Objective: The objective of this study is to describe what we consider to be the state-of-the-art procedure for the treatment of tympanic membrane perforations, and to present the results attained in our institution. Study Design: A retrospective cohort study, using data of Verona University Hospital, Italy. This medical record includes the data of 98 patients who underwent 100 transcanal endoscopic type I tympanoplasties from November 2014 to October 2017. Setting: Tertiary referral...
Mon Oct 21, 2019 03:00
Objectives: It is imperative to acquire a simple, objective, and mathematical method for the assessment of facial nerve palsy which can be universally accepted and implemented. A grading scale which is convenient, continuous and economical was attempted for the first time for global and region-specific assessment of facial nerve palsy. Study Design: Hospital-based observational study. Setting: Medical college hospital. Patients: Ten normal subjects and 51 patients with facial paralysis. ...
Mon Oct 21, 2019 03:00
Objective: To evaluate the effect of communication mode on the spoken language outcomes of children who received a cochlear implant. Study Design: Retrospective analysis of postoperative speech and language and reading scores for children who received a cochlear implant and used three different modes of communication: auditory-verbal (AV) (n = 39), oral communication (OC) (n = 107), and total communication (TC) (n = 57). Setting: A single tertiary cochlear implant clinic. Patients:...
Mon Oct 21, 2019 03:00
Objective: This study is to investigate the hemodynamic changes of pulsatile tinnitus (PT) patients induced by sigmoid sinus wall anomalies (SSWA). Study Design: Prospective study. Setting: Tertiary referral university hospital. Patients: Fifteen unilateral PT patients with SSWA identified on computed tomography images and surgery and 15 age-, sex-, and body mass index-matched healthy volunteers underwent velocity-encoded, cine magnetic resonance imaging. Intervention: Hemodynamic...
Mon Oct 21, 2019 03:00
Objective: To define clear clinical characteristics and management strategies of herniation of temporomandibular joint (TMJ) into the external auditory canal (EAC). Data Source: MEDLINE, PubMed, and EMBASE databases. Study Selection: A search was conducted using the keywords “temporomandibular joint” and “herniation” with all of their synonyms. Literature selection criteria included articles published in English, and articles dating back no further than 1970. Results: Forty articles...
Mon Oct 21, 2019 03:00
Hypothesis: Autophagy and its enhancement may have a role in the pathogenesis of acquired cholesteatoma. Background: The etiopathogenesis of acquired cholesteatoma remains unclear. Some clinical features of cholesteatoma are similar to those of cancer. The study of autophagy in cancer has indicated that enhanced autophagy enables tumor cell survival and growth. Methods: Cholesteatoma epithelium and normal external auditory canal (EAC) epithelium were obtained from patients with acquired...
Mon Oct 21, 2019 03:00
No abstract available
Mon Oct 21, 2019 03:00
Objective: To determine the presence of sex differences in cochlear implant outcomes. Study Design: Retrospective chart review. Setting: Tertiary referral center. Patients: Adult patients having undergone cochlear implantation from 2009 to 2017. Intervention(s): Standard electrode length cochlear implantation. Main Outcome Measure(s): AzBio scores in quiet of the implanted ear at the 1 to 3 months and 6 to 9 months postoperative time points. Results: Of 55 patients...
Mon Oct 21, 2019 03:00
Objective: Cochlear obliteration after vestibular schwannoma excision has been noted, with implications on cochlear implantation. Early postoperative cochlear enhancement with gadolinium on magnetic resonance imaging (MRI) has also been observed. Timing of enhancement and association with obliteration is described here. Study Design: Retrospective case review. Setting: Tertiary referral center, ambulatory. Patients: Patients receiving vestibular schwannoma excision surgery by the...
Mon Oct 21, 2019 03:00
Objective: The objective of the study was to measure auditory brainstem responses elicited by stimulation via a semi-implantable active middle ear implant with an electromagnetically driven floating mass transducer to quantify the coupling efficacy (=vibroplasty in situ thresholds – bone conduction thresholds) in a patient during a revision surgery. Patients: One patient, reimplanted with an active middle ear implant in a revision surgery. Intervention(s): Diagnostic. Main Outcome...
