Abstract A prostate cancer risk single‐nucleotide polymorphism (SNP), rs13426236, is significantly associated with melanophilin (MLPH) expression. To functionally characterize role of the rs13426236 in prostate cancer, we first performed splicing‐specific expression quantitative trait loci analysis and refined the significant association of rs13426236 allele G with an increased expression of MLPH splicing transcript variant 4 (V4) (P = 7.61E−5) but not other protein‐coding variants (V1‐V3) (P > .05)....
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Related ArticlesPeter Plus Syndrome: A Neurosurgeon's Perspective. J Pediatr Neurosci. 2019 Jul-Sep;14(3):148-153 Authors: Khatri D, Gosal JS, Das KK, Bhaisora KS Abstract Peter plus syndrome (PPS) is a rare, hereditary (autosomal recessive) disorder characterized by a mutation in the beta-1,3-galactosyltransferase-like gene (chromosome 13q12), which causes impaired glycosylation of several structural and functional proteins throughout the body. Clinical...
Related ArticlesUtility of Hyperbaric Oxygen Therapy for Acute Acoustic Trauma: 20 years' Experience at the Japan Maritime Self-Defense Force Undersea Medical Center. Int Arch Otorhinolaryngol. 2019 Oct;23(4):e408-e414 Authors: Oya M, Tadano Y, Takihata Y, Ikomi F, Tokunaga T Abstract Introduction Acute acoustic trauma, which is a kind of sensorineural hearing loss, is caused by acoustic overstimulation. Hyperbaric oxygen therapy (HBOT) is reported...
Related ArticlesPossible Association between the Lack of Regular Physical Activity with Tinnitus and Headache: Cross-sectional Study. Int Arch Otorhinolaryngol. 2019 Oct;23(4):e375-e379 Authors: Bazoni JA, Dias ACM, Meneses-Barriviera CL, Marchiori LLM, Teixeira DC Abstract Introduction Physical inactivity is an important risk factor for many aging-related symptoms. Studies suggest that physical activity may help to relieve tinnitus and headache. Objective...
Related ArticlesOtotoxic Adverse Drug Reactions: A Disproportionality Analysis Using the Italian Spontaneous Reporting Database. Front Pharmacol. 2019;10:1161 Authors: Barbieri MA, Cicala G, Cutroneo PM, Mocciaro E, Sottosanti L, Freni F, Galletti F, Arcoraci V, Spina E Abstract Introduction: The panorama of drug-induced ototoxicity has widened in the last decades; moreover, post-marketing data are necessary to gain a better insight on ototoxic adverse...
Related ArticlesLipochoristoma of the Internal Auditory Canal: Long-Term Surveillance. Otolaryngol Head Neck Surg. 2019 02;160(2):359-360 Authors: Kedarisetty S, Surapaneni K PMID: 30322341 [PubMed - indexed for MEDLINE]
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Related Articles[The immune microenvironment in malignant lymphoma]. Rinsho Ketsueki. 2019;60(9):1229-1235 Authors: Nishikori M Abstract Recent advances in immunotherapy have highlighted the importance of the tumor microenvironment. Lymphomas are a heterogeneous group of malignancies that arise from lymphocytes and typically develop in lymphoid tissues. It has been recognized that the elements of the lymphoma microenvironment are not mere bystanders...
Related Articles[Diffuse large B-cell lymphoma: standard treatment and research questions]. Rinsho Ketsueki. 2019;60(9):1193-1198 Authors: Ohmachi K Abstract In 2018 the practical guidelines for hematological malignancies, edited by Japanese Society of Hematology, underwent major revision for the first time in five years. R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) remains the standard treatment for diffuse large B-cell...
Related Articles[Molecular classification and its clinical relevance in diffuse large B-cell lymphoma]. Rinsho Ketsueki. 2019;60(9):1186-1192 Authors: Ennishi D Abstract Hematopoietic tumors represent a range of clinically and biologically diverse diseases, and within this, the lymphoid malignancies, especially B-cell lymphomas, are classified into many entities in the WHO classification system. It is thought that various molecular genetic abnormalities...
Related Articles[Cereblon as a primary target of IMiDs]. Rinsho Ketsueki. 2019;60(9):1013-1019 Authors: Ito T, Handa H Abstract Various derivatives of thalidomide, a drug that is well-known for its teratogenicity, have recently been developed; among them, lenalidomide and pomalidomide, known as immunomodulatory drugs (IMiDs), have potent anticancer activity. These drugs have been approved by Food and Drug Administration for the treatment of several...
