Trigeminal neuralgia (TN) is a debilitating but treatable disease. Classic TN has referable vascular compression of the trigeminal nerve, but rarely secondary sources of anatomic compression will present, including vascular malformations, aneurysms, or tumors. Understanding the etiology of the patients’ symptoms leads to targeted treatment. Three patients presented with symptoms consistent with TN: shooting, paroxysmal pains in the distribution of the trigeminal nerve. However, imaging revealed no...
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Publication date: Available online 29 October 2019Source: The Journal of Prosthetic DentistryAuthor(s): Ying-hui Chen, Yi-ling Cheng, Hui Cheng, Hao YuAbstractStatement of problemVarious components of smile esthetics have been evaluated. However, whether these components affect smile esthetics in Han Chinese celebrities, dentists, and dental students is unknown.PurposeThe purpose of this study was to evaluate the smile esthetics of celebrities, dentists, and dental students in a Han Chinese population.Material...
Publication date: Available online 29 October 2019Source: The Journal of Prosthetic DentistryAuthor(s): Volkan Sahin, Hossein Jodati, Zafer EvisAbstractStatement of problemRecent commercial extended-pour irreversible hydrocolloid impression materials (EPIHIMs) claim to maintain dimensional stability up to 120 hours. However, data regarding their mechanical properties and performance after 120 hours of storage are lacking.PurposeThe purpose of this in vitro study was to test the elastic recovery,...
Publication date: Available online 29 October 2019Source: The Journal of Prosthetic DentistryAuthor(s): Shuxin Ren, Dean Morton, Wei-Shao LinAbstractStatement of problemIntraoral scans and virtual interocclusal records (VIRs) are widely used for contemporary prosthodontic treatment of patients with partial edentulism. The accuracy of VIRs in various clinical conditions is unclear.PurposeThe purpose of this in vitro study was to investigate whether the span and location of edentulous areas affect...
Publication date: Available online 29 October 2019Source: The Journal of Prosthetic DentistryAuthor(s): Amir-Alireza Khaledi, Mitra Farzin, Marzieh Akhlaghian, Soheil Pardis, Negar MirAbstractStatement of problemDigital systems have been developed as substitutes for the traditional fabrication of wax patterns and definitive restorations, but the accuracy of these systems is unclear.PurposeThe purpose of this in vitro study was to evaluate and compare the marginal fit of metal copings fabricated from...
Publication date: Available online 29 October 2019Source: The Journal of Prosthetic DentistryAuthor(s): Yang Yang, Zhen Yang, Jianfeng Zhou, Li Chen, Jianguo TanAbstractStatement of problemAlthough different preparation designs have been proposed for onlays fabricated by computer-aided design and computer-aided manufacturing (CAD-CAM), their effect on marginal adaptation is unclear.PurposeThe purpose of this in vitro study was to investigate the effect of tooth preparation designs on the marginal...
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Objective: To investigate whether TRIAP1inhibition affects the ovarian cancer cell resistance to cisplatin (DDP) via the Cyt c/Apaf-1/caspase-9 pathway by in vitro and in vivo experiments. Methods: CCK8 assay was performed to find out how treatment with both TRIAP1 siRNA and DDP affects the cell viability of SKOV3 cells and DDP-resistant human ovarian carcinoma cell line SKOV3/DDP. SKOV3/DDP cells were transfected with control siRNA or TRIAP1 siRNA before 24 h of treatment with DDP (5 μg/mL). Flow...
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Publication date: Available online 28 October 2019Source: European Journal of Pharmaceutical SciencesAuthor(s): Patrícia C. Pires, Diana Peixoto, Isaura Teixeira, Márcio Rodrigues, Gilberto Alves, Adriana O. SantosAbstractPhenytoin is a low solubility anticonvulsant drug. It has, nonetheless, other possible therapeutic indications, such as neuropathic pain, including trigeminal neuralgia, or wound healing. Its use has decreased due to side effects, but nasal/intranasal administration could significantly...
