Cancers, Vol. 11, Pages 1685: Intra-Patient Heterogeneity of Circulating Tumor Cells and Circulating Tumor DNA in Blood of Melanoma Patients Cancers doi: 10.3390/cancers11111685 Authors: Katharina Gorges Lisa Wiltfang Tobias M. Gorges Alexander Sartori Lina Hildebrandt Laura Keller Beate Volkmer Sven Peine Anna Babayan Ingrid Moll Stefan W. Schneider Sören Twarock Peter Mohr Jens W. Fischer Klaus Pantel Despite remarkable progress in melanoma...
Cancers, Vol. 11, Pages 1678: The Metabolic Inhibitor CPI-613 Negates Treatment Enrichment of Ovarian Cancer Stem Cells Cancers doi: 10.3390/cancers11111678 Authors: Chiara Bellio Celeste DiGloria David R. Spriggs Rosemary Foster Whitfield B. Growdon Bo R. Rueda One of the most significant therapeutic challenges in the treatment of ovarian cancer is the development of recurrent platinum-resistant disease. Cancer stem cells (CSCs) are postulated to contribute to recurrent...
Cancers, Vol. 11, Pages 1683: Role of Focal Adhesion Kinase in Small-Cell Lung Cancer and Its Potential as a Therapeutic Target Cancers doi: 10.3390/cancers11111683 Authors: Frank Aboubakar Nana Marie Vanderputten Sebahat Ocak Small-cell lung cancer (SCLC) represents 15% of all lung cancers and it is clinically the most aggressive type, being characterized by a tendency for early metastasis, with two-thirds of the patients diagnosed with an extensive stage (ES) disease and a five-year...
Cancers, Vol. 11, Pages 1681: Targeting STAT3 in Cancer with Nucleotide Therapeutics Cancers doi: 10.3390/cancers11111681 Authors: Yue-Ting K. Lau Malini Ramaiyer Daniel E. Johnson Jennifer R. Grandis Signal transducer and activator of transcription 3 (STAT3) plays a critical role in promoting the proliferation and survival of tumor cells. As a ubiquitously-expressed transcription factor, STAT3 has commonly been considered an “undruggable” target for therapy;...
Cancers, Vol. 11, Pages 1682: SL-BioDP: Multi-Cancer Interactive Tool for Prediction of Synthetic Lethality and Response to Cancer Treatment Cancers doi: 10.3390/cancers11111682 Authors: Xiang Deng Shaoli Das Kristin Valdez Kevin Camphausen Uma Shankavaram Synthetic lethality exploits the phenomenon that a mutation in a cancer gene is often associated with new vulnerability which can be uniquely targeted therapeutically, leading to a significant increase in favorable outcome....
Cancers, Vol. 11, Pages 1680: Radiomics Model Based on Non-Contrast CT Shows No Predictive Power for Complete Pathological Response in Locally Advanced Rectal Cancer Cancers doi: 10.3390/cancers11111680 Authors: Gordian Hamerla Hans-Jonas Meyer Peter Hambsch Ulrich Wolf Thomas Kuhnt Karl-Titus Hoffmann Alexey Surov (1) Background: About 15% of the patients undergoing neoadjuvant chemoradiation for locally advanced rectal cancer exhibit pathological complete response...
Cancers, Vol. 11, Pages 1679: Size Matters in the Cytotoxicity of Polydopamine Nanoparticles in Different Types of Tumors Cancers doi: 10.3390/cancers11111679 Authors: Celia Nieto Milena A. Vega Jesús Enrique Gema Marcelo Eva M. Martín del Valle Polydopamine has acquired great relevance in the field of nanomedicine due to its physicochemical properties. Previously, it has been reported that nanoparticles synthetized from this polymer are able to decrease the viability of...
