Antibiotics, Vol. 8, Pages 183: The Long-Term Persistence of Borrelia burgdorferi Antigens and DNA in the Tissues of a Patient with Lyme Disease Antibiotics doi: 10.3390/antibiotics8040183 Authors: Eva Sapi Rumanah S. Kasliwala Hebo Ismail Jason P. Torres Michael Oldakowski Sarah Markland Gauri Gaur Anthony Melillo Klaus Eisendle Kenneth B. Liegner Jenny Libien James E. Goldman Whether Borrelia burgdorferi, the causative agent of Lyme disease, can persist...
Fri Oct 11, 2019 03:00
Antibiotics, Vol. 8, Pages 182: Phage-Antibiotic Combination Treatments: Antagonistic Impacts of Antibiotics on the Pharmacodynamics of Phage Therapy? Antibiotics doi: 10.3390/antibiotics8040182 Authors: Stephen T. Abedon Bacteria can evolve resistance to antibiotics. Even without changing genetically, bacteria also can display tolerance to antibiotic treatments. Many antibiotics are also broadly acting, as can result in excessive modifications of body microbiomes. Particularly for antibiotics...
Fri Oct 11, 2019 03:00
Antibodies, Vol. 8, Pages 50: NR4A Expression by Human Marginal Zone B-Cells Antibodies doi: 10.3390/antib8040050 Authors: Kim Doyon-Laliberté Josiane Chagnon-Choquet Michelle Byrns Matheus Aranguren Meriam Memmi Pavel Chrobak John Stagg Johanne Poudrier Michel Roger We have previously characterized a human blood CD19+CD1c+IgM+CD27+CD21loCD10+ innate-like B-cell population, which presents features shared by both transitional immature and marginal zone (MZ) B-cells,...
Fri Oct 11, 2019 03:00
Antioxidants, Vol. 8, Pages 477: Experimental and Computational Study of the Antioxidative Potential of Novel Nitro and Amino Substituted Benzimidazole/Benzothiazole-2-Carboxamides with Antiproliferative Activity Antioxidants doi: 10.3390/antiox8100477 Authors: Maja Cindrić Irena Sović Marija Mioč Lucija Hok Ida Boček Petra Roškarić Kristina Butković Irena Martin-Kleiner Kristina Starčević Robert Vianello Marijeta Kralj Marijana Hranjec We present the...
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Antioxidants, Vol. 8, Pages 475: Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways Antioxidants doi: 10.3390/antiox8100475 Authors: J. Catharina Duvigneau Harald Esterbauer Andrey V. Kozlov The heme oxygenase (HO) system is essential for heme and iron homeostasis and necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon monoxide (CO) and ferrous iron. Although mostly beneficial, the HO reaction can also produce deleterious effects, predominantly...
Fri Oct 11, 2019 03:00
Antioxidants, Vol. 8, Pages 476: Coordination Complex Formation and Redox Properties of Kynurenic and Xanthurenic Acid Can Affect Brain Tissue Homeodynamics Antioxidants doi: 10.3390/antiox8100476 Authors: Lenka Kubicova Franz Hadacek Gert Bachmann Wolfram Weckwerth Vladimir Chobot Reactive oxygen species (ROS) are known for their participation in various physiological and pathological processes in organisms, including ageing or degeneration. Kynurenine pathway metabolites,...
Fri Oct 11, 2019 03:00
Antioxidants, Vol. 8, Pages 474: A New Natural Antioxidant Biomaterial from Cinnamomum osmophloeum Kanehira Leaves Represses Melanogenesis and Protects against DNA Damage Antioxidants doi: 10.3390/antiox8100474 Authors: Yung-Shu Ho Jane-Yii Wu Chi-Yue Chang Cinnamomoum osmophloeum Kanehira (COK) is an indigenous tree species in Taiwan. Chemical compositions, antioxidant activity, mushroom tyrosinase inhibition, melanin synthesis repression, and protection against DNA damage of...
