Endothelial dysfunction, subclinical atherosclerosis and LDL cholesterol are the independent predictors of left atrial functions in hypertension Abstract Left atrial function has an important role in determining optimal performance of the heart. Increase of left atrial dysfunction and volume are poor prognostic factors. In this study, we investigated independent determinants of left atrial function in non-diabetic patients with de novo hypertension. The study included 124 consecutive non-diabetic patients with de novo hypertension. Brachial artery flow-mediated dilatation, carotid intima-media thickness, transthoracic echocardiography, 24-h rhythm holter, and aortic stiffness measurements were recorded. In echocardiography, left atrial maximum (LAMaV) and minimum (LAMiV) volumes were calculated. Left atrium total emptying fraction (LATEF) and total emptying volume (LATEV) were divided into two groups according to the mean levels. Multivariate analysis was performed after correlation analysis for LATEV and LATEF mean levels. By logistic regression analysis, systolic blood pressure (OR 0.882, 95% CI 0.784–0.992, p = 0.036), percent of flow-mediated dilation (OR 0.747, 95% CI 0.595–0.938, p = 0.012), and presence of carotid plaque (OR 0.014, 95% CI 0.001–0.188, p = 0.001) were found as independent variables that determine LATEF. Age (OR  0.879, 95% CI 0.795–0.972, p = 0.012), smoking (OR  23.739, 95% CI 2.699–208.810, p = 0.004), left ventricular mass index (OR  1.052, 95% CI 1.012–1.094, p = 0.011), mitrale E-wave velocity (OR 1.108, 95% CI 1.031–1.191, p = 0.005) and LDL (low-density lipoprotein) cholesterol (OR 0.942, 95% CI 0.911–0.974, p = 0.001) were independent predictors of LATEV. In non-diabetic patients with de novo hypertension endothelial dysfunction, subclinical atherosclerosis and LDL cholesterol levels independently affect left atrial function.