IJMS, Vol. 21, Pages 1791: Systems Biology Analysis Reveals Eight SLC22 Transporter Subgroups, Including OATs, OCTs, and OCTNs International Journal of Molecular Sciences doi: 10.3390/ijms21051791 Authors: Darcy C. Engelhart Jeffry C. Granados Da Shi Milton H. Saier Jr. Michael E. Baker Ruben Abagyan Sanjay K. Nigam The SLC22 family of OATs, OCTs, and OCTNs is emerging as a central hub of endogenous physiology. Despite often being referred to as “drug”...
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1784: New Perspectives Related to the Bioluminescent System in Dinoflagellates: Pyrocystis lunula, a Case Study International Journal of Molecular Sciences doi: 10.3390/ijms21051784 Authors: Carlos Fajardo Marcos De Donato Hectorina Rodulfo Gonzalo Martinez-Rodriguez Benjamin Costas Juan Miguel Mancera Francisco Javier Fernandez-Acero Pyrocystis lunula is considered a model organism due to its bioluminescence capacity linked to circadian rhythms....
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1786: Using Serum Amino Acids to Predict Traumatic Brain Injury: A Systematic Approach to Utilize Multiple Biomarkers International Journal of Molecular Sciences doi: 10.3390/ijms21051786 Authors: Marzieh Hajiaghamemar Todd Kilbaugh Kristy B. Arbogast Christina L. Master Susan S. Margulies Traumatic brain injury (TBI) can cause biochemical and metabolomic alterations in the brain tissue and serum. These alterations can be used for diagnosis and prognosis...
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1785: (R)-(+)-β-Citronellol and (S)-(−)-β-Citronellol in Combination with Amphotericin B against Candida Spp. International Journal of Molecular Sciences doi: 10.3390/ijms21051785 Authors: Daniele Silva Hermes Diniz-Neto Laísa Cordeiro Maria Silva-Neta Shellygton Silva Francisco Andrade-Júnior Maria Leite Jefferson Nóbrega Maria Morais Juliana Souza Lyvia Rosa Thamara Melo Helivaldo Souza Aleson Sousa Gregório Rodrigues Abrahão...
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1787: Modulation of Energy Metabolism Is Important for Low-Oxygen Stress Adaptation in Brassicaceae Species International Journal of Molecular Sciences doi: 10.3390/ijms21051787 Authors: Ji-Hye Hwang Si-in Yu Byeong-ha Lee Dong-Hee Lee Low-oxygen stress, mainly caused by soil flooding, is a serious abiotic stress affecting crop productivity worldwide. To understand the mechanisms of low-oxygen stress responses and adaptation of plants, we characterized and...
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1782: The Complex Network between MYC Oncogene and microRNAs in Gastric Cancer: An Overview International Journal of Molecular Sciences doi: 10.3390/ijms21051782 Authors: Ana Carolina Anauate Mariana Ferreira Leal Danielle Queiroz Calcagno Carolina Oliveira Gigek Bruno Takao Real Karia Fernanda Wisnieski Leonardo Caires dos Santos Elizabeth Suchi Chen Rommel Rodríguez Burbano Marília Arruda Cardoso Smith Despite the advancements in cancer...
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1781: Comparative Root Transcriptomics Provide Insights into Drought Adaptation Strategies in Chickpea (Cicer arietinum L.) International Journal of Molecular Sciences doi: 10.3390/ijms21051781 Authors: Vijay Bhaskarla Gaurav Zinta Rebecca Ford Mukesh Jain Rajeev K. Varshney Nitin Mantri Drought adversely affects crop production across the globe. The root system immensely contributes to water management and the adaptability of plants to drought stress....
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1779: Upregulation of CD20 Positive B-Cells and B-Cell Aggregates in the Tumor Infiltration Zone is Associated with Better Survival of Patients with Pancreatic Ductal Adenocarcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21051779 Authors: Maximilian Brunner Katharina Maier Petra Rümmele Anne Jacobsen Susanne Merkel Alan Benard Christian Krautz Stephan Kersting Robert Grützmann Georg F. Weber Patients with pancreatic...
