Medicina, Vol. 56, Pages 114: Current Endoscopic Management of Malignant Biliary Stricture Medicina doi: 10.3390/medicina56030114 Authors: Wang Yang Sung Tsai Biliary and pancreatic cancers occur silently in the initial stage and become unresectable within a short time. When these diseases become symptomatic, biliary obstruction, either with or without infection, occurs frequently due to the anatomy associated with these cancers. The endoscopic management of these patients...
Thu Mar 05, 2020 02:00
Medicina, Vol. 56, Pages 113: Different Treatments in Patients with Temporomandibular Joint Disorders: A Comparative Randomized Study Medicina doi: 10.3390/medicina56030113 Authors: Sousa López-Valverde López-Valverde Caramelo Fraile Payo Rodrigues Background and Objectives: Temporomandibular joint disorders (TMJDs) are associated with pain and reduced jaw mobility. The aim of this study was to compare the outcome of patients with TMJ arthralgia when submitted...
Thu Mar 05, 2020 02:00
Medicina, Vol. 56, Pages 115: Epidemiology of Lyme Disease in a Highly Endemic European Zone Medicina doi: 10.3390/medicina56030115 Authors: Petrulionienė Radzišauskienė Ambrozaitis Čaplinskas Paulauskas Venalis Background and objective: Lyme disease, also known as Lyme borreliosis (LB), is a tick-borne infectious disease caused by the spirochete bacteria Borrelia. The risk of infection depends on the geographical area, ecological factors, and human behavior. Clinical...
Thu Mar 05, 2020 02:00
Medicina, Vol. 56, Pages 116: Non-Alcoholic Cirrhosis and Heart Rate Variability: A Systematic Mini-Review Medicina doi: 10.3390/medicina56030116 Authors: Amaral Salatini Arab Abreu Valenti Monteiro Tannuri Tannuri . Background and Objectives: Cirrhosis is a liver disease that causes about one million deaths annually worldwide. The estimated cirrhosis prevalence ranges from 4.5–9.5% in the general population. Up to 40% of cirrhotic patients are...
Thu Mar 05, 2020 02:00
Medicina, Vol. 56, Pages 112: Midpalatal Suture Density Evaluation after Rapid and Slow Maxillary Expansion with a Low-Dose CT Protocol: A Retrospective Study Medicina doi: 10.3390/medicina56030112 Authors: Rosamaria Fastuca Ambra Michelotti Riccardo Nucera Vincenzo D’Antò Angela Militi Antonino Logiudice Alberto Caprioglio Marco Portelli Background and objectives: The aim of the present paper is to use low-dose computed tomography (CT) to evaluate the changes in...
Thu Mar 05, 2020 02:00
Metabolites, Vol. 10, Pages 90: Exercise Promotes the Osteoinduction of HA/β-TCP Biomaterials via the Wnt Signaling Pathway Metabolites doi: 10.3390/metabo10030090 Authors: Cheng Khalaf Lin Ran Shi Wan Zhou Zou To investigate the osteoinductive mechanism triggered by hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) biomaterials in mice which keep exercising. Methods: The HA/β-TCP biomaterials were implanted in the muscle of bilateral...
Thu Mar 05, 2020 02:00
Metabolites, Vol. 10, Pages 93: Anion Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora Metabolites doi: 10.3390/metabo10030093 Authors: Vullo Lehneck Donald Pöggeler Supuran CAS3 is a newly cloned cytosolic β-class carbonic anhydrase (CA, EC 4.2.1.1) from the filamentous ascomycete Sordaria macrospora. This enzyme has a high catalytic activity for the physiological CO2 hydration reaction and herein,...
Thu Mar 05, 2020 02:00
Metabolites, Vol. 10, Pages 91: Food Targeting: Determination of the Cocoa Shell Content (Theobroma cacao L.) in Cocoa Products by LC-QqQ-MS/MS Metabolites doi: 10.3390/metabo10030091 Authors: Cain Marji von Wuthenau Segelke Fischer A targeted metabolomics LC-ESI-QqQ-MS/MS application for the determination of cocoa shell based on 15 non-polar key metabolites was developed, validated according to recognized guidelines, and used to predict the cocoa shell content in various...