Fri Oct 11, 2019 03:00
Antioxidants, Vol. 8, Pages 473: Iron-Binding and Anti-Fenton Properties of Novel Amino Acid-Derived Cyclic Imide Dioximes Antioxidants doi: 10.3390/antiox8100473 Authors: Janez Mravljak Žiga Jakopin We present a novel route for the preparation of amino acid-derived cyclic imide dioxime derivatives. Readily accessible amino acids were conveniently converted to their corresponding cyclic imide dioximes in simple synthetic steps. The aim of this work was to describe and compare the...
Fri Oct 11, 2019 03:00
Antioxidants, Vol. 8, Pages 471: Redox-Mediated Mechanism of Chemoresistance in Cancer Cells Antioxidants doi: 10.3390/antiox8100471 Authors: Eun-Kyung Kim MinGyeong Jang Min-Jeong Song Dongwoo Kim Yosup Kim Ho Hee Jang Cellular reactive oxygen species (ROS) status is stabilized by a balance of ROS generation and elimination called redox homeostasis. ROS is increased by activation of endoplasmic reticulum stress, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase...
Thu Oct 10, 2019 03:00
Arts, Vol. 8, Pages 131: Greek Painters for the Dominicans or Trecento at the Bosphorus? Once again about the Style and Iconography of the Wall Paintings in the Former Dominican Church of St. Paul in Pera Arts doi: 10.3390/arts8040131 Authors: Quirini-Popławski The recently discovered wall paintings of the Dominican church of St. Paul are perhaps the most fascinating part of the artistic heritage of Pera, the former Genoese colony at the Bosphorus. According to the researchers analyzing...
Fri Oct 11, 2019 03:00
Arts, Vol. 8, Pages 130: Artificial Intelligence & Popular Music: SKYGGE, Flow Machines, and the Audio Uncanny Valley Arts doi: 10.3390/arts8040130 Authors: Melissa Avdeeff This article presents an overview of the first AI-human collaborated album, Hello World, by SKYGGE, which utilizes Sony’s Flow Machines technologies. This case study is situated within a review of current and emerging uses of AI in popular music production, and connects those uses with myths and fears...
Fri Oct 11, 2019 03:00
Atmosphere, Vol. 10, Pages 615: A Preliminary Impact Study of Wind on Assimilation and Forecast Systems into the One-Dimensional Fog Forecasting Model COBEL-ISBA over Morocco Atmosphere doi: 10.3390/atmos10100615 Authors: Driss Bari The assimilation impact of wind data from aircraft measurements (AMDAR), surface synoptic observations (SYNOP) and 3D numerical weather prediction (NWP) mesoscale model, on short-range numerical weather forecasting (up to 12 h) and on the assimilation system,...
Fri Oct 11, 2019 03:00
Atmosphere, Vol. 10, Pages 616: The 10–20 d Low-Frequency Oscillation Characteristics of Summer Precipitation in Eastern China in the Decaying Year of CP ENSO Atmosphere doi: 10.3390/atmos10100616 Authors: Cong Cai Lijuan Wang Junyu Wang Zhiqiang Wang Using National Centers for Atmospheric Prediction/National Center for Atmospheric Research (NCEP/NCAR) reanalysis data and observational data, the low-frequency oscillation characteristics of precipitation in eastern China during...
Fri Oct 11, 2019 03:00
Biology, Vol. 8, Pages 78: Histone H2A and Bovine Neutrophil Extracellular Traps Induce Damage of Besnoitia besnoiti-Infected Host Endothelial Cells but Fail to Affect Total Parasite Proliferation Biology doi: 10.3390/biology8040078 Authors: Conejeros Velásquez Grob Zhou Salecker Hermosilla Taubert Besnoitia besnoiti tachyzoites infect and develop in bovine endothelial cells in vivo and trigger the release of neutrophil extracellular traps (NETs) from bovine...