Related ArticlesThe Role of Host Genetic Polymorphisms in Helicobacter pylori Mediated Disease Outcome. Adv Exp Med Biol. 2019;1149:151-172 Authors: Clyne M, Rowland M Abstract The clinical outcome of infection with the chronic gastric pathogen Helicobacter pylori is not the same for all individuals and also differs in different ethnic groups. Infection occurs in early life (<3 years of age), and while all infected persons mount an immune response...
Related ArticlesMalignant Helicobacter pylori-Associated Diseases: Gastric Cancer and MALT Lymphoma. Adv Exp Med Biol. 2019;1149:135-149 Authors: Hatakeyama M Abstract Helicobacter pylori is the first bacterium formally recognized to play a causative role in human malignancies, gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Evidence accumulates that H. pylori cagA-positive strains play a crucial role in the neoplastic...
Related ArticlesRisk factors for death and survival in paraneoplastic pemphigus associated with hematologic malignancies in adults. J Am Acad Dermatol. 2019 Jun;80(6):1544-1549 Authors: Ouedraogo E, Gottlieb J, de Masson A, Lepelletier C, Jachiet M, Salle de Chou C, Galicier L, Bagot M, Chevret S, Bouaziz JD Abstract BACKGROUND: Paraneoplastic pemphigus (PNP) occurs more often in patients with hematologic malignancies (HMs) than in patients with solid...
Related ArticlesDouble remission of simultaneously occurring secondary AML and CLL by venetoclax monotherapy. Acta Oncol. 2019 Jun;58(6):888-890 Authors: Niscola P, Noguera NI, Catalano G, Cupelli L, Fratoni S, Giovannini M, Mazzone C, Neri B, Scaramucci L, Trawinska MM, de Fabritiis P, Abruzzese E PMID: 30848978 [PubMed - indexed for MEDLINE]
Related ArticlesDysregulated TRAF3 and BCL2 Expression Promotes Multiple Classes of Mature Non-hodgkin B Cell Lymphoma in Mice. Front Immunol. 2018;9:3114 Authors: Perez-Chacon G, Adrados M, Vallejo-Cremades MT, Lefebvre S, Reed JC, Zapata JM Abstract TNF-Receptor Associated Factor (TRAF)-3 is a master regulator of B cell homeostasis and function. TRAF3 has been shown to bind and regulate various proteins involved in the control of innate and adaptive...
Related ArticlesUsing Gene Expression Profiling to Move Beyond MYC/BCL2 Rearrangements in High-Grade Lymphoma. J Clin Oncol. 2019 01 20;37(3):175-177 Authors: Chan WC PMID: 30523718 [PubMed - indexed for MEDLINE]
Related ArticlesSTAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial. J Immunother Cancer. 2018 11 16;6(1):119 Authors: Reilley MJ, McCoon P, Cook C, Lyne P, Kurzrock R, Kim Y, Woessner R, Younes A, Nemunaitis J, Fowler N, Curran M, Liu Q, Zhou T, Schmidt J, Jo M, Lee SJ, Yamashita M, Hughes SG, Fayad L, Piha-Paul S, Nadella MVP, Xiao X, Hsu J, Revenko A, Monia BP, MacLeod AR, Hong DS ...
Related ArticlesThe c-Jun and JunB transcription factors facilitate the transit of classical Hodgkin lymphoma tumour cells through G1. Sci Rep. 2018 10 30;8(1):16019 Authors: Zhang J, Wu Z, Savin A, Yang M, Hsu YR, Jantuan E, Bacani JTC, Ingham RJ Abstract Classical Hodgkin Lymphoma (cHL) is primarily a B cell lymphoid neoplasm and a member of the CD30-positive lymphomas. cHL and the other CD30-positive lymphomas are characterized by the elevated expression...
Related ArticlesCD38 Antibodies in Multiple Myeloma: Mechanisms of Action and Modes of Resistance. Front Immunol. 2018;9:2134 Authors: van de Donk NWCJ, Usmani SZ Abstract MM cells express high levels of CD38, while CD38 is expressed at relatively low levels on normal lymphoid and myeloid cells, and in some non-hematopoietic tissues. This expression profile, together with the role of CD38 in adhesion and as ectoenzyme, resulted in the development of...
