Head & NeckA pilot study of the pan‐class I PI3K inhibitor buparlisib in combination with cetuximab in patients with recurrent or metastatic head and neck cancerAbstract Background This study assessed the maximum tolerated dose (MTD) of the PI3K inhibitor buparlisib given concurrently with cetuximab in recurrent and metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). Methods Twelve patients with R/M HNSCC were enrolled. Patients were given oral buparlisib starting day 7 and daily...
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bioRxiv Subject Collection: Evolutionary BiologyThe effect of autopolyploidy on population genetic signals of hard sweeps [NEW RESULTS]Searching for the population genomic signals left behind by positive selection is a major focus of evolutionary biology, particularly as sequencing technologies develop and costs decline. The effect of the number of chromosome copies (i.e. ploidy) on the manifestation of these signals remains an outstanding question, despite a wide appreciation of ploidy being a...
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QJM: An International Journal of MedicineReport of the 113th Annual Meeting of the Association of Physicians of Great Britain and IrelandQJM: An International Journal of Medicine03:00Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and IrelandQJM: An International Journal of Medicine03:00Treating chronic cough—the definitive reviewThe QJM has provided a platform for publishing outstanding 'State-of-the-Art' clinical reviews1–4 and we continue...
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Photoelectron Spectroscopy and Theoretical Studies of PCSe−, AsCS−, AsCSe−, and NCSe−: Insights into the Electronic Structures of the Whole Family of ECX− Anions (E=N, P, As; X=O, S, Se)Heavyweights: Four heavier homologues ECX− (E=N, P, As; X=O, S, Se) of the cyanate anion have been investigated using negative‐ion photoelectron spectroscopy, photoelectron‐imaging spectroscopy, and quantum‐chemical computations. The measured electron affinities (EAs) and spin–orbit (SO) splittings serve as critical...
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Post-diagnostic allied health interventions for people with dementia in Australia: a spotlight on current practiceThe Clinical Practice Guidelines for Dementia in Australia provide evidence-based recommendations for the assessment, diagnosis, and care of people with dementia and their informal carers. The extent to which ...BMC Research NotesWed Sep 04, 2019 03:00Accuracy of prescribing documentation by UK junior doctors undertaking psychiatry placements: a multi-centre observational studyMedical...
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Journal of Medical Case Reports - Latest ArticlesEosinophilic esophagitis presenting with spontaneous esophageal rupture: a case reportEosinophilic esophagitis, once considered a rare disorder, has been increasingly recognized as a leading cause of dysphagia and food impaction in children and adults over the last few decades. It predominantly...Journal of Medical Case Reports - Latest ArticlesTue Sep 03, 2019 03:00Mark above section as read JoVE: Journal of Visualized ExperimentsPooled CRISPR-Based...
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Behaviorally conditioned immunosuppression with cyclosporine A forms long lasting memory tracePublication date: Available online 3 September 2019Source: Behavioural Brain ResearchAuthor(s): Tina Hörbelt, Elian Mireille Martínez-Gómez, Martin Hadamitzky, Manfred Schedlowski, Laura LückemannAbstractBehaviorally conditioned taste avoidance (CTA) paradigms using the novel taste saccharin as a conditioned stimulus (CS) and the immunosuppressive drug cyclosporine A (CsA) as unconditioned stimulus (US)...
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LarynxChondrolaryngoplasty-Thyroid Cartilage Reduction.Related ArticlesChondrolaryngoplasty-Thyroid Cartilage Reduction. Facial Plast Surg Clin North Am. 2019 May;27(2):267-272 Authors: Sturm A, Chaiet SR Abstract Chondrolaryngoplasty, also known as tracheal shave, is a surgical procedure performed for a prominent Adam's apple, usually in transfeminine patients with gender dysphoria to this marker of male sex. Although laryngeal anatomy is complex, knowledge of landmarks and techniques discussed...