Fri Oct 11, 2019 03:00
Biomedicines, Vol. 7, Pages 80: Survival Comparison between Melanoma Patients Treated with Patient-Specific Dendritic Cell Vaccines and Other Immunotherapies Based on Extent of Disease at the Time of Treatment Biomedicines doi: 10.3390/biomedicines7040080 Authors: Robert Owen Dillman Candace Hsieh Encouraging survival was observed in single arm and randomized phase 2 trials of patient-specific dendritic cell vaccines presenting autologous tumor antigens from autologous cancer cells...
Fri Oct 11, 2019 03:00
Biomolecules, Vol. 9, Pages 600: Transcriptional Modulation of the Host Immunity Mediated by Cytokines and Transcriptional Factors in Plasmodium falciparum-Infected Patients of North-East India Biomolecules doi: 10.3390/biom9100600 Authors: Md Zohaib Ahmed Nitin Bhardwaj Supriya Sharma Veena Pande Anupkumar R Anvikar Complications due to malaria are caused mostly by host immunological responses. Plasmodium falciparum subverts host immunity by various strategies, including...
Fri Oct 11, 2019 03:00
Biomolecules, Vol. 9, Pages 601: Allopurinol Prevents the Lipogenic Response Induced by an Acute Oral Fructose Challenge in Short-Term Fructose Fed Rats Biomolecules doi: 10.3390/biom9100601 Authors: García-Arroyo Monroy-Sánchez Muñoz-Jiménez Gonzaga Andrés-Hernando Zazueta Juárez-Rojas Lanaspa Johnson Sánchez-Lozada We investigated whether short term high fructose intake may induce early hepatic dysfunction in rats and to test whether allopurinol...
Fri Oct 11, 2019 03:00
Biomolecules, Vol. 9, Pages 599: A Landauer Formula for Bioelectronic Applications Biomolecules doi: 10.3390/biom9100599 Authors: Eszter Papp Dávid P. Jelenfi Máté T. Veszeli Gábor Vattay Recent electronic transport experiments using metallic contacts attached to proteins identified some “stylized facts”, which contradict conventional wisdom that increasing either the spatial distance between the electrodes or the temperature suppresses conductance exponentially....
Fri Oct 11, 2019 03:00
Biomolecules, Vol. 9, Pages 597: Modulating Linker Composition of Haptens Resulted in Improved Immunoassay for Histamine Biomolecules doi: 10.3390/biom9100597 Authors: Lin Luo Xiao-Qun Wei Bao-Zhu Jia Jin-Yi Yang Yu-Dong Shen Bruce Hammock Jie-Xian Dong Hong Wang Hong-Tao Lei Zhen-Lin Xu Histamine (HA) is an important food contaminant generated during food fermentation or spoilage. However, an immunoassay for direct (derivatization free) determination of HA...
Fri Oct 11, 2019 03:00
Biomolecules, Vol. 9, Pages 598: Temporin-SHa and Its Analogs as Potential Candidates for the Treatment of Helicobacter pylori Biomolecules doi: 10.3390/biom9100598 Authors: Olleik Baydoun Perrier Hijazi Raymond Manzoni Dupuis Pauleau Goudard Villéon Goin Sockeel Choudhary Pasquale Nadeem-ul-Haque Ali Khan Shaheen Maresca Helicobacter pylori is one of the most prevalent pathogens colonizing 50% of the world's population...
Fri Oct 11, 2019 03:00
Biomolecules, Vol. 9, Pages 596: Flumequine-Mediated Upregulation of p38 MAPK and JNK Results in Melanogenesis in B16F10 Cells and Zebrafish Larvae Biomolecules doi: 10.3390/biom9100596 Authors: Wisurumuni Arachchilage Hasitha Maduranga Karunarathne Ilandarage Menu Neelaka Molagoda Myung Sook Kim Yung Hyun Choi Matan Oren Eui Kyun Park Gi-Young Kim Flumequine is a well-known second generation quinolone antibiotic that induces phototoxicity. However, the effect of flumequine...
