IJMS, Vol. 21, Pages 2038: Macrophage-secreted Lipocalin-2 Promotes Regeneration of Injured Primary Murine Renal Tubular Epithelial Cells International Journal of Molecular Sciences doi: 10.3390/ijms21062038 Authors: Urbschat Thiemens Mertens Rehwald Meier Baer Jung Lipocalin-2 (Lcn-2) is rapidly upregulated in macrophages after renal tubular injury and acts as renoprotective and pro-regenerative agent. Lcn-2 possesses the ability to bind and transport iron with...
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IJMS, Vol. 21, Pages 2036: The Predictive Value of Salt Sensitivity and Osmotic Fragility in the Development of Cerebral Small Vessel Disease International Journal of Molecular Sciences doi: 10.3390/ijms21062036 Authors: Dobrynina Shabalina Shamtieva Gnedovskaya Berdalin Krotenkova Increased salt intake in food probably affects the progression of cerebral small vessel disease (CSVD), which justifies the study of disturbances in sodium homeostasis associated with...
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IJMS, Vol. 21, Pages 2029: Proanthocyanidins Ameliorated Deficits of Lipid Metabolism in Type 2 Diabetes Mellitus Via Inhibiting Adipogenesis and Improving Mitochondrial Function International Journal of Molecular Sciences doi: 10.3390/ijms21062029 Authors: Tie Wang Liang Zhu Wang Li Wang Proanthocyanidins are the major active compounds extracted from Iris lactea Pall. var. Chinensis (Fisch.) Koidz (I. lactea). Proanthocyanidins exhibit a variety of pharmacological...
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IJMS, Vol. 21, Pages 2030: The Role of Biofilms Developed under Different Anthropogenic Pressure on Recruitment of Macro-Invertebrates International Journal of Molecular Sciences doi: 10.3390/ijms21062030 Authors: Eva Cacabelos Patrício Ramalhosa João Canning-Clode Jesús S. Troncoso Celia Olabarria Cristina Delgado Sergey Dobretsov Ignacio Gestoso Microbial biofilms can be key mediators for settlement of macrofoulers. The present study examines the coupled effects...
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IJMS, Vol. 21, Pages 2031: Difference in Profiles of the Gut-Derived Tryptophan Metabolite Indole Acetic Acid between Transplanted and Non-Transplanted Patients with Chronic Kidney Disease International Journal of Molecular Sciences doi: 10.3390/ijms21062031 Authors: Liabeuf Laville Glorieux Cheddani Brazier Beauport Valholder Choukroun A.Massy Background: Uremic toxins have emerged as potential mediators of morbidity and mortality in patients with chronic...
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IJMS, Vol. 21, Pages 2033: Delocalization of the Unpaired Electron in the Quercetin Radical: Comparison of Experimental ESR Data with DFT Calculations International Journal of Molecular Sciences doi: 10.3390/ijms21062033 Authors: Li Moalin Zhang Vervoort Mommers Haenen In the antioxidant activity of quercetin (Q), stabilization of the energy in the quercetin radical (Q•) by delocalization of the unpaired electron (UE) in Q• is pivotal. The aim of...
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IJMS, Vol. 21, Pages 2032: Stem Cell Signaling Pathways in the Small Intestine International Journal of Molecular Sciences doi: 10.3390/ijms21062032 Authors: Takahashi Shiraishi The ability of stem cells to divide and differentiate is necessary for tissue repair and homeostasis. Appropriate spatial and temporal mechanisms are needed. Local intercellular signaling increases expression of specific genes that mediate and maintain differentiation. Diffusible signaling molecules provide...
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IJMS, Vol. 21, Pages 2035: Cardiovascular Changes Related to Metabolic Syndrome: Evidence in Obese Zucker Rats International Journal of Molecular Sciences doi: 10.3390/ijms21062035 Authors: Martinelli Tomassoni Moruzzi Roy Cifani Amenta Tayebati Metabolic syndrome (MetS) is a predictor of cardiovascular diseases, commonly associated with oxidative stress and inflammation. However, the pathogenic mechanisms are not yet fully elucidated. The aim of the study is...