Related ArticlesCancer-Specific Stress and Trajectories of Psychological and Physical Functioning in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia. Ann Behav Med. 2018 03 15;52(4):287-298 Authors: Goyal NG, Maddocks KJ, Johnson AJ, Byrd JC, Westbrook TD, Andersen BL Abstract Background: Chronic lymphocytic leukemia is the most prevalent adult leukemia. The disease is incurable with a cycling of treatment and relapse common. Little...
Related ArticlesNF-κB signaling and its relevance to the treatment of mantle cell lymphoma. J Hematol Oncol. 2018 06 15;11(1):83 Authors: Balaji S, Ahmed M, Lorence E, Yan F, Nomie K, Wang M Abstract Mantle cell lymphoma is an aggressive subtype of non-Hodgkin B cell lymphoma that is characterized by a poor prognosis determined by Ki67 and Mantle Cell International Prognostic Index scores, but it is becoming increasingly treatable. The majority of...
Related ArticlesPredictors of atrial fibrillation in ibrutinib-treated CLL patients: a prospective study. J Hematol Oncol. 2018 06 11;11(1):79 Authors: Reda G, Fattizzo B, Cassin R, Mattiello V, Tonella T, Giannarelli D, Massari F, Cortelezzi A Abstract BACKGROUND: Ibrutinib is an oral irreversible inhibitor of Bruton's tyrosine kinase, indicated for the treatment of chronic lymphocytic leukaemia. The drug is generally well tolerated; however, not...
Related ArticlesDecitabine demonstrates antileukemic activity in B cell precursor acute lymphoblastic leukemia with MLL rearrangements. J Hematol Oncol. 2018 05 04;11(1):62 Authors: Roolf C, Richter A, Konkolefski C, Knuebel G, Sekora A, Krohn S, Stenzel J, Krause BJ, Vollmar B, Murua Escobar H, Junghanss C Abstract BACKGROUND: Promotor hypermethylation of CpG islands is common in B cell precursor acute lymphoblastic leukemia (BCP-ALL) with mixed lineage...
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Related ArticlesMajor challenges in accurate mutation detection of multifocal lung adenocarcinoma by next-generation sequencing. Cancer Biol Ther. 2019 Oct 25;:1-8 Authors: Qiu T, Li W, Zhang F, Wang B, Ying J Abstract Background: Many patients with advanced non-small cell lung cancer manifested with metastasis, and molecular heterogeneity may exhibit between primary and metastatic tumors. We sought to investigate the clinical detection strategy of primary...
Related ArticlesSEMA4D under the posttranscriptional regulation of HuR and miR-4319 boosts cancer progression in esophageal squamous cell carcinoma. Cancer Biol Ther. 2019 Oct 25;:1-8 Authors: Wang Y, Zhao H, Zhi W Abstract Esophageal squamous cell carcinoma (ESCC) is the major type of esophageal carcinoma, one of the main reasons of cancer-caused death. While the therapeutic effect on ESCC patents is still unsatisfactory as a result of tumor aggression,...
Related ArticlesGSK343 induces programmed cell death through the inhibition of EZH2 and FBP1 in osteosarcoma cells. Cancer Biol Ther. 2019 Oct 25;:1-10 Authors: Xiong X, Zhang J, Li A, Dai L, Qin S, Wang P, Liu W, Zhang Z, Li X, Liu Z Abstract Enhancer of zeste homolog 2 (EZH2) is an important member of the epigenetic regulatory factor polycomb group proteins (PcG) and is abnormally expressed in a wide variety of tumors, including osteosarcoma. Scientists...
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Related ArticlesVocal Characteristics of Patients With Morbid Obesity. J Voice. 2019 Oct 21;: Authors: Bosso JR, Martins RHG, Pessin ABB, Tavares ELM, Leite CV, Naresse LE Abstract INTRODUCTION: Obesity modifies vocal characteristics, causing abnormal fat deposition in the abdominal region and upper airways. For some authors the voice of the obese is not different from nonobese and the vocal symptoms are scarce; for others dysphonia in obese is reported...
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Zusammenfassung Psychotherapie ist nachweislich wirksam. Diese Aussage trifft jedoch insbesondere auf den „Durchschnittspatienten“ in randomisiert-kontrollierten Studien zu. Da trotz der stetigen Entwicklung neuer Therapiemethoden konstant ein beträchtlicher Anteil an Patienten nicht profitiert und die Wirkmechanismen noch zu wenig verstanden werden, gilt es, innovative Psychotherapieforschung zu initiieren, die beide Probleme adressiert. Dabei sollte der aus der somatischen Medizin...