Fri Oct 11, 2019 03:00
Biosensors, Vol. 9, Pages 121: Polarization Induced Electro-Functionalization of Pore Walls: A Contactless Technology Biosensors doi: 10.3390/bios9040121 Authors: Bouchet-Spinelli Descamps Liu Ismail Pham Chatelain Leïchlé Leroy Marche Raillon Roget Roupioz Sojic Buhot Haguet Livache Mailley This review summarizes recent advances in micro- and nanopore technologies with a focus on the functionalization of pores using a...
Fri Oct 11, 2019 03:00
Biosensors, Vol. 9, Pages 122: FRET Microscopy in Yeast Biosensors doi: 10.3390/bios9040122 Authors: Skruzny Pohl Abella Förster resonance energy transfer (FRET) microscopy is a powerful fluorescence microscopy method to study the nanoscale organization of multiprotein assemblies in vivo. Moreover, many biochemical and biophysical processes can be followed by employing sophisticated FRET biosensors directly in living cells. Here, we summarize existing FRET experiments...
Fri Oct 11, 2019 03:00
Biosensors, Vol. 9, Pages 120: P-N Junction-Based Si Biochips with Ring Electrodes for Novel Biosensing Applications Biosensors doi: 10.3390/bios9040120 Authors: Mahdi Kiani Nan Du Manja Vogel Johannes Raff Uwe Hübner Ilona Skorupa Danilo Bürger Stefan E. Schulz Oliver G. Schmidt Heidemarie Schmidt In this work, we report on the impedance of p-n junction-based Si biochips with gold ring top electrodes and unstructured platinum bottom electrodes which allows...
Fri Oct 11, 2019 03:00
Brain Sciences, Vol. 9, Pages 273: Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure Brain Sciences doi: 10.3390/brainsci9100273 Authors: Bin Xu Li-Min Lang Shuai Lian Jing-Ru Guo Jian-Fa Wang Huan-Min Yang Shi-Ze Li Chronic stress can damage homeostasis and induce various primary diseases. Although chronic cold stress is becoming an increasing problem...
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Brain Sciences, Vol. 9, Pages 272: Safinamide in Clinical Practice: A Spanish Multicenter Cohort Study Brain Sciences doi: 10.3390/brainsci9100272 Authors: Gloria Martí-Andrés Rayco Jiménez-Bolaños José Matias Arbelo-González Javier Pagonabarraga Carmen Duran-Herrera Rafael Valenti-Azcarate Mª Rosario Luquin Background: Safinamide is an approved drug for the treatment of motor fluctuations of Parkinson’s Disease (PD) patients with a potential benefit on non-motor...
Fri Oct 11, 2019 03:00
Brain Sciences, Vol. 9, Pages 271: Mid-Frontal Theta Modulates Response Inhibition and Decision Making Processes in Emotional Contexts Brain Sciences doi: 10.3390/brainsci9100271 Authors: Siddharth Nayak ChiiShyang Kuo Arthur Chih-Hsin Tsai Inhibitory control is an integral part of executive functions. In this study, we report event-related spectral perturbation (ERSP) results from 15 healthy adults performing an emotional stop-signal task with the use of happy, disgusted, and...
Fri Oct 11, 2019 03:00
Cancers, Vol. 11, Pages 1540: Tumor Expression of Cyclin-Dependent Kinase 5 (Cdk5) Is a Prognostic Biomarker and Predicts Outcome of Oxaliplatin-Treated Metastatic Colorectal Cancer Patients Cancers doi: 10.3390/cancers11101540 Authors: Ruiz de Porras Bystrup Cabrero-de las Heras Musulén Palomero Alonso Nieto Arango Moreno Queralt Manzano Layos Bugés Martinez-Balibrea In recent years, an increasing number of studies have shown that...
Fri Oct 11, 2019 03:00
Cancers, Vol. 11, Pages 1539: PARP1 Co-Regulates EP300–BRG1-Dependent Transcription of Genes Involved in Breast Cancer Cell Proliferation and DNA Repair Cancers doi: 10.3390/cancers11101539 Authors: Sobczak Pitt Spickett Robaszkiewicz BRG1, an active subunit of the SWI/SNF chromatin-remodeling complex, enables the EP300-dependent transcription of proliferation and DNA repair genes from their E2F/CpG-driven promoters in breast cancer cells. In the current study, we show that...
