration of black phosphorus and hollow-core anti-resonant fiber enables two-order magnitude enhancement of sensitivity for bisphenol A detection
Publication date: Available online 28 October 2019Source: Biosensors and BioelectronicsAuthor(s): Pengfei Qiao, Xiu-Hong Wang, Shoufei Gao, Xiaoyan Yin, Yingying Wang, Pu WangAbstractHollow core anti-resonant fiber (HARF) has found a handful applications in optical communications, nonlinear optics and high power delivery. The intrinsic property of the fiber also renders it an ideal candidate for biosensing, which has not been explored intensively. Herein, we demonstrate an optical fiber sensing platform,...
Biosensors and Bioelectronics
2h
Two-photon fluorescent Zn<sup>2+</sup> probe for ratiometric imaging and biosensing of Zn<sup>2+</sup> in living cells and larval zebrafish
Publication date: Available online 28 October 2019Source: Biosensors and BioelectronicsAuthor(s): Wanying Li, Zhichao Liu, Bingqing Fang, Ming Jin, Yang TianAbstractAs an essential transition-metal ion in organism, zinc ion (Zn2+) plays a significant role in cellular metabolism, apoptosis and neurotransmission. Herein, we reported a new intramolecular charge transfer-based two-photon probe, (E)-1-(6-(4-(2-(2-(2-methoxyethoxy)ethoxy)eth-oxy)-3,5-dimethylstyryl)quinolin-2-yl)-N,N-bis(pyridin-2-ylmethyl)methanamine...
Biosensors and Bioelectronics
2h
Efficacy, pharmacokinetics, and safety of icatibant for the treatment of Japanese patients with an acute attack of hereditary angioedema: A phase 3 open-label study
Publication date: Available online 28 October 2019Source: Allergology InternationalAuthor(s): Michihiro Hide, Atsushi Fukunaga, Junichi Maehara, Kazunori Eto, James Hao, Moshe Vardi, Yuji NomotoAbstractBackgroundHereditary angioedema (HAE) is a genetic disease characterized by recurrent swelling episodes affecting the skin, gastrointestinal mucosa, and upper respiratory tract.MethodsA phase 3, single-arm, open-label study was performed to evaluate a selective bradykinin B2 receptor antagonist, icatibant,...
Allergology International
2h
Discrimination, Abuse, Harassment, and Burnout in Surgical Residency Training
Burnout, a syndrome of emotional exhaustion, cynicism, and reduced effectiveness at work, has been linked to poor health, alcoholism, depression, and suicide in physicians. Burnout has adverse effects on patient care and the physician workforce, since burned-out physicians are more likely to report…
NEJM : Research
2h
Traumatic Ulcerative Granuloma with Stromal Eosinophilia: CD30 analysis and clonality for T cell receptor gene re-arrangement
Publication date: Available online 29 October 2019Source: Acta HistochemicaAuthor(s): A. Aizic, V. Raiser, I. Solar, Z. Aharon, B. Shlomi, I. KaplanAbstractIntroductionTraumatic Ulcerative Granuloma with Stromal Eosinophilia (TUGSE) is a rare oral ulcerated lesion of uncertain etiology, showing eosinophil-rich granulation tissue, with occasional large atypical CD30 positive mononuclear cells. It had been suggested that it may represent an oral counterpart of cutaneous lymphomatoid papulosis, with...
Acta Histochemica
2h
iNOS as a metabolic enzyme under stress conditions
Publication date: Available online 28 October 2019Source: Free Radical Biology and MedicineAuthor(s): Sarit Anavi, Oren TiroshAbstractNitric oxide (NO) is a free radical acting as a cellular signaling molecule in many different biochemical processes. NO is synthesized from l-arginine through the action of the nitric oxide synthase (NOS) family of enzymes, which includes three isoforms: endothelial NOS (eNOS), neuronal NOS (nNOS) and inducible NOS (iNOS). iNOS-derived NO has been associated with the...
ScienceDirect Publication: Free Radical Biology and Medicine
2h
Pseudohypoxic Brain Swelling After Uncomplicated Lumbar Decompression and Fusion for Spondylolisthesis
Publication date: January 2020Source: World Neurosurgery, Volume 133Author(s): Swathi Chidambaram, Kevin Swong, Michael Ander, Russel P. NockelsBackgroundPseudohypoxic brain swelling (PHBS), also known as postoperative intracranial hypotension−associated venous congestion, is a rare complication after neurosurgery characterized by rapid and often severe postoperative deterioration in consciousness and distinct imaging findings on brain magnetic resonance imaging. Imaging findings associated with...
World Neurosurgery
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Delayed Rebleeding from Pseudoaneurysm After Mechanical Thrombectomy Using Stent Retriever Due to Small Artery Avulsion Confirmed by Open Surgery
Publication date: January 2020Source: World Neurosurgery, Volume 133Author(s): Taichiro Imahori, Yusuke Okamura, Junichi Sakata, Hiroyasu Shose, Shunsuke Yamanishi, Eiji KohmuraBackgroundPseudoaneurysm after mechanical thrombectomy (MT) is rare but is one of the potential complications associated with endovascular procedures. There is limited information regarding its mechanism of formation and the potential risk of delayed bleeding.Case DescriptionAn 84-year-old woman was admitted to our institution...
World Neurosurgery
2h

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