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Publication date: December 2019Source: Data in Brief, Volume 27Author(s): Marena Molano-Mendoza, Dayana Donneys-Victoria, Nilson Marriaga-Cabrales, Miguel Angel Mueses, Gianluca Li Puma, Fiderman Machuca-MartínezAbstractThe XRD profiles and FTIR analysis of sludge aggregates, Mg–Al layered double hydroxides, produced during electrocoagulation processes are presented. The data describes the composition of materials (LDH) produced at different operations conditions (atmospheric conditions and Mg2+/Al3+...
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Abstract In the August issue of JEADV, Piaserico et al. report the results of a study of “Zoon Balanitis in men” (ZB). It is gratifying to encounter in the literature publications concerning the oft‐neglected domain of male genital dermatoses and it is laudable of colleagues to take a clinical and investigative interest. However, in my opinion, this paper is significantly flawed and sadly therefore fails usefully to advance our understanding of the topic.
Abstract Immune checkpoint inhibitor (ICI) therapy has demonstrated impressive antitumor activity. However, it causes adverse effects, including lichenoid reactions. Cases of ICI‐triggered bullous pemphigoid (BP) and anecdotally mucous membrane pemphigoid (MMP) have also been reported. We describe two new cases of pembrolizumab‐triggered MMP, one of which was associated with cutaneous lichenoid lesions.
Abstract Hailey–Hailey disease (HHD; MIM 16960), also known as familial benign pemphigus, is a rare autosomal dominant acantholytic genodermatosis, with a prevalence estimated at 1/40000. HHD is characterized by recurrent grouped vesicles, blisters and erosions restricted almost entirely to the neck and symmetrical intertriginous areas. HHD is caused by mutations in ATP2C1, which encodes an intracellular calcium ATPase pump. ATP2C1 mutations lead to haploinsufficiency, which results in abnormal...
Abstract Zoon Balanitis: misdiagnosis or missed diagnosis? Zoon balanitis (ZB) is a chronic inflammatory benign mucositis showing well‐circumscribed orange red glazed areas on the glans (and sometimes the inside of the foreskin), with ‘cayenne pepper spots’ and a symmetrical distribution. Male genital dermatoses represent an oft‐neglected domain. ZB deserves more attention, as its impact on quality of life of the affected patients might be considerable.
Abstract Radiation recall dermatitis (RRD) is an inflammatory skin reaction that develops at a previously irradiated site and is triggered by administration of various drugs following radiotherapy. Although RRD is typically confined to the irradiated area, the lesion may occasionally spread or become generalized. The most common causative drugs are the conventional anticancer agents, including anthracycline (doxorubicin), taxanes (docetaxel and paclitaxel), and antimetabolites (gemcitabine and capecitabine)....
Abstract We read with great interest the original article by Tsai et al.1 Several studies have been previously showed that patients with acne receiving isotretinoin treatment revealed changes in the serum level of homocysteine, folate and vitamin B12: nevertheless, data still remain sparse. Tsai checked that isotretinoin may cause hyperhomocysteinemia and folate deficiency in acne patients and potentially increase cardiovascular and neuropsychiatric risks. Plasmatic homocysteine may contribute...
Abstract The special interest group on sensitive skin of the International Forum for the Study of Itch previously defined sensitive skin as a syndrome defined by the occurrence of unpleasant sensations (stinging, burning, pain, pruritus and tingling sensations) in response to stimuli that normally should not provoke such sensations. This additional paper focuses on the pathophysiology and the management of sensitive skin. Sensitive skin is not an immunological disorder but is related to alterations...
Abstract Background Cutaneous squamous cell carcinoma (cSCC) is one of the most common types of cancer in the Caucasian population, with an increasing incidence. cSCC is mostly a local invasive disease that can be treated surgically in the majority of the cases. However, in the case of advanced cSCC (acSCC), a multimodality approach also involving systemic therapies needs to be considered. Methods One hundred and ninety‐five patients diagnosed with acSCC (stages III and IV) treated in our...