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Related ArticlesClinical Practice Guideline: Tonsillectomy in Children (Update)-Executive Summary. Otolaryngol Head Neck Surg. 2019 02;160(2):187-205 Authors: Mitchell RB, Archer SM, Ishman SL, Rosenfeld RM, Coles S, Finestone SA, Friedman NR, Giordano T, Hildrew DM, Kim TW, Lloyd RM, Parikh SR, Shulman ST, Walner DL, Walsh SA, Nnacheta LC Abstract OBJECTIVE: This update of a 2011 guideline developed by the American Academy of Otolaryngology-Head and...
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Over 40 volunteers and several local agencies participated in the training drill at Hanscom Field in Bedford, Massachusetts
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Related ArticlesKinetic Analysis of Growth Activity in Enlarging Papillary Thyroid Microcarcinomas. Thyroid. 2019 Oct 25;: Authors: Ito Y, Miyauchi A, Kudo T, Higashiyama T, Masuoka H, Kihara M, Miya A Abstract BACKGROUND: Although papillary thyroid microcarcinoma (PMC) is generally stable on active surveillance, conversion surgery is recommended for enlarging tumors. However, it remains unclear which enlargement threshold should be considered sufficient...
Related ArticlesVps34 PI 3-kinase controls thyroid hormone production by regulating thyroglobulin iodination, lysosomal proteolysis and tissue homeostasis. Thyroid. 2019 Oct 25;: Authors: Grieco G, Wang T, Delcorte O, Spourquet C, Janssens V, Strickaert A, Gaide Chevronnay H, Liao XH, Bilanges B, Refetoff S, Vanhaesebroeck B, Maenhaut C, Courtoy PJ, Pierreux CE Abstract BACKGROUND: The production of thyroid hormones (T3, T4) depends on the organization...
Subclinical hypothyroidism is associated with lower ovarian reserve in women aged 35 years or older.
Related ArticlesSubclinical hypothyroidism is associated with lower ovarian reserve in women aged 35 years or older. Thyroid. 2019 Oct 25;: Authors: Rao M, Wang H, Zhao S, Liu J, Wen Y, Wu Z, Yang Z, Su C, Su Z, Wang K, Tang L Abstract BACKGROUND: Overt thyroid diseases have been identified as risk factors for female infertility. However, it remains largely unclear whether subclinical hypothyroidism (SCH), a very common thyroid disorder, is associated...
Related ArticlesGoiter in Residents of Salta, Argentina: An Artistic Rendition. Thyroid. 2019 Oct 25;: Authors: Jonklaas J, Mitchell C, Danielsen M Abstract None.PMID: 31650893 [PubMed - as supplied by publisher]
Related ArticlesA Novel ALK Fusion in Pediatric Medullary Thyroid Carcinoma. Thyroid. 2019 Oct 25;: Authors: Hillier K, Hughes A, Shamberger R, Shusterman S, Perez-Atayde A, Wassner AJ, Iafrate AJ, Dubuc A, Janeway K, Rothenberg SM, Cox MC, Randolph GW, Wirth LJ, Tsai HK, Church AJ, DuBois S Abstract BACKGROUND: Medullary thyroid carcinoma (MTC) is most commonly associated with RET gene mutations. ALK fusions have rarely been described, though not previously...
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OBJECTIVES: The gut microbiota is associated with obesity and weight loss after bariatric surgery and has been related to its changing pattern. Exactly how the bacterial population affects weight loss and the results of surgery remain controversial. This study aimed to evaluate the intestinal microbiota of superobese patients before and after gastric bypass surgery (RYGB). METHOD: DNA fragments for the microbiota obtained from stool samples collected from nine superobese patients before and after...
OBJECTIVE: The aim of the study was to analyze the relationship between gait speed and measurements of physical function in patients with symptomatic peripheral artery disease (PAD). METHODS: One hundred sixty-nine patients (age 66.6±9.4 years) with symptomatic PAD were recruited. Usual and fast gait speeds were assessed with a 4-meter walk test. Objective (balance, sit-to-stand, handrip strength, and six-minute walk test) and subjective (WIQ - Walking Impairment Questionnaire and WELCH - Walking...
OBJECTIVES: Our objective was to analyze, in a population treated for hepatitis C infection at a tertiary care treatment unit, the prevalence of comorbidities and extrahepatic manifestations, the range and degree of the clinical complexity and the associations between advanced liver disease and clinical variables. METHODS: Medical records from chronically infected hepatitis C patients seen at a dedicated treatment facility for complex cases in the Infectious Diseases Division of Hospital das Clínicas...