Thu Mar 05, 2020 02:00
Metabolites, Vol. 10, Pages 92: Volatile Metabolites in Liverworts of Ecuador Metabolites doi: 10.3390/metabo10030092 Authors: Valarezo Tandazo Galán Rosales Benítez Volatile metabolites from Frullania brasiliensis Raddi, Herbertus juniperoideus (Sw.) Grolle, Leptoscyphus hexagonus (Nees) Grolle, and Syzygiella anomala (Lindenb. & Gottsche) Steph collected in the south of Ecuador were investigated. Volatile secondary metabolites were extracted by hydrodistillation...
Thu Mar 05, 2020 02:00
Metabolites, Vol. 10, Pages 89: A Cross-Sectional Study of Obesity Effects on the Metabolomic Profile of a Leptin-Resistant Swine Model Metabolites doi: 10.3390/metabo10030089 Authors: M. Victoria Sanz-Fernandez Laura Torres-Rovira Jose L. Pesantez-Pacheco Marta Vazquez-Gomez Consolacion Garcia-Contreras Susana Astiz Antonio Gonzalez-Bulnes Identifying metabolite signatures associated with obesity and related diseases might represent a valuable preventive and therapeutic...
Thu Mar 05, 2020 02:00
Microorganisms, Vol. 8, Pages 368: Optimization of Preservation Methods Allows Deeper Insights into Changes of Raw Milk Microbiota Microorganisms doi: 10.3390/microorganisms8030368 Authors: Kennang Ouamba LaPointe Dufour Roy The temporal instability of raw milk microbiota drastically affects the reliability of microbiome studies. However, little is known about the microbial integrity in preserved samples. Raw cow milk samples were preserved with azidiol or bronopol and stored...
Thu Mar 05, 2020 02:00
Microorganisms, Vol. 8, Pages 369: Bioremediation of Historically Chlorimuron-Ethyl-Contaminated Soil by Co-Culture Chlorimuron-Ethyl-Degrading Bacteria Combined with the Spent Mushroom Substrate Microorganisms doi: 10.3390/microorganisms8030369 Authors: Zang Liu Cheng Wang An Sun Wang Hou Cui Li In this study, a novel chlorimuron-ethyl-degrading Pleurotus eryngiu-SMS-CB was successfully constructed for remediation of soil historically contaminated...
Thu Mar 05, 2020 02:00
Microorganisms, Vol. 8, Pages 367: Siboglinidae Tubes as an Additional Niche for Microbial Communities in the Gulf of Cádiz—A Microscopical Appraisal Microorganisms doi: 10.3390/microorganisms8030367 Authors: Blanca Rincón-Tomás Francisco Javier González Luis Somoza Kathrin Sauter Pedro Madureira Teresa Medialdea Jens Carlsson Joachim Reitner Michael Hoppert Siboglinids were sampled from four mud volcanoes in the Gulf of Cádiz (El Cid MV, Bonjardim...
Thu Mar 05, 2020 02:00
Microorganisms, Vol. 8, Pages 366: Comparative Genomic Analysis Confirms Five Genetic Populations of the Select Agent, Rathayibacter toxicus Microorganisms doi: 10.3390/microorganisms8030366 Authors: Jarred Yasuhara-Bell Mohammad Arif Grethel Y. Busot Rachel Mann Brendan Rodoni James P. Stack Rathayibacter toxicus is a Gram-positive, nematode-vectored bacterium that infects several grass species in the family Poaceae. Unique in its genus, R. toxicus has the smallest genome,...