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1783: UL36 Encoded by Marek’s Disease Virus Exhibits Linkage-Specific Deubiquitinase Activity International Journal of Molecular Sciences doi: 10.3390/ijms21051783 Authors: Junyan Lin Yongxing Ai Hongda Zhou Yan Lv Menghan Wang Jiacui Xu Cong Yu Huanmin Zhang Mengyun Wang (1) Background: Deubiquitinase (DUB) regulates various important cellular processes via reversing the protein ubiquitination. The N-terminal fragment of a giant tegument...
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1780: Oxylipin Profiles as Functional Characteristics of Acute Inflammatory Responses in Astrocytes Pre-Treated with IL-4, IL-10, or LPS International Journal of Molecular Sciences doi: 10.3390/ijms21051780 Authors: Dmitry V. Chistyakov Gleb E. Gavrish Sergei V. Goriainov Viktor V. Chistyakov Alina A. Astakhova Nadezda V. Azbukina Marina G. Sergeeva Functional phenotypes, which cells can acquire depending on the microenvironment, are currently the...
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1767: Counteracting Radio-Resistance Using the Optimization of Radiotherapy International Journal of Molecular Sciences doi: 10.3390/ijms21051767 Authors: François Chevalier Radiotherapy is an essential component of cancer therapy and remains one of the most (cost-) effective treatment options available [...]
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1775: The Role of NFκB in Healthy and Preeclamptic Placenta: Trophoblasts in the Spotlight International Journal of Molecular Sciences doi: 10.3390/ijms21051775 Authors: Brooke Armistead Leena Kadam Sascha Drewlo Hamid-Reza Kohan-Ghadr The NFκB protein family regulates numerous pathways within the cell—including inflammation, hypoxia, angiogenesis and oxidative stress—all of which are implicated in placental development. The...
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1778: A Systematic Test of Receptor Binding Kinetics for Ligands in Tumor Necrosis Factor Superfamily by Computational Simulations International Journal of Molecular Sciences doi: 10.3390/ijms21051778 Authors: Zhaoqian Su Yinghao Wu Ligands in the tumor necrosis factor (TNF) superfamily are one major class of cytokines that bind to their corresponding receptors in the tumor necrosis factor receptor (TNFR) superfamily and initiate multiple intracellular signaling...
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1776: A Possible Link of Genetic Variations in ER/IGF1R Pathway and Risk of Melanoma International Journal of Molecular Sciences doi: 10.3390/ijms21051776 Authors: Tze-An Yuan Vandy Yourk Ali Farhat Katherine L. Guo Angela Garcia Frank L. Meyskens Feng Liu-Smith The mechanism of gender disparity in cutaneous melanoma incidence remains unclear. Steroid hormones including estrogens have long been implicated in the course of melanoma, but the conclusion...
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1777: Synthetic HDL Nanoparticles Delivering Docetaxel and CpG for Chemoimmunotherapy of Colon Adenocarcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21051777 Authors: Lindsay M. Scheetz Minzhi Yu Dan Li María G. Castro James J. Moon Anna Schwendeman Colon carcinomas comprise over two-thirds of all colorectal cancers with an overall 5-year survival rate of 64%, which rapidly decreases to 14% when the cancer becomes metastatic....
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1774: The Arabidopsis GPI-Anchored LTPg5 Encoded by At3g22600 Has a Role in Resistance against a Diverse Range of Pathogens International Journal of Molecular Sciences doi: 10.3390/ijms21051774 Authors: Muhammad Amjad Ali Amjad Abbas Farrukh Azeem Mahpara Shahzadi Holger Bohlmann Arabidopsis contains 34 genes for glycosylphosphatidylinositol (GPI)-anchored LTPg proteins. A motif analysis has placed these into four groups. With one exception, all are produced...
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1769: EPA is More Effective than DHA to Improve Depression-Like Behavior, Glia Cell Dysfunction and Hippcampal Apoptosis Signaling in a Chronic Stress-Induced Rat Model of Depression International Journal of Molecular Sciences doi: 10.3390/ijms21051769 Authors: Zhilan Peng Cai Zhang Ling Yan Yongping Zhang Zhiyou Yang Jiajia Wang Cai Song Clinical evidence indicated that eicosapentaenoic acid (EPA) was more effective than docosahexaenoic acid (DHA)...
