Coronin 1A depletion restores the nuclear stability and viability of Aip1/Wdr1-deficient neutrophils
Actin dynamics is central for cells, and especially for the fast-moving leukocytes. The severing of actin filaments is mainly achieved by cofilin, assisted by Aip1/Wdr1 and coronins. We found that in Wdr1-deficient zebrafish embryos, neutrophils display F-actin cytoplasmic aggregates and a complete spatial uncoupling of phospho-myosin from F-actin. They then undergo an unprecedented gradual disorganization of their nucleus followed by eruptive cell death. Their cofilin is mostly unphosphorylated...
Mon Oct 07, 2019 16:00
Binding of kindlins to integrins is required for integrin activation, stable ligand binding, and subsequent intracellular signaling. How hematopoietic kindlin-3 contributes to the assembly and stability of the adhesion complex is not known. Here we report that kindlin-3 recruits leupaxin into podosomes and thereby regulates paxillin phosphorylation and podosome turnover. We demonstrate that the activity of the protein tyrosine phosphatase PTP-PEST, which controls paxillin phosphorylation, requires...
Mon Oct 07, 2019 16:00
Correct nuclear position is crucial for cellular function and tissue development. Depending on cell context, however, the cytoskeletal elements responsible for nuclear positioning vary. While these cytoskeletal mechanisms have been intensely studied in single cells, how nuclear positioning is linked to tissue morphology is less clear. Here, we compare apical nuclear positioning in zebrafish neuroepithelia. We find that kinetics and actin-dependent mechanisms of nuclear positioning vary in tissues...
Mon Oct 07, 2019 16:00
How mammalian cells regulate their physical size is currently poorly understood, in part due to the difficulty in accurately quantifying cell volume in a high-throughput manner. Here, using the fluorescence exclusion method, we demonstrate that the mechanosensitive transcriptional regulators YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif) are regulators of single-cell volume. The role of YAP/TAZ in volume regulation must go beyond its influence on total cell...
Mon Oct 07, 2019 16:00
Neuronal connectivity relies on molecular motor-based axonal transport of diverse cargoes. Yet the precise players and regulatory mechanisms orchestrating such trafficking events remain largely unknown. We here report the ATPase Fignl1 as a novel regulator of bidirectional transport during axon navigation. Using a yeast two-hybrid screen and coimmunoprecipitation assays, we showed that Fignl1 binds the kinesin Kif1bβ and the dynein/dynactin adaptor Bicaudal D-1 (Bicd1) in a molecular complex including...
Mon Oct 07, 2019 16:00
Ischemic stroke causes blood–brain barrier (BBB) breakdown due to significant damage to the integrity of BBB components. Recent studies have highlighted the importance of pericytes in the repair process of BBB functions triggered by PDGFRβ up-regulation. Here, we show that perlecan, a major heparan sulfate proteoglycan of basement membranes, aids in BBB maintenance and repair through pericyte interactions. Using a transient middle cerebral artery occlusion model, we found larger infarct volumes and...
Mon Oct 07, 2019 16:00
Vol. 218, No. 3, March 4, 2019. 10.1083/jcb.201804183. The authors were recently alerted that some of the blot images used to generate Fig. 2 E were inaccurate and similar to images shown in Fig. 1...
Mon Oct 07, 2019 16:00
Related ArticlesGeological collaboration at paleoanthropological sites in Ethiopia's lower Awash Valley. Evol Anthropol. 2019 Oct 06;: Authors: Campisano CJ, Lower Awash Valley Workshop Participants PMID: 31587434 [PubMed - as supplied by publisher]
Mon Oct 07, 2019 16:50
Journal of Investigative Medicine High Impact Case Reports, Volume 7, Issue , January-December 2019. Adenoid cystic carcinoma is an uncommon malignant neoplasm of the salivary gland. Liver metastasis from salivary gland cancer is a rare situation. In this article, we report the case of a 29-year-old woman treated 5 years previously for adenoid cystic carcinoma of the parotid gland by surgery and radiotherapy, who presented for a large hypervascularized hepatic metastasis of 20 cm. After 3-cycle chemotherapy...
Thu Sep 26, 2019 15:58
Journal of Investigative Medicine High Impact Case Reports, Volume 7, Issue , January-December 2019. Idiopathic non-cirrhotic portal hypertension is a rare diagnosis caused by an unknown etiology with elevated intrahepatic portal pressures in the absence of underlying liver disease. We present a unique case of a 57-year-old male with a left ventricular assist device and preserved right ventricular function that was found to have an elevated hepatic venous pressure gradient and sequelae of portal...
Thu Sep 26, 2019 09:17
Abstract As a result of the cancer immunotherapy revolution, more than 2000 immuno‐oncology agents are currently being tested or are in use to improve responses. Not unexpectedly, the 2018 Nobel Prize in Physiology or Medicine was awarded to James P. Allison and Tasuku Honjo for their development of cancer therapy by the blockade of co‐inhibitory signals. Unfortunately, manipulation of the co‐inhibitory receptors has also resulted in a safety issue: widespread iatrogenic immune‐related adverse events...
