IJMS, Vol. 20, Pages 5358: Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP+-Induced Mitochondrial Dysfunction in Cultured Dopaminergic Neurons International Journal of Molecular Sciences doi: 10.3390/ijms20215358 Authors: Ichiro Kawahata Luc Bousset Ronald Melki Kohji Fukunaga α-Synuclein is an abundant neuronal protein that accumulates in insoluble inclusions in Parkinson′s disease and other synucleinopathies. Fatty acids partially...
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IJMS, Vol. 20, Pages 5356: IGF-1 Inhibits Apoptosis of Porcine Primary Granulosa Cell by Targeting Degradation of BimEL International Journal of Molecular Sciences doi: 10.3390/ijms20215356 Authors: Ying Han Shumin Wang Yingzheng Wang Shenming Zeng Insulin-like growth factor-1 (IGF-1) is an intra-ovarian growth factor that plays important endocrine or paracrine roles during ovarian development. IGF-1 affects ovarian function and female fertility through reducing apoptosis of...
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IJMS, Vol. 20, Pages 5355: Melatonin-Induced Transcriptome Variation of Rapeseed Seedlings under Salt Stress International Journal of Molecular Sciences doi: 10.3390/ijms20215355 Authors: Xiaoyu Tan Weihua Long Liu Zeng Xiaoyu Ding Yong Cheng Xuekun Zhang Xiling Zou Salt stress inhibits the production of all crop species, including rapeseed (Brassica napus L.), the second most widely planted oil crop species. Although melatonin was confirmed to alleviate salt stress...
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IJMS, Vol. 20, Pages 5353: Progress in Tissue Culture and Genetic Transformation of Oil Palm: An Overview International Journal of Molecular Sciences doi: 10.3390/ijms20215353 Authors: Rajesh Yarra Longfei Jin Zhihao Zhao Hongxing Cao Oil palm (Elaeis guineensis, Jacq.) is a prominent vegetable-oil-yielding crop. Cultivating high-yielding oil palm with improved traits is a pre-requisite to meet the increasing demands of palm oil consumption. However, tissue culture and biotechnological...
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IJMS, Vol. 20, Pages 5352: Multivalent Carbonic Anhydrases Inhibitors International Journal of Molecular Sciences doi: 10.3390/ijms20215352 Authors: Fabrizio Carta Pascal Dumy Claudiu T. Supuran Jean-Yves Winum Biomolecular recognition using a multivalent strategy has been successfully applied, this last decade on several biological targets, especially carbohydrate-processing enzymes, proteases, and phosphorylases. This strategy is based on the fact that multivalent interactions...
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IJMS, Vol. 20, Pages 5354: Examination of Adsorption Orientation of Amyloidogenic Peptides Over Nano-Gold Colloidal Particle Surfaces International Journal of Molecular Sciences doi: 10.3390/ijms20215354 Authors: Kazushige Yokoyama Kieran Brown Peter Shevlin Jack Jenkins Elizabeth D’Ambrosio Nicole Ralbovsky Jessica Battaglia Ishan Deshmukh Akane Ichiki The adsorption of amyloidogenic peptides, amyloid beta 1–40 (Aβ1–40), alpha-synuclein...
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IJMS, Vol. 20, Pages 5351: Structural Insights into AQP2 Targeting to Multivesicular Bodies International Journal of Molecular Sciences doi: 10.3390/ijms20215351 Authors: Jennifer Virginia Roche Veronika Nesverova Caroline Olsson Peter MT Deen Susanna Törnroth-Horsefield Vasopressin-dependent trafficking of AQP2 in the renal collecting duct is crucial for the regulation of water homeostasis. This process involves the targeting of AQP2 to the apical membrane during dehydration...
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IJMS, Vol. 20, Pages 5350: The Impact of Dose Rate on DNA Double-Strand Break Formation and Repair in Human Lymphocytes Exposed to Fast Neutron Irradiation International Journal of Molecular Sciences doi: 10.3390/ijms20215350 Authors: Shankari Nair Monique Engelbrecht Xanthene Miles Roya Ndimba Randall Fisher Peter du Plessis Julie Bolcaen Jaime Nieto-Camero Evan de Kock Charlot Vandevoorde The lack of information on how biological systems respond to low-dose...
