Related ArticlesB7-H3 promotes the cell cycle-mediated chemoresistance of colorectal cancer cells by regulating CDC25A. J Cancer. 2020;11(8):2158-2170 Authors: Ma Y, Wang R, Lu H, Li X, Zhang G, Fu F, Cao L, Zhan S, Wang Z, Deng Z, Shi T, Zhang X, Chen W Abstract Colorectal cancer (CRC) is one of the most common malignancies, and chemoresistance is one of the key obstacles in the clinical outcome. Here, we studied the function of B7-H3 in regulating...
Thu Mar 05, 2020 13:43
Related ArticlesApigenin and Abivertinib, a novel BTK inhibitor synergize to inhibit diffuse large B-cell lymphoma in vivo and vitro. J Cancer. 2020;11(8):2123-2132 Authors: Huang S, Yu M, Shi N, Zhou Y, Li F, Li X, Huang X, Jin J Abstract Background: Apigenin, a flavonoid phytochemical extracted from fruits and vegetables, has shown anti-neoplastic effects in a variety of malignant tumors. DLBCL is the most common type of aggressive lymphoma in...
Thu Mar 05, 2020 13:43
Related ArticlesSynthesis and in-vitro anti-cancer evaluations of multi-methoxylated asymmetrical diarylpentanoids as intrinsic apoptosis inducer against colorectal cancer. Bioorg Med Chem Lett. 2020 Feb 26;:127065 Authors: Leong SW, Chia SL, Abas F, Yusoff K Abstract In the present study, a series of nine stable 3,4,5-methoxylphenyl-containing asymmetrical diarylpentanoids, derivatives of curcuminoids, have been synthesized, characterized and evaluated...
Thu Mar 05, 2020 13:43
Related ArticlesChitinase 3 like 1 suppresses the stability and activity of p53 to promote lung tumorigenesis. Cell Commun Signal. 2020 Mar 04;18(1):5 Authors: Park KR, Yun HM, Yoo K, Ham YW, Han SB, Hong JT Abstract BACKGROUND: Chitinase 3 like 1 protein (Chi3L1) is expressed in several cancers, and a few evidences suggest that the secreted Chi3L1 contributes to tumor development. However, the molecular mechanisms of intracellular Chi3L1 are unknown...
Thu Mar 05, 2020 13:43
Related ArticlesNext-generation paclitaxel-nanoparticle formulation for pancreatic cancer treatment. Nanomedicine. 2019 08;20:102027 Authors: Massey AE, Sikander M, Chauhan N, Kumari S, Setua S, Shetty AB, Mandil H, Kashyap VK, Khan S, Jaggi M, Yallapu MM, Hafeez BB, Chauhan SC Abstract Pancreatic cancer (PanCa) is a major cause of cancer-related death due to limited therapeutic options. As pancreatic tumors are highly desmoplastic, they prevent appropriate...
Thu Mar 05, 2020 13:43
Related ArticlesThe phenotype of target pancreatic cancer cells influences cell death by magnetic hyperthermia with nanoparticles carrying gemicitabine and the pseudo-peptide NucAnt. Nanomedicine. 2019 08;20:101983 Authors: Sanhaji M, Göring J, Couleaud P, Aires A, Cortajarena AL, Courty J, Prina-Mello A, Stapf M, Ludwig R, Volkov Y, Latorre A, Somoza Á, Miranda R, Hilger I Abstract In this paper we show that conjugation of magnetic nanoparticles (MNPs)...
Thu Mar 05, 2020 13:43
Related ArticlesEnhancing antitumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors. Ann Oncol. 2019 02 01;30(2):219-235 Authors: Heinhuis KM, Ros W, Kok M, Steeghs N, Beijnen JH, Schellens JHM Abstract BACKGROUND: Cancer immunotherapy has changed the standard of care for a subgroup of patients with advanced disease. Immune checkpoint blockade (ICB) in particular has shown improved survival compared with previous...
Thu Mar 05, 2020 13:43
Related ArticlesImmune biomarkers of response to immune-checkpoint inhibitors in head and neck squamous cell carcinoma. Ann Oncol. 2019 01 01;30(1):57-67 Authors: Oliva M, Spreafico A, Taberna M, Alemany L, Coburn B, Mesia R, Siu LL Abstract Anti-programmed cell death protein 1 (PD-1) agents have become the standard of care for platinum-refractory recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) and are currently being evaluated...
Thu Mar 05, 2020 13:43
Related ArticlesHealth-related quality of life in Japanese patients with prostate cancer following proton beam therapy: an institutional cohort study. Jpn J Clin Oncol. 2020 Mar 04;: Authors: Matsukawa K, Arimura T, Orita M, Kondo H, Chuman I, Ogino T, Taira Y, Kudo T, Takamura N Abstract OBJECTIVE: Many treatment options have guaranteed long-term survival in patients with localized prostate cancer and health-related quality of life has become a greater...