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Abstract We previously reviewed our study of the pharmacological properties of cardiac Na+/Ca2+ exchange (NCX1) inhibitors among cardioprotective drugs, such as amiodarone, bepridil, dronedarone, cibenzoline, azimilide, aprindine, and benzyl-oxyphenyl derivatives (Watanabe et al. in J Pharmacol Sci 102:7–16, 2006). Since then we have continued our studies further and found that some cardioprotective drugs are NCX1 stimulators. Cardiac Na+/Ca2+ exchange current (INCX1) was stimulated...
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Publication date: Available online 29 October 2019Source: American Journal of OtolaryngologyAuthor(s): Danny Jandali, Sarah Shearer, Richard Byrne, Peter Papagiannopoulos, Bobby A. Tajudeen, Pete S. BatraAbstractIntroductionMultiple options exist for sellar reconstruction after endoscopic transnasal, transsphenoidal surgery (TSS) including free mucosa, fat, bone and synthetic materials. The objective of this study was to assess healing and mucosalization of the sellar face following TSS without formal...
Publication date: Available online 29 October 2019Source: American Journal of OtolaryngologyAuthor(s): Belgin Tutar, Sevgi Atar, Güler Berkiten, Onur Üstün, Tolgar Lütfi Kumral, Yavuz UyarAbstractObjectivesChronic Subjective Tinnitus is a very highly prevalent disorder worldwide. There is no definitive treatment. The aim of this study is to investigate the efficacy of transcutaneous electrical nerve stimulation (TENS) applied to the auricula for treating tinnitus using the Depression Anxiety Stress...
Publication date: Available online 28 October 2019Source: American Journal of OtolaryngologyAuthor(s): David Strum, Sunny Kim, Timothy Shim, Ashkan Monfared
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Abstract Objective The present study aimed to evaluate the diagnostic performance and safety of PET/CT-guided percutaneous core bone biopsy and to compare the PET/CT-guided method to conventional CT-guided percutaneous core biopsies to diagnose Chinese patients with bone tumors and tumor-like lesions. Methods Data for 97 patients with bone tumors...
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Elegir un pastel de chocolate sobre unas zanahorias no indica falta de autocontrol
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Publication date: Available online 29 October 2019Source: European Journal of Vascular and Endovascular SurgeryAuthor(s): Adeline Schwein, Yannick Georg
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Condition: Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene FusionIntervention: Drug: larotrectinib(Vitrakvi, BAY2757556)Sponsor: BayerNot yet recruiting
Condition: Squamous Cell CarcinomasIntervention: Other: solar irradiation and biopsiesSponsor: Centre Hospitalier Universitaire de NiceNot yet recruiting
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Venöses Thoracic-outlet-Syndrom mit akuter Thrombose der V. subclavia (Paget-von-Schroetter-Syndrom)
Zusammenfassung Einleitung Der akute thrombotische Verschluss der V. subclavia oder V. axillaris wird in der Literatur als Paget-von-Schroetter-Syndrom bezeichnet. Es entsteht durch Mikrotraumen bzw. Intimaeinrisse der Vene und präsentiert sich klinisch mit venösem Rückstau, Prominenz der Oberarmvenen sowie infraklavikulärem oder axillärem Druckschmerz. Chronische Abflussstörungen der Vv. axillaris et subclavia aufgrund der anatomischen...
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Publication date: January 2020Source: Magnetic Resonance Imaging, Volume 65Author(s): Jonathan M. Hanna, Danielle Temares, Fahmeed Hyder, Douglas L. Rothman, Robert K. Fulbright, Veronica L. Chiang, Daniel ComanAbstractBackground and purposeGiven increasing interest in laser interstitial thermotherapy (LITT) to treat brain tumor patients, we explored if examining multiple MRI contrasts per brain tumor patient undergoing surgery can impact predictive accuracy of survival post-LITT.Materials and methodsMRI...
Publication date: Available online 29 October 2019Source: Magnetic Resonance ImagingAuthor(s): Jamal Sakhr, Blaine A. ChronikAbstractPassive reduction of gradient coil (GC) cylinder vibration depends critically on a thorough knowledge of how all pertinent physical parameters affect the vibration response. In this paper, we employ a recently introduced linear elastodynamic Z-coil model to study how the displacement response of a whole-body GC cylinder (subject to exclusive excitation of its Z-coil...
