OBJECTIVE: MicroRNA is an endogenous, non-coding small RNA that has a significant role in regulating organisms and pathology. Previous studies have demonstrated that microRNA-330-5p was a cancer-promoting gene. However, the role of microRNA-330-5p in osteosarcoma (OS) has not been reported. The aim of this work was to explore the characteristics of microRNA-330-5p expression in OS, and to further study its expression in OS and its relationship with clinicopathological parameters and prognosis. PATIENTS...
OBJECTIVE: Head and neck region is involved in a high percentage of malignant lesions, and oral squamous cell carcinoma (OSCC) is undoubtedly the most frequently found, accounting for over 90% of malignant tumors. Hormone receptor overexpression, like Estrogen Receptor (ER), Progesterone Receptor (PR) and Endothelial Growth Factor Receptor (EGFR), and signaling have been related to the pathogenesis of OSCC. For metastasis of OSCC, Cancer Stem Cells (CSCs) undergo epithelial to mesenchymal transition...
OBJECTIVE: Mesenchymal stem cells (MSCs) induce allograft immune tolerance, but low efficacy severely limits their wide application. In this work, Netrin-1 was used to maintain MSC function in an IR environment to study its role in the immune tolerance induction of the allograft. MATERIALS AND METHODS: The experiments were divided into three groups: the control group, the IR group and the Netrin-1 group (Netrin-1 was added to MSC medium and then cultured for 48 h). After digestion, MSCs were mixed...
OBJECTIVE: This work aimed to study the mechanism of lncRNATCF7 upregulating DNMT1 mediated by HPV-18 E6 and regulating the biological behavior of cervical cancer cells by inhibiting miR-155. PATIENTS AND METHODS: HPV-16 E6 enhanced DNMT1 expression in cervical cancer cells, which was detected by Western blotting. The expression of miR-155 in cervical cancer was detected by qPCR, the interaction between TCF-7 and miR-155 by dual-luciferase reporter gene. The changes in invasion ability of cervical...
OBJECTIVE: Recently, the vital role of circular RNAs (circRNAs) in human diseases has attracted much attention. The aim of this research was to verify the potential role of circRNA_0000285 in the development of cervical cancer (CC). PATIENTS AND METHODS: CircRNA_0000285 expression in both CC cells and tissue samples was detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Functional experiments were performed, including cell counting kit-8 (CCK-8) assay, cell cycle assay and transwell...
OBJECTIVE: To explore the role of long noncoding ribonucleic acid (lncRNA) KCNQ1OT1 in the proliferation, apoptosis, and migration of ovarian cancer cells via Wnt/β-catenin. MATERIALS AND METHODS: Ovarian cancer A2780 cells were divided into three groups, namely control group, KCNQ1OT1 overexpression group, and KCNQ1OT1 knockdown group. Next, the effect of KCNQ1OT1 on the proliferation of ovarian cancer A2780 cells was detected by cell counting kit-8 (CCK-8) assay. Wound healing assay and transwell...
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Publication date: Available online 28 October 2019Source: Bioorganic & Medicinal ChemistryAuthor(s): Weiwei Ma, Jingjing Bi, Chuanfang Zhao, Zhiguo Zhang, Tongxin Liu, Guisheng ZhangAbstractInvariant natural killer T-cells (iNKT-cells) are promising targets for manipulating the immune system, which can rapidly release a large amount of Th1 and Th2 cytokines upon the engagement of their T cell receptor with glycolipid antigens presented by CD1d. In this paper, we wish to report a novel series...
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Publication date: Available online 28 October 2019Source: Journal of EthnopharmacologyAuthor(s): Sarah Pedretti, Jonny Peter
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Abstract Purpose Laparoscopic intraperitoneal onlay mesh in hernia repair can result in adhesions leading to intestinal obstruction and fistulation. The aim of this systematic review is to compare the effects of mesh coatings reducing the tissue-to-mesh adhesion in animal studies. Methods Pubmed and Embase were systematically searched. Animal experiments...
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Publication date: Available online 28 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Vikram Shetty, Bylapudi BhanuPrakash, Anirudh Yadav, Nanda Kishore P, Akash MenonAbstractPurposeAny elective surgery should be as atraumatic to the patient as possible allowing for comfortable post-operative recovery. This study was carried out to evaluate the efficacy of pre-surgical regional blocks in reducing pain, discomfort and analgesic use in patients scheduled to undergo bimaxillary...