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IJMS, Vol. 20, Pages 5349: The Influence of a Nanopatterned Scaffold that Mimics Abnormal Renal Mesangial Matrix on Mesangial Cell Behavior International Journal of Molecular Sciences doi: 10.3390/ijms20215349 Authors: Chia-Jung Chang Rin Minei Takeshi Sato Akiyoshi Taniguchi The alteration of mesangial matrix (MM) components in mesangium, such as type IV collagen (COL4) and type I collagen (COL1), is commonly found in progressive glomerular disease. Mesangial cells (MCs) responding...
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IJMS, Vol. 20, Pages 5346: Functional Comparison of Human and Zebra Fish FKBP52 Confirms the Importance of the Proline-Rich Loop for Regulation of Steroid Hormone Receptor Activity International Journal of Molecular Sciences doi: 10.3390/ijms20215346 Authors: Diondra C. Harris Yenni A. Garcia Cheryl Storer Samaniego Veronica W. Rowlett Nina R. Ortiz Ashley N. Payan Tatsuya Maehigashi Marc B. Cox Previous studies demonstrated that the 52-kDa FK506-binding protein...
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IJMS, Vol. 20, Pages 5348: Immunomodulatory Protein from Nectria haematococca Induces Apoptosis in Lung Cancer Cells via the P53 Pathway International Journal of Molecular Sciences doi: 10.3390/ijms20215348 Authors: Jing-Jing Wang Yan Wang Lizhen Hou Fengjiao Xin Bei Fan Cong Lu Lijing Zhang Fengzhong Wang Shuying Li Our previous research has shown that a fungal immunomodulatory protein from Nectria haematococca (FIP-nha) possesses a wide spectrum of anti-tumor...
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IJMS, Vol. 20, Pages 5347: PD-L1/PD-1 Axis in Glioblastoma Multiforme International Journal of Molecular Sciences doi: 10.3390/ijms20215347 Authors: Jakub Litak Marek Mazurek Cezary Grochowski Piotr Kamieniak Jacek Roliński Glioblastoma (GBM) is the most popular primary central nervous system cancer and has an extremely expansive course. Aggressive tumor growth correlates with short median overall survival (OS) oscillating between 14 and 17 months. The survival rate of patients...
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IJMS, Vol. 20, Pages 5345: First Report of a Patient with MPS Type VII, Due to Novel Mutations in GUSB, Who Underwent Enzyme Replacement and Then Hematopoietic Stem Cell Transplantation International Journal of Molecular Sciences doi: 10.3390/ijms20215345 Authors: Patricia Dubot Frédérique Sabourdy Geneviève Plat Charlotte Jubert Claude Cancès Pierre Broué Guy Touati Thierry Levade We report the case of a boy who was diagnosed with mucopolysaccharidosis (MPS) VII...
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JCM, Vol. 8, Pages 1805: Microvascular Obstruction in ST-Segment Elevation Myocardial Infarction: Looking Back to Move Forward. Focus on CMR Journal of Clinical Medicine doi: 10.3390/jcm8111805 Authors: Cesar Rios-Navarro Victor Marcos-Garces Antoni Bayes-Genis Oliver Husser Julio Nuñez Vicente Bodi After a myocardial infarction (MI), despite the resolution of the coronary occlusion, the deterioration of myocardial perfusion persists in a considerable number of patients....
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JCM, Vol. 8, Pages 1804: Three-Dimensional Analysis of Initial Brace Correction in the Setting of Adolescent Idiopathic Scoliosis Journal of Clinical Medicine doi: 10.3390/jcm8111804 Authors: Haidara Almansour Wojciech Pepke Thomas Bruckner Bassel G. Diebo Michael Akbar The three-dimensional nature of adolescent idiopathic scoliosis (AIS) necessitates a tridimensional assessment and management. Bracing constitutes the mainstay conservative treatment for mild adolescent idiopathic...
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JCM, Vol. 8, Pages 1803: Impedance Aggregometry Reveals Increased Platelet Aggregation during Liver Transplantation Journal of Clinical Medicine doi: 10.3390/jcm8111803 Authors: Mohamed Soliman Matthias Hartmann In patients presenting for liver transplantation, increased platelet aggregation as well as thrombocytopenia have been demonstrated, but bedside assays have not been investigated. We compared platelet aggregation in liver transplantation patients and control surgical patients...