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IJMS, Vol. 21, Pages 2027: Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview International Journal of Molecular Sciences doi: 10.3390/ijms21062027 Authors: Torres Abdullah Brol Hellerbrand Fernandez Fiorotto Klein Königshofer Liedtke Lotersztajn Nevzorova Schierwagen Reiberger Uschner Tacke Weiskirchen Trebicka Molecular and cellular research modalities for the study of liver pathologies have...
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IJMS, Vol. 21, Pages 2028: Defects in Galactose Metabolism and Glycoconjugate Biosynthesis in a UDP-Glucose Pyrophosphorylase-Deficient Cell Line Are Reversed by Adding Galactose to the Growth Medium International Journal of Molecular Sciences doi: 10.3390/ijms21062028 Authors: Durrant Fuehring Willemetz Chrétien Sala Ghidoni Katz Rötig Thelestam Ermonval Moore UDP-glucose (UDP-Glc) is synthesized by UGP2-encoded UDP-Glc pyrophosphorylase (UGP)...
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IJMS, Vol. 21, Pages 2026: Regulating Divergent Transcriptomes through mRNA Splicing and Its Modulation Using Various Small Compounds International Journal of Molecular Sciences doi: 10.3390/ijms21062026 Authors: Ken-ichi Fujita Takaki Ishizuka Mizuki Mitsukawa Masashi Kurata Seiji Masuda Human transcriptomes are more divergent than genes and contribute to the sophistication of life. This divergence is derived from various isoforms arising from alternative splicing. In addition,...
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IJMS, Vol. 21, Pages 2023: Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain International Journal of Molecular Sciences doi: 10.3390/ijms21062023 Authors: Gyeong Joon Moon Minsang Shin Sang Ryong Kim Ras homolog protein enriched in brain (Rheb) is a key activator of mammalian target of rapamycin complex 1 (mTORC1). The activation of mTORC1 by Rheb is associated with various processes such as protein synthesis, neuronal growth, differentiation, axonal...
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IJMS, Vol. 21, Pages 2025: Validation of Liquid Chromatography-Tandem Mass Spectrometry-Based 5-Plex Assay for Mucopolysaccharidoses International Journal of Molecular Sciences doi: 10.3390/ijms21062025 Authors: Tsubasa Oguni Shunji Tomatsu Misa Tanaka Kenji Orii Toshiyuki Fukao Jun Watanabe Seiji Fukuda Yoshitomo Notsu Dung Chi Vu Thi Bich Ngoc Can Atsushi Nagai Seiji Yamaguchi Takeshi Taketani Michael H. Gelb Hironori Kobayashi Mucopolysaccharidoses...
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IJMS, Vol. 21, Pages 2024: Pituitary Hyperplasia, Hormonal Changes and Prolactinoma Development in Males Exposed to Estrogens—An Insight From Translational Studies International Journal of Molecular Sciences doi: 10.3390/ijms21062024 Authors: Branka Šošić-Jurjević Vladimir Ajdžanović Dragana Miljić Svetlana Trifunović Branko Filipović Sanja Stanković Sergey Bolevich Vladimir Jakovljević Verica Milošević Estrogen signaling plays an important role in pituitary development...
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IJMS, Vol. 21, Pages 2017: The Impact of Natural Compounds on S-Shaped Aβ42 Fibril: From Molecular Docking to Biophysical Characterization International Journal of Molecular Sciences doi: 10.3390/ijms21062017 Authors: Stefano Muscat Lorenzo Pallante Filip Stojceski Andrea Danani Gianvito Grasso Marco Agostino Deriu The pursuit for effective strategies inhibiting the amyloidogenic process in neurodegenerative disorders, such as Alzheimer’s disease (AD), remains...
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IJMS, Vol. 21, Pages 2021: On the Trail of Tetu1: Genome-Wide Discovery of CACTA Transposable Elements in Sunflower Genome International Journal of Molecular Sciences doi: 10.3390/ijms21062021 Authors: Maria Ventimiglia Claudio Pugliesi Alberto Vangelisti Gabriele Usai Tommaso Giordani Lucia Natali Andrea Cavallini Flavia Mascagni Much has been said about sunflower (Helianthus annuus L.) retrotransposons, representing the majority of the sunflower’s repetitive component....