Fri Oct 11, 2019 03:00
Cancers, Vol. 11, Pages 1538: Expression of Irisin/FNDC5 in Cancer Cells and Stromal Fibroblasts of Non-small Cell Lung Cancer Cancers doi: 10.3390/cancers11101538 Authors: Nowinska Jablonska Pawelczyk Piotrowska Partynska Gomulkiewicz Ciesielska Katnik Grzegrzolka Glatzel-Plucinska Ratajczak-Wielgomas Podhorska-Okolow Dziegiel Background: Recent in vitro studies have indicated that irisin inhibits proliferation, migration and epithelial-mesenchymal...
Fri Oct 11, 2019 03:00
Cancers, Vol. 11, Pages 1536: Understanding the Interplay between COX-2 and hTERT in Colorectal Cancer Using a Multi-Omics Analysis Cancers doi: 10.3390/cancers11101536 Authors: Georgios D. Ayiomamitis George Notas Thivi Vasilakaki Aikaterini Tsavari Styliani Vederaki Theodosis Theodosopoulos Elias Kouroumalis Apostolos Zaravinos Background: Cyclooxygenase 2 (COX-2) is involved in the initial steps of colorectal cancer (CRC) formation, playing a key role in the catalysis...
Fri Oct 11, 2019 03:00
Cancers, Vol. 11, Pages 1537: PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas Cancers doi: 10.3390/cancers11101537 Authors: Annalisa Passariello Maria Elena Errico Vittoria Donofrio Manuela Maestrini Alia Zerbato Laura Cerchia Maria Capasso Mario Capasso Monica Fedele Glial tumors are the leading cause of cancer-related death and morbidity in children. Their diagnosis, mainly based on clinical...
Fri Oct 11, 2019 03:00
Cancers, Vol. 11, Pages 1534: Natural Killer Cell Therapy: A New Treatment Paradigm for Solid Tumors
Cancers, Vol. 11, Pages 1534: Natural Killer Cell Therapy: A New Treatment Paradigm for Solid Tumors Cancers doi: 10.3390/cancers11101534 Authors: Sooyeon Oh Joo-Ho Lee KyuBum Kwack Sang-Woon Choi In treatments of solid tumors, adoptive transfer of ex vivo expanded natural killer (NK) cells has dawned as a new paradigm. Compared with cytotoxic T lymphocytes, NK cells take a unique position targeting tumor cells that evade the host immune surveillance by down-regulating self-antigen...
Fri Oct 11, 2019 03:00
Cancers, Vol. 11, Pages 1535: Detailed Characterization of Immune Cell Infiltrate and Expression of Immune Checkpoint Molecules PD-L1/CTLA-4 and MMR Proteins in Testicular Germ Cell Tumors Disclose Novel Disease Biomarkers Cancers doi: 10.3390/cancers11101535 Authors: João Lobo Ângelo Rodrigues Rita Guimarães Mariana Cantante Paula Lopes Joaquina Maurício Jorge Oliveira Carmen Jerónimo Rui Henrique Background: The immune infiltrate plays an important part in testicular...
Fri Oct 11, 2019 03:00
Cancers, Vol. 11, Pages 1533: 17β-Estradiol Activates HSF1 via MAPK Signaling in ERα-Positive Breast Cancer Cells Cancers doi: 10.3390/cancers11101533 Authors: Natalia Vydra Patryk Janus Agnieszka Toma-Jonik Tomasz Stokowy Katarzyna Mrowiec Joanna Korfanty Anna Długajczyk Bartosz Wojtaś Bartłomiej Gielniewski Wiesława Widłak Heat Shock Factor 1 (HSF1) is a key regulator of gene expression during acute environmental stress that enables the cell survival, which...
