Abstract Dermatomycoses, often caused by both dermatophytic and non dermatophytic fungi, affect the epidermis, nail, and hair. There is an increase in antifungal resistance against antimycotics of many dermatophytes and non-dermatophytes, and this has posed a serious global challenge. Therefore, the search for effective and easily consumable new substances with antimycotic activity is of great necessity. This study aims to isolate dermatomycotic agents from domestic animals and...
Abstract Hepatitis E virus (HEV) infection has been recognised as an important cause of acute viral hepatitis of zoonotic importance globally. This study evaluated the haematological, serum biochemical and histopathological changes in HEV seropositive pigs. A total of 120 pigs were sourced from the Bodija Municipal abattoir, Ibadan, Nigeria, for this study. The haematology and serum biochemistry of the sampled pigs seropositive to HEV antibodies using the ID Screen® Hepatitis...
Abstract Cutaneous horn (cornu cutaneum) is a circumscribed, conical, and hyperkeratotic epidermis projected from the skin surface. Cutaneous horn is described in domestic animals with unknown etiology in some of them. In this report, this lesion was observed on the apex of the ear in a female Pakistani goat. The size of the cutaneous horn was 12 cm length. It was removed under local anesthesia and fixed in 10% neutral buffered formalin. Histopathologic examination showed well-differentiated...
Abstract Nocardia spp. are causing various infections in human and animals. Nocardia isolation and identification are hard and need of professional experts and equipped laboratory. Sometimes there are various bugs in the isolation, identification, antibiogram, etc. according to some articles. The purpose of this study is to survey comments and questions in letters to the editor that have been published in the journals about nocardial infections (nocardiosis) in human, and we...
Abstract The aim of this study was to determine the haematological reference values of a population of dromedary camels (Camelus dromedarius) in northern Nigeria to provide data required during laboratory investigation of health. The haematological variables were determined with EDTA anti-coagulated blood samples collected from the jugular veins of 121 camels during antemortem sessions at the abattoir in Maiduguri (Borno State). Serum total protein, albumin and globulin concentrations...
Abstract Anthropogenic impact and environmental threats can cause diseases to marine turtles and in severe cases death, contributing to population decline worldwide. The Gulf of Ulloa (GU) represents an important foraging habitat for loggerhead sea turtles and olive ridley turtles; it is also considered a highly productive area for fisheries and is known for the mortality of marine turtles, which has been associated to bycatch. However, there is little information in the area...
Abstract A 3-year-old intact male mongrel dog was presented to the Referral Veterinary Polyclinic, ICAR-Indian Veterinary Research Institute, Izatnagar, with the history of inappetence, multiple subcutaneous swellings, and haematuria for the past 15 days. The dog had a history of mating with stray dogs, a few months ago. Physical examination revealed normal vital signs and generalized lymphadenopathy along with multiple subcutaneous hard masses of approximately 1–5 cm size was...
The affiliation of Abolfazl Hajibemani in the original published version of this article was incorrect. Instead of Tabriz University, it should have been University of Tabriz.
Abstract The aim of this study was to determine the normal hematological and biochemical parameters of the Thoroughbred Appaloosa horse breeds which reared in Tong and Issık-Kul regions of Kyrgyzstan. Fifty-six (n = 56) healthy horse breeds in different ages (0–12 months and 1–5 years) and gender (n = 29 male and n = 27 female) were clinically examined and blood samples were taken. Red blood cell (RBC) count, white blood cell (WBC) count, the count (#); the percentage (%) of...
Abstract Anti-inflammatory, analgesic, and leukocyte mobilization activities of ciprofloxacin, lincomycin, and erythromycin were evaluated in this study. The study involved two sets of thirty-three adult female Wistar rats assigned into five treatments, grouped into eleven of three rats per group. For agar-induced paw edema, the first three groups were treated 10 mg/kg, 20 mg/kg, and 40 mg/kg of ciprofloxacin, next three groups same doses of lincomycin, next three groups same...