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pubmed: "world neurosurg"[jo...A Novel Concept and Device for Holding the Rotational Hemostasis Valve during Neuroendovascular Procedures.Related ArticlesA Novel Concept and Device for Holding the Rotational Hemostasis Valve during Neuroendovascular Procedures. World Neurosurg. 2019 Aug 31;: Authors: Ohshima T, Nagano Y, Tadauchi H, Mase T, Miyachi S Abstract BACKGROUND: Hemostasis valves are commonly used in neurointerventions. We propose a novel concept for fixing hemostasis valves to the operating...
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pubmed: epilepsy treatmentPropofol-dexmedetomidine versus propofol-remifentanil conscious sedation for awake craniotomy during epilepsy surgery.Related ArticlesPropofol-dexmedetomidine versus propofol-remifentanil conscious sedation for awake craniotomy during epilepsy surgery. Minerva Anestesiol. 2017 Dec;83(12):1248-1254 Authors: Elbakry AE, Ibrahim E Abstract BACKGROUND: Conscious sedation during awake craniotomy requires balanced anesthesia technique to achieve optimum sedation and analgesia....
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pubmed: epilepsy treatmentPropofol-dexmedetomidine versus propofol-remifentanil conscious sedation for awake craniotomy during epilepsy surgery.Related ArticlesPropofol-dexmedetomidine versus propofol-remifentanil conscious sedation for awake craniotomy during epilepsy surgery. Minerva Anestesiol. 2017 Dec;83(12):1248-1254 Authors: Elbakry AE, Ibrahim E Abstract BACKGROUND: Conscious sedation during awake craniotomy requires balanced anesthesia technique to achieve optimum sedation and analgesia....
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AudiologyDatabank on Pediatric Hearing Loss Goes GlobalA new research has published the Victorian Childhood Hearing Impairment Longitudinal Databank (VicCHILD), which promises to help researchers across the globe in understanding why some children with hearing loss adapt and thrive better than others. The databank containing profiles children with hearing loss shows that language development and speech in hearing-impaired children are slower compared with the development of children with normal...
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Sonographic Evaluation of Genitourinary Inflammatory Pseudotumors and Its Mimics.Related ArticlesSonographic Evaluation of Genitourinary Inflammatory Pseudotumors and Its Mimics. Ultrasound Q. 2019 Jul 17;: Authors: Forrest A, Numbere N, Jean-Gilles J, Dogra V Abstract Inflammatory pseudotumor is a relatively rare, nonneoplastic lesion composed of inflammatory cells and myofibroblastic spindle cells that can be identified on sonographic evaluation of the genitourinary system. These lesions are thought...
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Poor Outcome Could Be Predicted by Lower Monocyte Human Leukocyte Antigen-DR Expression in Patients with Complicated Intra-Abdominal Infections: A ReviewSurgical Infections, Ahead of Print.Surgical InfectionsWed Sep 04, 2019 10:00The diversity and commonalities of the radiation-resistance mechanisms of Deinococcus and its up-to-date applicationsDeinococcus is an extremophilic microorganism found in a wide range of habitats, including hot springs, radiation-contaminated areas, Antarctic soils, deserts,...
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Efficacy and Safety of Ablative Resurfacing With A High‐Energy 1,064 Nd‐YAG Picosecond‐domain Laser for the Treatment of Facial Acne Scars in AsiansObjectives There have been few studies regarding the use of a picosecond‐domain laser for acne scars in Asians. This prospective study evaluated the efficacy and safety of a high‐energy 1,064 nm Nd:YAG picosecond‐domain laser for ablation and resurfacing of facial acne scars in Asians. Methods Subjects were treated with a 1,064 nm picosecond laser (8 mm...
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CD47 promotes cell growth and motility in epithelial ovarian cancerPublication date: November 2019Source: Biomedicine & Pharmacotherapy, Volume 119Author(s): Chiu-Lin Wang, Ming-Jie Lin, Chia-Yi Hsu, Hsiao-Yun Lin, Hung-Pei Tsai, Cheng-Yu Long, Eing-Mei Tsai, Tsung-Hua Hsieh, Chin-Hu WuAbstractEndometriosis is considered a high risk factor for the development of ovarian carcinoma, including clear cell and endometrioid malignancies. The mechanism by which endometriosis-associated ovarian cancer...
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Functional restoration of elbow flexion in nonobstetric brachial plexus injuries: A meta‐analysis...
Functional restoration of elbow flexion in nonobstetric brachial plexus injuries: A meta‐analysis of nerve transfers versus graftsBackground Restoration of elbow flexion is the priority in traumatic brachial plexus injuries. Surgical approaches commonly include nerve transfers and nerve grafting. Our objective was to evaluate the safety and efficacy profile of nerve transfers versus grafting for traumatic nonobstetric brachial plexus injuries. Methods This systematic literature review was performed...
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Stress effects on learning and feedback‐related neural activity depend on feedback delay Abstract...
Stress effects on learning and feedback‐related neural activity depend on feedback delayAbstract Depending on feedback timing, the neural structures involved in learning differ, with the dopamine system including the dorsal striatum and anterior cingulate cortex (ACC) being more important for learning from immediate than delayed feedback. As stress has been shown to promote striatum‐dependent learning, the current study aimed to explore if stress differentially affects learning from and processing...
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Clinical outcomes and prognostic factor analysis after salvage surgery for recurrent squamous cell carcinoma of the oral cavityThe purpose of this study was to analyze the oncological outcomes and predictive factors for successful curative salvage surgery after recurrent oral cavity squamous cell carcinoma. A retrospective study was conducted involving 73 patients who received surgery-based salvage treatment. The pattern of failure for primary treatment was local failure in 29 patients, regional...
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Clinical outcomes and prognostic factor analysis after salvage surgery for recurrent squamous cell carcinoma of the oral cavityThe purpose of this study was to analyze the oncological outcomes and predictive factors for successful curative salvage surgery after recurrent oral cavity squamous cell carcinoma. A retrospective study was conducted involving 73 patients who received surgery-based salvage treatment. The pattern of failure for primary treatment was local failure in 29 patients, regional...
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Orientation of the premaxilla in the origin of septal deviationAbstract Introduction While most people believe the nasal septum to have intrinsic deviation and overgrowth in patients seeking rhinoplasty, an alternative concept is that a mal-oriented premaxilla causes extrinsic septal buckling and external extrusion of the septal cartilage. In this sense, the premaxillary bone plays a significant role in the pathogenesis of septal deviation. This study was performed to determine if non-traumatically...European...
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Telomere length is associated with disability progression in multiple sclerosisAbstract Objective To assess whether biological aging as measured by leukocyte telomere length (LTL) is associated with clinical disability and brain volume loss in multiple sclerosis (MS). Methods Adults with MS/CIS in the UCSF‐EPIC cohort study were included. LTL was measured on DNA samples by quantitative PCR and expressed as telomere to somatic DNA ratio (T/S). Expanded Disability Status Scale (EDSS) and 3D T1‐weighted...
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Vendors Used in CT and MRI Neuroradiology Research [LETTERS]American Journal of Neuroradiology current issueWed Sep 04, 2019 18:00Reply: [LETTERS]American Journal of Neuroradiology current issueWed Sep 04, 2019 18:00Celebrating 35 Years of the AJNR: September 1984 edition [35 YEARS AGO IN AJNR]American Journal of Neuroradiology current issueWed Sep 04, 2019 18:00Can Trace-Weighted Images Be Used to Estimate Diffusional Kurtosis Imaging-Derived Indices of Non-Gaussian Water Diffusion in Head and Neck...