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Metabolites, Vol. 9, Pages 253: Lipidomics of Brain Tissues in Rats Fed Human Milk from Chinese Mothers or Commercial Infant Formula Metabolites doi: 10.3390/metabo9110253 Authors: Miya Su Arvind K. Subbaraj Karl Fraser Xiaoyan Qi Hongxin Jia Wenliang Chen Mariza Gomes Reis Mike Agnew Li Day Nicole C. Roy Wayne Young Holistic benefits of human milk to infants, particularly brain development and cognitive behavior, have stipulated that infant formula be tailored...
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Metabolites, Vol. 9, Pages 252: A Lipidomic Analysis of Docosahexaenoic Acid (22:6, ω3) Mediated Attenuation of Western Diet Induced Nonalcoholic Steatohepatitis in Male Ldlr -/- Mice Metabolites doi: 10.3390/metabo9110252 Authors: Manuel García-Jaramillo Kelli A. Lytle Melinda H. Spooner Donald B. Jump Nonalcoholic fatty liver disease (NAFLD) is a major public health problem worldwide. NAFLD ranges in severity from benign steatosis to nonalcoholic steatohepatitis (NASH), cirrhosis,...
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Microorganisms, Vol. 7, Pages 496: Systematic Culturomics Shows that Half of Chicken Caecal Microbiota Members can be Grown in Vitro Except for Two Lineages of Clostridiales and a Single Lineage of Bacteroidetes Microorganisms doi: 10.3390/microorganisms7110496 Authors: Magdalena Crhanova Daniela Karasova Helena Juricova Jitka Matiasovicova Eva Jahodarova Tereza Kubasova Zuzana Seidlerova Alois Cizek Ivan Rychlik Epidemiological data show that the composition...
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Microorganisms, Vol. 7, Pages 495: Comparative Transcriptomic Analysis of the Interaction between Penicillium expansum and Apple Fruit (Malus pumila Mill.) during Early Stages of Infection Microorganisms doi: 10.3390/microorganisms7110495 Authors: Kaili Wang Xiangfeng Zheng Xiaoyun Zhang Lina Zhao Qiya Yang Nana Adwoa Serwah Boateng Joseph Ahima Jia Liu Hongyin Zhang Blue mold, caused by Penicillium expansum, is an important postharvest disease of apple, and can...
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Molbank, Vol. 2019, Article M1087: 6-Bromo-N-(2-methyl-2H-benzo[d][1,2,3]triazol-5-yl)quinolin-4-amine Molbank doi: 10.3390/M1087 Authors: Christopher R. M. Asquith Graham J. Tizzard We describe a straightforward synthesis of the title compound, incorporating a relatively rare 2-methyl-2H-1,2,3-triazole heterocylic motif as a potential kinase inhibitor motif. The small molecule crystal structure has been resolved, revealing an interesting packing arrangement and overall conformation....
Sun Oct 27, 2019 03:00
Molecules, Vol. 24, Pages 3877: Enhanced Reactant Distribution in Redox Flow Cells Molecules doi: 10.3390/molecules24213877 Authors: Nicholas Gurieff Declan Finn Keogh Victoria Timchenko Chris Menictas Redox flow batteries (RFBs), provide a safe and cost-effective means of storing energy at grid-scale, and will play an important role in the decarbonization of global electricity networks. Several approaches have been explored to improve their efficiency and power density, and...
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Molecules, Vol. 24, Pages 3876: Eleutheroside B Protects against Acute Kidney Injury by Activating IGF Pathway Molecules doi: 10.3390/molecules24213876 Authors: Hongmei Zang Qin Yang Jun Li Acute kidney injury (AKI) is a common, complex, and severe clinical syndrome characterized by rapid decline in renal function, combined with tissue damage. Currently, the prevention and treatment of AKI are focused on symptomatic treatment, rather than treating the underlying causes. Therefore,...