Abstract In this project, red-backed salamanders, Plethodon cinereus, were collected from the heart of their range (Mountain Lake, Virginia, USA), in an effort to document the typical, or baseline, leukocyte profile of this species in its natural state. From microscopic examination of thin blood films, we determined relative proportions of all leukocyte types and determined the ratio of neutrophils to lymphocytes, which is a useful index of stress levels. In addition, individuals...
Abstract The purpose of this study was to evaluate the potential effect of different levels of Gracilaria corticata (Gracilaria), Sargassum cristaefolium (Sargassum), Rhus coriaria (sumac), and Punica granatum (pomegranate) peel powdered on growth performance, carcass characteristics, and immune responses of Japanese quails against avian influenza and Newcastle disease killed vaccine virus. A total of 360 one-day-old Japanese quails were randomly distributed into nine dietary...
Abstract The malignant ovine theileriosis due to Theileria lestoquardi is highly pathogenic in sheep. During an experimental study, clinical and pathological findings were investigated in sheep infected with T. lestoquardi. The common clinical signs were high fever, emaciation, enlarged lymph nodes, anemia, icterus, nasal discharge, cough, severe pneumonia, circling, opisthotonus, recumbency, and death. Schizonts of Theileria were detected in impression smears of the lymph nodes,...
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Sitzungsbericht der Arbeitsgemeinschaft Uropathologie der Deutschen Gesellschaft für Pathologie 2019
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Soft-tissue sarcomas are cancerous growths of mesenchymal tissues, most commonly arising from fat, muscles, and other connective tissues. Sarcomas are rare, representing only a small fraction of solid malignant tumors. Because of their scarcity and a relative paucity of data, the management of sarcomas can be challenging, especially for those who infrequently encounter these tumors. Herein, the authors review the current literature regarding the diagnosis, workup, and treatment of adult soft-tissue...
Bone sarcomas are rare tumors arising in bone, representing only a small fraction of solid malignant tumors. Desmoids are benign, infiltrative soft tissue neoplasms. Because of their scarcity and a paucity of data, the management of these tumors can be challenging, especially for clinicians who infrequently encounter these tumors. This article reviews the current literature regarding the diagnosis, work-up, and treatment of these uncommon mesenchymal tumors.
Radiation therapy plays a critical role in the management of a wide range of hematologic malignancies. The optimal radiation dose and target volume, and safe and effective ways of integrating radiation with systemic agents, vary depending on the histologic subtypes, stage at presentation, patient performance status, response to systemic therapy if given, treatment intent, and patient preferences. Limiting doses to surrounding organs without sacrificing disease control is of paramount importance....
This review outlines the history of the oligometastatic state from its first proposal to the current formulation. The article discusses the accumulating evidence for the biology of oligometastases, including clinical parameters, such as number and rate of progression, as well as ongoing molecular profiling efforts. The authors then discuss the current state of prospective clinical trials. They review the early site-specific as well as subsite agnostic studies using stereotactic body radiation therapy....
Radiotherapy remains one of the most common, although misunderstood, tools in the oncology management arsenal as up to two-thirds of all patients receive this modality at some point during their cancer continuum. Radiation Oncology is a rapidly evolving specialty, with substantial innovation in the technical and clinical aspects of radiation treatment over recent years. This 2-part series aims to update practicing oncologists and associated care team members on many of the exciting changes that are...
Although the use of ionizing radiation in malignant conditions has been well established, its application in benign conditions has not been fully accepted and has been inadequately recognized by health care providers outside of radiation therapy. Most frequently, radiation therapy in these benign conditions is used along with other treatment modalities, such as surgery, in instances where the condition causes significant disability or could even lead to death. Radiation therapy can be helpful for...
Randomized controlled trials provide evidence-driven clinical decision making in the management of newly diagnosed nonmetastatic and oligometastatic prostate cancer. Advances in technology (eg, multiparametric MRI, MR/transrectal ultrasound fusion biopsy, image-guided radiation therapy, stereotactic body radiation therapy) have transformed diagnosis and treatment of prostate cancer while improving cancer control and quality-of-life outcomes. Exciting breakthroughs are revealing possible new indications...