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Linezolid has been traditionally been used for variety of illnesses and many adverse effects are well known. However, the triad of hypoglycemia, bone marrow suppression and hyponatremia in a single elderly patient is rarely described previously. Abstract What is known and objective Linezolid, a member of the oxazolidinone class of antibacterial drugs, is approved by the US Food and Drug Administration (FDA) for the treatment of vancomycin‐resistant Enterococcus faecium infections,...
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IJMS, Vol. 20, Pages 5389: Alignment-Free Method to Predict Enzyme Classes and Subclasses International Journal of Molecular Sciences doi: 10.3390/ijms20215389 Authors: Riccardo Concu M. Natália D. S. Cordeiro The Enzyme Classification (EC) number is a numerical classification scheme for enzymes, established using the chemical reactions they catalyze. This classification is based on the recommendation of the Nomenclature Committee of the International Union of Biochemistry and Molecular...
IJMS, Vol. 20, Pages 5387: Role of Hypoxia and Metabolism in the Development of Neointimal Hyperplasia in Arteriovenous Fistulas International Journal of Molecular Sciences doi: 10.3390/ijms20215387 Authors: Nirvana Sadaghianloo Julie Contenti Alan Dardik Nathalie M. Mazure For patients with end-stage renal disease requiring hemodialysis, their vascular access is both their lifeline and their Achilles heel. Despite being recommended as primary vascular access, the arteriovenous...
IJMS, Vol. 20, Pages 5386: Substantial Overview on Mesenchymal Stem Cell Biological and Physical Properties as an Opportunity in Translational Medicine International Journal of Molecular Sciences doi: 10.3390/ijms20215386 Authors: Heba Abdelrazik Emanuele Giordano Giovanni Barbanti Brodano Cristiana Griffoni Elena De Falco Alessandra Pelagalli Mesenchymal stem cells (MSC) have piqued worldwide interest for their extensive potential to treat a large array of clinical indications,...
IJMS, Vol. 20, Pages 5388: Sepsis: Precision-Based Medicine for Pregnancy and the Puerperium International Journal of Molecular Sciences doi: 10.3390/ijms20215388 Authors: Orene Greer Nishel Mohan Shah Shiranee Sriskandan Mark R. Johnson Sepsis contributes significantly to global morbidity and mortality, particularly in vulnerable populations. Pregnant and recently pregnant women are particularly prone to rapid progression to sepsis and septic shock, with 11% of maternal deaths...
IJMS, Vol. 20, Pages 5385: SAR-mediated Similarity Assessment of the Property Profile for New, Silicon-Based AChE/BChE Inhibitors International Journal of Molecular Sciences doi: 10.3390/ijms20215385 Authors: Andrzej Bak Hana Pizova Violetta Kozik Katarina Vorcakova Jiri Kos Jakub Treml Klara Odehnalova Michal Oravec Ales Imramovsky Pavel Bobal Adam Smolinski Zdeněk Trávníček Josef Jampilek A set of 25 novel, silicon-based carbamate derivatives as...
IJMS, Vol. 20, Pages 5384: The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor International Journal of Molecular Sciences doi: 10.3390/ijms20215384 Authors: Catalina Carrasco-Pozo Kah Ni Tan Tayner Rodriguez Vicky M. Avery Androgen receptor (AR) stimulators, such as androgen and Tip60, play a pivotal role in prostatic carcinogenesis as androgen receptor signaling is critical for the growth and transformation...
IJMS, Vol. 20, Pages 5383: Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells International Journal of Molecular Sciences doi: 10.3390/ijms20215383 Authors: Li Zhang Feifei Wang Qing Zhang Qiuming Liang Shumei Wang Minghua Xian Feng Wang Inflammation is a key mediator in the progression of atherosclerosis (AS). Benzoinum, a resin secreted from the bark of Styrax tonkinensis, has been widely used as a form of traditional...
IJMS, Vol. 20, Pages 5380: Vitamin E but Not GSH Decreases Reactive Oxygen Species Accumulation and Enhances Sperm Production during In Vitro Maturation of Frozen-Thawed Prepubertal Mouse Testicular Tissue International Journal of Molecular Sciences doi: 10.3390/ijms20215380 Authors: Brahim Arkoun Ludovic Galas Ludovic Dumont Aurélie Rives Justine Saulnier Marion Delessard Christine Rondanino Nathalie Rives Freezing–thawing procedures and in vitro culture...
