IJERPH, Vol. 17, Pages 1832: ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061832 Authors: Denisse Duran-Merino Nelly Molina-Frechero Leonor Sánchez-Pérez Martina Nevárez-Rascón Rogelio González-González Omar Tremillo-Maldonado Diana Cassi Ronell Bologna-Molina The ENAM gene is important in the formation of tooth enamel; an alteration can affect the...
Thu Mar 12, 2020 02:00
IJERPH, Vol. 17, Pages 1833: Disambiguating “Mechanisms” in Pharmacy: Lessons from Mechanist Philosophy of Science International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061833 Authors: Ahmad Yaman Abdin Claus Jacob Lena Kästner Talk of mechanisms is ubiquitous in the natural sciences. Interdisciplinary fields such as biochemistry and pharmacy frequently discuss mechanisms with the assistance of diagrams. Such diagrams usually depict entities as...
Thu Mar 12, 2020 02:00
IJERPH, Vol. 17, Pages 1830: Management Options for Ixodes ricinus-Associated Pathogens: A Review of Prevention Strategies International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061830 Authors: Jiří Černý Geoffrey Lynn Johana Hrnková Maryna Golovchenko Natalia Rudenko Libor Grubhoffer Ticks are important human and animal parasites and vectors of many infectious disease agents. Control of tick activity is an effective tool to reduce the risk...
Thu Mar 12, 2020 02:00
IJERPH, Vol. 17, Pages 1828: Stroke Prediction with Machine Learning Methods among Older Chinese International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061828 Authors: Yafei Wu Ya Fang Timely stroke diagnosis and intervention are necessary considering its high prevalence. Previous studies have mainly focused on stroke prediction with balanced data. Thus, this study aimed to develop machine learning models for predicting stroke with imbalanced data in...
Thu Mar 12, 2020 02:00
IJERPH, Vol. 17, Pages 1829: Trajectories of Depressive Symptoms and Neighborhood Changes from Adolescence to Adulthood: Latent Class Growth Analysis and Multilevel Growth Curve Models International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17061829 Authors: Hyunjung Lee Lorena M. Estrada-Martínez The role of neighborhood socioeconomic status (SES) and racial/ethnic composition on depression has received considerable attention in the United States. This...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1948: Non-Invasive Cerebellar Stimulation in Neurodegenerative Ataxia: A Literature Review International Journal of Molecular Sciences doi: 10.3390/ijms21061948 Authors: Benussi Pascual-Leone Borroni Cerebellar ataxias are a heterogenous group of degenerative disorders for which we currently lack effective and disease-modifying interventions. The field of non-invasive brain stimulation has made much progress in the development of specific stimulation protocols...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1951: Humanization of Tumor Stroma by Tissue Engineering as a Tool to Improve Squamous Cell Carcinoma Xenograft International Journal of Molecular Sciences doi: 10.3390/ijms21061951 Authors: Guerrero-Aspizua González-Masa Conti García Chacón-Solano Larcher del Río The role of stroma is fundamental in the development and behavior of epithelial tumors. In this regard, limited growth of squamous cell carcinomas (SCC) or cell-lines derived from...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1952: Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2 – A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21061952 Authors: Kuespert Heydn Peters Wirkert Meyer Siebörger Johannesen Aigner Bogdahn Bruun Antisense Oligonucleotides (ASOs) are an emerging drug class in gene modification. In our study we developed a safe, stable,...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1949: Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle International Journal of Molecular Sciences doi: 10.3390/ijms21061949 Authors: Park Seo Both glucose and free fatty acids (FFAs) are used as fuel sources for energy production in a living organism. Compelling evidence supports a role for excess fatty acids synthesized in intramuscular space or dietary intermediates in the regulation of skeletal muscle function. Excess FFA and lipid...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1950: The Roles of miRNA in Glioblastoma Tumor Cell Communication: Diplomatic and Aggressive Negotiations International Journal of Molecular Sciences doi: 10.3390/ijms21061950 Authors: Buruiană Florian Florian Timiș Mihu Miclăuș Oșan Hrapșa Cataniciu Farcaș Șușman Glioblastoma (GBM) consists of a heterogeneous collection of competing cellular clones which communicate with each other and with the tumor microenvironment (TME)....