Thu Mar 05, 2020 14:40
Related ArticlesSimultaneous changes in expression levels of BAALC and miR-326: a novel prognostic biomarker for childhood ALL. Jpn J Clin Oncol. 2020 Mar 04;: Authors: Ghodousi ES, Aberuyi N, Rahgozar S Abstract OBJECTIVE: Multidrug resistance and consequent relapse are two major obstacles for treating children with acute lymphoblastic leukemia, the most frequent childhood malignancy. MicroRNAs have potential regulatory roles in response to chemotherapy....
Thu Mar 05, 2020 14:40
Related ArticlesUsefulness of carbon-11-labeled methionine positron-emission tomography for assessing the treatment response of primary central nervous system lymphoma. Jpn J Clin Oncol. 2020 Mar 04;: Authors: Miyakita Y, Ohno M, Takahashi M, Kurihara H, Katai H, Narita Y Abstract BACKGROUND: Primary central nervous system lymphoma (PCNSL) responds relatively quickly to chemotherapy or radiotherapy. However, determination of a complete response after...
Thu Mar 05, 2020 14:40
Related ArticlesCutaneous indicator of myelodysplastic syndrome: sudden bullous pyoderma gangrenosum. Jpn J Clin Oncol. 2020 Mar 04;: Authors: Kim YJ, Yang HJ, Lee MW, Lee WJ PMID: 32129441 [PubMed - as supplied by publisher]
Thu Mar 05, 2020 14:40
Related ArticlesDiltiazem Prophylaxis for the Prevention of Atrial Fibrillation in Patients Undergoing Thoracoabdominal Esophagectomy: A Retrospective Cohort Study. World J Surg. 2020 Mar 04;: Authors: Hochreiter M, Schmidt T, Siegler BH, Sisic L, Schmidt K, Bruckner T, Müller-Stich BP, Diener MK, Weigand MA, Büchler MW, Busch CJ Abstract BACKGROUND: Atrial fibrillation (AF) represents the most frequent arrhythmic disorder after thoracoabdominal esophageal...
Thu Mar 05, 2020 15:35
Related ArticlesMalignant Insulinoma: A Rare Form of Neuroendocrine Tumor. World J Surg. 2020 Mar 03;: Authors: Sada A, Glasgow AE, Vella A, Thompson GB, McKenzie TJ, Habermann EB Abstract INTRODUCTION: Due to the rarity of malignant insulinoma, a lack of the literature describing factors affecting outcomes exists. Our aim was to review malignant insulinoma incidence, characteristics and survival trends. METHODS: We identified all patients with...
Thu Mar 05, 2020 13:36
Abstract Craniofacial morphogenesis is regulated in part by signaling from the Endothelin receptor type A (EDNRA). Pathogenic variants in EDNRA signaling pathway components EDNRA, GNAI3, PCLB4, and EDN1 cause Mandibulofacial Dysostosis with Alopecia (MFDA), Auriculocondylar syndrome (ARCND) 1, 2, and 3, respectively. However, cardiovascular development is normal in MFDA and ARCND individuals, unlike Ednra knockout mice. One explanation may be that partial EDNRA signaling remains in MFDA and ARCND,...
Thu Mar 05, 2020 13:35
Related ArticlesReverse engineering forces responsible for dynamic clustering and spreading of multiple nuclei in developing muscle cells. Mol Biol Cell. 2020 Mar 04;:mbcE19120711 Authors: Manhart A, Azevedo M, Baylies M, Mogilner A Abstract How cells position organelles is a fundamental biological question. During Drosophila embryonic muscle development, multiple nuclei transition from being clustered together, to splitting into two smaller clusters,...
Thu Mar 05, 2020 15:35
Related ArticlesWnt Regulation: Exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex. Mol Biol Cell. 2020 Mar 04;:mbcE19110647 Authors: Schaefer KN, Pronobis M, Williams CE, Zhang S, Bauer L, Goldfarb D, Yan F, Major MB, Peifer M Abstract Wnt signaling plays key roles in embryonic development and adult stem cell homeostasis and is altered in human cancer. Signaling...
Thu Mar 05, 2020 15:35
Related ArticlesAbundances of transcripts, proteins, and metabolites in the cell cycle of budding yeast reveal coordinate control of lipid metabolism. Mol Biol Cell. 2020 Mar 04;:mbcE19120708 Authors: Blank HM, Papoulas O, Maitra N, Garge R, Kennedy BK, Schilling B, Marcotte EM, Polymenis M Abstract Establishing the pattern of abundance of molecules of interest during cell division has been a long-standing goal of cell cycle studies. Here, for the first...
