IJMS, Vol. 20, Pages 5035: Andrographolide Ameliorates Rheumatoid Arthritis by Regulating the Apoptosis–NETosis Balance of Neutrophils International Journal of Molecular Sciences doi: 10.3390/ijms20205035 Authors: Xiaohong Li Kai Yuan Qingqing Zhu Qingyi Lu Haixu Jiang Mengmeng Zhu Guangrui Huang Anlong Xu Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by symmetric polyarthritis with swelling and pain at synovial joints. In RA patients,...
Fri Oct 11, 2019 03:00
IJMS, Vol. 20, Pages 5038: Ibuprofen-Loaded Hyaluronic Acid Nanofibrous Membranes for Prevention of Postoperative Tendon Adhesion through Reduction of Inflammation International Journal of Molecular Sciences doi: 10.3390/ijms20205038 Authors: Chien-Tzung Chen Chih-Hao Chen Chialin Sheu Jyh-Ping Chen A desirable multi-functional nanofibrous membrane (NFM) for prevention of postoperative tendon adhesion should be endowed with abilities to prevent fibroblast attachment and penetration...
Fri Oct 11, 2019 03:00
IJMS, Vol. 20, Pages 5033: Functional Consequences of the SCN5A-p.Y1977N Mutation within the PY Ubiquitylation Motif: Discrepancy between HEK293 Cells and Transgenic Mice International Journal of Molecular Sciences doi: 10.3390/ijms20205033 Authors: Simona Casini Maxime Albesa Zizun Wang Vincent Portero Daniela Ross-Kaschitza Jean-Sébastien Rougier Gerard A. Marchal Wendy K. Chung Connie R. Bezzina Hugues Abriel Carol Ann Remme Dysfunction of the cardiac...
Fri Oct 11, 2019 03:00
IJMS, Vol. 20, Pages 5034: Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies International Journal of Molecular Sciences doi: 10.3390/ijms20205034 Authors: Ricardo O. S. Soares Daniele M. Losada Maria C. Jordani Paulo Évora Orlando Castro-e-Silva Ischemia/reperfusion injury (IRI) permeates a variety of diseases and is a ubiquitous concern in every transplantation proceeding, from whole organs to modest grafts. Given its significance,...
Fri Oct 11, 2019 03:00
IJMS, Vol. 20, Pages 5032: Function of miR825 and miR825* as Negative Regulators in Bacillus cereus AR156-elicited Systemic Resistance to Botrytis cinerea in Arabidopsis thaliana International Journal of Molecular Sciences doi: 10.3390/ijms20205032 Authors: Pingping Nie Chen Chen Qian Yin Chunhao Jiang Jianhua Guo Hongwei Zhao Dongdong Niu Small RNAs function to regulate plant defense responses to pathogens. We previously showed that miR825 and miR825* downregulate...
Fri Oct 11, 2019 03:00
IJMS, Vol. 20, Pages 5031: Ceramide and Sphingosine Regulation of Myelinogenesis: Targeting Serine Palmitoyltransferase Using microRNA in Multiple Sclerosis International Journal of Molecular Sciences doi: 10.3390/ijms20205031 Authors: Somsankar Dasgupta Swapan K. Ray Ceramide and sphingosine display a unique profile during brain development, indicating their critical role in myelinogenesis. Employing advanced technology such as gas chromatography–mass spectrometry, high...
Fri Oct 11, 2019 03:00
IJMS, Vol. 20, Pages 5030: Systematic Approach to Developing Splice Modulating Antisense Oligonucleotides International Journal of Molecular Sciences doi: 10.3390/ijms20205030 Authors: May T. Aung-Htut Craig S. McIntosh Kristin A. Ham Ianthe L. Pitout Loren L. Flynn Kane Greer Sue Fletcher Steve D. Wilton The process of pre-mRNA splicing is a common and fundamental step in the expression of most human genes. Alternative splicing, whereby different splice motifs and...
Fri Oct 11, 2019 03:00
IJMS, Vol. 20, Pages 5029: Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions International Journal of Molecular Sciences doi: 10.3390/ijms20205029 Authors: Shengmin Yan Bilon Khambu Honghai Hong Gang Liu Nazmul Huda Xiao-Ming Yin Alcohol-related liver disease (ALD) is caused by over-consumption of alcohol. ALD can develop a spectrum of pathological changes in the liver, including steatosis, inflammation, cirrhosis, and complications....
