Publication date: Available online 29 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Gonzalo Federico Mayol, María Victoria Revuelta, Agostina Salusso, María Carolina Touz, Andrea Silvana RópoloAbstractNuclear-cytoplasmic trafficking of proteins is a highly regulated process that modulates multiple biological processes in eukaryotic cells. In Giardia lamblia, shuttling has been described from the cytoplasm to nuclei of proteins during the biological cell...
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One of the most serious threats to public health worldwide is posed by antibiotic-resistant pathogens. The World Health Organization (WHO) warns of the imminent beginning of a post-antibiotic era in which harmless infections can no longer be treated and could once again become one of the most frequent non-natural causes of death. Decades of using various antibiotics as standard therapy have greatly reduced the spectrum of effective antibacterial drugs. At the same time, the development of new drugs...
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Hospital screening tests are failing to identify the true extent of microbial resistance, according to new research.
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Birds use odor to identify other birds, and researchers at Michigan State University have shown that if the bacteria that produce the odor is altered, it could negatively impact a bird's ability to communicate with other birds or find a mate.
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Abstract The randomized controlled trial (RCT) in surgery may not always be ethical, feasible, or necessary to address a particular research question about the effect of a surgical intervention. If so, properly designed and conducted observational (non-randomized) studies may be valuable alternatives for an RCT and produce credible results. In this paper, we discus differences between RCTs and observational studies and differentiate between three types of comparisons of surgical...
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Abstract Background Recent preclinical data suggest that androgen receptor (AR) signaling plays a significant role in subsets of breast cancer. Clinical trials testing AR-targeting therapies in breast cancer have been conducted. Assessment of AR-signal in breast cancer tissue maybe useful for treatment selections. Prostate specific antigen (PSA) is the product of an androgen-responsive gene. Serum PSA (sPSA) can be detected in women...
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Abstract Background The prognostic value of programmed death-ligand 1 (PD-L1) and BRAF expression in nasopharyngeal carcinoma (NPC) is not well-defined. In this study we investigated alterations in PD-L1, BRAF and EGFR by using immunohistochemistry analysis in a cohort of consecutively enrolled NPC patients. Methods A retrospective review of...
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Abstract Background Nivolumab is an immune checkpoint inhibitor specific to the programmed death 1 (PD-1) receptor. Nivolumab has shown clinical responses in many malignancies. Although immune-related adverse events (irAEs) associated with nivolumab are largely tolerable, severe irAEs have occurred in some patients. However, the mechanisms underlying the development of irAEs are not fully clarified. ...
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Cells, Vol. 8, Pages 1339: Mechanisms Underlying Cell Therapy in Liver Fibrosis: An Overview Cells doi: 10.3390/cells8111339 Authors: Daphne Pinheiro Isabelle Dias Karina Ribeiro Silva Ana Carolina Stumbo Alessandra Thole Erika Cortez Lais de Carvalho Ralf Weiskirchen Simone Carvalho Fibrosis is a common feature in most pathogenetic processes in the liver, and usually results from a chronic insult that depletes the regenerative capacity of hepatocytes and activates...
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Cells, Vol. 8, Pages 1340: A Low-Therapeutic Dose of Lithium Inhibits GSK3 and Enhances Myoblast Fusion in C2C12 Cells Cells doi: 10.3390/cells8111340 Authors: Kurgan Whitley Maddalena Moradi Stoikos Hamstra Rubie Kumar Roy Woodgett Stuart Fajardo : Glycogen synthase kinase 3 (GSK3) slows myogenic differentiation and myoblast fusion partly by inhibiting the Wnt/β-catenin signaling pathway. Lithium, a common medication for bipolar...
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Cells, Vol. 8, Pages 1342: Feeding Entrainment of the Zebrafish Circadian Clock Is Regulated by the Glucocorticoid Receptor Cells doi: 10.3390/cells8111342 Authors: Morbiato Frigato Dinarello Maradonna Facchinello Argenton Carnevali Dalla Valle Bertolucci Glucocorticoids (GCs) are steroid hormones mainly acting as key regulators of body homeostasis and stress responses. Their activities are primarily based on the binding to the GC receptor (GR), a member...
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Cells, Vol. 8, Pages 1341: MLL-Rearranged Acute Leukemia with t(4;11)(q21;q23)—Current Treatment Options. Is There a Role for CAR-T Cell Therapy? Cells doi: 10.3390/cells8111341 Authors: Britten Ragusa Tosi Kamel The MLL (mixed-lineage leukemia) gene, located on chromosome 11q23, is involved in chromosomal translocations in a subtype of acute leukemia, which represents approximately 10% of acute lymphoblastic leukemia and 2.8% of acute myeloid leukemia cases. These translocations...