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1772: PINK1/Parkin Mediated Mitophagy, Ca2+ Signalling, and ER–Mitochondria Contacts in Parkinson’s Disease International Journal of Molecular Sciences doi: 10.3390/ijms21051772 Authors: Lucia Barazzuol Flavia Giamogante Marisa Brini Tito Calì Endoplasmic reticulum (ER)–mitochondria contact sites are critical structures for cellular function. They are implicated in a plethora of cellular processes, including Ca2+ signalling and mitophagy, the selective...
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1771: Homocysteine Disrupts Balance between MMP-9 and Its Tissue Inhibitor in Diabetic Retinopathy: The Role of DNA Methylation International Journal of Molecular Sciences doi: 10.3390/ijms21051771 Authors: Ghulam Mohammad Renu A. Kowluru High homocysteine is routinely observed in diabetic patients, and this non-protein amino acid is considered as an independent risk factor for diabetic retinopathy. Homocysteine biosynthesis from methionine forms S-adenosyl methionine...
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1773: Obatoclax, a Pan-BCL-2 Inhibitor, Downregulates Survivin to Induce Apoptosis in Human Colorectal Carcinoma Cells Via Suppressing WNT/β-catenin Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21051773 Authors: Chi-Hung R. Or Chiao-Wen Huang Ching-Chin Chang You-Chen Lai Yi-Ju Chen Chia-Che Chang Colorectal cancer (CRC) is a highly prevailing cancer and the fourth leading cause of cancer mortality worldwide. Aberrant expression...
Thu Mar 05, 2020 02:00
IJMS, Vol. 21, Pages 1770: Insulin: The Friend and the Foe in the Development of Type 2 Diabetes Mellitus International Journal of Molecular Sciences doi: 10.3390/ijms21051770 Authors: Nadia Rachdaoui Insulin, a hormone produced by pancreatic β-cells, has a primary function of maintaining glucose homeostasis. Deficiencies in β-cell insulin secretion result in the development of type 1 and type 2 diabetes, metabolic disorders characterized by high levels of blood glucose....
Thu Mar 05, 2020 02:00
JCM, Vol. 9, Pages 712: New Horizons in the Genetic Etiology of Systemic Lupus Erythematosus and Lupus-Like Disease: Monogenic Lupus and Beyond Journal of Clinical Medicine doi: 10.3390/jcm9030712 Authors: Erkan Demirkaya Sezgin Sahin Micol Romano Qing Zhou Ivona Aksentijevich Systemic lupus erythematosus (SLE) is a clinically and genetically heterogeneous autoimmune disease. The etiology of lupus and the contribution of genetic, environmental, infectious and hormonal factors...
Thu Mar 05, 2020 02:00
JCM, Vol. 9, Pages 711: Deregulation of the Purine Pathway in Pre-Transplant Liver Biopsies Is Associated with Graft Function and Survival after Transplantation Journal of Clinical Medicine doi: 10.3390/jcm9030711 Authors: Jin Xu Mohammad Hassan-Ally Ana María Casas-Ferreira Tommi Suvitaival Yun Ma Hector Vilca-Melendez Mohamed Rela Nigel Heaton Jassem Wayel Cristina Legido-Quigley The current shortage of livers for transplantation has increased the use of...
Thu Mar 05, 2020 02:00
JCM, Vol. 9, Pages 713: Analysis of Cervical Spine Alignment and its Relationship with Other Spinopelvic Parameters After Laminoplasty in Patients with Degenerative Cervical Myelopathy Journal of Clinical Medicine doi: 10.3390/jcm9030713 Authors: Seok Woo Kim Seung Bo Jang Hyung Min Lee Jeong Hwan Lee Min Uk Lee Jeong Woo Kim Jae Sung Yee For patients with kyphosis of the cervical spine, laminoplasty is usually incapable of improving neurological symptoms as it worsens...
Thu Mar 05, 2020 02:00
JCM, Vol. 9, Pages 709: Stereolithographic Surgical Guide with a Combination of Tooth and Bone Support: Accuracy of Guided Implant Surgery in Distal Extension Situation Journal of Clinical Medicine doi: 10.3390/jcm9030709 Authors: Chia-Cheng Lin Masahiro Ishikawa Takeo Maida Hsin-Chung Cheng Keng-Liang Ou Takashi Nezu Kazuhiko Endo A distal free-end situation could result in insufficient stability of the surgical guide, and could reduce accuracy of the static guided...