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IJMS, Vol. 21, Pages 2022: Role of Autophagy in Von Willebrand Factor Secretion by Endothelial Cells and in the In Vivo Thrombin-Antithrombin Complex Formation Promoted by the HIV-1 Matrix Protein p17 International Journal of Molecular Sciences doi: 10.3390/ijms21062022 Authors: Antonella Bugatti Stefania Marsico Pietro Mazzuca Kai Schulze Thomas Ebensen Cinzia Giagulli Esther Peña Lina Badimón Mark Slevin Arnaldo Caruso Carlos A. Guzman Francesca Caccuri ...
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IJMS, Vol. 21, Pages 2015: Lysophosphatidic Acid and Hematopoiesis: From Microenvironmental Effects to Intracellular Signaling International Journal of Molecular Sciences doi: 10.3390/ijms21062015 Authors: Kuan-Hung Lin Jui-Chung Chiang Ya-Hsuan Ho Chao-Ling Yao Hsinyu Lee Vertebrate hematopoiesis is a complex physiological process that is tightly regulated by intracellular signaling and extracellular microenvironment. In recent decades, breakthroughs in lineage-tracing technologies...
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IJMS, Vol. 21, Pages 2020: Correlative Monitoring of Immune Activation and Tissue Damage in Malignant Melanoma—An Algorithm for Identification of Tolerance Breakage During Immune Checkpoint Inhibitor Therapy of Cancer International Journal of Molecular Sciences doi: 10.3390/ijms21062020 Authors: Renate U. Wahl Marike Leijs Arturo Araujo Albert Rübben We describe an innovative approach for identification of tolerance breakage during immune checkpoint inhibitor therapy in malignant...
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IJMS, Vol. 21, Pages 2019: Comprehensive Genome Analysis on the Novel Species Sphingomonas panacis DCY99T Reveals Insights into Iron Tolerance of Ginseng International Journal of Molecular Sciences doi: 10.3390/ijms21062019 Authors: Yeon-Ju Kim Joon Young Park Sri Renukadevi Balusamy Yue Huo Linh Khanh Nong Hoa Thi Le Deok Chun Yang Donghyuk Kim Plant growth-promoting rhizobacteria play vital roles not only in plant growth, but also in reducing biotic/abiotic stress....
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IJMS, Vol. 21, Pages 2018: A Silent Exonic Mutation in a Rice Integrin-α FG-GAP Repeat-Containing Gene Causes Male-Sterility by Affecting mRNA Splicing International Journal of Molecular Sciences doi: 10.3390/ijms21062018 Authors: Ting Zou Dan Zhou Wenjie Li Guoqiang Yuan Yang Tao Zhiyuan He Xu Zhang Qiming Deng Shiquan Wang Aiping Zheng Jun Zhu Yueyang Liang Huainian Liu Aijun Wang Lingxia Wang Ping Li Shuangcheng Li Pollen development...
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IJMS, Vol. 21, Pages 2016: Affinity-Bead Assisted Mass Spectrometry (Affi-BAMS): A Multiplexed Microarray Platform for Targeted Proteomics International Journal of Molecular Sciences doi: 10.3390/ijms21062016 Authors: Hamza Bergo Mamaev Wojchowski Toran Worsfold Castaldi Silva The ability to quantitatively probe diverse panels of proteins and their post-translational modifications (PTMs) across multiple samples would aid a broad spectrum of biological, biochemical...
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IJMS, Vol. 21, Pages 2014: Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes International Journal of Molecular Sciences doi: 10.3390/ijms21062014 Authors: Shuai Wang Hao Cheng Linlin Wang Rui Zhao Dawei Guan Increasing evidence indicates that human exposure to inorganic arsenic causes cutaneous diseases and skin cancers. Nuclear factor erythroid 2-like 1 (NRF1) belongs to the cap “n”...
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IJMS, Vol. 21, Pages 2012: Role of microRNAs in the Development of Cardiovascular Disease in Systemic Autoimmune Disorders International Journal of Molecular Sciences doi: 10.3390/ijms21062012 Authors: Chary Lopez-Pedrera Nuria Barbarroja Alejandra Mª Patiño-Trives Maria Luque-Tévar Carmen Torres-Granados Mª Angeles Aguirre-Zamorano Eduardo Collantes-Estevez Carlos Pérez-Sánchez Rheumatoid Arthritis (RA), Systemic lupus erythematosus (SLE) and antiphospholipid syndrome...