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1946: Disruption of Exocytosis in Sympathoadrenal Chromaffin Cells from Mouse Models of Neurodegenerative Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21061946 Authors: Antonio M. G.de Diego Diana Ortega-Cruz Antonio G. G. García Synaptic disruption and altered neurotransmitter release occurs in the brains of patients and in murine models of neurodegenerative diseases (NDDs). During the last few years, evidence has accumulated suggesting...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1945: Dopaminergic Modulation of Orofacial Mechanical Hypersensitivity Induced by Infraorbital Nerve Injury International Journal of Molecular Sciences doi: 10.3390/ijms21061945 Authors: Maegawa Usami Kudo Hanamoto Niwa While the descending dopaminergic control system is not fully understood, it is reported that the hypothalamic A11 nucleus is its principle source. To better understand the impact of this system, particularly the A11 nucleus, on neuropathic...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1944: Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants
IJMS, Vol. 21, Pages 1944: Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants International Journal of Molecular Sciences doi: 10.3390/ijms21061944 Authors: Lalmanach Saidi Bigot Chazeirat Lecaille Wartenberg Besides their primary involvement in the recycling and degradation of proteins in endo-lysosomal compartments and also in specialized biological functions, cysteine cathepsins are pivotal proteolytic contributors of various deleterious...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1947: Airway Ciliary Beating Affected by the Pcp4 Dose-Dependent [Ca2+]i Increase in Down Syndrome Mice, Ts1Rhr International Journal of Molecular Sciences doi: 10.3390/ijms21061947 Authors: Haruka Kogiso Matthieu Raveau Kazuhiro Yamakawa Daichi Saito Yukiko Ikeuchi-Yamamoto Tomonori Okazaki Shinji Asano Toshio Inui Yoshinori Marunaka Takashi Nakahari In Ts1Rhr, a Down syndrome model mouse, the airway ciliary beatings are impaired; that...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1943: Integrated miRNA/mRNA Counter-Expression Analysis Highlights Oxidative Stress-Related Genes CCR7 and FOXO1 as Blood Markers of Coronary Arterial Disease International Journal of Molecular Sciences doi: 10.3390/ijms21061943 Authors: Hueso Mallén Casas Guiteras Sbraga Blasco-Lucas Lloberas Torras Cruzado Navarro Our interest in the mechanisms of atherosclerosis progression (ATHp) has led to the recent identification of 13...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1941: Fighting Against Promoter DNA Hyper-Methylation: Protective Histone Modification Profiles of Stress-Resistant Intestinal Stem Cells International Journal of Molecular Sciences doi: 10.3390/ijms21061941 Authors: Thalheim Hopp Herberg Siebert Kerner Quaas Schweiger Aust Galle Aberrant DNA methylation in stem cells is a hallmark of aging and tumor development. Recently, we have suggested that promoter DNA hyper-methylation originates...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1940: How Does Epstein–Barr Virus Contribute to Chronic Periodontitis? International Journal of Molecular Sciences doi: 10.3390/ijms21061940 Authors: Imai Ogata Chronic periodontitis is spreading worldwide and mutually interacts with systemic diseases like diabetes mellitus. Although periodontopathic bacteria are inevitable pathogens in their onset and progression, many cases are not ascribable to the virulence of these bacteria because the effect of plaque...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1939: Cold Atmospheric Plasma and Silymarin Nanoemulsion Activate Autophagy in Human Melanoma Cells International Journal of Molecular Sciences doi: 10.3390/ijms21061939 Authors: Adhikari Adhikari Ghimire Baboota Choi Background: Autophagy is reported as a survival or death-promoting pathway that is highly debatable in different kinds of cancer. Here, we examined the co-effect of cold atmospheric plasma (CAP) and silymarin nanoemulsion (SN) treatment...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1942: Involvement of Salicylic Acid and Other Phenolic Compounds in Light-Dependent Cold Acclimation in Maize International Journal of Molecular Sciences doi: 10.3390/ijms21061942 Authors: Magda Pál Tibor Janda Imre Majláth Gabriella Szalai The exposure of plants to non-lethal low temperatures may increase their tolerance to a subsequent severe chilling stress. To some extent, this is also true for cold-sensitive species, including maize. In the present...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1934: Chromosome Missegregation in Single Human Oocytes Is Related to the Age and Gene Expression Profile International Journal of Molecular Sciences doi: 10.3390/ijms21061934 Authors: Stefano Barone Patrizia Sarogni Roberto Valli Maria Michela Pallotta Gazzi Silvia Annalisa Frattini Abdul Waheed Khan Erika Rapalini Cristiana Parri Antonio Musio The growing trend for women to postpone childbearing has resulted in a dramatic increase in...