The 2016 World Health Organization classification of central nervous system (CNS) tumors underwent significant restructuring and for the first time gliomas are classified according to both molecular and histologic parameters which guides glioma management. Radiation for intermediate-risk meningiomas improves the progression-free survival from historical controls, and studies are ongoing for atypical meningiomas. For brain metastases, use of stereotactic radiosurgery for a higher number of lesions...
Palliative radiotherapy is an effective treatment in alleviating many symptoms of advanced cancer. Short courses of radiotherapy provide rapid symptom relief and minimize impact on patients. Patients referred for palliative radiotherapy have many concerns beyond radiotherapy; often, these concerns are not fully addressed in traditional radiotherapy clinics. Discussions of prognosis, patient goals, and concerns are areas for improved collaboration. Innovative, dedicated palliative radiotherapy programs...
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Publication date: Available online 27 October 2019Source: Human PathologyAuthor(s): Daniela Lenggenhager, Achim WeberSummaryInfection with the hepatitis E virus (HEV) is one of the most common causes, if not the most common, of acute hepatitis worldwide. In the last decade, we have learned that in addition to the endemically and epidemically occurring form of hepatitis E, which is predominantly transmitted by contaminated drinking water, and constitutes a significant health problem in resource-poor...
Publication date: Available online 27 October 2019Source: Human PathologyAuthor(s): Glenda Scandura, Thomas Wagner, Luis Beltran, Constantine Alifrangis, Jonathan Shamash, Daniel M BerneyManagement of clinical stage (CS) 1 testicular seminoma is controversial. Treatment choice is based on a number of pathological risk factors. However, they have been inconsistently associated with risk of metastatic disease. The 8th edition of the American Joint Committee on Cancer (AJCC 8) Tumor-Node-Metastasis...
Publication date: Available online 27 October 2019Source: Human PathologyAuthor(s): Derek Jones, Jia Jun Guan, Carla Calagua, Donna E. Hansel, Jonathan I. Epstein, Huihui YePrimary adenocarcinoma of the bladder is a rare and highly aggressive disease with no standard therapy. Effectiveness of immune checkpoint blockade in bladder adenocarcinoma is unknown due to lack of clinical trials. Due to the disease rarity, the rate of PD-L1 expression and DNA mismatch repair deficiency is largely unknown....
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Mandibular bone formation was duplicated in mice with mesenchymal conditional deletion of Ift88. Abstract The mandible is a crucial organ in both clinical and biological fields due to the high frequency of congenital anomalies and the significant morphological changes during evolution. Primary cilia play a critical role in many biological processes, including the determination of left/right axis patterning, the regulation of signaling pathways, and the formation of bone and cartilage. Perturbations...
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Abstract Primary cutaneous EBV (Epstein‐Barr virus)‐positive diffuse large B‐cell lymphoma, not otherwise specified (DLBCL, NOS), is an extremely rare disease. The clinical and pathological features of DLBCL, NOS have not been clearly illustrated. We report a case of primary cutaneous EBV‐positive DLBCL, NOS in a 35‐year‐old Chinese male with multiple ulcerated and nodular lesions on his trunk and arms for 6 months. No other organs, except the skin, were involved. The lesions were localized in the...
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Modern Pathology, Published online: 28 October 2019; doi:10.1038/s41379-019-0390-xNew and evolving concepts of melanocytic nevi and melanocytomas
Modern Pathology, Published online: 28 October 2019; doi:10.1038/s41379-019-0391-9A multicenter analysis of genomic profiles and PD-L1 expression of primary lymphoepithelioma-like carcinoma of the lung
Modern Pathology, Published online: 28 October 2019; doi:10.1038/s41379-019-0389-3Pathologic separation of idiopathic pulmonary fibrosis from fibrotic hypersensitivity pneumonitis
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Abstract Purpose To evaluate the internal anatomy of paramolar tubercles (PTs) on molars, determine the existence of root canals in these structures that either communicate with or are isolated from the main root canals of teeth, and analyze the prevalence of root fusion and a C-shaped canal configuration using cone-beam computed tomography (CBCT). Materials and methods ...
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