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IJMS, Vol. 21, Pages 2013: Norepinephrine Regulation of Ventromedial Hypothalamic Nucleus Metabolic-Sensory Neuron 5′-AMP-Activated Protein Kinase Activity: Impact of Estradiol International Journal of Molecular Sciences doi: 10.3390/ijms21062013 Authors: A. S. M. Hasan Mahmood Md. Main Uddin Mostafa M. H. Ibrahim Karen P. Briski The mediobasal hypothalamus (MBH) shapes the neural regulation of glucostasis by 5′-AMP-activated protein kinase (AMPK)-dependent mechanisms....
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IJMS, Vol. 21, Pages 2011: The Fibroblast Growth Factor Receptors in Breast Cancer: from Oncogenesis to Better Treatments International Journal of Molecular Sciences doi: 10.3390/ijms21062011 Authors: Sobhani Navid Chunmei Fan Pedro O. Flores-Villanueva Daniele Generali Yong Li Breast cancer (BC) is the most frequent form of malignancy and second only to lung cancer as cause of deaths in women. Notwithstanding many progresses made in the field, metastatic BC has a very poor...
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IJMS, Vol. 21, Pages 2010: Adiponectin and Cognitive Decline International Journal of Molecular Sciences doi: 10.3390/ijms21062010 Authors: Rizzo Fasano Paolisso Adiponectin (ADPN) is a plasma protein secreted by adipose tissue showing pleiotropic effects with anti-diabetic, anti-atherogenic, and anti-inflammatory properties. Initially, it was thought that the main role was only the metabolism control. Later, ADPN receptors were also found in the central nervous system (CNS)....
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IJMS, Vol. 21, Pages 2009: Potential Mechanisms of AtNPR1 Mediated Resistance against Huanglongbing (HLB) in Citrus International Journal of Molecular Sciences doi: 10.3390/ijms21062009 Authors: Wenming Qiu Juliana Soares Zhiqian Pang Yixiao Huang Zhonghai Sun Nian Wang Jude Grosser Manjul Dutt Huanglongbing (HLB), a bacterial disease caused by Candidatus Liberibacter asiaticus (CLas), is a major threat to the citrus industry. In a previous study conducted by our...
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IJMS, Vol. 21, Pages 2008: The Role of Autophagy and Autophagy Receptor NDP52 in Microbial Infections International Journal of Molecular Sciences doi: 10.3390/ijms21062008 Authors: Shuangqi Fan Keke Wu Mengpo Zhao Erpeng Zhu Shengming Ma Yuming Chen Hongxing Ding Lin Yi Mingqiu Zhao Jinding Chen Autophagy is a general protective mechanism for maintaining homeostasis in eukaryotic cells, regulating cellular metabolism, and promoting cell survival by degrading...
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JCM, Vol. 9, Pages 811: Cervical Myelopathy in Patients Suffering from Rheumatoid Arthritis—A Case Series of 9 Patients and A Review of the Literature Journal of Clinical Medicine doi: 10.3390/jcm9030811 Authors: Insa Janssen Aria Nouri Enrico Tessitore Bernhard Meyer Cervical myelopathy occurs in approximately 2.5% of patients suffering from rheumatoid arthritis (RA) and is associated with notable morbidity and mortality. However, the surgical management of patients affected...
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JCM, Vol. 9, Pages 810: Understanding Primary Ciliary Dyskinesia: Experience From a Mediterranean Diagnostic Reference Centre Journal of Clinical Medicine doi: 10.3390/jcm9030810 Authors: Miguel Armengot-Carceller Ana Reula Manuel Mata-Roig Jordi Pérez-Panadés Lara Milian-Medina Carmen Carda-Batalla Background: Due to the lack of a gold standard diagnostic test, reference centres with experienced personnel and costly procedures are needed for primary ciliary dyskinesia...