Mon Oct 21, 2019 03:00
Objective: To study the development of dichotic listening, ear advantage, and speech perception in cochlear implant (CI) recipients using five audiometric tests. Study Design: Prospective cohort analysis. Setting: University Hospital. Patients: One hundred twenty one participants who received simultaneous bilateral CIs and had at least 12 months of regular bilateral CI use. Age at time of testing ranged from 4 to 18 years with a mean age of 9 years (standard deviation [SD]: 3.0)....
Mon Oct 21, 2019 03:00
Objective: To develop and implement a streamlined, patient-centered service delivery model for patients referred for cochlear implantation (CI) at a high-volume academic center. Patients: CI candidate adults. Interventions: CI, implementation of new CI delivery model. Main Outcome Measures: Referral-to-surgery time, patient travel burden. Results: Data from 206 adults that underwent CI were used to develop a process map of the initial operational state from referral date to...
Mon Oct 21, 2019 03:00
Purpose: The purpose of this study is to determine if a cognitive test, Self-administered Gerocognitive Examination (SAGE), correlates with speech recognition outcomes 1 year after cochlear implantation in adults over 65 years of age. Methods: Retrospective study was conducted at a single institution. Surgery was performed by two surgeons on adult patients (>65 yrs) with postlingual bilateral sensorineural hearing loss meeting clinical and audiological candidacy for unilateral cochlear...
Mon Oct 21, 2019 03:00
Objective: To examine the association between hearing impairment and cognitive decline and to identify possible risk factors for presbycusis. Study Design: Cross-sectional survey in prospective cohort study. Setting: University hospital. Patients: A total of 322 participants aged >60 years, for whom all the below data were available, were enrolled in the study. There were 168 females and 154 males with a median age of 71 years (range: 60–89 yrs). Interventions: PROST (Project...
Mon Oct 21, 2019 03:00
Background: A significant number of adults suffer from conductive hearing loss due to chronic otitis media, otosclerosis, or other pathologies. An objective measurement of ossicular mobility is needed to avoid unnecessarily invasive middle ear surgery and to improve hearing outcomes. Methods: Minimally invasive intraoperative laser vibrometry provides a method that is compatible with middle ear surgery, where the tympanic membrane is elevated. The ossicles were driven by a floating mass transducer...
Mon Oct 21, 2019 03:00
Abstract This is the first study to demonstrate vestibular deficit in patients with vestibular schwannoma who do not have clinical symptoms of imbalance. Balance can have significant impact on patient’s quality of life, and vHIT can potentially identify those at risk of balance problems. vHIT is the only validated test for six‐canal vestibular function. vHIT is quick and easily tolerated and can be useful in helping patients understand their balance symptoms. The posterior semi‐circular canal...
Tue Oct 29, 2019 18:35
Abstract Objectives The United States has a heterogenous health insurance landscape for patients <65 years. We sought to characterize the impact of primary payer on overall survival (OS) in insured patients younger than 65 with head and neck squamous cell carcinoma (HNSCC) treated with definitive radiotherapy. Design/Study/Participants The National Cancer Data Base was queried for patients <65 diagnosed from 2004‐2014 undergoing definitive radiotherapy ± chemotherapy for cancers of...
Tue Oct 29, 2019 15:16
Abstract Background We evaluated the prognostic value of lymph node ratio (LNR) in patients with advanced laryngeal and hypopharyngeal squamous cell carcinoma. Study Design: Retrospective chart review. Methods Between 1994 and 2018, 79 patients underwent total laryngopharyngectomy and adjuvant therapy. LNR was determined and statistically compared to patients’ overall survival (OS), disease‐specific survival (DSS), disease‐free survival (DFS), locoregional and distant failure. Results...