IJMS, Vol. 20, Pages 5382: Translational Control in p53 Expression: The Role of 5′-Terminal Region of p53 mRNA International Journal of Molecular Sciences doi: 10.3390/ijms20215382 Authors: Agata Swiatkowska Mariola Dutkiewicz Paulina Zydowicz-Machtel Joanna Szpotkowska Damian M. Janecki Jerzy Ciesiołka In this review, the latest research concerning the structure and function of the 5′-terminal region of p53 mRNA was discussed. Special attention was focused on...
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Abstract The posterior arch defects of the cervical spine are rare, and they arise out of deviations of the normal intrauterine development of the spine (4–8 weeks of development). The defects range from a cleft to the total agenesis of the posterior arch, with a reported prevalence of 4% and 0.15%, respectively. The pedicle agenesis is most frequently found in C6. A diagnosis is usually made after a traumatic incident in a previously asymptomatic patient. 35% of a patient’s current...
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Loot boxes are items in video games that may be paid for with real-world money, but which contain randomised contents. There is a reliable correlation between loot box spending and problem gambling severity: the more money gamers spend on loot boxes, the more severe their problem gambling tends to be. However, it is unclear whether this link represents a case in which loot box spending causes problem gambling; a case in which the gambling-like nature of loot boxes cause problem gamblers to spend...
Background The potential of unidentified microorganisms for academic and other applications is limitless. Plants have diverse microbial communities associated with their biomes. However, few studies have focused on the microbial community structure relevant to tree bark. Methods In this report, the microbial community structure of bark from the broad-leaved tree Acer palmatum was analyzed. Both a culture-independent approach using polymerase chain reaction (PCR) amplification and next...
In 2010, the Conference of the Parties of the Convention on Biological Diversity agreed on the Strategic Plan for Biodiversity 2011–2020 in Aichi Prefecture, Japan. As this plan approaches its end, we discussed whether marine biodiversity and prediction studies were nearing the Aichi Targets during the 4th World Conference on Marine Biodiversity held in Montreal, Canada in June 2018. This article summarises the outcome of a five-day group discussion on how global marine biodiversity studies should...
Background Soil aggregate-size classes, structural units of soil, are the important factors regulating soil organic carbon (SOC) turnover. However, the processes of litter C mineralization and storage in different aggregates-size classes are poorly understood, especially in the highly alkaline soils of north China. Here, we ask how four different aggregate sizes influence rates of C release (Cr) and SOC storage (Cs) in response to three types of plant litter added to an un-grazed natural grassland....
Gene drives may be used in two ways to curtail vectored diseases. Both involve engineering the drive to spread in the vector population. One approach uses the drive to directly depress vector numbers, possibly to extinction. The other approach leaves intact the vector population but suppresses the disease agent during its interaction with the vector. This second application may use a drive engineered to carry a genetic cargo that blocks the disease agent. An advantage of the second application is...
Tree aging is a new research area and has attracted research interest in recent years. Trees show extraordinary longevity; Platycladus orientalis L. (Cupressaceae) has a lifespan of thousands of years. Ancient trees are precious historical heritage and scientific research materials. However, tree aging and tree senescence have different definitions and are poorly understood. Since leaves are the most sensitive organ of a tree, we studied the structural response of leaves to tree age. Experiments...
There is growing interest within regulatory agencies and toxicological research communities to develop, test, and apply new approaches, such as toxicogenomics, to more efficiently evaluate chemical hazards. Given the complexity of analyzing thousands of genes simultaneously, there is a need to identify reduced gene sets. Though several gene sets have been defined for toxicological applications, few of these were purposefully derived using toxicogenomics data. Here, we developed and applied a systematic...
The number of people suffering from eye fatigue induced by visual display terminal (VDT) viewing is expected to increase in the modern world. Eye dysfunction is suggested to induce a decrease in cognitive function, at least in the long term. Furthermore, considering other previous findings, it may be reasonable to think that acute or relatively short-term eye dysfunction attenuates cognitive function for not only older but also young individuals. Hence, clarification of the effect of eye fatigue...
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