Abstract Background Well-differentiated thyroid carcinoma is defined as locally advanced in the presence of an extra thyroid extension, e.g., when the surrounding structures such as the trachea, larynx, esophagus and main blood vessels are invaded by cancer. The 8th edition AJCC Cancer Staging Manual states that this is the main characteristic to evaluate for the staging and consequently for the prognosis in patients over 55 years...
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Evaluate the relationship between anxiety, quality of life (QL) and sociodemographic aspects with Temporomandibular Disorder (TMD); and the predisposition of low QL anxious patients to present TMD.
Due to long-term and consecutive consumption of different causative agents, clinicians are increasingly facing the problem of restoring the stomatognathic system after surgical resection of highly advanced necroses of the jaw. For plastic restoration in these cases, microvascular reconstruction seems to represent the most viable option. According to the limited data available, the risks of this operation are considered comparable to those in other patient cohorts. We report about a patient who subsequently...
The notable features of ameloblastoma do not typically include prominent vascularity. However, rarely, vascular ameloblastoma has been described under a variety of names. We present a case of vascularized ameloblastoma that had a bloody return on FNA. The English literature had a total of 16 reports (18 cases) of vascular or hemangioma-like ameloblastoma. The clinical, pathologic and radiographic features of the 19 cases are examined, but further study and more cases are needed. The recognition of...
The purpose of this study was to investigate factors that have a significant impact on decision-making for treatment strategies and resultant outcomes in elderly oral squamous cell carcinoma (OSCC) patients.
To assess diagnosis and treatment of submandibular duct stenosis caused by dental prostheses.
To investigate clinical characteristics and treatment outcomes of patients with temporomandibular disorders (TMD) according to the presence of upper cervical spine abnormalities and craniofacial morphology.
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Abstract Long noncoding RNAs (lncRNAs) have been shown to be aberrantly expressed in oral squamous cell carcinoma (OSCC), but the biological role and function of BRAF‐activated long noncoding RNA (BANCR) in OSCC remain poorly understood. In this study, we found that the expression of BANCR was up‐regulated in OSCC tissues and cell lines compared to the negative control. The decreased expression of BANCR in vitro markedly inhibited OSCC cell proliferation, migration, and invasion while the opposite...
Abstract Objective To investigate possible associations between disease specific survival (DSS) of oral cancer and single nucleotide polymorphisms (SNPs) in transforming growth factor beta receptor 1 (TGFBR1). Methods Using iPLEX Sequenom MassARRAY platform, three SNPs in TGFBR1 gene were genotyped in 356 newly diagnosed patients with histologically confirmed primary oral cancer. Demographic and clinical information of all cases were obtained from face‐to‐face interviews and electronic...
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Objective The use of microvascular free tissue transfer (MVFTT) for defects of the scalp and lateral temporal bone in patients with cochlear implants (CI) is uncommon. Herein, we report our experience with the utility, indications, and outcomes for MVFTT in patients with cochlear implants. Methods A retrospective review of patients at our institution from September 2016 to December 2017 identified subjects with coexistent cochlear implant and ipsilateral MVFTT of the lateral temporal bone...
Primary laryngectomy versus salvage laryngectomy: A comparison of outcomes in the chemoradiation era
Objective To compare primary total laryngectomy (TL) versus salvage TL and analyze the functional outcomes, complications, recurrence rates, and survival. Study Design Case series with chart review. Setting Tertiary care center. Subjects and Methods Fifteen‐year retrospective analysis of 208 patients with laryngeal squamous cell carcinoma treated by TL was completed. Outcome measures included survival, swallowing rehabilitation, speech rehabilitation, complications, and assessment...
Objective Competing risk analysis is a powerful assessment for cancer risk factors and covariates. This method can better elucidate insurance status and other social determinants of health covariates in oral cavity cancer treatment, survival, and disparities. Study Design Retrospective cohort study using the Surveillance, Epidemiology, and End Results (SEER) database. Methods Data regarding patient characteristics, clinical stage at diagnosis, treatment, and survival data for 20,271...
Objectives/Hypothesis The incidence of cognitive impairment (CI) in the elderly general population is 10% to 20%. The incidence of CI in the elderly laryngology treatment–seeking population is unknown, and CI may impact decision making for elective medical/surgical treatment and negatively impact the outcome of voice/swallowing therapy. We sought to determine the prevalence of CI in elderly patients who are seeking laryngology care and to evaluate the feasibility of administering a cognitive screening...