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Molecules, Vol. 24, Pages 3875: Icariin Promotes the Osteogenic Action of BMP2 by Activating the cAMP Signaling Pathway Molecules doi: 10.3390/molecules24213875 Authors: Meng Chen Yazhou Cui Hui Li Jing Luan Xiaoyan Zhou Jinxiang Han Icariin (ICA) is the main active flavonoid glucoside from herbs of the genus Epimedium; in traditional Chinese medicine, these herbs have long been prescribed for the treatment of bone fractures and osteoporosis. Several studies have shown...
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Molecules, Vol. 24, Pages 3874: Evaluation of Microbial Transformation of 10-deoxoartemisinin by UPLC-ESI-Q-TOF-MSE Molecules doi: 10.3390/molecules24213874 Authors: Yue Bai Dong Zhang Peng Sun Yifan Zhao Xiaoqiang Chang Yue Ma Lan Yang 10-deoxoartemisinin is a semisynthetic derivative of artemisinin that lacks a lactone carbonyl group at the 10-position, and has stronger antimalarial properties than artemisinin. However, 10-deoxoartemisinin has limited utility as a...
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Molecules, Vol. 24, Pages 3873: Comparative Pharmacokinetics of Gallic Acid, Protocatechuic Acid, and Quercitrin in Normal and Pyelonephritis Rats after Oral Administration of a Polygonum capitatum Extract Molecules doi: 10.3390/molecules24213873 Authors: Yong Huang Zuying Zhou Wu Yang Zipeng Gong Yueting Li Siying Chen Yonglin Wang Aimin Wang Yanyu Lan Ting Liu Lin Zheng Polygonum capitatum Buch.-Ham. ex D. Don is traditionally used by Hmong for the treatment...
Sun Oct 27, 2019 03:00
Nanomaterials, Vol. 9, Pages 1530: Dewetting Metal Nanofilms—Effect of Substrate on Refractive Index Sensitivity of Nanoplasmonic Gold Nanomaterials doi: 10.3390/nano9111530 Authors: Nikhil Bhalla Aditya Jain Yoonjoo Lee Amy Q. Shen Doojin Lee The localized surface plasmon resonance (LSPR) sensitivity of metal nanostructures is strongly dependent on the interaction between the supporting substrate and the metal nanostructure, which may cause a change in the local refractive...
Sun Oct 27, 2019 03:00
Nutrients, Vol. 11, Pages 2589: Breast Milk Supply of MicroRNA Associated with Leptin and Adiponectin Is Affected by Maternal Overweight/Obesity and Influences Infancy BMI Nutrients doi: 10.3390/nu11112589 Authors: Rocío Zamanillo Juana Sánchez Francisca Serra Andreu Palou Breast milk constitutes a dietary source of leptin, adiponectin and microRNAs (miRNAs) for newborns. Expression of miRNAs previously associated with maternal obesity, leptin or adiponectin function were assessed...
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Nutrients, Vol. 11, Pages 2588: Polyphenol Effects on Cholesterol Metabolism via Bile Acid Biosynthesis, CYP7A1: A Review Nutrients doi: 10.3390/nu11112588 Authors: Karen F. Chambers Priscilla E. Day Hassan T. Aboufarrag Paul A. Kroon Atherosclerosis, the main contributor to coronary heart disease, is characterised by an accumulation of lipids such as cholesterol in the arterial wall. Reverse cholesterol transport (RCT) reduces cholesterol via its conversion into bile acids...
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Pathogens, Vol. 8, Pages 208: Detection of Second Line Drug Resistance among Drug Resistant Mycobacterium Tuberculosis Isolates in Botswana Pathogens doi: 10.3390/pathogens8040208 Authors: Tuelo Mogashoa Pinkie Melamu Brigitta Derendinger Serej D. Ley Elizabeth M. Streicher Thato Iketleng Lucy Mupfumi Margaret Mokomane Botshelo Kgwaadira Goabaone Rankgoane-Pono Thusoyaone T. Tsholofelo Ishmael Kasvosve Sikhulile Moyo Robin M. Warren Simani Gaseitsiwe...
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Pharmaceutics, Vol. 11, Pages 557: Extracellular Vesicles as Natural, Safe and Efficient Drug Delivery Systems Pharmaceutics doi: 10.3390/pharmaceutics11110557 Authors: Federico Villa Rodolfo Quarto Roberta Tasso Extracellular vesicles (EVs) are particles naturally released from cells, delimited by a lipid bilayer, carrying functionally active biological molecules. In addition to their physiological role in cellular communication, the interest of the scientific community has recently...
