• Metabolomics for Improved Treatment Monitoring of Phenylketonuria: Urinary Biomarkers for Non-invasive Assessment of Dietary Adherence and Nutritional Deficiencies

  Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01642B, PaperJennifer Wild, Meera Shanmuganathan, Mika Hayashi, Murray Potter, Philip Britz-McKibbinManagement of phenylketonuria (PKU) requires lifelong restriction of phenylalanine (Phe) intake using specialized medical foods to prevent neurocognitive impairment in affected patients. However, dietary adherence is challenging to maintain while...The content of this RSS Feed (c) The Royal Society

  Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)

  Wed Oct 02, 2019 16:00
• Journal of Sleep Research
• Slow‐wave activity preceding the onset of 10–15‐Hz sleep spindles and 5–9‐Hz oscillations in electroencephalograms in rats with and without absence seizures

  Abstract Cortico‐thalamocortical networks generate sleep spindles and slow waves during non‐rapid eye movement sleep, as well as paroxysmal spike‐wave discharges (i.e. electroencephalogram manifestation of absence epilepsy) and 5–9‐Hz oscillations in genetic rat models (i.e. pro‐epileptic activity). Absence epilepsy is a disorder of the thalamocortical network. We tested a hypothesis that absence epilepsy associates with changes in the slow‐wave

  Journal of Sleep Research

  Wed Oct 02, 2019 06:53
• Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)
• An Intramolecular Charge Transfer and Excited State Intramolecular Proton Transfer based Fluorescence Probe for Highly Selective Detection and Imaging of Formaldehyde in Living Cells

  Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01778J, PaperWen Chen, Mei Yang, Na Luo, Fenglin Wang, Ruqin Yu, Jian-Hui JiangFormaldehyde (FA), as a reactive carbonyl species, is endogenously generated in various biological processes. Abnormal levels of FA could lead to various cellular dysfunction and pathological conditions. Here we develop...The content of this RSS Feed (c) The Royal Society of Chemistry

  Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)

  Wed Oct 02, 2019 16:00
• Imaging
• HRCT imaging of acquired cholesteatoma: a pictorial review

  Abstract Chronically discharging ear is a common cause of morbidity in developing countries, and it is also associated with intratemporal and intracranial complications. The surgeon is often able to detect the disease. However, cholesteatoma in the “hidden areas” like anterior epitympanic recess and sinus tympani can be missed. Facial nerve involvement and cholesteatomatous erosion of the bony labyrinth are dreaded complicati

  Imaging

  Wed Oct 02, 2019 17:00
• Pediatric Radiology
• An image processing algorithm to aid diagnosis of mesial temporal sclerosis in children: a case-control study

  Abstract Background Mesial temporal sclerosis (MTS) is an important cause of intractable epilepsy. Early and accurate diagnosis of MTS is essential to providing curative and life-changing therapy but can be challenging in children in whom the impact of diagnosis is particularly high. Magnetic resonance imaging (MRI) plays an important role in the diagnosis of MTS, and image processing

  Pediatric Radiology

  Tue Oct 01, 2019 17:00
• Analytical Chemistry
• [ASAP] Cadmium Assisted Photochemical Vapor Generation of Tungsten for Detection by Inductively Coupled Plasma Mass Spectrometry

  Analytical ChemistryDOI: 10.1021/acs.analchem.9b04241

  Analytical Chemistry

  Tue Oct 01, 2019 21:00
• [ASAP] Quantitative Assessment of Vapor Molecule Adsorption to Solid Surfaces by Flow Rate Monitoring in Microfluidic Channels

  Analytical ChemistryDOI: 10.1021/acs.analchem.9b02543

  Analytical Chemistry

  Tue Oct 01, 2019 21:00
• BioMed Research International
• Prospects for Malaria Vaccines: Pre-Erythrocytic Stages, Blood Stages, and Transmission-Blocking Stages

  Malaria is a disease of public health importance in many parts of the world. Currently, there is no effective way to eradicate malaria, so developing safe, efficient, and cost-effective vaccines against this disease remains an important goal. Current research on malaria vaccines is focused on developing vaccines against pre-erythrocytic stage parasites and blood-stage parasites or on developing a transmission-blocking vaccine. Here, we briefly de

  BioMed Research International

  Wed Oct 02, 2019 17:05
• The New England Journal of Medicine: Search Results in Emergency Medicine
• Pathology of Vaping-Associated Lung Injury

  To the Editor: Despite the accumulating data on the clinical and imaging features of vaping-associated lung injury, its pathology is poorly understood. We reviewed lung biopsies from 17 patients (13 men; median age, 35 years [range, 19–67]), all of whom had a history of vaping (71% with marijuana…

  The New England Journal of Medicine: Search Results in Emergency Medicine

  Tue Oct 01, 2019 17:00
• Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm

  In accordance with the 2015 guidelines of the International Liaison Committee on Resuscitation (ILCOR), targeted temperature management with a target of 32°C to 36°C (moderate therapeutic hypothermia) is currently advocated for all patients with coma after successful resuscitation from cardiac…

  The New England Journal of Medicine: Search Results in Emergency Medicine

  Tue Oct 01, 2019 17:00
• American Journal of Clinical Oncology - Current Issue
• Clinical Outcomes of Surgically Unresectable Endometrial Cancers

  Objective: The objective of this study was to determine the outcomes of patients with unresectable endometrial cancer managed with definitive or neoadjuvant radiation (RT) and/or chemotherapy. Materials and Methods: Patients with unresectable stages II to IVA endometrial cancer who were treated with curative intent between January 2000 and March 2018 were identified. Overall survival (OS) and disease-free survival (DFS) were analyzed usin

  American Journal of Clinical Oncology - Current Issue

  Mon Sep 30, 2019 17:00
• Systematic Literature Review and Meta-Analysis of Response to First-Line Therapies for Advanced/Metastatic Urothelial Cancer Patients Who Are Cisplatin Ineligible

  Objective: The purpose of this systematic literature review (SLR) and meta-analysis was to compile the response of historic treatment options in first-line settings for patient populations who are cisplatin ineligible. Materials and Methods: SLR was conducted to compile objective response rate (ORR), duration of response (DOR), progression-free survival (PFS), and overall survival (OS) of historic therapies for this population based on st

  American Journal of Clinical Oncology - Current Issue

  Mon Sep 30, 2019 17:00
• Extraskeletal Myxoid Chondrosarcomas: Combined Modality Therapy With Both Radiation and Surgery Improves Local Control

  Objective: We evaluated our experience treating patients with localized extraskeletal myxoid chondrosarcomas (EMCs) to evaluate outcomes and relapse rates in order to better inform treatment decisions for these rare soft tissue sarcomas. Materials and Methods: We reviewed the records of 41 consecutive patients with localized EMC treated at our institution from 1990 to 2016. Most patients (n=33, 80%) received combined modality therapy with

  American Journal of Clinical Oncology - Current Issue

  Mon Sep 30, 2019 17:00
• Gastrointestinal Adverse Events Observed After Chimeric Antigen Receptor T-Cell Therapy

  Background: Chimeric antigen receptor T-cell (CART) therapy can significantly improve outcomes for patients with certain hematologic malignancies. The most notable drawbacks of CART are cytokine release syndrome and CART-related encephalopathy syndrome. Gastrointestinal adverse events (GI-AEs) have not yet been reported in association with CART. Herein, we describe the incidence and clinical features of GI-AEs observed after CART. Materials

  American Journal of Clinical Oncology - Current Issue

  Mon Sep 30, 2019 17:00
• Patterns of Care and Survival in Elderly Patients With Locally Advanced Soft Tissue Sarcoma

  Objectives: The aim of this study was to analyze patterns of care in elderly soft tissue sarcoma (STS) patients and their impact on clinical outcome and treatment-related toxicity. Materials and Methods: We retrospectively collected data of >65-year-old patients diagnosed with locally advanced STS between 1991 and 2017 in a single institution. Results: The study included 111 patients: 105 (94.6%) patients underwent surgery, associate

  American Journal of Clinical Oncology - Current Issue

  Mon Sep 30, 2019 17:00
• Oncologic Accuracy of Image-guided Percutaneous Core-Needle Biopsy of Peripheral Nerve Sheath Tumors at a High-volume Sarcoma Center

  Objectives: Peripheral nerve sheath tumors (PNSTs) are clinically heterogenous, comprising benign (BPNST) and malignant (MPNST) variants. BPNSTs can be managed with nerve-sparing excision or observation. MPNSTs require radical resection and multidisciplinary oncologic management (1, 15). Image-guided core-needle biopsy (IGCNBx) is the well-established standard to obtain preoperative tissue diagnosis of soft tissue tumors. However, there has be

  American Journal of Clinical Oncology - Current Issue

  Mon Sep 30, 2019 17:00
• Phase I/II Trial of Neoadjuvant Oregovomab-based Chemoimmunotherapy Followed by Stereotactic Body Radiotherapy and Nelfinavir For Locally Advanced Pancreatic Adenocarcinoma

  Objective: Cancer antigen (CA)-125 influences progression, metastasis, and outcomes in pancreatic cancer. This phase I/II trial (NCT01959672) evaluated the safety, efficacy, and immunologic correlates of chemoimmunotherapy (CIT) with oregovomab (anti–CA-125), followed by stereotactic body radiotherapy (SBRT) with the radiosensitizer nelfinavir. Materials and Methods: Following imaging, pathologic confirmation, and staging laparoscopy, sub

  American Journal of Clinical Oncology - Current Issue

  Mon Sep 30, 2019 17:00
• Surgical, Urinary, and Survival Outcomes of Nerve-sparing Versus Traditional Radical Hysterectomy: A Retrospective Cohort Study in China

  Purpose: The purpose of this retrospective study was to compare the surgical, urinary, and survival outcomes between nerve-sparing radical hysterectomy (NSRH) and traditional radical hysterectomy (TRH) for stage IB cervical cancer, in which all the primary procedures were performed by a single physician. Methods: Patients with cervical cancer of International Federation of Gynecology and Obstetrics (FIGO) stage IB were included if they re

  American Journal of Clinical Oncology - Current Issue

  Mon Sep 30, 2019 17:00
• Pathologic Response to Primary Systemic Therapy With FOLFIRINOX in Patients With Resectable Pancreatic Cancer

  Background: Primary systemic therapy in resectable pancreatic cancer is currently under investigation. FOLFIRINOX has been shown to be effective in both the adjuvant and metastatic settings and is increasingly being used on and off study in the neoadjuvant setting. The objective pathologic response elicited by this regimen in truly resectable disease has not as yet been widely reported. Methods: This analysis focuses on 14 patients with r

  American Journal of Clinical Oncology - Current Issue

  Mon Sep 30, 2019 17:00
• Practical Heart Sparing Breast Cancer Radiation Therapy Using Continuous Positive Airway Pressure (CPAP) in Resource-Limited Radiation Oncology Clinics

  Purpose: The purpose of this study was to report experiences of practical heart sparing breast radiation therapy (RT) using continuous positive airway pressure (CPAP) in resource-limited radiation oncology clinics. Patients and Methods: Twelve patients underwent computed tomography-simulations with both free-breathing (FB) and CPAP under the individual maximum tolerable air pressure. For each patient, left-sided breast RT plans (9 with br

  American Journal of Clinical Oncology - Current Issue

  Mon Sep 30, 2019 17:00
• Autophagy-related Proteins as a Prognostic Factor of Patients With Colorectal Cancer

  Objectives: Autophagy plays a dual role in tumorigenesis. In the initial stages, it promotes cell survival and suppresses carcinogenesis, whereas in cancer development, it induces cancer cell survival. In this study, we investigate the role of autophagy as a protective or tumor suppressor mechanism in colorectal cancer (CRC) cell lines and evaluate its role as a potential biomarker in human tumor samples. Materials and Methods: The data o

  American Journal of Clinical Oncology - Current Issue

  Mon Sep 30, 2019 17:00
• Incidence of Neonatal Neutropenia, Leukopenia, and Anemia After In Utero Exposure to Chemotherapy For Maternal Cancer

  No abstract available

  American Journal of Clinical Oncology - Current Issue

  Mon Sep 30, 2019 17:00
• Hormon- und Stoffwechselforschung
• Relationship of Biological Markers of Body Fat Distribution and Corticosteroidogenic Enzyme Activities in Women with Polycystic Ovary Syndrome

  Horm Metab Res 2019; 51: 639-648DOI: 10.1055/a-0975-9207The aim of the study is to determine the impact of different anthropometric measurements of fat distribution on baseline sex-steroid concentrations and corticosteroidogenic enzyme activity in women with polycystic ovary syndrome compared to those with regular menstrual cycles. The current cross-sectional study included 106 normal cycling controls and 268 polycystic ovary syndrome patients. P

  Hormon- und Stoffwechselforschung

  Tue Oct 01, 2019 16:00
• Definition of the Response to Initial Therapy with Radioiodine in Patients with Differentiated Thyroid Carcinoma: Basal or Stimulated Thyroglobulin?

  Horm Metab Res 2019; 51: 634-638DOI: 10.1055/a-0991-0231Basal thyroglobulin (b-Tg) measured with second-generation assay or stimulated Tg (s-Tg) can be used to define the response to therapy of differentiated thyroid carcinoma. However, they do not always define the same category and guidelines do not establish “if” or “when” s-Tg needs to be obtained. We studied 304 patients without clinically apparent disease or disease detected by neck ultraso

  Hormon- und Stoffwechselforschung

  Tue Oct 01, 2019 16:00
• bioRxiv Subject Collection: Evolutionary Biology
• Ancestral Mitochondrial Protein Secretion Machinery [NEW RESULTS]

  Modern mitochondria have preserved few traits of the original bacterial endosymbiont. Unexpectedly, we find that certain representatives of heteroloboseans, jakobids and malawimonads possess homologues of four core components of the type 2 secretion system (T2SS) so far restricted to eubacteria. We show that these components are localized to the mitochondrion, and their behaviour in functional assays is consistent with the formation of a mitochon

  bioRxiv Subject Collection: Evolutionary Biology

  Tue Oct 01, 2019 17:00
• Pathology & Oncology Research
• Differential Expression and Diagnostic Significance of Pre-Albumin, Fibrinogen Combined with D-Dimer in AFP-Negative Hepatocellular Carcinoma

  Abstract Hepatocellular carcinoma (HCC) is one of the most malignant cancers with high morbidity and mortality. Nowadays, AFP-negative hepatocellular carcinoma (AFP-NHCC) has been found in many HCC patients and AFP analysis can’t be used to screen HCC in these cases. In this study, we have examined the expression patterns of pre-albumin (PA), fibrinogen, D-Dimer and their clinical significance in AFP-NHCC. We recruited 214 AFP-

  Pathology & Oncology Research

  Tue Oct 01, 2019 17:00
• bioRxiv Subject Collection: Evolutionary Biology
• Artificial incubation in species with temperature-dependent sex determination. How hot is too hot? [NEW RESULTS]

  Reptiles are declining globally, and turtles in particular are among the most imperiled group of vertebrates on earth. Common turtle conservation strategies include artificial incubation and head-starting to rear healthy juvenile turtles for release into wild populations. Temperature-dependent sex determination (TSD) in turtles and other reptiles allows conservation managers to bias sex ratios towards females by using high incubation temperatures

  bioRxiv Subject Collection: Evolutionary Biology

  Tue Oct 01, 2019 17:00
• Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)
• An evaluation of monovalent, divalent, and trivalent cations as aggregating agents for surface enhanced Raman spectroscopy (SERS) analysis of synthetic cannabinoids

  Analyst, 2019, Accepted ManuscriptDOI: 10.1039/C9AN01309A, PaperThaddeus Mostowtt, Jonathan Munoz , Bruce McCordIn this study monovalent, divalent, and trivalent chloride, sulfate and nitrate salts were examined to determine the critical coagulation concentration (CCC) for each salt and its corresponding effect on detection...The content of this RSS Feed (c) The Royal Society of Chemistry

  Royal Society of Chemistry (Great Britain) Society for Analytical Chemistry Society of Public Analysts (Great Britain)

  Tue Oct 01, 2019 16:00