Sinus, cold, and allergy remedies comprise the most widely used sector of the over‐the‐counter (OTC) drug market. Direct‐to‐consumer advertising (DTCA) of pharmaceutical products has increased over the past 30 years, including the promotion of OTC drugs. The influence of DTCA on OTC sinonasal remedies comprises several positive and negative effects. Favorable aspects of this influence include empowerment and promotion of autonomy among patients, avoidance of low‐value clinical encounters, self‐directed...
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The purpose of this systematic review was to evaluate implant survival in irradiated nasal, auricular, orbital sites and to compare them with non-irradiated respective sites. Four electronic databases and seven related journals were searched until December and March 2018, respectively. A total of 7892 articles were identified, 18 of which were included in this review; one non-randomized clinical trial, two prospective cohort, eight retrospective cohort and seven cross-sectional studies. Using the...
Thank you for asking us to comment on the letter received from the reader. The photograph in our article is of the same patient at 6 months post-treatment1. The photograph was taken in the same room with a similar environment; unfortunately the patient wore the same shirt. We have enclosed a more recent photograph taken at 6 years post-treatment with a similar profile (Fig. 1).
Acinic cell adenocarcinoma (ACA) is a malignant epithelial neoplasm of the salivary glands. The patient reported herein presented with an unusual case of a metastatic ACA originating from the right parapharyngeal region, which eventually metastasized to the ipsilateral cavernous sinus and the contralateral mandibular ramus. The trigeminal nerve may have served as a channel for the spread of the cancer from the right parapharyngeal region to the cavernous sinus, and subsequently to the left mandibular...
The objective of this study was to compare the effect of intraosseous dexamethasone injection and submucosal dexamethasone injection on postoperative sequelae after mandibular third molar surgery. This was a randomized, triple-blind, split-mouth clinical trial. Fifty-four mandibular third molars (27 patients) were subdivided according to the side (right and left); intraosseous injection of dexamethasone (4mg) was randomly assigned to one side and submucosal injection to the other. All surgeries were...
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Publication date: Available online 26 October 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): M.A. ElKhashab, I.A.W. Radi, A.H. ElkhademAbstractThe purpose of this systematic review was to evaluate implant survival in irradiated nasal, auricular, orbital sites and to compare them with non-irradiated respective sites. Four electronic databases and seven related journals were searched until December and March 2018, respectively. A total of 7892 articles were identified,...
Publication date: Available online 25 October 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): A. Sayan, V. Ilankovan
Publication date: Available online 25 October 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): C.W. Yong, J.L. Lum, A. Makmur, J.E. Seet, A.A.T. LimAbstractAcinic cell adenocarcinoma (ACA) is a malignant epithelial neoplasm of the salivary glands. The patient reported herein presented with an unusual case of a metastatic ACA originating from the right parapharyngeal region, which eventually metastasized to the ipsilateral cavernous sinus and the contralateral mandibular...
Publication date: Available online 25 October 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): S. Kaewkumnert, K. Phithaksinsuk, C. Changpoo, N. Nochit, Y. Muensaiyat, S. Wilaipornsawai, U. Piriyaphokai, W. PowcharoenAbstractThe objective of this study was to compare the effect of intraosseous dexamethasone injection and submucosal dexamethasone injection on postoperative sequelae after mandibular third molar surgery. This was a randomized, triple-blind, split-mouth clinical...
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Publication date: December 2019Source: Ultrasound in Medicine & Biology, Volume 45, Issue 12Author(s):
Publication date: December 2019Source: Ultrasound in Medicine & Biology, Volume 45, Issue 12Author(s):
Publication date: December 2019Source: Ultrasound in Medicine & Biology, Volume 45, Issue 12Author(s):
Publication date: December 2019Source: Ultrasound in Medicine & Biology, Volume 45, Issue 12Author(s):
Publication date: Available online 25 October 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Adam Kositsky, Basílio A.M. Gonçalves, Lauri Stenroth, Rod S. Barrett, Laura E. Diamond, David J. SaxbyAbstractThe purpose of this study was to determine the reliability and validity of ultrasonography for measurement of hamstring muscle and semitendinosus (ST) tendon cross-sectional area (CSA). On two consecutive days, muscle anatomical CSA (ACSA) and ST tendon CSA were measured at standardized...