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JCM, Vol. 9, Pages 808: Platelet Counting: Ugly Traps and Good Advice. Proposals from the French-Speaking Cellular Hematology Group (GFHC) Journal of Clinical Medicine doi: 10.3390/jcm9030808 Authors: Baccini Geneviève Jacqmin Chatelain Girard Wuilleme Vedrenne Guiheneuf Toussaint-Hacquard Everaere Soulard Lesesve Bardet Despite the ongoing development of automated hematology analyzers to optimize complete blood count results, platelet...
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JCM, Vol. 9, Pages 809: Comparative In Vitro Study of Various α2-Adrenoreceptor Agonist Drugs for Ticagrelor Reversal Journal of Clinical Medicine doi: 10.3390/jcm9030809 Authors: Guillaume Porta Bonete Anne Godier Pascale Gaussem Tiphaine Belleville-Rolland Alexandre Leuci Sonia Poirault-Chassac Christilla Bachelot-Loza Anne-Céline Martin Ticagrelor, an antiplatelet adenosine diphosphate (ADP)-P2Y12 receptor antagonist, increases the risk of bleeding. Its management...
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JCM, Vol. 9, Pages 804: Effect of Low Intensity Pulsed Ultrasound (LIPUS) on Tooth Movement and Root Resorption: A Prospective Multi-Center Randomized Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm9030804 Authors: Tarek El-Bialy Khaled Farouk Terry D. Carlyle William Wiltshire Robert Drummond Tim Dumore Kevin Knowlton Bryan Tompson The aim of this study was to evaluate the possible effect of low intensity pulsed ultrasound (LIPUS) on tooth movement...
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JCM, Vol. 9, Pages 806: Anatomical Considerations of Intramedullary Humeral Nailing and Lengthening Journal of Clinical Medicine doi: 10.3390/jcm9030806 Authors: Gilbert Manuel Schwarz Lukas Zak Lena Hirtler Gerald Eliot Wozasek Intramedullary lengthening, in cases of extensive humeral shortening, offers the advantages of preventing external-fixator-associated problems. The humeral cavity, as the main parameter in nailing, however, has been neglected in recent literature. It...
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JCM, Vol. 9, Pages 805: Does Treating Hearing Loss in Older Adults Improve Cognitive Outcomes? A Review Journal of Clinical Medicine doi: 10.3390/jcm9030805 Authors: Hélène Amieva Camille Ouvrard Hearing loss is the third most prevalent health condition in older age. In recent years, research has consistently reported an association between hearing loss and mental health outcomes, including poorer cognitive performances. Whether treating hearing loss in elders improves cognition has...
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JCM, Vol. 9, Pages 807: Acute Phase Proteins and Vitamin D Seasonal Variation in End-Stage Renal Disease Patients Journal of Clinical Medicine doi: 10.3390/jcm9030807 Authors: Małgorzata Maraj Paulina Hetwer Paulina Dumnicka Piotr Ceranowicz Małgorzata Mazur-Laskowska Anna Ząbek-Adamska Zygmunt Warzecha Beata Kuśnierz-Cabala Marek Kuźniewski End-stage renal disease (ESRD) patients are vulnerable to vitamin D deficiency due to impaired renal hydroxylation, low...
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JCM, Vol. 9, Pages 803: Ultrasonographic Changes of Major Salivary Glands in Primary Sjögren’s Syndrome Journal of Clinical Medicine doi: 10.3390/jcm9030803 Authors: Kyung-Ann Lee Sang-Heon Lee Hae-Rim Kim We aimed to evaluate the changes over time in salivary gland (SG) abnormalities by ultrasound (US) in patients with primary Sjögren’s syndrome (pSS). Patients with pSS (n = 70) and idiopathic sicca syndrome (n = 18) underwent baseline salivary gland ultrasound...
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JCM, Vol. 9, Pages 802: Landscape of Tumor Suppressor Mutations in Acute Myeloid Leukemia Journal of Clinical Medicine doi: 10.3390/jcm9030802 Authors: Panuzzo Signorino Calabrese Ali Petiti Bracco Cilloni Acute myeloid leukemia is mainly characterized by a complex and dynamic genomic instability. Next-generation sequencing has significantly improved the ability of diagnostic research to molecularly characterize and stratify patients. This detailed outcome allowed...
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