Related ArticlesProgress in extracellular vesicle biology and their application in cancer medicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2020 Mar 04;:e1621 Authors: Srivastava A, Amreddy N, Pareek V, Chinnappan M, Ahmed R, Mehta M, Razaq M, Munshi A, Ramesh R Abstract Under the broader category of extracellular vesicles (EVs), exosomes are now well recognized for their contribution and potential for biomedical research. During the last ten years,...
Thu Mar 05, 2020 15:20
Related ArticlesThe Development of a Multi-physics Simulation Tool to Estimate the Background Dose by Systemic Targeted Alpha Therapy. Med Phys. 2020 Mar 04;: Authors: Xu T, Liu T, Li G, Dugal C, Aydemir NA, Liu Y, Roeske JC Abstract PURPOSE: To predict biological effects of Targeted Alpha Therapy (TAT) in pre-clinical studies, dosimetry calculations based on the micro-level distributions of emitters are essential. Due to the saturation of the tumor...
Thu Mar 05, 2020 15:20
Related ArticlesPatient Experience Captured by Quality-of-Life Measurement in Oncology Clinical Trials. JAMA Netw Open. 2020 Mar 02;3(3):e200363 Authors: Haslam A, Herrera-Perez D, Gill J, Prasad V Abstract Importance: Quality of life (QoL) is an important consideration in cancer medicine, especially because drugs are becoming more costly and may only result in modest gains in overall survival. However, there has been no descriptive analysis for...
Thu Mar 05, 2020 15:20
Related ArticlesAssociation of various dietary habits and risk of lung cancer: an updated comprehensive literature review. Tumori. 2020 Mar 04;:300891619900675 Authors: Fakhri G, Al Assaad M, Tfayli A Abstract Lung cancer remains the leading cause of cancer death in both men and women worldwide. Tobacco smoking remains the single most important factor. Recent research has focused on the role of nutrition and dietary habits on lung tumorigenesis....
Thu Mar 05, 2020 15:20
Related ArticlesBladder-sparing treatment options in localized muscle-invasive bladder cancer. Expert Rev Anticancer Ther. 2020 Mar 04;: Authors: Nason GJ, Khaled A, Tan GH, Kulkarni GS Abstract INTRODUCTION: Bladder cancer is the 9th most common cancer in the world and the 4th and 8th most common cancer diagnosed in men in the United States and United Kingdom respectively. The standard of care for the treatment of MIBC is radical cystectomy. Bladder...
Thu Mar 05, 2020 15:20
Related ArticlesIllness Uncertainty, Coping, and Quality of Life among Patients with Prostate Cancer. Psychooncology. 2020 Mar 03;: Authors: Guan T, Santacroce SJ, Chen DG, Song L Abstract OBJECTIVE: Illness uncertainty is a significant source of psychological distress that affects cancer patients' quality of life (QOL). Mishel's Uncertainty in Illness Theory (UIT) proposes that illness uncertainty influences an individual's use of coping strategies,...
Thu Mar 05, 2020 13:18
Related ArticlesCT images with expert manual contours of thoracic cancer for benchmarking auto-segmentation accuracy. Med Phys. 2020 Mar 03;: Authors: Yang J, Veeraraghavan H, van Elmpt W, Dekker A, Gooding M, Sharp G Abstract PURPOSE: Automatic segmentation offers many benefits for radiotherapy treatment planning; however, the lack of publicly available benchmark datasets limits the clinical use of automatic segmentation. In this work, we present...
Thu Mar 05, 2020 13:18
Related ArticlesChemo-radiotherapy integration in unresectable locally advanced non-small-cell lung cancer: a review. Clin Transl Oncol. 2020 Mar 04;: Authors: Baldini E, Tibaldi C, Delli Paoli C Abstract Approximately one-third of all non-small-cell lung cancer (NSCLC) are locally-advanced at diagnosis, and 15-17% of these tumors are unresectable at presentation. Definitive chemo-radiotherapy (CRT) represents the standard therapeutic approach. However,...