Publication date: Available online 25 October 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Wei Dong, Pengying Wu, Di Zhou, Jixiu Huang, Mengfan Qin, Xinxing Yang, Mingxi Wan, Yujin ZongAbstractThe PIK3 CA gene encodes the p110α protein subunit and is one of the most efficient cancer genes in solid and hematological tumors including hepatocellular carcinoma (HCC). There are currently ongoing therapies against tumors based on PIK3 CA inhibition. Because microRNAs (miRNAs) play an important...
Publication date: Available online 25 October 2019Source: Ultrasound in Medicine & BiologyAuthor(s): Antonios N. Pouliopoulos, Shih-Ying Wu, Mark T. Burgess, Maria Eleni Karakatsani, Hermes A.S. Kamimura, Elisa E. KonofagouAbstractFocused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is currently being investigated in clinical trials. Here, we describe a portable clinical system with a therapeutic transducer suitable for humans, which eliminates the need for in-line magnetic resonance...
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Publication date: Available online 25 October 2019Source: International Journal of Food MicrobiologyAuthor(s): David C. Love, Lillian M. Kuehl, Robert M. Lane, Jillian P. Fry, Jamie Harding, Benjamin J.K. Davis, Kate Clancy, Bobbi HudsonAbstractVibrio bacteria can accumulate in molluscan shellfish and cause human diseases. The United States (U.S.) has implemented Vibrio Control Plans to mitigate risks associated with these bacteria, which include time and temperature requirements for post-harvest...
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Abstract Objectives Partial loss of hippocampal striation (PLHS) is recently described in 3 T and 7 T MR imaging as a sensitive indicator of hippocampal sclerosis. Primary objective: We described the demographic characteristics of the population with seizure disorder having PLHS at 1.5 T MR imaging and tried to see the relation of PLHS to the classic signs of hippocampal sclerosis. Secondary objective: PLHS was also looked for in...
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Publication date: Available online 25 October 2019Source: Archives of Oral BiologyAuthor(s): S. Rajan, A. Ljunggren, D.J. Manton, A.E Björkner, M. McCulloughAbstractObjectiveDescription of the odontoblast lifecycle, an overview of the known complex molecular interactions that occur when the health of the dental pulp is challenged and the current and future management strategies on vital and non-vital teeth.MethodsA literature search of the electronic databases included MEDLINE (1966-April 2019),...
Publication date: Available online 24 October 2019Source: Archives of Oral BiologyAuthor(s): L. Nibali, S.A. Almofareh, J. Bayliss-Chapman, Y. Zhou, A.R. Vieira, K. DivarisAbstractObjectiveThe aim of this study was to quantify the heritability of periodontitis via a systematic appraisal of the existing evidence derived from animal studies.DesignA search was conducted through the electronic databases MEDLINE, Embase, LILACS, Cochrane Library, Open Grey, Google Scholar and ResearchGate, complemented...
Publication date: Available online 24 October 2019Source: Archives of Oral BiologyAuthor(s): Jorge MartinsAbstractObjectiveTo assess the influence of cone-beam computed tomographic (CBCT) voxel size and population demographic aspects (age, gender and geographic region) on the prevalence of the second mesiobuccal root canal (MB2) in maxillary first and second molars.DesignPrevalence studies using CBCT technology on MB2 canal were searched between May and September 2019. The protocol was registered...
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Abstract To study the clinical presentation, management and mechanism of fractured outer metallic tracheostomy tube presenting as tracheobronchial foreign body. A retrospective chart review patients with fracture outer metallic tracheostomy tube. Data regarding the patients’ demographic data, diagnosis, clinical presentation, type of tracheostomy tube and site of fracture were analyzed. Total 4 cases of fracture outer metallic tracheostomy tube were found. There were 3 males and...
Abstract Cochlear implantation (CI) is used for rehabilitation of children with bilateral severe to profound sensorineural hearing loss. Recently, treatment of such children has been influenced by diagnostic technological advances. Infants and toddlers are now increasingly included for CI. The primary aim of this study was to determine the effects of ‘age at CI’ on CI outcome. The primary aim of this study was to determine the effects of ‘age at CI’ on CI outcome. In this prospective...
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Abstract Background We investigated the association between the pretreatment quality of life (QOL) and overall survival (OS) in patients with urothelial carcinoma (UC), as the influence of pretreatment QOL on prognosis remains unclear in patients with localized and metastatic UC. Methods Between June 2013 and May 2019, we retrospectively investigated 205...