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1937: STAT3 for Cardiac Regenerative Medicine: Involvement in Stem Cell Biology, Pathophysiology, and Bioengineering International Journal of Molecular Sciences doi: 10.3390/ijms21061937 Authors: Shu Nakao Tasuku Tsukamoto Tomoe Ueyama Teruhisa Kawamura Heart disease is the most common cause of death in developed countries, but the medical treatments for heart failure remain limited. In this context, the development of cardiac regeneration therapy for severe...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1938: Effects of High-Dose Ionizing Radiation in Human Gene Expression: A Meta-Analysis International Journal of Molecular Sciences doi: 10.3390/ijms21061938 Authors: Kanakoglou Michalettou Vasileiou Gioukakis Maneta Kyriakidis Georgakilas Michalopoulos The use of high-dose Ionizing Radiation (IR) is currently one of the most common modalities in treatment of many types of cancer. The objective of this work was to investigate the effects...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1936: Nutraceutical Boom in Cancer: Inside the Labyrinth of Reactive Oxygen Species International Journal of Molecular Sciences doi: 10.3390/ijms21061936 Authors: Calvani Pasha Favre In recent years, epidemiological studies have shown that food is a very powerful means for maintaining a state of well-being and for health prevention. Many degenerative, autoimmune and neoplastic diseases are related to nutrition and the nutrient–organism interaction...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1935: Molecular Characterization of PGC-1β (PPAR Gamma Coactivator 1β) and its Roles in Mitochondrial Biogenesis in Blunt Snout Bream (Megalobrama amblycephala) International Journal of Molecular Sciences doi: 10.3390/ijms21061935 Authors: Lu Policar Song Rahimnejad This study aimed at achieving the molecular characterization of peroxisome proliferator-activated receptor-gamma coactivator 1β (PGC-1β) and exploring its modulatory roles...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1933: Neuronal Activity and Its Role in Controlling Antioxidant Genes International Journal of Molecular Sciences doi: 10.3390/ijms21061933 Authors: Qiu Dando Febery Fowler Chandran Hardingham Forebrain neurons have relatively weak intrinsic antioxidant defenses compared to astrocytes, in part due to hypo-expression of Nrf2, an oxidative stress-induced master regulator of antioxidant and detoxification genes. Nevertheless, neurons do possess...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1930: In Vitro Biophysical and Biological Characterization of Lipid Nanoparticles Co-Encapsulating Oncosuppressors miR-199b-5p and miR-204-5p as Potentiators of Target Therapy in Metastatic Melanoma International Journal of Molecular Sciences doi: 10.3390/ijms21061930 Authors: Luigi Fattore Virginia Campani Ciro Francesco Ruggiero Valentina Salvati Domenico Liguoro Lorena Scotti Gerardo Botti Paolo Antonio Ascierto Rita Mancini Giuseppe De Rosa...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1929: Endocrine Disruptors in Water and Their Effects on the Reproductive System International Journal of Molecular Sciences doi: 10.3390/ijms21061929 Authors: Andressa Gonsioroski Vasiliki E. Mourikes Jodi A. Flaws Anthropogenic contaminants in water can impose risks to reproductive health. Most of these compounds are known to be endocrine disrupting chemicals (EDCs). EDCs can impact the endocrine system and subsequently impair the development and fertility...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1932: Tumor Cell Invasion in Glioblastoma International Journal of Molecular Sciences doi: 10.3390/ijms21061932 Authors: Arabel Vollmann-Zwerenz Verena Leidgens Giancarlo Feliciello Christoph A. Klein Peter Hau Glioblastoma (GBM) is a particularly devastating tumor with a median survival of about 16 months. Recent research has revealed novel insights into the outstanding heterogeneity of this type of brain cancer. However, all GBM subtypes share the hallmark...
Thu Mar 12, 2020 02:00
IJMS, Vol. 21, Pages 1931: FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles International Journal of Molecular Sciences doi: 10.3390/ijms21061931 Authors: Franz L. Ricklefs Cecile L. Maire Jakob Matschke Lasse Dührsen Thomas Sauvigny Mareike Holz Katharina Kolbe Sven Peine Christel Herold-Mende Bob Carter E. Antonio Chiocca Sean E. Lawler Manfred Westphal Katrin Lamszus Extracellular vesicles (EVs) are known for their...
Thu Mar 12, 2020 02:00
IJNS, Vol. 6, Pages 19: Inconclusive Diagnosis after Newborn Screening for Cystic Fibrosis International Journal of Neonatal Screening doi: 10.3390/ijns6010019 Authors: Anne Munck An unintended consequence of newborn screening for cystic fibrosis (CF) is the identification of infants with a positive screening test but an inconclusive diagnostic testing. These infants are designated as CF transmembrane conductance regulator-related metabolic syndrome (CRMS) in the US and CF screen-positive,...
Thu Mar 12, 2020 02:00
JCM, Vol. 9, Pages 778: Alcohol Hangover Differentially Modulates the Processing of Relevant and Irrelevant Information Journal of Clinical Medicine doi: 10.3390/jcm9030778 Authors: Opitz Beste Stock Elevated distractibility is one of the major contributors to alcohol hangover-induced behavioral deficits. Yet, the basic mechanisms driving increased distractibility during hangovers are still not very well understood. Aside from impairments in attention and psychomotor functions,...