Thu Mar 05, 2020 13:18
Related ArticlesProtective Effect and Mechanism of Action of Rosmarinic Acid on Radiation-Induced Parotid Gland Injury in Rats. Dose Response. 2020 Jan-Mar;18(1):1559325820907782 Authors: Zhang T, Liu C, Ma S, Gao Y, Wang R Abstract The parotid glands are damaged by oxidative stress and a series of pathophysiological changes after irradiation. Rosmarinic acid (RA) is a natural antioxidant that provides a radioprotective effect against harmful damage...
Thu Mar 05, 2020 13:18
Related ArticlesGeneration of a conditional Flpo/FRT mouse model expressing constitutively active TGFβ in fibroblasts. Sci Rep. 2020 Mar 03;10(1):3880 Authors: Cardot-Ruffino V, Chauvet V, Caligaris C, Bertrand-Chapel A, Chuvin N, Pommier RM, Valcourt U, Vincent DF, Martel S, Aires S, Kaniewski B, Dubus P, Cassier P, Sentis S, Bartholin L Abstract Transforming growth factor (TGFβ) is a secreted factor, which accumulates in tissues during many physio-...
Thu Mar 05, 2020 13:18
Related ArticlesSalvage therapy for progressive, treatment-refractory or recurrent pediatric medulloblastoma: a systematic review protocol. Syst Rev. 2020 Mar 04;9(1):47 Authors: Adile AA, Kameda-Smith MM, Bakhshinyan D, Banfield L, Salim SK, Farrokhyar F, Fleming AJ Abstract BACKGROUND: Central nervous system tumors remain the leading cause of cancer-related mortality amongst children with solid tumors, with medulloblastoma (MB) representing the...
Thu Mar 05, 2020 13:18
Related ArticlesActigraphic estimates of sleep and the sleep-wake rhythm, and 6-sulfatoxymelatonin levels in healthy Dutch children. Chronobiol Int. 2020 Mar 04;:1-13 Authors: Rensen N, Steur LMH, Wijnen N, van Someren EJW, Kaspers GJL, van Litsenburg RRL Abstract Sleep and the sleep-wake rhythm are essential for children's health and well-being, yet reference values are lacking. This study therefore aimed to assess actigraphic estimates of sleep...
Thu Mar 05, 2020 13:18
Related ArticlesThe Process of Self-Management: A Qualitative Case Study Reporting on Cancer Survivors' and Program Staff's Experiences Within One Self-Management Support Intervention. Health Educ Behav. 2020 Mar 03;:1090198120902029 Authors: Brunet J, Wurz A, Srivastava D Abstract Background. Cancer survivors must manage a range of adverse symptoms and side effects postdiagnosis. These effects often co-occur with preexisting comorbid conditions....
Thu Mar 05, 2020 13:18
Related ArticlesAn Overview of Oncology Researches in Iran: A Scientometric Approach (1974 - February 2019). Arch Iran Med. 2020 Mar 01;23(3):181-188 Authors: Masjedi MR, Bazrafshan A, Mosavi Jarrahi A, Mohagheghi MA, Abasahl A, Attarian H, Omranipour R, Afsharpad M Abstract BACKGROUND: With the growing rate of tumors, cancer has become one of the most important health concerns in Iran. The urgency with which Iranian researchers and health professionals...
Thu Mar 05, 2020 13:18
Related ArticlesOral pH sensitive GNS@ab nanoprobes for targeted therapy of Helicobacter pylori without disturbance gut microbiome. Nanomedicine. 2019 08;20:102019 Authors: Zhi X, Liu Y, Lin L, Yang M, Zhang L, Zhang L, Liu Y, Alfranca G, Ma L, Zhang Q, Fu H, Conde J, Ding X, Chen D, Ni J, Song J, Cui D Abstract How to eradicate Helicobacter pylori (H. pylori) in vivo with antibiotic resistance owns tremendous clinical requirement. Herein, gold nanostars...