Thu Mar 05, 2020 15:35
Related ArticlesApical Constriction Reversal upon Mitotic Entry Underlies Different Morphogenetic Outcomes of Cell Division. Mol Biol Cell. 2020 Mar 04;:mbcE19120673 Authors: Ko CS, Kalakuntla P, Martin AC Abstract During development, coordinated cell shape changes and cell divisions sculpt tissues. While these individual cell behaviors have been extensively studied, how cell shape changes and cell divisions that occur concurrently in epithelia influence...
Thu Mar 05, 2020 15:35
Related ArticlesPhosphorylation of multiple proteins involved in ciliogenesis by Tau Tubulin kinase 2. Mol Biol Cell. 2020 Mar 04;:mbcE19060334 Authors: Bernatik O, Pejskova P, Vyslouzil D, Hanakova K, Zdrahal Z, Cajanek L Abstract Primary cilia (PCs) are organelles necessary for proper implementation of developmental and homeostasis processes. To initiate their assembly, coordinated actions of multiple proteins are needed. Tau tubulin kinase 2 (TTBK2)...
Thu Mar 05, 2020 15:35
Related ArticlesMeasurement properties from the Brazilian Portuguese version of the QUIP-RS. NPJ Parkinsons Dis. 2020;6:6 Authors: Guerra DF, Lemos Silva AE, Paz TDSR, Filho LNS, Vasconcellos LF, de Britto VLS, Allodi S, Weintraub D, Swarowsky A, Correa CL Abstract Parkinson's disease (PD) has numerous motor and non-motor symptoms. Among non-motor manifestations impulse control disorders (ICDs) stand out. ICDs include compulsions for gambling, shopping,...
Thu Mar 05, 2020 13:32
Related ArticlesAlcohol consumption of UK members of parliament: cross-sectional survey. BMJ Open. 2020 Mar 03;10(3):e034929 Authors: Rao R, Bakolis I, Das-Munshi J, Poulter D, Votruba N, Thornicroft G Abstract OBJECTIVES: This study examined the prevalence of risky drinking by members of parliament (MPs), as well as the relationship between risky drinking and age, years spent as an MP, working outside parliament, awareness of the Parliamentary Health...
Thu Mar 05, 2020 13:31
Related ArticlesOutcome of the 2016 United States presidential election and the subsequent sex ratio at birth in Canada: an ecological study. BMJ Open. 2020 Mar 03;10(2):e031208 Authors: Retnakaran R, Ye C Abstract OBJECTIVES: The sex ratio at birth (proportion of boys to girls) generally shows slight male preponderance but may decrease in response to societal stressors. Discrete adverse events such as terrorist attacks and disasters typically lead to...
Thu Mar 05, 2020 13:31
Related ArticlesAcute alcohol exposure in early gestation programmes sex-specific insulin resistance in offspring: A shifting tide in prenatal alcohol exposure models. J Physiol. 2020 Mar 04;: Authors: Lee XA, Mostafaie Y PMID: 32129474 [PubMed - as supplied by publisher]
Thu Mar 05, 2020 15:26
Related ArticlesMuscle spindle function in muscular dystrophy: A potential target for therapeutic intervention. J Physiol. 2020 Mar 03;: Authors: Papaioannou S, Dimitriou M PMID: 32128822 [PubMed - as supplied by publisher]
Thu Mar 05, 2020 13:29
Related ArticlesFast responses to stepping-target displacements when walking. J Physiol. 2020 Mar 03;: Authors: Zhang Y, Smeets JBJ, Brenner E, Verschueren S, Duysens J Abstract It is well-known that goal-directed hand movements can be adjusted to small changes in target location with a latency of about 100 ms. We tested whether people make similar fast adjustments when a target location for foot placement changes slightly as they walk over a flat surface....
Thu Mar 05, 2020 13:29
Abstract Tongue pressure is often used to evaluate swallowing muscle strength in dysphagia patients with sarcopenia. However, the amount of tongue pressure that reflects pharyngeal swallowing function is unclear. The aims of this descriptive study were (1) to assess the association between tongue pressure and swallowing function using high-resolution manometry (HRM), (2) to evaluate whether manometric parameters were related to maximum tongue pressure (MTP) and other sarcopenia-related...
Thu Mar 05, 2020 02:00
Abstract Background Optimal exercise doses for exercise-based approaches to dysphagia treatment are unclear. To address this gap in knowledge, we performed a scoping review to provide a record of doses reported in the literature. A larger goal of this work was to promote detailed consideration of dosing parameters in dysphagia exercise treatments in intervention planning and outcome reporting. ...