Fri Oct 11, 2019 03:00
JCDD, Vol. 6, Pages 36: Mitochondrial DNA Mutations and Rheumatic Heart Diseases Journal of Cardiovascular Development and Disease doi: 10.3390/jcdd6040036 Authors: Fatou Balla Wade Marie Parsine Sall Fatimata Mbaye Mbacké Sembene Acute rheumatic fever (ARF) is an autoimmune disease affecting the heart-valve endocardium in its final stage. Although rare in developing countries, ARF persists in third-world countries, particularly Senegal, where rheumatic heart diseases (RHDs)...
Fri Oct 11, 2019 03:00
JCM, Vol. 8, Pages 1666: The Extended Postoperative Care-Score (EXPO-Score)—An Objective Tool for Early Identification of Indication for Extended Postoperative Care Journal of Clinical Medicine doi: 10.3390/jcm8101666 Authors: Timo Iden Amke Caliebe Jochen Renner Maj-Britt Hertz Jan Höcker Päivi Suvanto-Scholz Markus Steinfath Norbert Weiler Matthias Gruenewald Extended postoperative care and intensive care unit capacity is limited and efficient patient allocation...
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JCM, Vol. 8, Pages 1665: A 3D Follow-Up Study of Cranial Asymmetry from Early Infancy to Toddler Age after Preterm versus Term Birth Journal of Clinical Medicine doi: 10.3390/jcm8101665 Authors: Anniina M. Launonen Henri Aarnivala Panagiotis Kyteas Ville Vuollo Tuomo Heikkinen Chung H. Kau Pertti Pirttiniemi Virpi Harila A. Marita Valkama Preterm infants are at higher risk for both symmetrical and asymmetrical head molding. This study involved 3D stereophotogrammetry...
Fri Oct 11, 2019 03:00
JCM, Vol. 8, Pages 1663: Revealing Associations between Diagnosis Patterns and Acupoint Prescriptions Using Medical Data Extracted from Case Reports Journal of Clinical Medicine doi: 10.3390/jcm8101663 Authors: Cheol-Han Kim Da-Eun Yoon Ye-Seul Lee Won-Mo Jung Joo-Hee Kim Younbyoung Chae Objective: The optimal acupoints for a particular disease can be determined by analysis of diagnosis patterns. The objective of this study was to reveal the association between such patterns...
Fri Oct 11, 2019 03:00
JCM, Vol. 8, Pages 1664: Polyphenol-Rich Extracts from Toona sinensis Bark and Fruit Ameliorate Free Fatty Acid-Induced Lipogenesis through AMPK and LC3 Pathways Journal of Clinical Medicine doi: 10.3390/jcm8101664 Authors: Yung-Chia Chen Hsin-Ju Chen Bu-Miin Huang Yu-Chi Chen Chi-Fen Chang Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease found worldwide. The present study aimed to evaluate the mechanisms of inhibiting lipid accumulation in free fatty...
Fri Oct 11, 2019 03:00
JCM, Vol. 8, Pages 1661: Circulating miRNAs as Diagnostic and Prognostic Biomarkers in Common Solid Tumors: Focus on Lung, Breast, Prostate Cancers, and Osteosarcoma Journal of Clinical Medicine doi: 10.3390/jcm8101661 Authors: Michela Bottani Giuseppe Banfi Giovanni Lombardi An early cancer diagnosis is essential to treat and manage patients, but it is difficult to achieve this goal due to the still too low specificity and sensitivity of classical methods (imaging, actual biomarkers),...
Fri Oct 11, 2019 03:00
JCM, Vol. 8, Pages 1662: Long Term Follow-Up of 103 Untreated Adult Patients with Type 1 Gaucher Disease Journal of Clinical Medicine doi: 10.3390/jcm8101662 Authors: Dinur Zimran Becker-Cohen Arkadir Cozma Hovakimyan Oppermann Demuth Rolfs Revel-Vilk The introduction of disease-specific therapy for patients with type I Gaucher disease (GD1) was a revolution in the management of patients, but not without cost. Thus, the management of mildly affected...
Fri Oct 11, 2019 03:00
JCM, Vol. 8, Pages 1653: The Relationship between Sleep Bruxism and Obstructive Sleep Apnea Based on Polysomnographic Findings Journal of Clinical Medicine doi: 10.3390/jcm8101653 Authors: Helena Martynowicz Pawel Gac Anna Brzecka Rafal Poreba Anna Wojakowska Grzegorz Mazur Joanna Smardz Mieszko Wieckiewicz Obstructive sleep apnea (OSA) is the most common sleep disorder. Sleep bruxism (SB) is a masticatory muscle activity during sleep that commonly co-occurs with...