Thu Mar 05, 2020 02:00
Microorganisms, Vol. 8, Pages 365: The Photoreceptor Components FaWC1 and FaWC2 of Fusarium asiaticum Cooperatively Regulate Light Responses but Play Independent Roles in Virulence Expression Microorganisms doi: 10.3390/microorganisms8030365 Authors: Ying Tang Pinkuan Zhu Zhengyu Lu Yao Qu Li Huang Ni Zheng Yiwen Wang Haozhen Nie Yina Jiang Ling Xu Fusarium asiaticum belongs to one of the phylogenetical subgroups of the F. graminearum species complex and is...
Thu Mar 05, 2020 02:00
Molbank, Vol. 2020, Article M1118: 6-Imino-1,2,3,4,8,9,10,11-octahydropyrido[1,2-a]pyrido[1′,2′:1,2]imidazo[4,5-f]benzimidazole-13-one: Synthesis and Cytotoxicity Evaluation Molbank doi: 10.3390/M1118 Authors: Conboy Aldabbagh The first report of an iminoquinone of imidazo[4,5-f]benzimidazole is described. The 2D-NOESY spectrum of 1,2,3,4,8,9,10,11-octahydropyrido[1,2-a]pyrido[1’,2’:1,2]imidazo[4,5-f]benzimidazol-6-amine was used to confirm the location of the...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1186: Biodegradation of Conventional and Emerging Pollutants Molecules doi: 10.3390/molecules25051186 Authors: Łukasz Chrzanowski Łukasz Ławniczak The concerns associated with the contamination of the environment remain a topic of great importance and growing interest [...]
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Molecules, Vol. 25, Pages 1184: Combination of High Hydrostatic Pressure and Ultrafiltration to Generate a New Emulsifying Ingredient from Egg Yolk Molecules doi: 10.3390/molecules25051184 Authors: Giarratano Duffuler Chamberland Brisson House Pouliot Doyen Egg yolk granule phosvitin (45 kDa) is a phosphoprotein known for its emulsifying properties. Recently, high hydrostatic pressure (HHP) treatment of granule induced the transfer of phosvitin to the soluble...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1185: Nanoscale Quantum Thermal Conductance at Water Interface: Green’s Function Approach Based on One-Dimensional Phonon Model Molecules doi: 10.3390/molecules25051185 Authors: Toshihito Umegaki Shigenori Tanaka We have derived the fundamental formula of phonon transport in water for the evaluation of quantum thermal conductance by using a one-dimensional phonon model based on the nonequilibrium Green’s function method. In our model, phonons are...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1182: Novel Tamoxifen Nanoformulations for Improving Breast Cancer Treatment: Old Wine in New Bottles Molecules doi: 10.3390/molecules25051182 Authors: Day Hickey Song Plush Garg Breast cancer (BC) is one of the leading causes of death from cancer in women; second only to lung cancer. Tamoxifen (TAM) is a hydrophobic anticancer agent and a selective estrogen modulator (SERM), approved by the FDA for hormone therapy of BC. Despite having striking...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1181: Redox-Sensitive and Hyaluronic Acid-Functionalized Nanoparticles for Improving Breast Cancer Treatment by Cytoplasmic 17α-Methyltestosterone Delivery Molecules doi: 10.3390/molecules25051181 Authors: Rezaei Kashanian Bahrami Cruz Motiei Abstract: Novel reduction-responsive hyaluronic acid–chitosan–lipoic acid nanoparticles (HACSLA-NPs) were designed and synthesized for effective treatment of breast cancer by targeting...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1180: Synthesis and Antiproliferative Screening Of Novel Analogs of Regioselectively Demethylated Colchicine and Thiocolchicine Molecules doi: 10.3390/molecules25051180 Authors: Czerwonka Sobczak Maj Wietrzyk Katrusiak Huczyński Colchicine, a pseudoalkaloid isolated from Colchicum autumnale, has been identified as a potent anticancer agent because of its strong antimitotic activity. It was shown that colchicine modifications by regioselective...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1179: Preparation of Lignan-Rich Extract from the Aerial Parts of Phyllanthus niruri Using Nonconventional Methods Molecules doi: 10.3390/molecules25051179 Authors: Meselhy Abdel-Sattar El-Mekkawy EL-Desoky Mohamed Mohsen Abdel-Sattar El-Halawany Phyllanthin and related lignans were found to be responsible, at least in part, for most of the activity of Phyllanthus species. This observation encouraged the authors to develop methods...