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Publication date: Available online 25 October 2019Source: Radiotherapy and OncologyAuthor(s): Wei Wei, Ke Wang, Zhenyu Liu, Kaibing Tian, Liang Wang, Jiang Du, Junpeng Ma, Shuo Wang, Longfei Li, Rui Zhao, Luo Cui, Zhen Wu, Jie TianAbstractBackground and purposeWe used radiomic analysis to establish a radiomic signature based on anatomical magnetic resonance imaging (MRI) sequences and explore its effectiveness as a novel prognostic biomarker for skull base chordoma (SBC).Materials and methodsIn this...
Publication date: Available online 25 October 2019Source: Radiotherapy and OncologyAuthor(s): Nicolas Audag, Geneviève Van Ooteghem, Giuseppe Liistro, Armand Salini, Xavier Geets, Gregory ReychlerAbstractWe developed a training protocol based on Intrapulmonary Percussive Ventilation in order to prolong breath-hold while nearly suppressing the thorax motion. This protocol allowed ten subjects to achieve a 20-minutes-breath-hold, while reducing the residual surface motion to 1 mm around its mean position...
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Publication date: March 2020Source: Food Control, Volume 109Author(s): Jingwen Gao, Karl R. MatthewsAbstractThis study investigated the antimicrobial efficacy of the water-soluble photosensitizer curcumin (PSC) on liquid media and chicken skin. The water-soluble PSC showed strong absorption at 410 nm, and the light-emitting diode (LED) used to activate PSC had strong emission at 430 nm with power density of 107 W/m2. Listeria monocytogenes (3 isolates) and Salmonella (8 isolates) were evaluated in...
Publication date: March 2020Source: Food Control, Volume 109Author(s): Chandisree Rajbux, Joel Pereira, Maria do Céu Selbourne, Ana Rita Costa-Pinto, Fátima PoçasAbstractPlastic baby Bibs are, according to the European legislation, food contact materials. Therefore, compositional and migration limits applicable to plastics should be observed. This work aimed at identifying potential migrants in Bibs from European market and determining the migration into artificial saliva. Bibs were subjected to...
Publication date: March 2020Source: Food Control, Volume 109Author(s): Jitender P. Dubey, Dolores E. Hill, Valsin Fournet, Diane Hawkins-Cooper, Camila K. Cerqueira-Cézar, Fernando H.A. Murata, Shiv K. Verma, Oliver C.H. Kwok, Surabhi Rani, Jorrell Fredericks, Brandon Adams, Jeffrey L. Jones, Ryan E. Wiegand, Yuqing Ying, Miao Guo, Chunlei Su, Abani K. PradhanAbstractIn a national survey of fresh, unfrozen, American pasture-raised lamb and pork, the prevalence of viable Toxoplasma gondii was determined...
Publication date: March 2020Source: Food Control, Volume 109Author(s): Birgitta Maria Kunz, Felicitas Wanko, Sabine Kemmlein, Arnold Bahlmann, Sascha Rohn, Ronald MaulAbstractMycotoxin contamination is a well-known problem in grains, nuts, and oilseeds. Similarly, grain legumes (pulses) are affected by fungal infections and, consequently, the formation of mycotoxins as well. However, only little data on mycotoxin occurrence exists for this commodity and only few validated quantification methods for...
Publication date: March 2020Source: Food Control, Volume 109Author(s): Sika Abrokwah, Bernard Ekumah, Francis Kwame AbrokwahAbstractPatronage of bottled water in Ghana has increased over the years as a more hygienic source of drinking water. This shift has however resulted in increased generation of waste bottles without any formal regulated management system to handle them sustainably. This has encouraged an informal system which involves the retrieval and reuse of the bottles by market women and...
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SummarySelf-learning healthcare systems are becoming a reality. As boundaries between research and healthcare delivery become increasingly blurred, there is an emerging opportunity to accelerate learning through the cyclical integration and analysis of patient phenotype, treatment and clinical outcome. Opportunities already exist to save money through the more efficient use of targeted and immune-based therapies Morgillo et al. [11], Zhao et al. [21], Keenan et al. [5], with a self-learning healthcare...
