Accuracy of position determination in Ca^{2+} signaling.

Accuracy of position determination in Ca^{2+} signaling.:

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Accuracy of position determination in Ca^{2+} signaling.

Phys Rev E. 2019 Aug;100(2-1):022401

Authors: Wasnik VH, Lipp P, Kruse K

Abstract

A living cell senses its environment and responds to external signals. In this paper, we study theoretically the precision at which cells can determine the position of a spatially localized transient extracellular signal. To this end, we focus on the case where the stimulus is converted into the release of a small molecule that acts as a second messenger, for example, Ca^{2+}, and activates kinases that change the activity of enzymes by phosphorylating them. We analyze the spatial distribution of phosphorylation events using stochastic simulations as well as a mean-field approach. Kinases that need to bind to the cell membrane for getting activated provide more accurate estimates than cytosolic kinases. Our results could explain why the rate of Ca^{2+} detachment from the membrane-binding conventional protein kinase Cα is larger than its phosphorylation rate.

PMID: 31574643 [PubMed - in process]