Public schools in Rhode Island are a mess. The situation in the state is considered so extreme by activists, elected officials, students, and parents that last year they filed a class-action lawsuit claiming that Rhode Island had deprived the students of the literacy skills necessary to participate in a democracy. Things in Providence are particularly dire. When Johns Hopkins released a report about the state capital’s public schools this summer, each line was more damning than the last. Teachers...
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Publication date: Available online 28 October 2019Source: NeuroscienceAuthor(s): Doug J. Peterson, Darcy N. Marckini, Jordan L. Straight, Elizabeth M. King, William Johnson, Sarala S. Sarah, Puneet K. Chowdhary, Merritt K. DeLano-TaylorAbstractThe floor plate of the developing midbrain gives rise to dopaminergic (DA) neurons, an important class of cells involved in Parkinson’s disease (PD). Neural progenitors of the midbrain floor plate utilize key genes in transcriptional networks to drive dopamine...
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Publication date: Available online 28 October 2019Source: NeuroscienceAuthor(s): Alexander V. Kedrov, Olga A. Mineyeva, Grigori N. Enikolopov, Konstantin V. AnokhinAbstractThe production of new neurons and their incorporation into preexisting neuronal circuits occur throughout adulthood in the olfactory bulb and the hippocampal dentate gyrus of the mammalian brain. To determine whether the adult-born neurons are engaged in the acquisition and retrieval of olfactory associative memory, we developed...
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Publication date: Available online 28 October 2019Source: NeuroscienceAuthor(s): Gerry Handara, Stephan KrögerAbstractAgrin is a multi-domain protein best known for its essential function during formation of the neuromuscular junction. Alternative mRNA splicing at sites named y and z in the C-terminal part of agrin regulates its interaction with a receptor complex consisting of the agrin-binding protein low-density lipoprotein receptor-related protein 4 (Lrp4) and the tyrosine kinase muscle specific...
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Publication date: Available online 28 October 2019Source: NeuroscienceAuthor(s): I. Berkiks, A. Mesfioui, A. Ouichou, R. Nakache, D.C. Ajonijebu, A. El hessniAbstractMid-adulthood represents the critical window period usually associated with the development of age-related diseases. Despite several attempts to delineate the pathological mechanisms underlying postnatal immune challenge and altered brain functions, the role of sex-dependent changes in affective behaviors of middle-aged animals requires...
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Publication date: Available online 28 October 2019Source: Biochimica et Biophysica Acta (BBA) - BioenergeticsAuthor(s): Sandrine Bujaldon, Natsumi Kodama, Mithun Kumar Rathod, Nicolas Tourasse, Shin-Ichiro Ozawa, Julien Sellés, Olivier Vallon, Yuichiro Takahashi, Francis-André WollmanAbstractTwo pale green mutants of the green alga Chlamydomonas reinhardtii, which have been used over the years in many photosynthesis studies, the BF4 and p71 mutants, were characterized and their mutated gene identified...
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Spending over £25,000 by the Department for Education (DfE) and its executive agencies during the financial year 2019 to 2020.
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Publication date: January 2020Source: World Neurosurgery, Volume 133Author(s): Swathi Chidambaram, Kevin Swong, Michael Ander, Russel P. NockelsBackgroundPseudohypoxic brain swelling (PHBS), also known as postoperative intracranial hypotension−associated venous congestion, is a rare complication after neurosurgery characterized by rapid and often severe postoperative deterioration in consciousness and distinct imaging findings on brain magnetic resonance imaging. Imaging findings associated with...
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Publication date: January 2020Source: World Neurosurgery, Volume 133Author(s): Taichiro Imahori, Yusuke Okamura, Junichi Sakata, Hiroyasu Shose, Shunsuke Yamanishi, Eiji KohmuraBackgroundPseudoaneurysm after mechanical thrombectomy (MT) is rare but is one of the potential complications associated with endovascular procedures. There is limited information regarding its mechanism of formation and the potential risk of delayed bleeding.Case DescriptionAn 84-year-old woman was admitted to our institution...
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Viruses, Vol. 11, Pages 993: Pan-European Study on the Prevalence of the Feline Leukaemia Virus Infection – Reported by the European Advisory Board on Cat Diseases (ABCD Europe) Viruses doi: 10.3390/v11110993 Authors: Nadine Studer Hans Lutz Claude Saegerman Enikö Gönczi Marina L. Meli Gianluca Boo Katrin Hartmann Margaret J. Hosie Karin Moestl Séverine Tasker Sándor Belák Albert Lloret Corine Boucraut-Baralon Herman F. Egberink Maria-Grazia Pennisi...