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1178: Thermal Stability of Chromium-Iron Oxidation Mixture Cermet-Based Solar Selective Absorbing Coatings Molecules doi: 10.3390/molecules25051178 Authors: Yu Li Zhang Pang Yan Li The solar selective absorber coating (SSAC) are at the core of the efficient solar-thermal system. In this paper, for the first time, the Chromium-iron oxidation mixture cermet was successfully prepared on the surface of ultra-pure ferritic stainless steel by...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1177: Protective Effects of Methoxsalen Supplementation on Chronic Alcohol-Induced Osteopenia and Steatosis in Rats Molecules doi: 10.3390/molecules25051177 Authors: Ham Choi Lee Lee Osteopenia or osteoporosis occurs frequently in alcoholics and patients with alcoholic fatty liver disease. Methoxsalen (MTS), 8-methoxypsoralen, improved osteoporosis in ovariectomized and diabetic mouse models; however, its effects on alcohol-induced osteopenia and...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1183: 1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity Molecules doi: 10.3390/molecules25051183 Authors: Jenny Desantis Serena Massari Angela Corona Andrea Astolfi Stefano Sabatini Giuseppe Manfroni Deborah Palazzotti Violetta Cecchetti Christophe Pannecouque Enzo Tramontano Oriana Tabarrini Despite great efforts have been made in the prevention...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1175: Synthesis of Tetrabenazine and Its Derivatives, Pursuing Efficiency and Selectivity Molecules doi: 10.3390/molecules25051175 Authors: Paek Tetrabenazine is a US Food and Drug Administration (FDA)-approved drug that exhibits a dopamine depleting effect and is used for the treatment of chorea in Huntington’s disease. Mechanistically, tetrabenazine binds and inhibits vesicular monoamine transporter type 2, which is responsible for importing neurotransmitters...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1174: Primary Human Hepatocytes, but Not HepG2 or Balb/c 3T3 Cells, Efficiently Metabolize Salinomycin and Are Resistant to Its Cytotoxicity Molecules doi: 10.3390/molecules25051174 Authors: Radko Olejnik Posyniak Salinomycin is a polyether antibiotic showing anticancer activity. There are many reports of its toxicity to animals but little is known about the potential adverse effects in humans. The action of the drug may be connected to its metabolism....
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1173: Surface Treatment of Acetabular Cups with a Direct Deposition of a Composite Nanostructured Layer Using a High Electrostatic Field Molecules doi: 10.3390/molecules25051173 Authors: Marek Pokorný Tomáš Suchý Adéla Kotzianová Jan Klemeš František Denk Monika Šupová Zbyněk Sucharda Radek Sedláček Lukáš Horný Vlastimil Králík Vladimír Velebný Zdeněk Čejka A composite nanofibrous layer containing collagen and hydroxyapatite...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1176: The Effect of Enriching Honey with Propolis on the Antioxidant Activity, Sensory Characteristics, and Quality Parameters Molecules doi: 10.3390/molecules25051176 Authors: Habryka Socha Juszczak Bee products, including propolis, are a valuable source of biologically active substances. The most natural way to introduce propolis in the diet seems to be its addition to honey. The aim of this study was to analyze the effect of honey enrichment with...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1170: Phytochemical Composition and Biological Activity of Berries and Leaves from Four Romanian Sea Buckthorn (Hippophae Rhamnoides L.) Varieties Molecules doi: 10.3390/molecules25051170 Authors: Adriana Criste Adriana Cristina Urcan Andrea Bunea Flavia Roxana Pripon Furtuna Neli Kinga Olah Robert H. Madden Nicolae Corcionivoschi Hippophae rhamnoides L. is an important source of natural antioxidant and antimicrobial agents. Phytochemical compounds,...