Fri Oct 11, 2019 03:00
JCM, Vol. 8, Pages 1656: The Sulfate-Reducing Microbial Communities and Meta-Analysis of Their Occurrence during Diseases of Small–Large Intestine Axis Journal of Clinical Medicine doi: 10.3390/jcm8101656 Authors: Ivan Kushkevych Oľga Leščanová Dani Dordević Simona Jančíková Jan Hošek Monika Vítězová Leona Buňková Lorenzo Drago Sulfate-reducing bacteria (SRB) are often isolated from animals and people with ulcerative colitis and can be involved in the IBD development...
Fri Oct 11, 2019 03:00
JCM, Vol. 8, Pages 1659: Antioxidant Therapies for Neuroprotection-A Review Journal of Clinical Medicine doi: 10.3390/jcm8101659 Authors: Teleanu Chircov Grumezescu Volceanov Teleanu Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are crucial for various physiological processes within the human body, their overproduction leads to oxidative stress, defined as the imbalance between the production and accumulation of...
Fri Oct 11, 2019 03:00
JCM, Vol. 8, Pages 1657: 18F–Choline PET/CT Identifies High-Grade Prostate Cancer Lesions Expressing Bone Biomarkers Journal of Clinical Medicine doi: 10.3390/jcm8101657 Authors: Nicoletta Urbano Manuel Scimeca Antonio Crocco Alessandro Mauriello Elena Bonanno Orazio Schillaci The main aim of this study was to investigate the possible association between 18F–choline uptake and histopathological features of prostate biopsies such as the Gleason Group and the expression...
Fri Oct 11, 2019 03:00
JCM, Vol. 8, Pages 1658: Wnt Signaling in Ovarian Cancer Stemness, EMT, and Therapy Resistance Journal of Clinical Medicine doi: 10.3390/jcm8101658 Authors: Teeuwssen Fodde Ovarian cancers represent the deadliest among gynecologic malignancies and are characterized by a hierarchical structure with cancer stem cells (CSCs) endowed with self-renewal and the capacity to differentiate. The Wnt/β-catenin signaling pathway, known to regulate stemness in a broad spectrum of stem...
Fri Oct 11, 2019 03:00
JCM, Vol. 8, Pages 1652: Gait Classification in Unilateral Cerebral Palsy Journal of Clinical Medicine doi: 10.3390/jcm8101652 Authors: Stefanos Tsitlakidis Axel Horsch Felix Schaefer Fabian Westhauser Marco Goetze Sebastien Hagmann Matthias C. M. Klotz As unilateral cerebral palsy represents a complex disorder, gait classification is difficult. Knowledge of the most frequent gait patterns and functional impairment is crucial for proper decision-making. This study analyzes...
Fri Oct 11, 2019 03:00
JCM, Vol. 8, Pages 1660: Sensitivity and Specificity of Ultrawide-Field Fundus Photography for the Staging of Sickle Cell Retinopathy in Real-Life Practice at Varying Expertise Level Journal of Clinical Medicine doi: 10.3390/jcm8101660 Authors: Roxane Bunod Alexandra Mouallem-Beziere Francesca Amoroso Vittorio Capuano Karen Bitton Cynthia Kamami-Levy Camille Jung Eric H. Souied Alexandra Miere Purpose: To evaluate the sensitivity and specificity of ultrawide-field...
Fri Oct 11, 2019 03:00
JCM, Vol. 8, Pages 1654: New Imaging Markers of Clinical Outcome in Asymptomatic Patients with Severe Aortic Regurgitation Journal of Clinical Medicine doi: 10.3390/jcm8101654 Authors: Radka Kočková Hana Línková Zuzana Hlubocká Alena Pravečková Andrea Polednová Lucie Súkupová Martin Bláha Jiří Malý Eva Honsová David Sedmera Martin Pěnička Background: Determining the value of new imaging markers to predict aortic valve (AV) surgery in asymptomatic patients...