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Viruses, Vol. 11, Pages 994: Contribution of Host Immune Responses Against Influenza D Virus Infection Toward Secondary Bacterial Infection in a Mouse Model Viruses doi: 10.3390/v11110994 Authors: Raegan M. Skelton Kelly M. Shepardson Alexis Hatton Patrick T. Wilson Chithra Sreenivasan Jieshi Yu Dan Wang Victor C. Huber Agnieszka Rynda-Apple Influenza D viruses (IDV) are known to co-circulate with viral and bacterial pathogens in cattle and other ruminants. Currently,...
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Viruses, Vol. 11, Pages 995: Phylodynamic and Phylogeographic Analysis of Hepatitis Delta Virus Genotype 3 Isolated in South America Viruses doi: 10.3390/v11110995 Authors: Felipe Souza Nogueira-Lima Luan Felipo Botelho-Souza Tárcio Peixoto Roca Alcione Oliveira dos Santos Suyane da Costa Oliveira Jackson Alves da Silva Queiroz Fabianne Araújo Gomes dos Santos-Alves Juan Miguel Villalobos Salcedo Deusilene Souza Vieira The hepatitis delta virus (HDV) is a globally...
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Viruses, Vol. 11, Pages 992: Root Transcriptomic Analysis Reveals Global Changes Induced by Systemic Infection of Solanum lycopersicum with Mild and Severe Variants of Potato Spindle Tuber Viroid Viruses doi: 10.3390/v11110992 Authors: Anna Góra-Sochacka Aneta Więsyk Anna Fogtman Maciej Lirski Włodzimierz Zagórski-Ostoja Potato spindle tuber viroid (PSTVd) causes systemic infection in plant hosts. There are many studies on viroid-host plant interactions, but they have predominantly...
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Trigeminal neuralgia (TN) is a debilitating but treatable disease. Classic TN has referable vascular compression of the trigeminal nerve, but rarely secondary sources of anatomic compression will present, including vascular malformations, aneurysms, or tumors. Understanding the etiology of the patients’ symptoms leads to targeted treatment. Three patients presented with symptoms consistent with TN: shooting, paroxysmal pains in the distribution of the trigeminal nerve. However, imaging revealed no...
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Current research trends resemble the early 21st century’s financial bubble -- Read more on ScientificAmerican.com
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Diagnostics, Vol. 9, Pages 167: Phospholipids are A Potentially Important Source of Tissue Biomarkers for Hepatocellular Carcinoma: Results of a Pilot Study Involving Targeted Metabolomics Diagnostics doi: 10.3390/diagnostics9040167 Authors: Erin B. Evangelista Sandi A. Kwee Miles M. Sato Lu Wang Christoph Rettenmeier Guoxiang Xie Wei Jia Linda L. Wong Background: Hepatocellular carcinoma (HCC) pathogenesis involves the alteration of multiple liver-specific metabolic...
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Diagnostics, Vol. 9, Pages 166: Comparison of Commercial ELISA Kits, a Prototype Multiplex Electrochemoluminescent Assay, and a Multiplex Bead-Based Immunoassay for Detecting a Urine-Based Bladder-Cancer-Associated Diagnostic Signature Diagnostics doi: 10.3390/diagnostics9040166 Authors: Hideki Furuya Ian Pagano Keanu Chee Takashi Kobayashi Regan S. Wong Riko Lee Charles J. Rosser The ability to accurately measure multiple proteins simultaneously in a single assay has...
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Publication date: Available online 29 October 2019Source: The Journal of Prosthetic DentistryAuthor(s): Ying-hui Chen, Yi-ling Cheng, Hui Cheng, Hao YuAbstractStatement of problemVarious components of smile esthetics have been evaluated. However, whether these components affect smile esthetics in Han Chinese celebrities, dentists, and dental students is unknown.PurposeThe purpose of this study was to evaluate the smile esthetics of celebrities, dentists, and dental students in a Han Chinese population.Material...