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1171: In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain Molecules doi: 10.3390/molecules25051171 Authors: Paramita Basu Arpita Basu Neuropathic pain is a common symptom and is associated with an impaired quality of life. It is caused by the lesion or disease of the somatosensory system. Neuropathic pain syndromes can be subdivided into two categories: central and peripheral neuropathic pain. The present review highlights the peripheral...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1168: Design and Synthesis of Molecular Hybrids of Sophora Alkaloids and Cinnamic Acids as Potential Antitumor Agents Molecules doi: 10.3390/molecules25051168 Authors: Hai Shang Lingyu Li Liyan Ma Yu Tian Hongmei Jia Tao Zhang Meng Yu Zhongmei Zou Twenty-five sophora alkaloids-cinnamic acid hybrids (including matrine-cinnamic acid hybrids, sophoridine-cinnamic acid hybrids, and sophocarpine-cinnamic acid hybrids) were designed, synthesized,...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1169: Scanning Electrochemical Microscopy of Electrically Heated Wire Substrates Molecules doi: 10.3390/molecules25051169 Authors: Stefan Wert Alexander Fußstetter Christian Iffelsberger Frank-Michael Matysik We report a new configuration for enhancing the performance of scanning electrochemical microscopy (SECM) via heating of the substrate electrode. A flattened Pt microwire was employed as the substrate electrode. The substrate was heated by an alternating...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1172: Natural Psychoplastogens As Antidepressant Agents Molecules doi: 10.3390/molecules25051172 Authors: Jakub Benko Stanislava Vranková Increasing prevalence and burden of major depressive disorder presents an unavoidable problem for psychiatry. Existing antidepressants exert their effect only after several weeks of continuous treatment. In addition, their serious side effects and ineffectiveness in one-third of patients call for urgent action. Recent advances...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1160: Formation of Tetrahydrofurano-, Aryltetralin, and Butyrolactone Norlignans through the Epoxidation of 9-Norlignans Molecules doi: 10.3390/molecules25051160 Authors: Patrik A. Runeberg Dominique Agustin Patrik C. Eklund Epoxidation of the C=C double bond in unsaturated norlignans derived from hydroxymatairesinol was studied. The intermediate epoxides were formed in up to quantitative conversions and were readily further transformed into tetrahydrofuran,...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1167: Effect of Heat Treatment on the Chemical Structure and Thermal Properties of Softwood-Derived Glycol Lignin Molecules doi: 10.3390/molecules25051167 Authors: Thi Thi Nge Yuki Tobimatsu Masaomi Yamamura Shiho Takahashi Eri Takata Toshiaki Umezawa Tatsuhiko Yamada A large-scale glycol lignin (GL) production process (50 kg wood meal per batch) based on acid-catalyzed polyethylene glycol (PEG) solvolysis of Japanese cedar (JC) was developed...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1166: Chemical Characterization of Capsule-Brewed Espresso Coffee Aroma from the Most Widespread Italian Brands by HS-SPME/GC-MS Molecules doi: 10.3390/molecules25051166 Authors: Veronica Lolli Animesh Acharjee Donato Angelino Michele Tassotti Daniele Del Rio Pedro Mena Augusta Caligiani Coffee capsules market is on the rise as it allows access to a wide selection of coffee, differing in taste and brand. However, few data about the chemical...
Thu Mar 05, 2020 02:00
Molecules, Vol. 25, Pages 1164: Beneficial Regulation of Cellular Oxidative Stress Effects, and Expression of Inflammatory, Angiogenic, and the Extracellular Matrix Remodeling Proteins by 1α,25-Dihydroxyvitamin D3 in a Melanoma Cell Line Molecules doi: 10.3390/molecules25051164 Authors: Neena Philips Philips Samuel Thomas Keller Asma Alharbi Samar Alshalan Sara-Ali Shamlan The causes of cancer include the cellular accumulation reactive oxygen species (ROS), which overrides...
Thu Mar 05, 2020 02:00
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