Fri Oct 11, 2019 03:00
JCM, Vol. 8, Pages 1655: ZIEL: Internet-Based Self-Help for Adjustment Problems: Results of a Randomized Controlled Trial Journal of Clinical Medicine doi: 10.3390/jcm8101655 Authors: Christian Moser Rahel Bachem Thomas Berger Andreas Maercker Adjustment Disorder (AjD) represents a healthcare paradox. On the one hand, it is one of the most diagnosed mental disorders worldwide. On the other hand, AjD and its possible treatment options remain a severely neglected field of research....
Fri Oct 11, 2019 03:00
JCM, Vol. 8, Pages 1651: Comparison of Placental Three-Dimensional Power Doppler Vascular Indices and Placental Volume in Pregnancies with Small for Gestational Age Neonates Journal of Clinical Medicine doi: 10.3390/jcm8101651 Authors: Sue-Jar Chen Chie-Pein Chen Fang-Ju Sun Chen-Yu Chen This prospective observational study aimed to compare the changes in placental vascular indices and placental volume using three-dimensional power Doppler (3DPD) ultrasound in pregnancies with...
Fri Oct 11, 2019 03:00
JoF, Vol. 5, Pages 98: Evaluation of a Novel Mitochondrial Pan-Mucorales Marker for the Detection, Identification, Quantification, and Growth Stage Determination of Mucormycetes Journal of Fungi doi: 10.3390/jof5040098 Authors: Rita Caramalho Lisa Madl Katharina Rosam Günter Rambach Cornelia Speth Johannes Pallua Thomas Larentis Ricardo Araujo Ana Alastruey-Izquierdo Cornelia Lass-Flörl Michaela Lackner Mucormycosis infections are infrequent yet aggressive...
Fri Oct 11, 2019 03:00
JoF, Vol. 5, Pages 97: Antifungal Drugs: Special Problems Treating Central Nervous System Infections
JoF, Vol. 5, Pages 97: Antifungal Drugs: Special Problems Treating Central Nervous System Infections Journal of Fungi doi: 10.3390/jof5040097 Authors: Elizabeth Dodds Ashley Treating fungal infections in the central nervous system (CNS) remains a challenge despite the availability of new antifungal agents. Therapy is limited by poor understanding of the kinetic properties of antifungal drugs in the CNS compounded by lack of data for many agents. In some cases, clinical response rates...
Fri Oct 11, 2019 03:00
Medicines, Vol. 6, Pages 101: In Vitro Anti-Inflammatory and Immunomodulatory Activities of an Extract from the Roots of Bupleurum rotundifolium Medicines doi: 10.3390/medicines6040101 Authors: Cholet Decombat Vareille-Delarbre Gainche Berry Senejoux Ripoche Delort Vermerie Fraisse Felgines Ranouille Berthon Priam Saunier Tourrette Troin Thebaud Chalard Caldefie-Chezet Background: Some Bupleurum species, such...
Fri Oct 11, 2019 03:00
Medicines, Vol. 6, Pages 100: Efficacy of a Validated Yoga Protocol on Dyslipidemia in Diabetes Patients: NMB-2017 India Trial Medicines doi: 10.3390/medicines6040100 Authors: Raghuram Nagarathna Rahul Tyagi Gurkeerat Kaur Vetri Vendan Ishwara N. Acharya Akshay Anand Amit Singh Hongasandra R. Nagendra Background: Dyslipidemia is considered a risk factor in Type 2 diabetes mellitus (T2DM) resulting in cardio-vascular complications. Yoga practices have shown promising...
Fri Oct 11, 2019 03:00
Membranes, Vol. 9, Pages 131: Inkjet Printed Y-Substituted Barium Zirconate Layers as Electrolyte Membrane for Thin Film Electrochemical Devices Membranes doi: 10.3390/membranes9100131 Authors: Theodor Schneller David Griesche In this work, the inkjet printing of proton conducting Y-substituted barium zirconate (BZY) thin films was studied. Two different kinds of precursor inks, namely a rather molecular BZY precursor solution and a BZY nanoparticle dispersion, have been synthesized...
Fri Oct 11, 2019 03:00
Metabolites, Vol. 9, Pages 222: Chemical Diversity and Classification of Secondary Metabolites in Nine Bryophyte Species Metabolites doi: 10.3390/metabo9100222 Authors: Peters Treutler Döll Kindt Hankemeier Neumann The central aim in ecometabolomics and chemical ecology is to pinpoint chemical features that explain molecular functioning. The greatest challenge is the identification of compounds due to the lack of constitutive reference spectra, the large number of...