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Publication date: Available online 29 October 2019Source: The Journal of Prosthetic DentistryAuthor(s): Volkan Sahin, Hossein Jodati, Zafer EvisAbstractStatement of problemRecent commercial extended-pour irreversible hydrocolloid impression materials (EPIHIMs) claim to maintain dimensional stability up to 120 hours. However, data regarding their mechanical properties and performance after 120 hours of storage are lacking.PurposeThe purpose of this in vitro study was to test the elastic recovery,...
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Publication date: Available online 29 October 2019Source: The Journal of Prosthetic DentistryAuthor(s): Shuxin Ren, Dean Morton, Wei-Shao LinAbstractStatement of problemIntraoral scans and virtual interocclusal records (VIRs) are widely used for contemporary prosthodontic treatment of patients with partial edentulism. The accuracy of VIRs in various clinical conditions is unclear.PurposeThe purpose of this in vitro study was to investigate whether the span and location of edentulous areas affect...
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Publication date: Available online 29 October 2019Source: The Journal of Prosthetic DentistryAuthor(s): Amir-Alireza Khaledi, Mitra Farzin, Marzieh Akhlaghian, Soheil Pardis, Negar MirAbstractStatement of problemDigital systems have been developed as substitutes for the traditional fabrication of wax patterns and definitive restorations, but the accuracy of these systems is unclear.PurposeThe purpose of this in vitro study was to evaluate and compare the marginal fit of metal copings fabricated from...
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Publication date: Available online 29 October 2019Source: The Journal of Prosthetic DentistryAuthor(s): Yang Yang, Zhen Yang, Jianfeng Zhou, Li Chen, Jianguo TanAbstractStatement of problemAlthough different preparation designs have been proposed for onlays fabricated by computer-aided design and computer-aided manufacturing (CAD-CAM), their effect on marginal adaptation is unclear.PurposeThe purpose of this in vitro study was to investigate the effect of tooth preparation designs on the marginal...
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Company: Health Care And Medical Jobs (HCMJ)Experience: 2 to 5location: United Arab Emirates, DubaiRef: 24227739Summary: Our Client Home Health Care is a leading provider of home care nursing services in Dubai Job Requirement We are looking for a DHA licensed / approved Home Care Nurse / Filipino Homecare Nurse with ....
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The original version of this article unfortunately contained a mistake in Fig. 6.
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Objective: To investigate whether TRIAP1inhibition affects the ovarian cancer cell resistance to cisplatin (DDP) via the Cyt c/Apaf-1/caspase-9 pathway by in vitro and in vivo experiments. Methods: CCK8 assay was performed to find out how treatment with both TRIAP1 siRNA and DDP affects the cell viability of SKOV3 cells and DDP-resistant human ovarian carcinoma cell line SKOV3/DDP. SKOV3/DDP cells were transfected with control siRNA or TRIAP1 siRNA before 24 h of treatment with DDP (5 μg/mL). Flow...
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Abstract Mutations in LRRK2 are currently recognized as the most common monogenetic cause of Parkinsonism. The elevation of kinase activity of LRRK2 that frequently accompanies its mutations is widely thought to contribute to its toxicity. Accordingly, many groups have developed LRRK2-specific kinase inhibitors as a potential therapeutic strategy. Given that protein phosphorylation is a reversible event, we sought to elucidate the phosphatase(s) that can reverse LRRK2-mediated...
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Publication date: Available online 28 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Patrícia C. Pires, Diana Peixoto, Isaura Teixeira, Márcio Rodrigues, Gilberto Alves, Adriana O. SantosAbstractPhenytoin is a low solubility anticonvulsant drug. It has, nonetheless, other possible therapeutic indications, such as neuropathic pain, including trigeminal neuralgia, or wound healing. Its use has decreased due to side effects, but nasal/intranasal administration could significantly...
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Antioxidants, Vol. 8, Pages 518: A Role for H2O2 and TRPM2 in the Induction of Cell Death: Studies in KGN Cells Antioxidants doi: 10.3390/antiox8110518 Authors: Carsten Theo Hack Theresa Buck Konstantin Bagnjuk Katja Eubler Lars Kunz Doris Mayr Artur Mayerhofer Recent studies showed that KGN cells, derived from a human granulosa cell tumor (GCT), express NADPH oxidase 4 (NOX4), an important source of H2O2. Transient receptor potential melastatin 2 (TRPM2) channel is...