OBJECTIVES: To compare the amount of ultrasound energy and irrigation volume in conventional phacoemulsification cataract surgery versus femtosecond laser-assisted phacoemulsification at different nuclear-cortical cataract grades. METHOD: This was a prospective, consecutive, investigator-masked nonrandomized parallel cohort study. Patients were divided into 4 groups (Phaco1, Phaco2, Femto1 and Femto2) according to the surgical technique (conventional phacoemulsification [Group Phaco] or femtosecond...
OBJECTIVES: Nonalcoholic fatty pancreas disease (NAFPD) is characterized by excessive fat deposition in the pancreas in the absence of alcohol consumption. In this study, we aimed to detect a possible relationship between adipose tissue accumulation, prediabetes and diabetes. METHODS: This cross-sectional and retrospective study included 110 patients. Three groups were classified as controls, patients with prediabetes and patients with type 2 diabetes. The abdominal computed tomography (CT) attenuation...
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Related ArticlesISO 4037:2019 VALIDATION OF RADIATION QUALITIES BY MEANS OF HALF-VALUE LAYER AND HP(10) DOSIMETRY. Radiat Prot Dosimetry. 2019 Oct 25;: Authors: Bandalo V, Greiter MB, Brönner J, Hoedlmoser H Abstract Radiation qualities were characterised and validated at the fully automated X-ray calibration facility of the Individual Monitoring Service at Helmholtz Zentrum München by using half-value layer and Hp(10) dosimetry approaches specified...
Related ArticlesVARIATION SIMULATION OF RADON CONCENTRATION IN THE TISSUES AND ORGANS OF THE BODY BY AN ELECTRICAL CIRCUIT. Radiat Prot Dosimetry. 2019 Oct 25;: Authors: Pirmoradi M, Negarestani A, Baghizadeh A Abstract In this study, a new model based on electric circuit theory has been introduced to simulate the dynamics of radioactive chemically inert gases in the human body. For this manner, it is assumed that inert gas is transported through the...
Related ArticlesSTUDY OF EFFECT OF CONSECUTIVE HEATING ON THERMOLUMINESCENCE GLOW CURVES OF MULTI-ELEMENT TL DOSEMETER IN HOT GAS-BASED READER SYSTEM. Radiat Prot Dosimetry. 2019 Oct 25;: Authors: Pathan MS, Pradhan SM, Datta D, Selvam TP Abstract The objective of this paper is to study the effect of consecutive heating of TL elements of a thermoluminescence dosemeter (TLD) card in hot N2 gas-based TLD badge reader. The effect is studied by theoretical...
Related ArticlesCHARACTERISATION AND EVALUATION OF AL2O3:C-BASED OPTICALLY STIMULATED LUMINESCENT DOSEMETER SYSTEM FOR DIAGNOSTIC X-RAYS: PERSONAL AND IN VIVO DOSIMETRY. Radiat Prot Dosimetry. 2019 Oct 25;: Authors: Wong JHD, Bakhsh M, Cheah YY, Jong WL, Khor JS, Ng KH Abstract This study characterises and evaluates an Al2O3:C-based optically stimulated luminescent dosemeter (OSLD) system, commercially known as the nanoDot™ dosemeter and the InLight®...
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Related ArticlesExploratory studies with NX-13: oral toxicity and pharmacokinetics in rodents of an orally active, gut-restricted first-in-class therapeutic for IBD that targets NLRX1. Drug Chem Toxicol. 2019 Oct 25;:1-6 Authors: Leber A, Hontecillas R, Zoccoli-Rodriguez V, Ehrich M, Chauhan J, Bassaganya-Riera J Abstract Nucleotide-binding oligomerization domain, leucine rich repeat containing X1 (NLRX1) is an emerging therapeutic target for a spectrum...
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Related ArticlesSuppression of Zika Virus Infection in the Brain by the Antiretroviral Drug Rilpivirine. Mol Ther. 2019 Oct 11;: Authors: Sariyer IK, Gordon J, Burdo TH, Wollebo HS, Gianti E, Donadoni M, Bellizzi A, Cicalese S, Loomis R, Robinson JA, Carnevale V, Steiner J, Ozdener MH, Miller AD, Amini S, Klein ML, Khalili K Abstract Zika virus (ZIKV) infection is associated with microcephaly in neonates and Guillain-Barré syndrome in adults. ZIKV produces...
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