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The Pharmacogenomics Journal, Published online: 25 October 2019; doi:10.1038/s41397-019-0116-yThe effect of genetic and nongenetic factors on warfarin dose variability in Qatari population
The Pharmacogenomics Journal, Published online: 24 October 2019; doi:10.1038/s41397-019-0114-0The efficacy of interferon-beta therapy in multiple sclerosis patients: investigation of the RORA gene as a predictive biomarker
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Publication date: Available online 26 October 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Esther L.B. Childers, Lekidelu Taddasse-Heath, Andrea Bonnick, Tammey NaabAbstractThe notable features of ameloblastoma do not typically include prominent vascularity. However, rarely, vascular ameloblastoma has been described under a variety of names. We present a case of vascularized ameloblastoma that had a bloody return on FNA. The English literature had a total of...
Publication date: Available online 25 October 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Ji Rak Kim, Jung Hwan Jo, Jin Woo Chung, Ji Woon ParkAbstractObjectiveTo investigate clinical characteristics and treatment outcomes of patients with temporomandibular disorders (TMD) according to the presence of upper cervical spine abnormalities and craniofacial morphology.Study DesignClinical examinations were conducted on 43 TMD patients. Upper cervical spine characteristics...
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Publication date: Available online 25 October 2019Source: Experimental Cell ResearchAuthor(s): Lijuan Ma, Zhiwei Zhang, Kun Dong, Yuyan MaAbstractPreeclampsia (PE), especially severe and early-onset preeclampsia is one of the major causes of maternal and neonatal morbidity and mortality. However, the exact mechanism is not fully understood. In this study, we first demonstrated that the expression of TWIST1 was decreased in the placental tissues of patients with early-onset severe preeclampsia, compared...
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Every year in the United States 52 MILLION school hours are lost because children have cavities. TWO out of THREE adults have dental disease and we know many of these oral health problems impact systemic body health by exacerbating chronic inflammatory... Read More ›
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Abstract The participants in randomized trials and other studies used for causal inference are often not representative of the populations seen by clinical decision-makers. To account for differences between populations, researchers may consider standardizing results to a target population. We discuss several different types of homogeneity conditions that are relevant for standardization: Homogeneity of effect measures, homogeneity of counterfactual outcome state transition parameters,...
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Abstract Introduction This study aims to explore the similarities in functional connectivity (FC) patterns in individuals when listening to different music genres and, in comparison, to the spoken word, using a novel data-driven approach. Our model and findings can potentially be utilized for evaluating the neurological effects of therapeutic music interventions. Materials...
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Abstract Introduction This study aims to explore the similarities in functional connectivity (FC) patterns in individuals when listening to different music genres and, in comparison, to the spoken word, using a novel data-driven approach. Our model and findings can potentially be utilized for evaluating the neurological effects of therapeutic music interventions. Materials...
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Abstract Composite scaffolds can improve regenerative capacities of scaffolds in various tissue-engineering approaches. In order to generate a 3D printable scaffold that is capable of cartilage regeneration, decellularized extracellular matrix (DECM) of porcine nasal cartilage was added to 3D printed polycaprolactone (PCL) scaffolds. Subsequently, scaffolds (PCL, PCL/DECM and DECM) were seeded with human primary nasoseptal chondrocytes and differentiated with cartilage inductive...
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Abstract Purpose In most industrialized countries, the share of workers in the age 55+ age group is increasing while there is a shortage of young workers. Although data suggest that at least one in five older workers suffers from chronic musculoskeletal pain, most will continue working despite pain. The objective of this study is to explore factors associated with staying at work for workers with musculoskeletal pain. Methods An interpretive descriptive method was used. Semi-structured...
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Abstract Purpose The present study aimed to determine the extent of information that healthy volunteers need in an informed consent form (ICF) to support their decision whether to participate in a bioequivalence study, a type of clinical studies involving the testing of pharmacokinetic equivalence of a generic drug with a brand-name drug in volunteer subjects. Methods...
Abstract Purpose This study investigated the effects of clotrimazole troche on the risk of transplant rejection and the pharmacokinetics of tacrolimus. Methods The data mining approach was used to investigate whether the use of clotrimazole increased the risk of transplant rejection in patients receiving tacrolimus therapy. Patient data were acquired from...
Abstract Purpose We aimed to develop a meropenem population pharmacokinetic (PK) model in critically ill children and simulate dosing regimens in order to optimize patient exposure. Methods Meropenem plasma concentration was quantified by high-performance liquid chromatography. Meropenem PK was investigated using a non-linear mixed-effect modeling approach....
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