Tue Oct 29, 2019 13:59
Abstract A Modified Cormack‐Lehane score of 2b or 3 has a predicted endoscopic stapling failure rate of 81% and so previous anaesthetic records may be useful in surgical planning. Small pouch size is not a predictor for failure when other factors are favourable, and endoscopic surgery should not be ruled out on this basis. Patients with a high BMI have a higher chance of pouch recurrence.
Tue Oct 29, 2019 13:59
A 42-year-old African American male without any past medical history presented with 1 month’s duration of headache, photophobia, fever, and nodular skin lesions on the palms, soles, face, and tongue. All lesions were intermittently painful, without pruritus or bleeding. Associated symptoms included confusion and fatigue. He reported living in a motel and working as a day laborer in construction, after moving from St. Louis, Missouri to California. He denied any sick contacts, intravenous drug use,...
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Genes, Vol. 10, Pages 859: Cell Cycle-Dependent Control and Roles of DNA Topoisomerase II Genes doi: 10.3390/genes10110859 Authors: Joyce H. Lee James M. Berger Type II topoisomerases are ubiquitous enzymes in all branches of life that can alter DNA superhelicity and unlink double-stranded DNA segments during processes such as replication and transcription. In cells, type II topoisomerases are particularly useful for their ability to disentangle newly-replicated sister chromosomes....
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Genes, Vol. 10, Pages 857: Comparative Chromosome Mapping of Musk Ox and the X Chromosome among Some Bovidae Species Genes doi: 10.3390/genes10110857 Authors: Proskuryakova Kulemzina Perelman Yudkin Lemskaya Okhlopkov Kirillin Farré Larkin Roelke-Parker O’Brien Bush Graphodatsky : Bovidae, the largest family in Pecora infraorder, are characterized by a striking variability in diploid number of chromosomes between species and among individuals...
Tue Oct 29, 2019 02:00
Genes, Vol. 10, Pages 858: Genetic Biomonitoring and Biodiversity Assessment Using Portable Sequencing Technologies: Current Uses and Future Directions Genes doi: 10.3390/genes10110858 Authors: Krehenwinkel Pomerantz Prost We live in an era of unprecedented biodiversity loss, affecting the taxonomic composition of ecosystems worldwide. The immense task of quantifying human imprints on global ecosystems has been greatly simplified by developments in high-throughput DNA sequencing...
Tue Oct 29, 2019 02:00
Genes, Vol. 10, Pages 856: Predominance of Dystrophinopathy Genotypes in Mexican Male Patients Presenting as Muscular Dystrophy with A Normal Multiplex Polymerase Chain Reaction DMD Gene Result: A Study Including Targeted Next-Generation Sequencing Genes doi: 10.3390/genes10110856 Authors: Miguel Angel Alcántara-Ortigoza Miriam Erandi Reyna-Fabián Ariadna González-del Angel Bernardette Estandia-Ortega Cesárea Bermúdez-López Gabriela Marisol Cruz-Miranda Matilde Ruíz-García...
Tue Oct 29, 2019 02:00
Genes, Vol. 10, Pages 855: Chromatin-Mediated Regulation of Genome Plasticity in Human Fungal Pathogens Genes doi: 10.3390/genes10110855 Authors: Buscaino Human fungal pathogens, such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans, are a public health problem, causing millions of infections and killing almost half a million people annually. The ability of these pathogens to colonise almost every organ in the human body and cause life-threating infections relies...
Mon Oct 28, 2019 02:00
Genes, Vol. 10, Pages 854: Self-Organization of the Biological Evolution Genes doi: 10.3390/genes10110854 Authors: Werner Arber We report here experiments carried out with nonpathogenic Escherichia coli bacterial strains and their phages. This research yielded interesting insights into their activities, occasionally producing genetic variants of different types. In order to not interfere with the genetic stability of the parental strains involved, we found that the bacteria are genetically...