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Cells, Vol. 8, Pages 1343: Absence of the Tks4 Scaffold Protein Induces Epithelial-Mesenchymal Transition-Like Changes in Human Colon Cancer Cells Cells doi: 10.3390/cells8111343 Authors: Szeder Tárnoki-Zách Lakatos Vas Kudlik Merő Koprivanacz Bányai Hámori Róna Czirók Füredi Buday Epithelial to mesenchymal transition (EMT) is a multipurpose process involved in wound healing, development, and certain pathological processes, such as metastasis...
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Michael Lev, MD, speaks with Dr. Meir H. Scheinfeld, about his article, “CT of the Neck: Image Analysis and Reporting in the Emergency Setting” See Cunqueiro et al, RadioGraphics 2019; 39:1760–1781.
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Atmosphere, Vol. 10, Pages 660: Investigating the Influence of the Implementation of an Energy Development Plan on Air Quality Using WRF-CAMx Modeling Tools: A Case Study of Shandong Province in China Atmosphere doi: 10.3390/atmos10110660 Authors: Luo He Yu He Zhang Ma In this paper, the Weather Research Forecast (WRF) Comprehensive Air Quality Model with Extensions (CAMx) modeling system with the particulate source apportionment technology (PSAT) module was used...
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»Deutsche Staatschefs und deutsche Botschafter in Moskau kamen und gingen - aber Gustav Hilger blieb.« - Mit diesen Worten umschrieb Stalin jenen Mann, dessen Biografie im Mittelpunkt von Jörn Happels Studie steht. Als Experte, Diplomat und Dolmetscher war der gebürtige Moskauer von 1918 bis 1941 aus den deutsch-sowjetischen Beziehungen nicht wegzudenken. Er beriet zahlreiche Politiker und Wirtschaftsvertreter und übersetzte für Stalin und Molotov, Hitler und Ribbentrop. Ab 1941 arbeitete Hilger...
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The tetratopic ligands 1,4-bis(2-ethylbutoxy)-2,5-bis(3,2':6',3''-terpyridin-4'-yl)benzene ( 1 ) and 1,4-bis(3-methylbutoxy)-2,5-bis(3,2':6',3''-terpyridin-4'-yl)benzene ( 2 ) have been prepared and characterized by 1 H and 13 C{ 1 H} NMR, IR, and absorption spectroscopies and mass spectrometry. Reactions of 1 and 2 with cobalt(II) thiocyanate under conditions of crystal growth at room temperature result in the formation of [{Co( 1 )(NCS) 2 }·MeOH·3CHCl 3 ] n and [{Co( 2 )(NCS) 2 }·0.8MeOH·1.8CHCl...
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Background Parasympathetic nerve hypersensitivity contributes to the severity of allergic rhinitis (AR), but the precise mechanism underlying neuroimmune regulation in patients with AR remains unclear. This study investigated the effect of cholinergic nerve inhibition on AR CD4+ T‐helper (Th)2‐cell polarization and the underlying regulatory mechanism in vitro. Methods An in‐vitro neuroimmune coculture model of D‐U87 cells and CD4+ T cells was established. D‐U87 cells with cholinergic neuron...
Mon Oct 28, 2019 21:24
Abstract Purpose To investigate changes in bone mineral density (BMD) following denosumab after previous bisphosphonate therapy and the impact of chronic kidney disease (CKD) on response. Methods A retrospective study of 134 patients (11 M, 123 F) aged [mean (SD)] 72 [11] years on denosumab was undertaken. Ninety-five patients had previously been on oral...
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For millions of people who suffer from sleep apnea, getting a good night's sleep is an elusive dream. Patients with obstructive sleep apnea have blockage of breathing while they sleep, leading to snoring, disruption of sleep and the drowsiness or fatigue that often occur. The ailment also can lead to serious health problems such as high blood pressure and a risk of heart attack or stroke.
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In 1855, the Brooklyn Daily Eagle reported on the gruesome murder of a bride by her new husband. The story came from the French countryside, where the woman's parents had initially prevented the couple's engagement "on account of the strangeness of conduct sometimes observed in the young man," although he "otherwise was a most eli[g]ible match."
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A new study has shed light on a debilitating autoimmune condition by identifying a number of subtypes of the disease which could lead to personalised treatment for patients.
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Children may learn new words better when they learn them in the context of other words they are just learning—according to new research from the University of East Anglia.