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Pharmaceutics, Vol. 11, Pages 556: Fibrin as a Multipurpose Physiological Platform for Bone Tissue Engineering and Targeted Delivery of Bioactive Compounds Pharmaceutics doi: 10.3390/pharmaceutics11110556 Authors: Bruno Bujoli Jean-Claude Scimeca Elise Verron Although bone graft is still considered as the gold standard method, bone tissue engineering offers promising alternatives designed to mimic the extracellular matrix (ECM) and to guide bone regeneration process. In this attempt,...
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Pharmaceutics, Vol. 11, Pages 555: Synthesis and Characterization of pH-Sensitive Inulin Conjugate of Isoniazid for Monocyte-Targeted Delivery Pharmaceutics doi: 10.3390/pharmaceutics11110555 Authors: Franklin Afinjuomo Thomas G. Barclay Ankit Parikh Rosa Chung Yunmei Song Gayathri Nagalingam Jamie Triccas Lixin Wang Liang Liu John D. Hayball Nikolai Petrovsky Sanjay Garg The use of particles for monocyte-mediated delivery could be a more efficient strategy...
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Pharmaceutics, Vol. 11, Pages 554: Novel Approaches for the Delivery of Anti-HIV Drugs—What Is New? Pharmaceutics doi: 10.3390/pharmaceutics11110554 Authors: José das Neves HIV/AIDS continues to be one of the most challenging individual and public health concerns of our days [...]
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Plants, Vol. 8, Pages 457: Screening for Plant Volatile Emissions with Allelopathic Activity and the Identification of L-Fenchone and 1,8-Cineole from Star Anise (Illicium verum) Leaves Plants doi: 10.3390/plants8110457 Authors: Gaowa Kang Maryia Mishyna Kwame Sarpong Appiah Masaaki Yamada Akihito Takano Valery Prokhorov Yoshiharu Fujii One hundred and thirty-nine medicinal plant species were screened for their allelopathic activity through volatile emissions using...
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Plants, Vol. 8, Pages 456: The Changing Distribution of Anthocyanin in Mikania micrantha Leaves as an Adaption to Low-Temperature Environments Plants doi: 10.3390/plants8110456 Authors: Qilei Zhang Junjie Zhai Guangxin Chen Wei Lin Changlian Peng Anthocyanins, a protective substance in plant leaves, can accumulate in large quantities under low-temperature induction. In order to explore the effect of anthocyanins in Mikania micrantha leaves, the Rubisco, photosynthesis, pigments,...
Sun Oct 27, 2019 03:00
Religions, Vol. 10, Pages 597: The Discarded Image and the Debunked Tao: Objective Value in C.S. Lewis’ Medieval Model and His Critique of Modernity † Religions doi: 10.3390/rel10110597 Authors: Yuxiao Su This paper considers C.S. Lewis’ “doctrine of objective value” in two of his major works, The Abolition of Man and The Discarded Image. Lewis uses the Chinese name Tao, albeit with an incomplete understanding of its origins, for the objective worldview....
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Religions, Vol. 10, Pages 596: Looking Back at the Evolution of James Cone’s Theological Anthropology: A Brief Commentary Religions doi: 10.3390/rel10110596 Authors: Sekhmet Ra Em Kht Maat Reverend Dr. James Hal Cone has unquestionably been a key architect in defining Black liberation theology. Trained in the Western theological tradition at Garrett Theological Seminary, Cone became an expert on the theology of Twentieth-century Swiss-German theologian Karl Barth. Cone’s study...
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Social Sciences, Vol. 8, Pages 300: Retailing, Consumers, and Territory: Trends of an Incipient Circular Model Social Sciences doi: 10.3390/socsci8110300 Authors: María D. De-Juan-Vigaray Ana I. Espinosa Seguí The aim of this theoretical research is to analyze the state of retail distribution nowadays, reviewing the dynamics of action that contribute to the move from a linear to an incipient circular retail model. The framework is based on the Retail Wheel Spins Theory and the Retail...
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