Thu Mar 05, 2020 13:18
Related ArticlesEndonasal endoscopic transpterygoid approach to the upper parapharyngeal space. Head Neck. 2020 Mar 04;: Authors: Li L, London NR, Prevedello DM, Carrau RL Abstract BACKGROUND: Lesions of the upper parapharyngeal space (UPPS) present a surgical challenge. The objective of this study was to ascertain the feasibility of a novel technique of modified transpterygoid approach to the UPPS. METHODS: Six fresh cadaveric specimens (12...
Thu Mar 05, 2020 15:14
Related ArticlesIntroduction of Image‑Guided Pencil Beam for Skull Base Tumors in India: A Report of Two Cases and a Brief Review of the Literature. Neurol India. 2020 Jan-Feb;68(1):42-44 Authors: Tonse R, Chilikuri S, Shamurailatpam D, Jalali R Abstract Chordoma and chondrosarcoma are locally aggressive tumors occurring in one-third cases at the base of the skull. These tumors often recur locally with significant morbidity and mortality. The mainstay...
Thu Mar 05, 2020 15:14
Related ArticlesMultimodal strategy for the management of sphenoid osteoradionecrosis: Preliminary results. Laryngoscope Investig Otolaryngol. 2020 Feb;5(1):19-23 Authors: Daoudi H, Labeyrie MA, Guillerm S, Delanian S, Guichard JP, Jourdaine C, Faivre S, Gauthier H, Ferrand FR, Verillaud B, Herman P Abstract Objective: Osteoradionecrosis (ORN) of the sphenoid is a rare but potentially lethal complication that can occur after irradiation of nasopharyngeal...
Thu Mar 05, 2020 13:17
Related ArticlesPrevalence and significance of cranial nerve imaging abnormalities in patients with hereditary neuropathies: Clinical implications at the skull base. Laryngoscope Investig Otolaryngol. 2020 Feb;5(1):11-18 Authors: Bartholomew RA, Zamani AA, Kim GS, Alyono JC, Steinert H, Fridman V, Sadjadi R, Jackler RK, Corrales CE Abstract Objective: To estimate the prevalence and significance of cranial nerve (CN) imaging abnormalities in patients...
Thu Mar 05, 2020 13:17
Related ArticlesKleeblattschädel in Pfeiffer syndrome type II. Radiol Case Rep. 2020 May;15(5):474-478 Authors: Pfeifer CM Abstract Pfeiffer syndrome is an uncommon autosomal dominant disorder that results in craniosynostosis of multiple calvarial sutures with resulting abnormal facies and turribrachycephaly. Presented here is a case of Pfeiffer syndrome type II demonstrating a cloverleaf skull configuration and multiple facial and skull base abnormalities...
Thu Mar 05, 2020 13:17
Abstract Artificial intelligence (AI) has contributed substantially to the resolution of a variety of biomedical problems, including cancer, over the last decade. Deep learning, a subfield of AI that is highly flexible and supports automatic feature extraction, is increasingly being applied in various areas of both basic and clinical cancer research. In this review, we describe numerous recent examples of the application of AI in oncology—including cases in which deep learning has efficiently solved...
Thu Mar 05, 2020 13:14
Abstract The histone demethylase KDM4A is reported to be overexpressed and plays a vital in multiple cancers through controlling gene expression by epigenetic regulation of H3K9 or H3K36 methylation marks. However, the biological role and mechanism of KDM4A in prostate cancer remain unclear. Herein, we reported KDM4A expression was upregulation in PTEN knockout mouse prostate tissue. Depletion of KDM4A in prostate cancer cells inhibited their proliferation and survival in vivo and vitro. Further...
Thu Mar 05, 2020 13:14
Abstract Lung cancer is the most commonly diagnosed cancer worldwide, and metastasis in lung cancer is the leading cause of cancer‐related deaths. Thus, understanding the mechanism of lung cancer metastasis will improve the diagnosis and treatment of lung cancer patients. Herein, we found that expression of cluster of differentiation 109 (CD109) was correlated with the invasive and metastatic capacities of lung adenocarcinoma cells. CD109 is upregulated in tumorous tissues, and CD109 overexpression...