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Abstract Early life adversity is a risk factor for psychiatric disorders, yet the mechanisms by which adversity increases this risk are still being delineated. Here we used a limited bedding and nesting (LBN) manipulation in rats that models a low resource environment to examine effects on growth, developmental milestones, and endocrine endpoints. In LBN, dams and pups, from pups’ postnatal days 2–9, are exposed to a limited resource environment where dams lack proper materials to build a nest....
Abstract Cross‐frequency phase‐phase coupling (PPC) has been suggested to play a role in cognitive processing and, in particular, in memory consolidation during sleep. Controversial results have been reported regarding the existence of spontaneous phase‐phase coupling in the hippocampus. Here, we investigated this phenomenon in intracranial EEG recordings from the human hippocampus acquired during waking state and different sleep stages. We estimated the strength of interactions between different...
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Publication date: Available online 29 October 2019Source: Computer Speech & LanguageAuthor(s): Craig S. Greenberg, Lisa P. Mason, Seyed Omid Sadjadi, Douglas A. ReynoldsAbstractThe National Institute of Standards and Technology has been conducting Speaker Recognition Evaluations (SREs) for over 20 years. This article provides an overview of the practice of evaluating speaker recognition technology as it has evolved during this time. Focus is given to the current state of speaker recognition evaluation....
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Abstract Background Bladder cancer (BC) is a common urothelial malignancy, characterized by a high recurrence rate. The biology of bladder cancer is complex and needs to be deciphered. The latest evidence reveals the critical role of the non-coding RNAs, particularly microRNAs (miRNAs), as vital regulatory elements in cancer. Method We performed...
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Abstract Background Breast cancer (BC) is the most frequent malignant tumor in females and the 2nd most common cause of brain metastasis (BM), that are associated with a fatal prognosis. The increasing incidence from 10% up to 40% is due to more effective treatments of extracerebral sites with improved prognosis and increasing use of MRI in diagnostics. A frequently administered, potent chemotherapeutic group of drugs for BC treatment...
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Abstract Background BMP3 gene is often found hypermethylated and hence inactivated in several types of cancers including colorectal cancer (CRC), indicating that it has a suppressor role in carcinogenesis. Though BMP3 is a reliable biomarker for screening CRC, the molecular mechanism of BMP3 in carcinogenesis remains largely unknown. Methods ...
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Abstract Background Our previous work demonstrated that lncRNA-MALAT1 was overexpressed in recurrent colorectal cancer (CRC) and metastatic sites in post-surgical patients. However, the upstream regulatory mechanism of MALAT1 is not well-defined. Histone demethylase JMJD2C holds great potential of epigenetic regulating mechanism in tumor diseases, especially the moderating effect on the promoter activity of targeted genes associated...
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-- Most of the time, your urine should be a pale yellow color, says Harvard Medical School. Though food or medication can change urine's color, if your urine truly looks abnormal, you should always consult a doctor without delay. Harvard Medical...
-- Determining if you have a cold, the flu or an allergy can be difficult when you're having common symptoms, such as sneezing or a sore throat. The common symptoms reflect that each condition affects your respiratory system, says the National...
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Objective. To explore the incidence and significance of intra- and extra-osseous edema associated with benign tumors and tumor-like diseases. Methods. Magnetic resonance imaging (MRI) data from 300 benign osseous tumors and tumor-like diseases diagnosed by pathology were retrospectively reviewed. Borderline tumors, cases associated with pathological fractures, and skull lesions were excluded from the study. Bone marrow and soft tissue edema were defined on T2WI with fat suppression on MRI in all...
Metal wear debris and released ions (CoCrMo), which are widely generated in metal-on-metal bearings of hip implants, are also found in patients with metal-on-polyethylene bearings due to the mechanically assisted crevice corrosion of modular taper junctions, including head-neck and neck-stem taper interfaces. The resulting adverse reactions to metal debris and metal ions frequently lead to early arthroplasty revision surgery. National guidelines have since been published where the blood metal ion...