Mon Oct 28, 2019 02:00
Genes, Vol. 10, Pages 853: Comparative Physiological and Transcriptomic Analyses Reveal Mechanisms of Improved Osmotic Stress Tolerance in Annual Ryegrass by Exogenous Chitosan Genes doi: 10.3390/genes10110853 Authors: Zhao Pan Zhou Yang Meng Zhang Water deficit adversely affects the growth and productivity of annual ryegrass (Lolium multiflorum Lam.). The exogenous application of chitosan (CTS) has gained extensive interests due to its effect on improving drought...
Mon Oct 28, 2019 02:00
Genes, Vol. 10, Pages 852: Genome-Wide Small RNA Sequencing Identifies MicroRNAs Deregulated in Non-Small Cell Lung Carcinoma Harboring Gain-of-Function Mutant p53 Genes doi: 10.3390/genes10110852 Authors: Arindam Datta Pijush Das Sanjib Dey Sangeeta Ghuwalewala Dishari Ghatak Sk. Kayum Alam Raghunath Chatterjee Susanta Roychoudhury Mutations in the TP53 gene are one of the most frequent events in cancers. Certain missense mutant p53 proteins gain oncogenic functions...
Mon Oct 28, 2019 02:00
Genes, Vol. 10, Pages 851: Population Genomics of Bettongia lesueur: Admixing Increases Genetic Diversity with no Evidence of Outbreeding Depression Genes doi: 10.3390/genes10110851 Authors: Kate Rick Kym Ottewell Cheryl Lohr Rujiporn Thavornkanlapachai Margaret Byrne W. Jason Kennington Small and isolated populations are subject to the loss of genetic variation as a consequence of inbreeding and genetic drift, which in turn, can affect the fitness and long-term viability...
Mon Oct 28, 2019 02:00
Genes, Vol. 10, Pages 850: Diversity and Horizontal Transfer of Antarctic Pseudomonas spp. Plasmids Genes doi: 10.3390/genes10110850 Authors: Krzysztof Romaniuk Michal Styczynski Przemyslaw Decewicz Oliwia Buraczewska Witold Uhrynowski Marco Fondi Marcin Wolosiewicz Magdalena Szuplewska Lukasz Dziewit Pseudomonas spp. are widely distributed in various environments around the world. They are also common in the Antarctic regions. To date, almost 200 plasmids of...
Mon Oct 28, 2019 02:00
In classical singing techniques, it is common to manipulate the vocal tract to channel airflow to increase voice quality and volume. Technique varies according to the style of the music, the voice type, and range of a given singer. Although these practices are intentional, fixed physiological aspects of a singer's vocal instrument also play an extremely impactful role in determining voice quality. (Source: Journal of Voice)
Tue Oct 29, 2019 00:00
Έχετε αναρωτηθεί πώς επηρεάζουν την υγεία ορισμένες από τις τροφές, που καταναλώνουμε συχνότερα;
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Τα τελευταία χρόνια όλο και περισσότερες έρευνες επισημαίνουν ότι, υπάρχει σχέση μεταξύ διατροφής και κληρονομικότητας και εμφάνιση της νόσου.
Tue Oct 29, 2019 22:00
Πολλά μωρά κοιμούνται με ελαφρώς ανοιχτά τα ματάκια τους, είτε στους διάφορους ύπνους που παίρνουν κατά τη διάρκεια της ημέρας, είτε το βράδυ.
Tue Oct 29, 2019 21:00
Τα ποσοστά καρκίνου του θυρεοειδούς έχουν διπλασιαστεί από τη δεκαετία του '70 και μετά, με τις γυναίκες να διατρέχουν τον μεγαλύτερο κίνδυνο.
Tue Oct 29, 2019 19:00
Για να προστατευθείς από δερματικά προβλήματα και ακμή.
Tue Oct 29, 2019 18:30
Το μεταβολικό σύνδρομο επηρεάζει 1 στους 3 ενήλικες, έχει ανοδική τάση και οδηγεί σε δυνητικά θανατηφόρες καταστάσεις.
Tue Oct 29, 2019 18:00
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