Thu Mar 05, 2020 13:14
Abstract The use of allogeneic, pluripotent stem‐cell‐derived immune cells for cancer immunotherapy has been the subject of recent clinical trials. In Japan, investigator‐initiated clinical trials will soon begin for ovarian cancer treatment using human leukocyte antigen (HLA)‐homozygous‐induced pluripotent stem cell (iPSC)‐derived anti‐glypican‐3 (GPC3) chimeric antigen receptor (CAR)‐expressing natural killer/innate lymphoid cells (NK/ILC). Using pluripotent stem cells as the source for allogeneic...
Thu Mar 05, 2020 09:14
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Actinomyces species are gram-positive, facultative anaerobic bacilli. Infection caused by Actinomyces species is usually limited to cervicofacial, thoracic, and abdominopelvic regions. Infective endocarditis due to Actinomyces species is extremely rare with only 30 reported cases since 1939. We report a case of Actinomyces oris endocarditis in a 14-year-old boy who had a 2-week history of dyspnea...
Thu Mar 05, 2020 11:56
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Coccidioidomycosis is an infection caused by inhalation of arthroconidia produced by dimorphic fungi in the genus Coccidioides. Forty percent of patients will develop an influenza-like illness with symptoms suggestive of a mild and self-limited respiratory infection; however, 5% of these individuals will develop extrapulmonary disseminated disease. An immunocompromised patient presented with right...
Thu Mar 05, 2020 11:55
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Among patients with proximal iliofemoral deep vein thrombosis (DVT) and an elevated Villalta score, anticoagulation therapy alone may not be a sufficient management strategy in select cases. In this article, we report a case of severe bilateral iliofemoral DVT that resisted the standard treatment for DVT, requiring catheter-directed thrombolysis and subsequent mechanical thrombectomy.
Thu Mar 05, 2020 11:54
Journal of Investigative Medicine High Impact Case Reports, Volume 8, Issue , January-December 2020. Globally, schistosomal infections affect over 200 million people resulting in the loss of 70 million disability-adjusted life years. In the sub-Saharan Africa region, where over 85% of the global schistosomal infections are found, it is estimated that about 120 million people become symptomatic, over 20 million have severe disease, and nearly 200 000 die every year. Renal impairment is a severe consequence...
Thu Mar 05, 2020 11:53
Related ArticlesClinical parameters predicting tonsillar malignancy. Eur Arch Otorhinolaryngol. 2020 Mar 04;: Authors: Fellner A, Gavriel H, Pitaro J, Muallem Kalmovich L Abstract PURPOSE: Tonsillectomy is indicated in unilateral tonsillar enlargement (UTE) to rule out malignancy, which eventually is found in about 1.4% of the patients. The aim of this study was to evaluate the presenting symptoms of patients who underwent tonsillectomy for UTE and...
Thu Mar 05, 2020 14:45
Related ArticlesPost-extubation stridor after prolonged intubation in the pediatric intensive care unit (PICU): a prospective observational cohort study. Eur Arch Otorhinolaryngol. 2020 Mar 04;: Authors: Veder LL, Joosten KFM, Schlink K, Timmerman MK, Hoeve LJ, van der Schroeff MP, Pullens B Abstract PURPOSE: Prolonged endotracheal intubation may lead to laryngeal damage, with stridor being the most relevant clinical symptom. Our objective was to...
Thu Mar 05, 2020 14:45
Related Articles[Nutritional aspects of the palliative care of head and neck cancer patients]. HNO. 2020 Mar 04;: Authors: Büntzel J, Kratzing K, Joch H, Büntzel H Abstract Nutrition remains a relevant issue until the end of life, both for patients and their relatives. This is particularly true for palliative patients with advanced head and neck cancer. In addition to local problems caused by the disease and its treatment, patients suffer from social...