Thu Mar 05, 2020 02:00
JCM, Vol. 9, Pages 705: Treatment of Somatosensory Tinnitus: A Randomized Controlled Trial Studying the Effect of Orofacial Treatment as Part of a Multidisciplinary Program Journal of Clinical Medicine doi: 10.3390/jcm9030705 Authors: Annemarie Van der Wal Sarah Michiels Paul Van de Heyning Marc Braem Corine Visscher Vedat Topsakal Annick Gilles Laure Jacquemin Vincent Van Rompaey Willem De Hertogh Background: Tinnitus, or ringing in the ears, is a perception...
Thu Mar 05, 2020 02:00
JCM, Vol. 9, Pages 708: Influence of Preformed Antibodies in Liver Transplantation Journal of Clinical Medicine doi: 10.3390/jcm9030708 Authors: Isabel Legaz Francisco Boix Manuela López Rafael Alfaro José A. Galián Santiago Llorente Jose A. Campillo Carmen Botella Pablo Ramírez Francisco Sánchez-Bueno José A. Pons María R. Moya-Quiles Alfredo Minguela Manuel Muro The significance of human leukocyte antigen (HLA) matching and preformed donor-specific...
Thu Mar 05, 2020 02:00
JCM, Vol. 9, Pages 707: Relationship between Maternal Body Mass Index and Obstetric and Perinatal Complications Journal of Clinical Medicine doi: 10.3390/jcm9030707 Authors: Ana Ballesta-Castillejos Juan Gómez-Salgado Julián Rodríguez-Almagro Inmaculada Ortiz-Esquinas Antonio Hernández-Martínez Over the past few decades, overweight and obesity have become a growing health problem of particular concern for women of reproductive age as obesity in pregnancy has been associated...
Thu Mar 05, 2020 02:00
JCM, Vol. 9, Pages 704: KCP10043F Represses the Proliferation of Human Non-Small Cell Lung Cancer Cells by Caspase-Mediated Apoptosis via STAT3 Inactivation Journal of Clinical Medicine doi: 10.3390/jcm9030704 Authors: Jeong-Hun Lee Hwi-Ho Lee Ki Deok Ryu Misong Kim Dohyeong Ko Kyung-Sook Chung Ahmed H.E. Hassan Seung Hyeun Lee Jae Yeol Lee Kyung-Tae Lee We previously reported that 4-(4-fluorobenzylcarbamoylmethyl)-3-(4-cyclohexylphenyl)-2-[3-(N,N-dimethylureido)-N′-methylpropylamino]-3,4-dihydroquinazoline...
Thu Mar 05, 2020 02:00
JCM, Vol. 9, Pages 706: Physical Activity: A Missing Link in Asthma Care Journal of Clinical Medicine doi: 10.3390/jcm9030706 Authors: Marios Panagiotou Nikolaos G. Koulouris Nikoletta Rovina Asthma is the commonest respiratory disease and one of unceasingly increasing prevalence and burden. As such, asthma has attracted a major share or scientific interest and clinical attention. With the various clinical and pathophysiological aspects of asthma having been extensively investigated,...
Thu Mar 05, 2020 02:00
JCM, Vol. 9, Pages 710: Differences in the Outcome of Patients with COPD according to Body Mass Index Journal of Clinical Medicine doi: 10.3390/jcm9030710 Authors: Zichen Ji Javier de Miguel-Díez Christian Reynaldo Castro-Riera José María Bellón-Cano Virginia Gallo-González Walther Iván Girón-Matute Rodrigo Jiménez-García Ana López-de Andrés Virginia Moya-Álvarez Luis Puente-Maestu Julio Hernández-Vázquez Background: In chronic obstructive pulmonary disease...