Virus-like particles (VLPs) are being used for therapeutic developments such as vaccines and drug nanocarriers. Among these, plant virus capsids are gaining interest for the formation of VLPs because they can be safely handled and are noncytotoxic. A paradigm in virology, however, is that plant viruses cannot transfect and deliver directly their genetic material or other cargos into mammalian cells. In this work, we prepared VLPs with the CCMV capsid and the mRNA-EGFP as a cargo and reporter gene....
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Abstract Background Cardiac metastasis from renal cell carcinoma is an exceptional event, particularly when there is lack of inferior vena cava involvement. Only a few cases have been reported worldwide so far. Case presentation We presented a case of a 58-year-old man diagnosed with isolated right ventricular metastasis of renal cell carcinoma...
Abstract Background Internal hemorrhoids are the most common anal diseases. Aluminum potassium sulfate and tannic acid (ALTA) injection is a new sclerosing therapy for the treatment of internal hemorrhoids. Although ALTA injection has been widely used, there are no previous reports of rectal cancer patients who underwent robot-assisted low anterior resection (Rob-LAR) after ALTA injection to treat internal hemorrhoids. ...
Abstract Background Systemic lupus erythematosus (SLE), an autoimmune disease characterized by systemic inflammatory lesions, is often associated with obesity. Obesity aggravates symptoms of SLE; however, these symptoms can be improved by weight loss through diet therapy and bariatric surgery. However, there are only a few reports regarding the effectiveness of bariatric surgery in obese patients with SLE. Herein, we discuss the...
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Publication date: Available online 28 October 2019Source: Cancer Treatment ReviewsAuthor(s): Hiroyuki Arai, Francesca Battaglin, Jingyuan Wang, Jae Ho Lo, Shivani Soni, Wu Zhang, Heinz-Josef LenzAbstractRegorafenib is a multi-targeting kinase inhibitor approved for the treatment of metastatic colorectal cancer patients in refractory to standard chemotherapy. Similarly to sorafenib, this agent was originally developed as a RAF1 inhibitor. However, the kinase inhibitory profile is distinct from sorafenib....
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The Editor-in-Chief is retracting this article [1] because the authors have not been able to provide documentary evidence that they obtained consent to publish from the patient whose details are described in this case report
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Publication date: Available online 28 October 2019Source: Trends in Cognitive SciencesAuthor(s): Louis Renoult, Muireann Irish, Morris Moscovitch, Michael D. RuggThe distinction between episodic and semantic memory was first proposed in 1972 by Endel Tulving and is still of central importance in cognitive neuroscience. However, data obtained over the past 30 years or so support the idea that the frontiers between perception and knowledge and between episodic and semantic memory are not as clear cut...
Publication date: Available online 28 October 2019Source: Trends in Cognitive SciencesAuthor(s): Bernhard P. Staresina, Maria WimberEpisodic memory allows us to mentally travel through time. How does the brain convert a simple reminder cue into a full-blown memory of past events and experiences? In this review, we integrate recent developments in the cognitive neuroscience of human memory retrieval, pinpointing the neural chronometry underlying successful recall. Electrophysiological recordings suggest...
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Abstract Small cell carcinoma of the bladder (SCCB) is a rare disease associated with high invasiveness and mortality. Histologically, SCCB is difficult to distinguish from small cell lung cancer (SCLC); however, it shares more similar molecular alterations with urothelial carcinoma (UC). As a result, now, the widely accepted theory about the cells of origin is that SCCB and UC probably have a common clone origin. Even the former probably comes from a preexisting UC. At present,...
Abstract The development of drug resistance affecting the prognosis of patients with hepatocellular carcinoma (HCC) leads to low survival rate of HCC patients. Caffeine is reported to have a function of protecting the liver and anti-tumor activity. Therefore, caffeine may be an ideal enhancer for HCC chemotherapy regimens. Our study showed that the combination of caffeine and 5-FU significantly inhibited the proliferation of HCC cells in vivo and in vitro comparing with caffeine...
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