Fri Oct 11, 2019 03:00
MPs, Vol. 2, Pages 81: Simple and Quick Visualization of Periodical Data Using Microsoft Excel Methods and Protocols doi: 10.3390/mps2040081 Authors: Oike Ogawa Oishi Actograms are well-established methods used for visualizing periodic activity of animals in chronobiological research. They help in the understanding of the overall characteristics of rhythms and are instrumental in defining the direction of subsequent detailed analysis. Although there exists specialized software...
Fri Oct 11, 2019 03:00
Microorganisms, Vol. 7, Pages 445: Diversity, Distribution, and Ecology of Fungi in the Seasonal Snow of Antarctica Microorganisms doi: 10.3390/microorganisms7100445 Authors: Graciéle C.A. de Menezes Soraya S. Amorim Vívian N. Gonçalves Valéria M. Godinho Jefferson C. Simões Carlos A. Rosa Luiz H. Rosa We characterized the fungal community found in the winter seasonal snow of the Antarctic Peninsula. From the samples of snow, 234 fungal isolates were obtained and could...
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Microorganisms, Vol. 7, Pages 444: A Diverse Repertoire of Exopolysaccharide Biosynthesis Gene Clusters in Lactobacillus Revealed by Comparative Analysis in 106 Sequenced Genomes Microorganisms doi: 10.3390/microorganisms7100444 Authors: Dipti Deo Dimple Davray Ram Kulkarni Production of exopolysaccharides (EPS) is one of the unique features of Lactobacillus genus. EPS not only have many physiological roles such as in stress tolerance, quorum sensing and biofilm formation, but...
Fri Oct 11, 2019 03:00
Microorganisms, Vol. 7, Pages 442: Antibody Testing in Estimating Past Exposure to Chlamydia trachomatis in the Netherlands Chlamydia Cohort Study Microorganisms doi: 10.3390/microorganisms7100442 Authors: Hoenderboom van Willige Land Pleijster Götz van Bergen Dukers-Muijrers Hoebe van Benthem Morré The asymptomatic course of Chlamydia trachomatis (CT) infections can result in underestimated CT lifetime prevalence. Antibody testing might improve...
Fri Oct 11, 2019 03:00
Microorganisms, Vol. 7, Pages 443: Dual RNA-Seq Unveils the Role of the Pseudomonas plecoglossicida fliA Gene in Pathogen-Host Interaction with Larimichthys crocea Microorganisms doi: 10.3390/microorganisms7100443 Authors: Sun Nie Zhao Huang Qin Xu Zhang Yan In the present study, Larimichthys crocea and Pseudomonas plecoglossicida were selected as a host-pathogen interaction model for teleosts and prokaryotic pathogens. Five shRNAs were designed and synthesized...
Fri Oct 11, 2019 03:00
Microorganisms, Vol. 7, Pages 441: Changes in the Bacterioplankton Community Structure from Southern Gulf of Mexico During a Simulated Crude Oil Spill at Mesocosm Scale Microorganisms doi: 10.3390/microorganisms7100441 Authors: Sonia S. Valencia-Agami Daniel Cerqueda-García Sébastien Putzeys María Magdalena Uribe-Flores Norberto Ulises García-Cruz Daniel Pech Jorge Herrera-Silveira M. Leopoldina Aguirre-Macedo José Q. García-Maldonado The southern Gulf of Mexico...
Fri Oct 11, 2019 03:00
Microorganisms, Vol. 7, Pages 439: Performance of Winter Wheat Cultivars Grown Organically and Conventionally with Focus on Fusarium Head Blight and Fusarium Trichothecene Toxins Microorganisms doi: 10.3390/microorganisms7100439 Authors: Tomasz Góral Aleksander Łukanowski Elżbieta Małuszyńska Kinga Stuper-Szablewska Maciej Buśko Juliusz Perkowski Growing acreage and changing consumer preferences cause increasing interest in the cereal products originating from organic...
Fri Oct 11, 2019 03:00
Microorganisms, Vol. 7, Pages 438: Expression of DinJ-YafQ System of Lactobacillus casei Group Strains in Response to Food Processing Stresses Microorganisms doi: 10.3390/microorganisms7100438 Authors: Alessia Levante Claudia Folli Barbara Montanini Alberto Ferrari Erasmo Neviani Camilla Lazzi Toxin-antitoxin (TA) systems are widely distributed in bacterial genomes and are involved in the adaptive response of microorganisms to stress conditions. Few studies have addressed...
Fri Oct 11, 2019 03:00
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