Thu Mar 05, 2020 02:00
JCM, Vol. 9, Pages 702: Do Nutritional Factors Interact with Chronic Musculoskeletal Pain? A Systematic Review Journal of Clinical Medicine doi: 10.3390/jcm9030702 Authors: Ömer Elma Sevilay Tümkaya Yilmaz Tom Deliens Iris Coppieters Peter Clarys Jo Nijs Anneleen Malfliet Dietary patterns may play an important role in musculoskeletal well-being. However, the link between dietary patterns, the components of patients’ diet, and chronic musculoskeletal pain remains...
Thu Mar 05, 2020 02:00
JCM, Vol. 9, Pages 703: Sepsis-Associated Encephalopathy: From Delirium to Dementia? Journal of Clinical Medicine doi: 10.3390/jcm9030703 Authors: Ha-Yeun Chung Jonathan Wickel Frank M. Brunkhorst Brunkhorst Christian Geis Sepsis is a major cause of death in intensive care units worldwide. The acute phase of sepsis is often accompanied by sepsis-associated encephalopathy, which is highly associated with increased mortality. Moreover, in the chronic phase, more than 50% of surviving...
Thu Mar 05, 2020 02:00
JCM, Vol. 9, Pages 701: The Development and Testing of a Chemotherapy-Induced Phlebitis Severity (CIPS) Scale for Patients Receiving Anthracycline Chemotherapy for Breast Cancer Journal of Clinical Medicine doi: 10.3390/jcm9030701 Authors: Valerie Harris Meinir Hughes Rosie Roberts Gina Dolan E. Mark Williams A chemotherapy induced phlebitis severity (CIPS) scale was developed in patients receiving anthracycline chemotherapy for breast cancer. A five-point severity scoring...
Thu Mar 05, 2020 02:00
JCM, Vol. 9, Pages 700: Interstitial Lung Disease Associated with Lung Cancer: A Case–Control Study Journal of Clinical Medicine doi: 10.3390/jcm9030700 Authors: Quentin Gibiot Isabelle Monnet Pierre Levy Anne-Laure Brun Martine Antoine Christos Chouaïd Jacques Cadranel Jean-Marc Naccache Interstitial lung disease (ILD) seems to be associated with an increased risk of lung cancer (LC) and to have a poorer prognosis than LC without ILD. The frequency of ILD in an...
Thu Mar 05, 2020 02:00
JDB, Vol. 8, Pages 6: Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes Journal of Developmental Biology doi: 10.3390/jdb8010006 Authors: Roberts This review focuses on the role of the Cytochrome p450 subfamily 26 (CYP26) retinoic acid (RA) degrading enzymes during development and regeneration. Cyp26 enzymes, along with retinoic acid synthesising enzymes, are absolutely required for RA homeostasis in these processes by regulating...
Thu Mar 05, 2020 02:00
JoF, Vol. 6, Pages 33: Posaconazole Alone and in Combination with Caspofungin for Treatment of Experimental Exserohilum rostratum Meningoencephalitis: Developing New Strategies for Treatment of Phaeohyphomycosis of the Central Nervous System Journal of Fungi doi: 10.3390/jof6010033 Authors: Ruta Petraitiene Vidmantas Petraitis BoBo Win Maung Ethan Naing Povilas Kavaliauskas Thomas J. Walsh Phaeohyphomycosis of the central nervous system (CNS) is a life-threatening infection...
Thu Mar 05, 2020 02:00
J. Imaging, Vol. 6, Pages 11: Approximate Depth Shape Reconstruction for RGB-D Images Captured from HMDs for Mixed Reality Applications Journal of Imaging doi: 10.3390/jimaging6030011 Authors: Naoyuki Awano Depth sensors are important in several fields to recognize real space. However, there are cases where most depth values in a depth image captured by a sensor are constrained because the depths of distal objects are not always captured. This often occurs when a low-cost depth sensor...
Thu Mar 05, 2020 02:00
J. Imaging, Vol. 6, Pages 10: Automated Harmonic Signal Removal Technique Using Stochastic Subspace-Based Image Feature Extraction Journal of Imaging doi: 10.3390/jimaging6030010 Authors: Muhammad Danial Bin Abu Hasan Zair Asrar Bin Ahmad Mohd Salman Leong Lim Meng Hee This paper presents automated harmonic removal as a desirable solution to effectively identify and discard the harmonic influence over the output signal by neglecting any user-defined parameter at start-up and...
Thu Mar 05, 2020 02:00
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