Mon Oct 07, 2019 16:31
Girl Offering to Hindu gods in a Balinese templeHindu Tradition Accepts worship of several forms of the One Supreme GodIn the Hindu tradition of worship of several forms of Avathãras of the Supreme,... Thank's for Subscribing. This Email Newsletter is just plain to Read in Short Words.. Please visit Our Website for More Great Articles at: www.thehinduportal.com or our blog www.resurginghinduism.blogspot.com
Mon Oct 07, 2019 16:04
Vaccines, Vol. 7, Pages 140: Adverse Events Following Measles-Mumps-Rubella-Varicella Vaccination and the Case of Seizures: A Post Marketing Active Surveillance in Puglia Italian Region, 2017–2018 Vaccines doi: 10.3390/vaccines7040140 Authors: Stefanizzi Stella Ancona Malcangi Bianchi De Nitto Ferorelli Germinario Tafuri Since 2012, the Italian Ministry of Health has recommended to improve the surveillance of adverse events following the measles-mumps-rubella-varicella...
Mon Oct 07, 2019 03:00
Vaccines, Vol. 7, Pages 139: Factors Influencing Persistence of Diphtheria Immunity and Immune Response to a Booster Dose in Healthy Slovak Adults Vaccines doi: 10.3390/vaccines7040139 Authors: Petráš Oleár Molitorisová Dáňová Čelko Nováková Štefkovičová Krištúfková Malinová Lesná We assessed the long-term persistence of humoral immunity against diphtheria in adults with childhood vaccination and the immunogenicity of a booster dose considering demographic,...
Mon Oct 07, 2019 03:00
This work aims to assess the efficacy of x-ray quality assurance tests undertaken on fluoroscopy units in the UK. Information was gathered on the results of dosimetry and safety tests recommended by the reports of the Institute of Physics and Engineering in Medicine, and those additionally undertaken by medical physics departments. The assessment of efficacy considers the frequency with which a test result breaches the remedial level or other relevant threshold where applicable. The third...
Mon Oct 07, 2019 02:00
Objective/Background: We report efficacy and toxicity outcomes with stereotactic radiosurgery (SRS) for intracranial and spinal ependymoma. Methods: We analyzed adult and pediatric patients with newly diagnosed or recurrent intracranial or spinal ependymoma lesions treated with SRS at our institution. Following SRS, local failure (LF) was defined as failure within or adjacent to the SRS target volume, while distant failure (DF) was defined as failure outside of the SRS target volume. Time to LF and...
Mon Oct 07, 2019 13:54
Abstract Background Despite extensive research in atherosclerosis, the mechanisms of coronary atherothrombosis in ST‐elevation myocardial infarction (STEMI) patients are undetermined. Objectives Our aim was to find candidate genes involved in STEMI by analysing leucocyte gene expression in STEMI patients, without the influence of secondary inflammation from innate immunity, which was assumed to be a consequence rather than the cause of coronary atherothrombosis. Methods Fifty‐one...
Mon Oct 07, 2019 15:15
Journal of International Medical Research, Ahead of Print.
Mon Oct 07, 2019 09:25
Journal of International Medical Research, Ahead of Print.
Fri Oct 04, 2019 09:38
Journal of International Medical Research, Ahead of Print.
Fri Oct 04, 2019 09:30
Journal of International Medical Research, Ahead of Print.
Fri Oct 04, 2019 06:48
Journal of International Medical Research, Ahead of Print.
Thu Oct 03, 2019 14:41
Journal of International Medical Research, Ahead of Print.
Thu Oct 03, 2019 13:48
Journal of International Medical Research, Ahead of Print.
Thu Oct 03, 2019 12:14
Journal of International Medical Research, Ahead of Print.
Mon Sep 30, 2019 15:04
Journal of International Medical Research, Ahead of Print.
Mon Sep 30, 2019 15:04
Journal of International Medical Research, Ahead of Print.
Mon Sep 30, 2019 15:04
Journal of International Medical Research, Ahead of Print.
Mon Sep 30, 2019 15:02
Journal of International Medical Research, Ahead of Print.
Mon Sep 30, 2019 15:01
Journal of International Medical Research, Ahead of Print.
Mon Sep 30, 2019 15:00
Journal of International Medical Research, Ahead of Print.
Mon Sep 30, 2019 13:58
Journal of International Medical Research, Ahead of Print.
Fri Sep 27, 2019 08:14
Journal of International Medical Research, Ahead of Print.
Fri Sep 27, 2019 08:12
Journal of International Medical Research, Ahead of Print.
Fri Sep 27, 2019 08:10
Journal of International Medical Research, Ahead of Print.
Fri Sep 27, 2019 08:05
Journal of International Medical Research, Ahead of Print.
Fri Sep 27, 2019 08:02
Knockdown of RAD54B expression reduces cell proliferation and induces apoptosis in lung cancer cells
Journal of International Medical Research, Ahead of Print.
Fri Sep 27, 2019 07:59
Journal of International Medical Research, Ahead of Print.
Fri Sep 27, 2019 07:57
Journal of International Medical Research, Ahead of Print.
Thu Sep 26, 2019 12:02
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου