Related ArticlesElectrochemical aptamer-based determination of protein tyrosine kinase-7 using toehold-mediated strand displacement amplification on gold nanoparticles and graphene oxide. Mikrochim Acta. 2019 Oct 26;186(11):720 Authors: Li Z, Zhou Z, Xue N, Wu S, Miao X Abstract An electrochemical method is described for ultrasensitive determination of protein tyrosine kinase-7 (PTK7). It is based on (a) the use of positively charged gold nanoparticles...
Related ArticlesExpression of melanoma cell adhesion molecule-1 (MCAM-1) in natalizumab-treated multiple sclerosis. J Neuroimmunol. 2019 Oct 13;337:577085 Authors: Petersen ER, Ammitzbøll C, Søndergaard HB, Oturai AB, Sørensen PS, Nilsson AC, Börnsen L, von Essen M, Sellebjerg F Abstract The objectives were to study the expression of very late antigen (VLA)-4, melanoma cell adhesion molecule-1 (MCAM-1) and activated leukocyte cell adhesion molecule (ALCAM)...
Related ArticlesFrom bench to counter: Discovery and validation of a peony extract as tyrosinase inhibiting cosmeceutical. Eur J Med Chem. 2019 Sep 25;184:111738 Authors: Rainer B, Revoltella S, Mayr F, Moesslacher J, Scalfari V, Kohl R, Waltenberger B, Pagitz K, Siewert B, Schwaiger S, Stuppner H Abstract The anti-melanogenic principle of peony (Paeonia officinalis subsp. officinalis) seeds was elucidated via activity-guided isolation. Resveratroloside...
Related ArticlesEffective oral delivery of gp100 plasmid vaccine against metastatic melanoma through multi-faceted blending-by-blending nanogels. Nanomedicine. 2019 Oct 23;:102114 Authors: Shen Y, Qiu L Abstract Plasmid DNA gp100 is able to act as an available vaccine against metastatic melanoma, but its administration is usually limited to parenteral route. Since oral delivery of plasmid DNA is intervened by various physical obstacles, here we constructed...
Related ArticlesThe Mutational Landscape of Mucosal Melanoma. Semin Cancer Biol. 2019 Oct 23;: Authors: Nassar KW, Tan AC Abstract Mucosal melanoma is a rare and aggressive subtype of melanoma that has a less favorable prognosis due to the lack of understanding and identification of oncogenic drivers. Recently, whole genome and whole exome sequencing have unveiled the molecular landscape and potential oncogenic drivers of mucosal melanoma, which remains...
Related ArticlesBrain Malignancies: Cancer Cell Trafficking in and out of the Niches. Semin Cancer Biol. 2019 Oct 22;: Authors: Lah TT, Novak M, Breznik B Abstract Brain, the major organ of the central nervous system controls and processes most of our body activities and therefore the most aggressive brain tumor - glioblastoma and metastases from other organs to the bran are lethal, leaving the patients with very low survival time. The brain tissue landscape...
Related ArticlesRisk factors for the development of cutaneous melanoma after allogeneic hematopoietic cell transplantation. J Am Acad Dermatol. 2019 Oct 22;: Authors: Herr MM, Curtis RE, Tucker MA, Tecca HR, Engels EA, Cahoon EK, Battiwalla M, Buchbinder D, Flowers ME, Brazauskas R, Shaw BE, Morton LM Abstract Melanoma risk is increased after allogeneic hematopoietic cell transplantation (HCT), but specific risk factors are unknown. We conducted a nested...
Related ArticlesOrphan nuclear receptor TR3/Nur77 biologics inhibit tumor growth by targeting angiogenesis and tumor cells. Microvasc Res. 2019 Oct 22;:103934 Authors: Chen C, Li Y, Hou S, Bourbon PM, Qin L, Zhao K, Ye T, Zhao D, Zeng H Abstract Pathological angiogenesis is a hallmark of many diseases. Previously, we reported that orphan nuclear receptor TR3/Nur77 was a critical mediator of angiogenesis to regulate tumor growth, sepsis and skin wound...
Related ArticlesThe national comprehensive cancer network distress thermometer as a screening tool for the evaluation of quality of life in uveal melanoma patients. Acta Ophthalmol. 2019 Oct 25;: Authors: Klingenstein A, Samel C, Garip-Kuebler A, Miller C, Liegl RG, Priglinger SG, Foerster PI Abstract PURPOSE: To assess quality of life (QoL) status via the National Comprehensive Cancer Network (NCCN) distress thermometer as a psychooncological screening...
Related ArticlesSimultaneous endocrine expression and loss of melanoma markers in malignant melanoma metastases, a retrospective analysis. Pathol Oncol Res. 2019 Oct 25;: Authors: Steppert C, Krugmann J, Sterlacci W Abstract Malignant melanoma metastases are chameleons of histopathology. In 4 primary malignant melanomas and 20 melanoma metastases expression of S-100, HMB-45 and melan-A as melanoma markers and CD56, synaptophysin and chromogranin-A as...
Related ArticlesASO Author Reflections: Surgical Margins for Melanoma-What's Next? Ann Surg Oncol. 2019 Oct 25;: Authors: Angeles CV, Wong SL, Karakousis G PMID: 31654159 [PubMed - as supplied by publisher]
Related ArticlesSmall extracellular vesicles convey the stress-induced adaptive responses of melanoma cells. Sci Rep. 2019 Oct 25;9(1):15329 Authors: Harmati M, Gyukity-Sebestyen E, Dobra G, Janovak L, Dekany I, Saydam O, Hunyadi-Gulyas E, Nagy I, Farkas A, Pankotai T, Ujfaludi Z, Horvath P, Piccinini F, Kovacs M, Biro T, Buzas K Abstract Exosomes are small extracellular vesicles (sEVs), playing a crucial role in the intercellular communication in physiological...
Related ArticlesGenomic Prediction of 16 Complex Disease Risks Including Heart Attack, Diabetes, Breast and Prostate Cancer. Sci Rep. 2019 Oct 25;9(1):15286 Authors: Lello L, Raben TG, Yong SY, Tellier LCAM, Hsu SDH Abstract We construct risk predictors using polygenic scores (PGS) computed from common Single Nucleotide Polymorphisms (SNPs) for a number of complex disease conditions, using L1-penalized regression (also known as LASSO) on case-control...
Related ArticlesAcute kidney injury from immune checkpoint inhibitor use. BMJ Case Rep. 2019 Oct 25;12(10): Authors: Gordon L, Dokouhaki P, Hagel K, Prasad B Abstract Immune checkpoint inhibitors are novel oncological medications, current classes of which include monoclonal antibodies that target inhibitory receptors cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), programmed death 1 protein (PD-1) and programmed death-ligand 1. While they are novel...
Related ArticlesConfirmatory trial of non-amputative digit preservation surgery for subungual melanoma: Japan Clinical Oncology Group study (JCOG1602, J-NAIL study protocol). BMC Cancer. 2019 Oct 25;19(1):1002 Authors: Tanaka K, Nakamura Y, Mizutani T, Shibata T, Tsutsumida A, Fukuda H, Matsushita S, Aoki M, Namikawa K, Ohe S, Fukushima S, Yamazaki N, Dermatologic Oncology Group of the Japan Clinical Oncology Group Abstract BACKGROUND: Amputation is...
Related ArticlesEfficacy, Safety, and Tolerability of Approved Combination BRAF and MEK Inhibitor Regimens for BRAF-Mutant Melanoma. Cancers (Basel). 2019 Oct 24;11(11): Authors: Hamid O, Cowey CL, Offner M, Faries M, Carvajal RD Abstract No head-to-head studies exist comparing BRAF inhibitor/MEK inhibitor (BRAFi/MEKi) combination treatments for BRAF-mutant melanoma. A side-by-side analysis of randomized phase III trials is presented that evaluated dabrafenib/trametinib,...
Related ArticlesIdentification of 15 T Cell Restricted Genes Evaluates T Cell Infiltration of Human Healthy Tissues and Cancers and Shows Prognostic and Predictive Potential. Int J Mol Sci. 2019 Oct 22;20(20): Authors: Cari L, De Rosa F, Petrillo MG, Migliorati G, Nocentini G, Riccardi C Abstract T cell gene signatures are used to evaluate T cell infiltration of non-lymphoid tissues and cancers in both experimental and clinical settings. However, some...
Related ArticlesIdentification of a Synergistic Multi-Drug Combination Active in Cancer Cells via the Prevention of Spindle Pole Clustering. Cancers (Basel). 2019 Oct 22;11(10): Authors: Weiss A, Le Roux-Bourdieu M, Zoetemelk M, Ramzy GM, Rausch M, Harry D, Miljkovic-Licina M, Falamaki K, Wehrle-Haller B, Meraldi P, Nowak-Sliwinska P Abstract A major limitation of clinically used cancer drugs is the lack of specificity resulting in toxicity. To address...
Related ArticlesTumor Cells Develop Defined Cellular Phenotypes After 3D-Bioprinting in Different Bioinks. Cells. 2019 Oct 22;8(10): Authors: Schmidt SK, Schmid R, Arkudas A, Kengelbach-Weigand A, Bosserhoff AK Abstract Malignant melanoma is often used as a model tumor for the establishment of novel therapies. It is known that two-dimensional (2D) culture methods are not sufficient to elucidate the various processes during cancer development and progression....
Related ArticlesDevelopment of the Melanoma Concerns Questionnaire© (MCQ-28©); refinement of the EORTC QLQ-MEL38 Module. Psychooncology. 2019 Oct 25;: Authors: Winstanley J, White E, Saw R, Young T, Burmeister B, Nikolic D, Busto-Cornide I, Iglesias-Pena N, Boyle F Abstract OBJECTIVE: Few patient-reported outcome measures (PROMs) have been developed that adequately measure the patient-experience following diagnosis and treatment of melanoma. Building...
Related ArticlesBenserazide is a novel inhibitor targeting PKM2 for melanoma treatment. Int J Cancer. 2019 Oct 25;: Authors: Zhou Y, Huang Z, Su J, Li J, Zhao S, Wu L, Zhang J, He Y, Zhang G, Tao J, Zhou J, Chen X, Peng C Abstract The M2 splice isoform of pyruvate kinase (PKM2) is a key enzyme for generating pyruvate and ATP in the glycolytic pathway, whereas the role of PKM2 in tumorigenesis remains a subject of debate. In this study, we found PKM2...
Related ArticlesOPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY DETECTS SUBCLINICAL RADIAL PERIPAPILLARY CAPILLARY DENSITY REDUCTION AFTER PLAQUE RADIOTHERAPY FOR CHOROIDAL MELANOMA. Retina. 2019 Oct 24;: Authors: Chien JL, Sioufi K, Ferenczy SR, Say EAT, Shields CL Abstract PURPOSE: To evaluate radial peripapillary capillary density (RPCD) in irradiated eyes without radiation papillopathy clinically. METHODS: Patients treated with plaque radiotherapy...
Related ArticlesAsymptomatic Metastasis to Thyroid Cartilage Detected by 18F-Choline and 64Cu-PSMA PET/CT as a Single Site of Disease Relapse in a Patient With Castration-Resistant Prostate Carcinoma. Clin Nucl Med. 2019 Oct 17;: Authors: Annovazzi A, Faiella A, Pescarmona E, Sanguineti G, Sciuto R Abstract Metastatic involvement of the larynx is rare due to the absence of vessels within the cartilaginous tissue. The probability of metastatic spread...
Related ArticlesAberrant hTERT promoter methylation predicts prognosis in Chinese patients with acral and mucosal melanoma: A CONSORT-compliant article. Medicine (Baltimore). 2019 Oct;98(43):e17578 Authors: Xu H, Wang W, Zhao J, Li T, Kang X Abstract BACKGROUND: To evaluate the methylation levels of human telomerase reverse transcriptase (hTERT) promoter three CpG island (CGIs) regions and its prognostic impact in Chinese patients with acral and mucosal...
Related ArticlesExternal validation of the American Joint Committee on Cancer 8th edition melanoma staging system: who needs adjuvant treatment? Melanoma Res. 2019 Oct 22;: Authors: Madu MF, Franke V, Van de Wiel BA, Klop WMC, Jóźwiak K, van Houdt WJ, Wouters MWJM, van Akkooi ACJ Abstract Now effective adjuvant therapy has arrived in melanoma, accurate staging and patient selection to optimize its risk/benefit ratio is crucial. The American Joint Committee...
Related ArticlesAnti-angiogenic effects of mangiferin and mechanism of action in metastatic melanoma. Melanoma Res. 2019 Oct 22;: Authors: Delgado-Hernández R, Hernández-Balmaseda I, Rodeiro-Guerra I, Cesar Rodriguez Gonzalez J, De Wever O, Logie E, Declerck K, Pérez-Novo C, Vanden Berghe W Abstract Advanced metastatic melanoma, one of the most aggressive skin malignancies, is currently without reliable therapy. The process of angiogenesis is crucial...
Related ArticlesCombination Therapy of Ipilimumab and Nivolumab-associated Toxic Epidermal Necrolysis (TEN) in a Patient With Metastatic Melanoma: A Case Report and Literature Review. J Immunother. 2019 Oct 23;: Authors: Logan IT, Zaman S, Hussein L, Perrett CM Abstract Ipilimumab and nivolumab are immune checkpoint inhibitors used in the treatment of metastatic melanoma. The authors report the case of a 62-year-old white male individual with metastatic...
Related ArticlesFactors Impacting Fertility Preservation in Adolescents and Young Adults with Cancer: A Retrospective Study. J Adolesc Young Adult Oncol. 2019 Oct 25;: Authors: Mobley EM, Ryan GL, Sparks AE, Monga V, Terry WW Abstract Purpose: Fertility preservation before therapy is underutilized for those diagnosed with cancer as an adolescent or young adult (AYA). The purpose of this study was to describe factors impacting utilization of fertility...
Related ArticlesEmbolization of variant hepatic arteries in patients undergoing percutaneous hepatic perfusion for unresectable liver metastases of ocular melanoma. Diagn Interv Radiol. 2019 Oct 25;: Authors: Meijer TS, Geus-Oei LF, Martini C, Tijl F, Sitsen E, Erkel AV, Meer RV, Kapiteijn E, Vahrmeijer A, Burgmans M Abstract PURPOSE: In patients undergoing percutaneous liver perfusion with melphalan (M-PHP), the presence of variant hepatic arteries...
Bacitracin is a non-competitive inhibitor of porcine M1 family neutral and glutamyl aminopeptidases.
Related ArticlesBacitracin is a non-competitive inhibitor of porcine M1 family neutral and glutamyl aminopeptidases. Nat Prod Res. 2019 Oct 25;:1-5 Authors: Arrebola Y, Rivera L, Pedroso A, McGuire R, Tresanco MEV, Bergado G, Charli JL, Sánchez B, Pascual Alonso I Abstract Membrane alanyl and glutamyl aminopeptidases (APN and APA, respectively) are established targets for the development of biomedical tools in human pathologies. APN overexpression correlates...
Related ArticlesChoroidal Melanoma Metastatic to the Contralateral Medial Rectus After Orbital Exenteration Turk J Ophthalmol. 2019 Oct 24;49(5):305-309 Authors: Mcelnea EM, Stevenson LJ, La Rosa CS, Liew S, Hardy TG Abstract A 78-year-old Caucasian woman presented with pain in her right and only eye that was worse on abduction. Her history was significant for a choroidal melanoma affecting her left eye for which she underwent an orbital exenteration...
Related ArticlesSurgical management of the neck in patients with metastatic melanoma in parotid lymph nodes. J Surg Oncol. 2019 Oct 25;: Authors: Den Hondt M, Starr MW, Millett MC, Smyth J, Scolyer RA, Shannon KF, Thompson JF, Ch'ng S Abstract BACKGROUND: The role and extent of neck dissection in patients with parotid metastatic cutaneous head and neck melanoma remain unclear. The aims of this study were to determine the incidence and patterns of cervical...
Related ArticlesThe challenge of overcoming the language barrier for brain tumor awake surgery in migrants: a feasibility study in five patient cases. Acta Neurochir (Wien). 2019 Oct 25;: Authors: Aubrun S, Poisson I, Barberis M, Draou C, Toure M, Madadaki C, Froelich S, Gayat E, Mandonnet E Abstract OBJECTIVE: To assess the feasibility of awake surgery for a brain tumor in a population of non-French-speaking migrants in Paris, France. METHODS:...
Related ArticlesMiT/TFE Family of Transcription Factors, Lysosomes, and Cancer. Annu Rev Cancer Biol. 2019 Mar;3:203-222 Authors: Perera RM, Malta CD, Ballabio A Abstract Cancer cells have an increased demand for energy sources to support accelerated rates of growth. When nutrients become limiting, cancer cells may switch to nonconventional energy sources that are mobilized through nutrient scavenging pathways involving autophagy and the lysosome. Thus,...
Necrotic uveal melanoma presenting as orbital cellulitis with intraocular hemorrhage: A case report.
Related ArticlesNecrotic uveal melanoma presenting as orbital cellulitis with intraocular hemorrhage: A case report. Am J Ophthalmol Case Rep. 2019 Dec;16:100557 Authors: Li AL, Kang JY, Berry DE, Patel KB, Hendrick AM Abstract Purpose: To report a case of necrotic uveal melanoma presenting as orbital cellulitis with an intraocular hemorrhage. Observations: A 61 year-old non-verbal male presented with a two-week history of right eyelid swelling...
Related ArticlesCombination Therapy with Reovirus and ATM Inhibitor Enhances Cell Death and Virus Replication in Canine Melanoma. Mol Ther Oncolytics. 2019 Dec 20;15:49-59 Authors: Igase M, Shibutani S, Kurogouchi Y, Fujiki N, Hwang CC, Coffey M, Noguchi S, Nemoto Y, Mizuno T Abstract Oncolytic virotherapy using reovirus is a promising new anti-cancer treatment with potential for use in humans and dogs. Because reovirus monotherapy shows limited efficacy...
Related ArticlesComplete clinical response to intralesional talimogene laherparepvec injection in a patient with recurrent, regionally advanced Merkel cell carcinoma. JAAD Case Rep. 2019 Oct;5(10):849-851 Authors: Nguyen MHK, Leong SP, Abendroth R, Kashani-Sabet M, Kim KB PMID: 31649970 [PubMed]
Related ArticlesPrognostic Value of Peripheral Inflammatory Markers in Preoperative Mucosal Melanoma: A Multicenter Retrospective Study. Front Oncol. 2019;9:995 Authors: Wang Y, Zhang H, Yang Y, Zhang T, Ma X Abstract Background: Peripheral neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) have been widely reported prognostic predictors for many cancers. However, data predicting prognosis...
Related ArticlesComprehensive Analysis of a Competing Endogenous RNA Network Identifies Seven-lncRNA Signature as a Prognostic Biomarker for Melanoma. Front Oncol. 2019;9:935 Authors: Liu N, Liu Z, Liu X, Chen H Abstract Long non-coding RNAs (LncRNAs) can act as competing endogenous RNA (ceRNA) involving in tumor initiation and progression. Nevertheless, the prognostic roles of lncRNAs in lncRNA-related ceRNA network of melanoma remain elusive. In this...
Related ArticlesPrognostic Implications of the Complement Protein C1q in Gliomas. Front Immunol. 2019;10:2366 Authors: Mangogna A, Belmonte B, Agostinis C, Zacchi P, Iacopino DG, Martorana A, Rodolico V, Bonazza D, Zanconati F, Kishore U, Bulla R Abstract The contribution of the complement system in the pathophysiology of brain cancers has been recently considered in light of its well-known involvement in carcinogenesis. Complement system represents...
Related ArticlesDendritic Cell Vaccination in Metastatic Melanoma Turns "Non-T Cell Inflamed" Into "T-Cell Inflamed" Tumors. Front Immunol. 2019;10:2353 Authors: Bulgarelli J, Tazzari M, Granato AM, Ridolfi L, Maiocchi S, de Rosa F, Petrini M, Pancisi E, Gentili G, Vergani B, Piccinini F, Carbonaro A, Leone BE, Foschi G, Ancarani V, Framarini M, Guidoboni M Abstract Dendritic cell (DC)-based vaccination effectively induces anti-tumor immunity, although...
Related ArticlesCombination of Selected MET and EGFR Inhibitors Decreases Melanoma Cells' Invasive Abilities. Front Pharmacol. 2019;10:1116 Authors: Simiczyjew A, Pietraszek-Gremplewicz K, Dratkiewicz E, Podgórska M, Matkowski R, Ziętek M, Nowak D Abstract We have previously shown that combination of foretinib, an inhibitor of MET (hepatocyte growth factor receptor), with gefitinib or lapatinib, inhibitors of EGFR (epidermal growth factor receptor),...
Related ArticlesTumor infiltrating lymphocytes in malignant melanoma - allies or foes? Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2019 Oct 24;: Authors: Zidlik V, Bezdekova M, Brychtova S Abstract This is an overview of current problematics regarding the role of tumor infiltrating lymphocytes (TILs) in malignant melanomas. Various and often conflicting data have been published, correlating tumor type, stage, prognosis, as well as sex and age...
Related ArticlesUveal melanoma-associated survival in Scotland. Eye (Lond). 2019 Oct 25;: Authors: Jamison A, Bhatti LA, Sobti MM, Chadha V, Cauchi P, Kemp EG Abstract BACKGROUND/OBJECTIVES: The Scottish Ocular Oncology Service (SOOS) manages all patients with uveal melanoma (UM) in Scotland. Our aim was to determine the long-term all-cause and cause-specific survival of patients with UM, irrespective of treatment modality. SUBJECTS/METHODS:...
Related ArticlesMillimeter-wave pulsed heating in vitro: cell mortality and heat shock response. Sci Rep. 2019 Oct 24;9(1):15249 Authors: Orlacchio R, Le Page Y, Le Dréan Y, Le Guével R, Sauleau R, Alekseev S, Zhadobov M Abstract Millimeter wave (MMW)-induced heating represents a promising alternative for non-invasive hyperthermia of superficial skin cancer, such as melanoma. Pulsed MMW-induced heating of tumors allows for reaching high peak temperatures...
Related ArticlesSerum 5-S-cysteinyl-dopa levels as a predictive marker for the efficacy of nivolumab in advanced malignant melanoma. Int J Biol Markers. 2019 Oct 24;:1724600819883658 Authors: Umemura H, Kaji T, Tachibana K, Morizane S, Yamasaki O Abstract PURPOSE: With the recent developments in novel molecular targeted therapy such as immune-checkpoint blockades, serine/threonine-protein kinase B-Raf, and mitogen-activated protein kinase kinase inhibitors,...
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