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The three-body problem has vexed mathematicians and physicists for 300 years, but AI can find solutions far faster than any other method anyone has come up with
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Video game developer Ninja Theory has previously worked with scientists to portray psychosis and now plans to create games to aid mental health
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Background The originality of divergent thinking (DT) production is one of the most critical indicators of creative potential. It is commonly scored using the statistical infrequency of responses relative to all responses provided in a given sample. Aims Response frequency estimates vary in terms of measurement precision. This issue has been widely overlooked and is addressed in the current study. Sample and method Secondary data analysis of 202 participants was performed. A total of...
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Abstract Background Pituitary metastasis is a rare condition with a poor prognosis. Very few patients with pituitary metastasis are symptomatic. It is often associated with presence of co-existing metastases to other organs. Isolated pituitary metastasis as the first presentation of primary malignancy is uncommon. Case presentation A 72-year-old...
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Publication date: Available online 28 October 2019Source: Journal of Genetics and GenomicsAuthor(s): Shuangquan Chen, Juan Zhang, Dongming Zhang, Jianwei JiaoAbstractIdentifying approaches for treating neurodegeneration is a thorny task but is important for a growing number of patients. Researchers have focused on discovering the underlying molecular mechanisms of reprogramming and optimizing the technologies for acquiring neurons. Direct conversion is one of the most important processes for treating...
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Title: Halloween Can Be Frightful for Kids With Allergies, AsthmaCategory: Health NewsCreated: 10/26/2019 12:00:00 AMLast Editorial Review: 10/28/2019 12:00:00 AM (Source: MedicineNet Allergies General)
Mon Oct 28, 2019 08:00
Introduction. Severe fecal incontinence describes a condition of complete loss of control over fundamental physiological functions and loss of abilities to fulfil psychosocial functions by the patients. The last-step procedure, that is, to restore hope for improvement of biopsychosocial functioning and quality of life determined by the patient’s health status is implantation of an artificial anal sphincter. Objective. The study was a comparative analysis of the effect of the employed surgical procedure...
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Big firms are again offering more generous health plans alongside or instead of policies with sky-high deductibles. Why? They need to do so to stay competitive and recruit top talent.(Image credit: PeopleImages/Getty Images)
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bmj;367/oct29_17/l6267/FAF1faElizabeth Donald Hibbard started her professional life in Aberdeen, caring for sick children. She then turned to obstetrics and moved to London, where she met her future...
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A paraplegic man made the first kick of the World Cup in Brazil in 2014; another paralyzed man was able to move all four of his limbs through mind-control, and yet another could walk down the aisle with the love of his life due to robotic structures called exoskeletons. These are just a few mind-blowing and heart-warming stories about their current power, but they haven’t reached their full potential yet. We looked around what exoskeleton technology can do today and what it promises for tomorrow....
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Publication date: Available online 28 October 2019Source: NeuroscienceAuthor(s): Doug J. Peterson, Darcy N. Marckini, Jordan L. Straight, Elizabeth M. King, William Johnson, Sarala S. Sarah, Puneet K. Chowdhary, Merritt K. DeLano-TaylorAbstractThe floor plate of the developing midbrain gives rise to dopaminergic (DA) neurons, an important class of cells involved in Parkinson’s disease (PD). Neural progenitors of the midbrain floor plate utilize key genes in transcriptional networks to drive dopamine...
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Publication date: Available online 28 October 2019Source: NeuroscienceAuthor(s): Alexander V. Kedrov, Olga A. Mineyeva, Grigori N. Enikolopov, Konstantin V. AnokhinAbstractThe production of new neurons and their incorporation into preexisting neuronal circuits occur throughout adulthood in the olfactory bulb and the hippocampal dentate gyrus of the mammalian brain. To determine whether the adult-born neurons are engaged in the acquisition and retrieval of olfactory associative memory, we developed...
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Publication date: Available online 28 October 2019Source: NeuroscienceAuthor(s): Gerry Handara, Stephan KrögerAbstractAgrin is a multi-domain protein best known for its essential function during formation of the neuromuscular junction. Alternative mRNA splicing at sites named y and z in the C-terminal part of agrin regulates its interaction with a receptor complex consisting of the agrin-binding protein low-density lipoprotein receptor-related protein 4 (Lrp4) and the tyrosine kinase muscle specific...
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Publication date: Available online 28 October 2019Source: NeuroscienceAuthor(s): I. Berkiks, A. Mesfioui, A. Ouichou, R. Nakache, D.C. Ajonijebu, A. El hessniAbstractMid-adulthood represents the critical window period usually associated with the development of age-related diseases. Despite several attempts to delineate the pathological mechanisms underlying postnatal immune challenge and altered brain functions, the role of sex-dependent changes in affective behaviors of middle-aged animals requires...
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