Publication date: Available online 28 October 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): K. Willinger, J. Cede, G. Guevara-Rojas, K. Sinko, M. Figl, K. Schicho, S. Nemec, Klug CAbstractPurposeFor planning an intraoral quadrangular Le Fort II osteotomy (IQLFIIO), simulation of hard- and soft tissue changes is important at the infraorbital, Le Fort I and incisor level. The aim of this study was to evaluate a new method for visualization and quantification.Material and MethodsThree...
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Using mice modelling patients’ variant, this study demonstrates that a homozygous DNAH17 missense variant causes asthenozoospermia and specifically destabilizes microtubule doublets 4–7 in flagella, which could be largely due to the storage of sperm in epididymis.
CRISPR-mediated disruption of a mosquito gene, mosGILT, impairs ovarian development and vitellogenesis, resulting in enhanced anti-Plasmodium immunity in the malaria vector Anopheles gambiae.
This work identifies an integrin-dependent tissue niche that supports both collective invasion and radiation resistance and can be eradicated by joint targeting of β1 and αV integrins, but neither alone. The additive effect of multiple-integrin interference indicates that clinical efficacy of integrin-based therapy will depend on multi-integrin-targeted strategies.
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OBJECTIVE: To explore the mechanism microRNA-378 in smoking-induced airway inflammation and mucus hypersecretion.MATERIALS AND METHODS: Human bronchial epithelial (HBE) cells were treated with cigarette smoke extract (CSE) to construct the in vitro COPD model. Expression levels of microRNA-378, inflammatory factors and MUC5AC in CSE-treated HBE cells were determined by quantitative real-time polymerase chain reaction (qRT-PCR), Western blot and enzyme-linked immunosorbent assay (ELISA). The regulatory...
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Violence and Gender, Ahead of Print.
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Abstract Background The safety and feasibility of laparoscopic colectomy for T4 colorectal cancer remain controversial. We believe that setting a “Goal” that will guide the surgeons in returning from the deep layer could be the key to safe en bloc resection of neighboring organs. For descending colon cancer, the cranial-first approach makes it possible to clearly visualize the pancreas and origin of the transverse mesocolon, leading...
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Journal of Medicinal Food, Ahead of Print.
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Abstract Background Parkinsonism is a complex multifactorial neurodegenerative disorder, in which genetic and environmental risk factors may both play a role. Among environmental risk factors cocaine was earlier ambiguously linked to Parkinsonism. Former single case reports described Parkinsonism in chronic cocaine users, but an epidemiological study did not confirm an increased risk of Parkinson’s disease. Here we report a patient,...
Abstract Background The aim of this study was to evaluate the correlation between significant asymptomatic carotid artery stenosis (ACAS) and severity of peripheral arterial occlusive disease (PAOD) in the lower limb, and to investigate the risk factors for significant ACAS in patients with lower limb PAOD. Methods Two hundred patients with...
Abstract Background Multiple sclerosis (MS) is prevalent among working age individuals (20–60 years), leading to high burden on work productivity. Few data are available about the absenteeism and presenteeism in employed individuals with MS in comparison to non-MS personnel. This study aimed to quantify the burden of illness of employed US adults with relapsing-remitting multiple sclerosis (RRMS) and examine burden by levels of work...
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Gallium nitride (GaN)-based nanowires (NWs) have attracted much attention for the fabrication of novel nanostructured devices. In this paper, the influence of an AlN seeding layer on the nucleation of self-assembled GaN NWs grown by plasma-assisted molecular beam epitaxy (MBE) on Si (111) substrates has been investigated. Not only is the formation of a two-dimensional compact GaN layer at the bottom of the NWs suppressed, but also a high density of vertically aligned well-separated GaN...
Advances in flexible electronic and optoelectronic devices have caused higher requirements for fabricating high-performance and low cost flexible transparent conductive electrodes (TCEs). Copper nanowires (Cu NWs) possess excellent electrical and optical properties, but the large contact resistance and poor stability limit their practical application in optoelectronic devices. In this work, we report a robust, convenient and environment-friendly method to assemble copper nanowires/reduced...
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Abstract Background Pulsed diode array laser systems are utilized extensively for various aesthetic indications such as removal of unwanted hair, treatment of vascular and pigmented lesions, and wrinkle reduction. Objective The purpose of this study was to report and assess the experience of using a diode laser system delivering pulsed infrared laser light at the near‐infrared (NIR) spectrum at wavelengths of 805 and 1060 nm. Methods The study was a retrospective analysis of treatment...