Fri Oct 11, 2019 03:00
Cells, Vol. 8, Pages 1241: Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells Cells doi: 10.3390/cells8101241 Authors: Tan Jin Wang Huang Wu Ren : Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide. Reactive oxygen species (ROS), as potent oxidants in cells, have been shown to promote the development of NAFLD. Previous studies reported that for ROS-induced cellular oxidative...
Fri Oct 11, 2019 03:00
Cells, Vol. 8, Pages 1238: Lack of a Retinal Phenotype in a Syne-2/Nesprin-2 Knockout Mouse Model Cells doi: 10.3390/cells8101238 Authors: Falk Joachimsthaler Kessler Lux Noegel Kremers Brandstätter Gießl Falk Joachimsthaler Kessler Lux Noegel Kremers Brandstätter Gießl Syne-2 (also known as Nesprin-2) is a member of a family of proteins that are found primarily in the outer nuclear membrane, as well as other subcellular compartments....
Fri Oct 11, 2019 03:00
Cells, Vol. 8, Pages 1239: Mechanisms of Collagen Crosslinking in Diabetes and Keratoconus Cells doi: 10.3390/cells8101239 Authors: McKay Priyadarsini Karamichos Collagen crosslinking provides the mechanical strength required for physiological maintenance of the extracellular matrix in most tissues in the human body, including the cornea. Aging and diabetes mellitus (DM) are processes that are both associated with increased collagen crosslinking that leads to increased corneal...
Fri Oct 11, 2019 03:00
Cells, Vol. 8, Pages 1240: Stem Cell-Derived Extracellular Vesicles and Kidney Regeneration Cells doi: 10.3390/cells8101240 Authors: Grange Skovronova Marabese Bussolati Extracellular vesicles (EVs) are membranous vesicles containing active proteins, lipids, and different types of genetic material such as miRNAs, mRNAs, and DNAs related to the characteristics of the originating cell. They possess a distinctive capacity to communicate over long distances. EVs have been involved...
Fri Oct 11, 2019 03:00
Cells, Vol. 8, Pages 1235: Contextual Regulation of TGF-β Signaling in Liver Cancer Cells doi: 10.3390/cells8101235 Authors: Tu Huang Huang Luo Yan Primary liver cancer is one of the leading causes for cancer-related death worldwide. Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that signals through membrane receptors and intracellular Smad proteins, which enter the nucleus upon receptor activation and act as transcription factors. TGF-β...
Fri Oct 11, 2019 03:00
Cells, Vol. 8, Pages 1236: From OPC to Oligodendrocyte: An Epigenetic Journey Cells doi: 10.3390/cells8101236 Authors: Assia Tiane Melissa Schepers Ben Rombaut Raymond Hupperts Jos Prickaerts Niels Hellings Daniel van den Hove Tim Vanmierlo Oligodendrocytes provide metabolic and functional support to neuronal cells, rendering them key players in the functioning of the central nervous system. Oligodendrocytes need to be newly formed from a pool of oligodendrocyte...
Fri Oct 11, 2019 03:00
Cells, Vol. 8, Pages 1237: Cell Cycle Arrest by Supraoptimal Temperature in the Alga Chlamydomonas reinhardtii Cells doi: 10.3390/cells8101237 Authors: Zachleder Ivanov Vítová Bišová Temperature is one of the key factors affecting growth and division of algal cells. High temperature inhibits the cell cycle in Chlamydomonas reinhardtii. At 39 °C, nuclear and cellular divisions in synchronized cultures were blocked completely, while DNA replication was partly affected....
Fri Oct 11, 2019 03:00
Cells, Vol. 8, Pages 1234: IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis Cells doi: 10.3390/cells8101234 Authors: Angelika Rose Caroline von Spee-Mayer Lutz Kloke Kaiyin Wu Anja Kühl Philipp Enghard Gerd-Rüdiger Burmester Gabriela Riemekasten Jens Y. Humrich An acquired deficiency of interleukin-2 (IL-2) and related disturbances in regulatory T cell (Treg) homeostasis play an important...
Fri Oct 11, 2019 03:00
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