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Antioxidants, Vol. 8, Pages 519: Vitamin C in Plants: From Functions to Biofortification Antioxidants doi: 10.3390/antiox8110519 Authors: Costantino Paciolla Stefania Fortunato Nunzio Dipierro Annalisa Paradiso Silvana De Leonardis Linda Mastropasqua Maria Concetta de Pinto Vitamin C (l-ascorbic acid) is an excellent free radical scavenger, not only for its capability to donate reducing equivalents but also for the relative stability of the derived monodehydroascorbate...
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Expert, tailored advice can help translate a masters in management into the perfect role
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Abstract Background The role of tumor-infiltrating B-cells (TIBs) and intratumorally-produced antibodies in cancer-immunity interactions essentially remains terra incognita. In particular, it remains unexplored how driver mutations could be associated with distinct TIBs signatures and their role in tumor microenvironment. Methods Here we analyzed...
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Publication date: Available online 29 October 2019Source: Computer Speech & LanguageAuthor(s): Craig S. Greenberg, Lisa P. Mason, Seyed Omid Sadjadi, Douglas A. ReynoldsAbstractThe National Institute of Standards and Technology has been conducting Speaker Recognition Evaluations (SREs) for over 20 years. This article provides an overview of the practice of evaluating speaker recognition technology as it has evolved during this time. Focus is given to the current state of speaker recognition evaluation....
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Publication date: Available online 29 October 2019Source: American Journal of OtolaryngologyAuthor(s): Danny Jandali, Sarah Shearer, Richard Byrne, Peter Papagiannopoulos, Bobby A. Tajudeen, Pete S. BatraAbstractIntroductionMultiple options exist for sellar reconstruction after endoscopic transnasal, transsphenoidal surgery (TSS) including free mucosa, fat, bone and synthetic materials. The objective of this study was to assess healing and mucosalization of the sellar face following TSS without formal...
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Publication date: Available online 29 October 2019Source: American Journal of OtolaryngologyAuthor(s): Belgin Tutar, Sevgi Atar, Güler Berkiten, Onur Üstün, Tolgar Lütfi Kumral, Yavuz UyarAbstractObjectivesChronic Subjective Tinnitus is a very highly prevalent disorder worldwide. There is no definitive treatment. The aim of this study is to investigate the efficacy of transcutaneous electrical nerve stimulation (TENS) applied to the auricula for treating tinnitus using the Depression Anxiety Stress...
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Publication date: Available online 28 October 2019Source: American Journal of OtolaryngologyAuthor(s): David Strum, Sunny Kim, Timothy Shim, Ashkan Monfared
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Abstract Objective The present study aimed to evaluate the diagnostic performance and safety of PET/CT-guided percutaneous core bone biopsy and to compare the PET/CT-guided method to conventional CT-guided percutaneous core biopsies to diagnose Chinese patients with bone tumors and tumor-like lesions. Methods Data for 97 patients with bone tumors...
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Elegir un pastel de chocolate sobre unas zanahorias no indica falta de autocontrol
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Publication date: Available online 28 October 2019Source: Wilderness & Environmental MedicineAuthor(s): Dennis S. Mazingi, Precious Mutambanengwe, Taurai Zimunhu, Tungamirai Gwatirisa, Bothwell A. Mbuwayesango, Kudzayi Munanzvi, Constantine Muparadzi, Mugove Moyo, Yvette MwanzaPig bite injuries are an infrequently described consequence of human–animal conflict. The domestic pig is thought to be a placid animal not given to unprovoked aggression. We report 2 separate cases of children managed...
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Publication date: Available online 28 October 2019Source: Wilderness & Environmental MedicineAuthor(s): Charles Haviland Mize, Lhab Dorji, Ken ZafrenIntroductionAlthough bear attacks on humans are uncommon, the incidence has slowly risen as human populations increasingly encroach on wilderness habitat. In the Kingdom of Bhutan, Himalayan black bear attacks occur regularly. Bears preferentially attack the face, often causing injuries that require surgical airway management. We sought to determine...
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Publication date: Available online 28 October 2019Source: Wilderness & Environmental MedicineAuthor(s): Christopher Davis, Michael Caudell, Tracy Cushing
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Publication date: Available online 28 October 2019Source: Wilderness & Environmental MedicineAuthor(s): Brian M. Strickland, Nicholas C. KanaanAbstractIntroductionEducational materials are important tools in the prevention of altitude illness among individuals traveling to high altitude destinations. Travelers obtain information about altitude illness from many different educational resources. Our objective was to determine which educational resources for altitude illness prevention were used...
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