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Abstract Quantitative echocardiographic evaluation is important for systemic right ventricles, but its asymmetric shape makes this challenging and time consuming when performed manually. Semi-automated software could make these quantitative measures easier to accomplish in the clinical setting. We hypothesized that semi-automated software would approximate manual measures of right ventricular size and function. Children with hypoplastic left heart who had echocardiograms were prospectively...
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Abstract Background Surgical site infection is a common complication in women undergoing Caesarean section and the second most common cause of maternal mortality in obstetrics. In Ethiopia, prevalence and root causes of surgical site infection post-Caesarean section are highly variable. This systematic review and meta-analysis estimate the overall prevalence of surgical site infection and its root causes among women undergoing Caesarean...
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A new study has found that sugar-sweetened acidic drinks, such as soft drinks, is the common factor between obesity and tooth wear among adults.
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Zusammenfassung Bei einer 16-jährigen Patientin entwickelte sich am Stamm thorakal 2 Wochen nach kompletter Exzision eines Granuloma pyogenicum ein Satellitenrezidiv in Form zahlreicher bis zu 3 mm durchmessender Angiome. Durch Behandlung mit einem gepulsten Farbstofflaser konnte der Befund vollständig zur Rückbildung gebracht werden. Die beim Granuloma pyogenicum nachgewiesenen BRAF- und RAS-Mutationen gelten als maßgebliche Driver-Mutationen. Ob die molekularbiologischen Befunde...
Zusammenfassung Hintergrund Lange Behandlungszeiträume und hohe Rezidivraten von chronischen Wunden verursachen neben der Einschränkung der Lebensqualität der Betroffenen hohe Kosten für das Gesundheitswesen. Des Weiteren ist eine Unter- bzw. Fehlversorgung in Deutschland zu beobachten. Deshalb sind neue Versorgungsformen wie die Telekonsultation verstärkt in der Diskussion. Aktuelle Änderungen im Einheitlichen Bewertungsmaßstab und der...
Zusammenfassung Hintergrund Das gesetzliche Hautkrebsscreening (gHKS) beim Hautarzt oder Hausarzt wurde im Jahr 2008 in Deutschland eingeführt, um Hautkrebs früher zu erkennen und die Patientenversorgung zu verbessern. Um den Erfolg des gHKS beurteilen zu können und die Inanspruchnahme zu erhöhen, ist die Meinung der Bevölkerung über den Zugang zum gHKS sehr relevant. Ziel der...
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Herein I will discuss the approach to large (>20 mm) laterally spreading lesions (LSLs). These are generally removed by endoscopic mucosal resection (EMR).
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This study aims to evaluate the total bacterial and fungal count of tools, devices and surfaces of kitchens of the centers affiliated to Birjand University of Medical Sciences. In this study, 200 samples from ...
The purpose of this study was to determine the prevalence of intestinal parasitic infections among patients who had attended Hawassa University students’ clinic, Southern Ethiopia.
Canine tooth bud removal is a process of gouging out an infant’s canine tooth buds, using unsterile tools such as Sharpe blade, garlic, or knitting needle, without anesthesia. The aim of the study was to revea...
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Abstract Background Fungal infections are highly prevalent and are responsible for high rates of morbidity and mortality. In this context the search for new treatment alternatives is very relevant. Objectives Analyze chemical compounds for antifungal potential against dermatomycosis fungi. Methods The antifungal activity of one hundred and twenty‐one compounds, intermediates or derivatives of 1,3‐bis(aryloxy)propane substituted at C‐2 (one hundred and eleven compounds) and isothiouronium...
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Publication date: Available online 28 October 2019Source: Medical HypothesesAuthor(s): James R KennedyAbstractThe phosphatidylserine (PS) molecule is present in cell membranes where it is actively kept on their inner leaflets but when cells are damaged it moves to the surface and become a signal for their removal, the platform upon which the coagulation cascade takes place and a ligand that activates a feedback cycle of inflammatory cytokine secretion and initiates the wakeup call for the innate...
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Publication date: Available online 28 October 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Monique Barnard, Elahe A. Mostaghel, Richard J. Auchus, Karl-Heinz StorbeckAbstractCastration resistant prostate cancer (CRPC) remains androgen dependant despite castrate levels of circulating testosterone following androgen deprivation therapy, the first line of treatment for advanced metstatic prostate cancer. CRPC is characterized by alterations in the expression levels...
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