Thu Mar 05, 2020 14:45
Related Articles[The situation of education in ENT-residency-training in Germany]. HNO. 2020 Mar 04;: Authors: Linke J, Eichhorn T, Kemper M, Zahnert T, Neudert M Abstract BACKGROUND: As a starting point for developing concrete suggestions for optimizing specialty training in German ENT departments, the present study analysed the current status of residency training in order to identify weaknesses. METHODS: Residents at German ENT departments...
Thu Mar 05, 2020 14:45
Related ArticlesNormal Gaze Patterns of the Face in Lateral View. Facial Plast Surg Aesthet Med. 2020 Mar/Apr;22(2):80-85 Authors: Huynh PP, Ishii M, Juarez M, Liao D, Darrach HM, Fung N, Nellis JC, Byrne PJ, Boahene KDO, Papel ID, Kontis TC, Ishii LE Abstract Importance: Current efforts to quantify the attentional distraction of facial deformities have been limited to deformities that are best perceived when the face is in frontal view, and there...
Thu Mar 05, 2020 14:45
Related ArticlesLateral Crural Insertion Graft for External Nasal Valve Collapse. Facial Plast Surg Aesthet Med. 2020 Mar/Apr;22(2):110-111 Authors: Vernon D, Lee A, Papel I PMID: 32130064 [PubMed - as supplied by publisher]
Thu Mar 05, 2020 14:45
Related ArticlesResponse to Kantor re: "Measuring Outcomes of Mohs Defect Reconstruction Using Eye-Tracking Technology". Facial Plast Surg Aesthet Med. 2020 Mar/Apr;22(2):123 Authors: Dey JK, Ishii LE, Ishii M PMID: 32130063 [PubMed - as supplied by publisher]
Thu Mar 05, 2020 14:45
Related ArticlesAn Update on Level of Evidence Trends in Facial Plastic Surgery Research. Facial Plast Surg Aesthet Med. 2020 Mar/Apr;22(2):105-109 Authors: Eggerstedt M, Shay AD, Brown HJ, Ganti A, Varelas E, Smith RM, Revenaugh PC Abstract Background: Knowledge of the quality of evidence in facial plastic surgery research is essential for the implementation of evidence-based practices. The purpose of this study is to provide an update over the...
Thu Mar 05, 2020 14:45
Related ArticlesBeyond Botox: Contemporary Management of Nonflaccid Facial Palsy. Facial Plast Surg Aesthet Med. 2020 Mar/Apr;22(2):65-70 Authors: Miller MQ, Hadlock TA Abstract Many transient facial nerve insults, including Bell's palsy, Ramsay Hunt syndrome, Lyme-associated facial paralysis, and temporal bone fractures, ultimately lead to nonflaccid facial palsy (NFFP). NFFP is associated with significant functional, aesthetic, psychological, and...
Thu Mar 05, 2020 14:45
Related ArticlesPain assessment and management in children in the postoperative period: A review of the most commonly used postoperative pain assessment tools, new diagnostic methods and the latest guidelines for postoperative pain therapy in children. Adv Clin Exp Med. 2020 Mar 04;: Authors: Zieliński J, Morawska-Kochman M, Zatoński T Abstract Pain is one of the most common complaints expressed by hospital patients and is the main reason they seek...
Thu Mar 05, 2020 14:45
Related ArticlesDetermination of high-risk HPV status of head and neck squamous cell carcinoma using the Roche cobas HPV test on cytologic specimens and acellular supernatant fluid. Cancer Cytopathol. 2020 Mar 04;: Authors: Wright MF, Weiss VL, Lewis JS, Schmitz JE, Ely KA Abstract BACKGROUND: High-risk human papillomavirus-positive (hrHPV+) oropharyngeal squamous cell carcinomas comprise a subset of head and neck squamous cell carcinomas (HNSCCs)...
Thu Mar 05, 2020 14:45
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