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A Smartphone-Based Weber Test May Discriminate between a Conductive and a Sensorineural Hearing Loss.Related ArticlesA Smartphone-Based Weber Test May Discriminate between a Conductive and a Sensorineural Hearing Loss. Audiol Neurootol. 2019 Sep 03;:1-6 Authors: Ungar OJ, Handzel O, Cavel O, Oron Y Abstract OBJECTIVE: The aim of this paper was to compare the accuracy of a smartphone-based Weber test (SPWT) with the traditional tuning fork Weber test (TFWT) in identifying and differentiating between...
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Obituary: Antonio Richieri‐Costa (1946–2019)American Journal of Medical Genetics Part AWed Sep 04, 2019 17:37Multiple Functions of the Essential Gene PpV in Drosophila Early DevelopmentProtein phosphatase V (PpV) encodes the Drosophila homologue of the evolutionarily conserved Protein Phosphatase 6 (PP6). The physiological and developmental functions of PpV/PP6 have not been well characterized due to lack of a genetically defined mutant. Here, we identified a PpV non-sense mutation and describe multiple...
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Evaluating the July Effect in Oral and Maxillofacial Surgery: Part II – Orthognathic SurgeryPublication date: Available online 4 September 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Hossein E. Jazayeri, Thomas Xu, Nima Khavanin, Amir H. Dorafshar, Zachary S. PeacockAbstractPurposeThe purpose of this study was to determine if there is an increased postoperative complication rate in orthognathic surgery during the first academic quarter (July - September).MethodsThe American College...
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Olaparib in the treatment of ovarian cancer. Related ArticlesOlaparib in the treatment of ovarian...
Olaparib in the treatment of ovarian cancer.Related ArticlesOlaparib in the treatment of ovarian cancer. Future Oncol. 2019 Sep 03;: Authors: Washington CR, Richardson DL, Moore KN Abstract The poly ADP ribose polymerase olaparib is currently approved in front line BRCA-associated epithelial ovarian cancer (EOC), platinum-sensitive recurrence agnostic to BRCA status and for gBRCA as treatment in the fourth line and beyond. Women who are diagnosed with advanced stage EOC face a formidable challenge...Future...
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Automated extraction of treatment patterns from social media posts: an exploratory analysis in renal cell carcinomaFuture Oncology, Ahead of Print.Future OncologyWed Sep 04, 2019 04:22Cancers, Vol. 11, Pages 1307: Comment on "Osteopontin, Macrophage Migration Inhibitory Factor and Anti-Interleukin-8 Autoantibodies Complement CA125 for Detection of Early Stage Ovarian Cancer" Cancers 2019, 11, 596: Markers for Early Detection of Ovarian CancerCancers, Vol. 11, Pages 1307: Comment on "Osteopontin,...
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A multiplexed FRET aptasensor for simultaneous detection of mycotoxins with magnetically controlled graphene oxide/Fe3O4 as single energy acceptor†Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01593K, PaperChengquan Wang, Xingyi Huang, Xiaoyu Tian, Xiaorui Zhang, Shanshan Yu, Xianhui Chang, Yi Ren, Jing QianAflatoxin B1 (AFB1) and fumonisin B1 (FB1) are the most common mycotoxins and often coexist in agricultural products, which are known to be a toxic superposition and even carcinogenic effects...The...
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External Quality Assurance of Current Technology for the Testing of Cancer-Associated Circulating...
External Quality Assurance of Current Technology for the Testing of Cancer-Associated Circulating Free DNA VariantsAbstract Liquid biopsy testing is rapidly emerging as a diagnostic means of identifying circulating free DNA (cfDNA) disease-associated variants. However, the reporting of cfDNA variants remains inconsistent due in part to the application of multiple testing pipelines which raise uncertainty about current cfDNA detection efficiency. External quality assurance (EQA) programs are required...
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Environmental Exposures and Asthma in Active Duty Service MembersAbstract Purpose of Review Reports of respiratory symptoms, including asthma and hyper-reactive airway disease, have been more numerous in the media and medical literature since active duty service members (SM) began to support campaigns in South West Asia (SWA). Numerous environmental exposures have been reported and this review assesses the available evidence surrounding exposures, confounding conditions, and attempts to develop...Current...