Thu Mar 12, 2020 02:00
JCM, Vol. 9, Pages 777: Analysis of Faecal Zonulin and Calprotectin Concentrations in Healthy Children During the First Two Years of Life. An Observational Prospective Cohort Study Journal of Clinical Medicine doi: 10.3390/jcm9030777 Authors: Beata Łoniewska Karolina Adamek Dagmara Węgrzyn Mariusz Kaczmarczyk Karolina Skonieczna-Żydecka Jeremy Clark Grażyna Adler Joanna Tousty Izabela Uzar Piotr Tousty Igor Łoniewski Factors affecting the intestinal-barrier...
Thu Mar 12, 2020 02:00
JCM, Vol. 9, Pages 775: High-Sensitivity Troponin T Testing: Consequences on Daily Clinical Practice and Effects on Diagnosis of Myocardial Infarction Journal of Clinical Medicine doi: 10.3390/jcm9030775 Authors: Christian Frédéric Zachoval Ramona Dolscheid-Pommerich Ingo Graeff Bernd Goldschmidt Andreas Grigull Birgit Stoffel-Wagner Georg Nickenig Sebastian Zimmer It remains unclear how introduction of high-sensitivity troponin T testing, as opposed to conventional...
Thu Mar 12, 2020 02:00
JCM, Vol. 9, Pages 774: Accuracy of Edentulous Computer-Aided Implant Surgery as Compared to Virtual Planning: A Retrospective Multicenter Study Journal of Clinical Medicine doi: 10.3390/jcm9030774 Authors: R. Vinci M. Manacorda R. Abundo A.G. Lucchina A. Scarano C. Crocetta L. Lo Muzio E.F. Gherlone F. Mastrangelo Purpose: To evaluate the accuracy of computer-aided dental implant positions obtained with mucosal-supported templates as compared to Three-Dimensional...
Thu Mar 12, 2020 02:00
JCM, Vol. 9, Pages 776: Breast Mammographic Density: Stromal Implications on Breast Cancer Detection and Therapy Journal of Clinical Medicine doi: 10.3390/jcm9030776 Authors: Patricia Fernández-Nogueira Mario Mancino Gemma Fuster Paloma Bragado Miquel Puig Pere Gascón Francisco Casado Neus Carbó Current evidences state clear that both normal development of breast tissue as well as its malignant progression need many-sided local and systemic communications between...
Thu Mar 12, 2020 02:00
JCM, Vol. 9, Pages 767: Impaired Release of Neutrophil Extracellular Traps and Anemia-Associated T Cell Deficiency in Hereditary Hemorrhagic Telangiectasia Journal of Clinical Medicine doi: 10.3390/jcm9030767 Authors: Freya Droege Ekaterina Pylaeva Elena Siakaeva Sharareh Bordbari Ilona Spyra Kruthika Thangavelu Carolin Lueb Maksim Domnich Stephan Lang Urban Geisthoff Jadwiga Jablonska Hereditary hemorrhagic telangiectasia (HHT) is characterized by mucocutaneous...
Thu Mar 12, 2020 02:00
JCM, Vol. 9, Pages 770: Abuse of Licit and Illicit Psychoactive Substances in the Workplace: Medical, Toxicological, and Forensic Aspects Journal of Clinical Medicine doi: 10.3390/jcm9030770 Authors: Ricardo Jorge Dinis-Oliveira Teresa Magalhães About one-third of adult life is spent in the workplace. The use of psychoactive substances is a major preventable cause of morbidity and mortality. The consumption of psychoactive substances during or outside working hours greatly increases...
Thu Mar 12, 2020 02:00
JCM, Vol. 9, Pages 769: Salivary Oxidative Stress Increases With the Progression of Chronic Heart Failure Journal of Clinical Medicine doi: 10.3390/jcm9030769 Authors: Anna Klimiuk Anna Zalewska Robert Sawicki Małgorzata Knapp Mateusz Maciejczyk The aim of the study was to evaluate the rate of reactive oxygen species (ROS) production, antioxidant barrier, and oxidative damage in non-stimulated (NWS) and stimulated (SWS) saliva as well as plasma/erythrocytes of 50 patients...
Thu Mar 12, 2020 02:00
JCM, Vol. 9, Pages 772: Bioactivity and Physico-Chemical Properties of Dental Composites Functionalized with Nano- vs. Micro-Sized Bioactive Glass Journal of Clinical Medicine doi: 10.3390/jcm9030772 Authors: Reto Odermatt Matej Par Dirk Mohn Daniel B. Wiedemeier Thomas Attin Tobias T. Tauböck Bioactive resin composites can contribute to the prevention of secondary caries, which is one of the main reasons for failure of contemporary dental restorations. This study investigated...
Thu Mar 12, 2020 02:00
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