Thu Mar 05, 2020 02:00
Abstract The superior laryngeal nerve provides detailed sensory information from the mucosal surfaces of laryngeal structures superior to the vocal folds, including the valleculae. Injury to this nerve results in airway penetration and aspiration. Furthermore, such injuries might have an impact on the function of multiple structures involved in intraoral transport and swallowing due to connections within the brainstem. We sought to determine the effects of a surgical lesion of...
Thu Mar 05, 2020 02:00
Related ArticlesLarotrectinib, a selective tropomyosin receptor kinase inhibitor for adult and pediatric tropomyosin receptor kinase fusion cancers. Future Oncol. 2020 Mar 04;: Authors: Farago AF, Demetri GD Abstract Gene fusions involving NTRK1, NTRK2 and NTRK3 are oncogenic drivers across a wide variety of cancer types. Inhibitors of the chimeric TRKA/B/C protein kinases encoded by these fusions are now available, including larotrectinib, a potent...
Thu Mar 05, 2020 15:23
Related ArticlesIncidental Diagnosis of Pediatric Arytenoid Cartilage Dislocation During Videofluoroscopic Swallowing Study: A Case Report. Ann Rehabil Med. 2020 Feb;44(1):94-98 Authors: Lee Y, Park H, Park JE, Kim SK, Park ES, Rha DW Abstract Arytenoid cartilage dislocation is one of the most common mechanical causes of vocal fold immobility. The most common etiologies are intubation and external trauma, but its incidence is lower than 0.1%. Its symptoms...
Thu Mar 05, 2020 15:28
Related ArticlesCharacteristics of Patients With Esophageal Dysphagia Assessed by Chest X-Ray Imaging After Videofluoroscopic Swallowing Study. Ann Rehabil Med. 2020 Feb;44(1):38-47 Authors: Min YK, Baek S, Kang EK, Nam SJ Abstract OBJECTIVE: To evaluate the prevalence rate, types, characteristics, and associated factors of esophageal dysphagia detected on chest X-ray images after videofluoroscopic swallowing study (VFSS). METHODS: The medical...
Thu Mar 05, 2020 15:28
Related ArticlesEpiglottic Retroflexion is a Key Indicator of Functional Recovery of Post-stroke Dysphagia. Ann Rehabil Med. 2020 Feb;44(1):1-10 Authors: Choi JS, Bang H, Lee GJ, Seo HG, Oh BM, Han TR Abstract OBJECTIVE: To evaluate the longitudinal changes of swallowing kinematics based on videofluoroscopic swallowing studies (VFSSs) in subacute stroke patients grouped according to the method of dietary intake. METHODS: Sixty-nine subacute...
Thu Mar 05, 2020 15:28
Related ArticlesSpeech and language therapy best practice for patients in prolonged disorders of consciousness: a modified Delphi study. Int J Lang Commun Disord. 2019 09;54(5):841-854 Authors: Roberts H, Greenwood N Abstract BACKGROUND: Research regarding speech and language therapy (SLT) for patients in prolonged disorders of consciousness (PDOC) is very limited. The Royal College of Physicians' (RCP) PDOC guideline provides recommendations regarding...
Thu Mar 05, 2020 13:23
British Journal of Cancer, Published online: 05 March 2020; doi:10.1038/s41416-020-0753-6Associations of accelerometer-measured physical activity and physical activity-related cancer incidence in older women: results from the WHI OPACH Study
Thu Mar 05, 2020 02:00
Thu Mar 05, 2020 02:00
Abstract We examined the changes in the bone metabolism of the jaw in response to BP treatment, and we used bone SPECT-CT to analyze the site-specific bone metabolism between the jaw and other sites of bone. We compared the changes in the bone metabolism of each part of bone in response to BP treatment by performing a quantitative analysis of bone scintigraphy images between patients treated with low-dose BP for osteoporosis (LBP group; n = 17), those treated with high-dose BP...
Thu Mar 05, 2020 02:00
Abstract Masticatory performance of subjects from a general urban population was examined by measurement at baseline and again at follow-up, to clarify whether periodical utilization of dental services (PUDS) is effective in maintaining masticatory performance. Subjects comprised 1010 people (414 males, 596 females; mean age at baseline, 65.7 ± 7.8 years) who participated in the Suita study with dental checkups at both baseline and follow-up (mean follow-up, 5.2 ± 1.5 years)....
Thu Mar 05, 2020 02:00
In the original publication of the article, Fig. 2 was published incorrectly.
Thu Mar 05, 2020 02:00
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