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Νόσος Αλτσχάιμερ: Η «ορμόνη της πείνας» μπορεί να οδηγήσει σε νέα θεραπείαΕπιστήμονες από το Πανεπιστήμιο του Τέξας βρήκαν στοιχεία που υποδεικνύουν ότι η αντίσταση στην «ορμόνη της πείνας», τη γκρελίνη που βρίσκεται στον εγκέφαλο, συνδέεται με γνωστικές βλάβες και απώλεια μνήμης, φαινόμενα σχετικά με τη νόσο Αλτσχάιμερ. Τα ευρήματα της έρευνας που δημοσιεύθηκε στο Science Translational Medicine υποδεικνύουν επίσης μια πιθανή θεραπευτική στρατηγική για την νευροεκφυλιστική διαταραχή που δεν επιδέχεται...
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Nutrients, Vol. 11, Pages 2088: A Multi-Year Examination of Gardening Experience and Fruit and Vegetable Intake During CollegeNutrients, Vol. 11, Pages 2088: A Multi-Year Examination of Gardening Experience and Fruit and Vegetable Intake During College Nutrients doi: 10.3390/nu11092088 Authors: Daniel Staub Sarah E. Colby Melissa D. Olfert Kendra Kattelmann Wenjun Zhou Tanya M. Horacek Geoffrey W. Greene Ivana Radosavljevic Lisa Franzen-Castle Anne E. Mathews Gardening has been positively associated...
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International Journal of Molecular SciencesIJMS, Vol. 20, Pages 4349: Inhibition of Mitochondrial Complex I Impairs Release of α-Galactosidase by Jurkat CellsIJMS, Vol. 20, Pages 4349: Inhibition of Mitochondrial Complex I Impairs Release of α-Galactosidase by Jurkat Cells International Journal of Molecular Sciences doi: 10.3390/ijms20184349 Authors: Jonathan R. A. Lambert Steven J. Howe Ahad A. Rahim Derek G. Burke Simon J. R. Heales Fabry disease (FD) is caused by mutations in the GLA gene that...
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International Journal of Molecular SciencesIJMS, Vol. 20, Pages 4340: Inhibition of Tyrosine-Phosphorylated STAT3 in Human Breast and Lung Cancer Cells by Manuka Honey is Mediated by Selective Antagonism of the IL-6 ReceptorIJMS, Vol. 20, Pages 4340: Inhibition of Tyrosine-Phosphorylated STAT3 in Human Breast and Lung Cancer Cells by Manuka Honey is Mediated by Selective Antagonism of the IL-6 Receptor International Journal of Molecular Sciences doi: 10.3390/ijms20184340 Authors: Priyanka Aryappalli...
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Geriatrics, Vol. 4, Pages 50: The Attitudes Towards the Use of Restraint and Restrictive Intervention Amongst Healthcare Staff on Acute Medical and Frailty Wards—A Brief Literature ReviewGeriatrics, Vol. 4, Pages 50: The Attitudes Towards the Use of Restraint and Restrictive Intervention Amongst Healthcare Staff on Acute Medical and Frailty Wards—A Brief Literature Review Geriatrics doi: 10.3390/geriatrics4030050 Authors: Gunawardena Smithard Restraint in modern non-psychiatric-based healthcare is...
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Antibiotics, Vol. 8, Pages 138: Bacteriophages as Alternatives to Antibiotics in Clinical CareAntibiotics, Vol. 8, Pages 138: Bacteriophages as Alternatives to Antibiotics in Clinical Care Antibiotics doi: 10.3390/antibiotics8030138 Authors: Danitza Romero-Calle Raquel Guimarães Benevides Aristóteles Góes-Neto Craig Billington Antimicrobial resistance is increasing despite new treatments being employed. With a decrease in the discovery rate of novel antibiotics, this threatens to take humankind back...
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