Sustainability, Vol. 11, Pages 5531: Corporate Public Transparency on Financial Performance: The Moderating Role of Political Embeddedness Sustainability doi: 10.3390/su11195531 Authors: Yuxuan Li Xin Miao Dequan Zheng Yanhong Tang Corporate public transparency (CPT) is instrumental for companies to establish communications and trust with the public by disclosing and communicating information concerning corporate environmental and social impacts. However, it is still in dispute...
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Mathematics, Vol. 7, Pages 928: Gradient Methods with Selection Technique for the Multiple-Sets Split Equality Problem Mathematics doi: 10.3390/math7100928 Authors: Dianlu Tian Lining Jiang Luoyi Shi The inverse problem is one of the four major problems in computational mathematics. There is an inverse problem in medical image reconstruction and radiotherapy that is called the multiple-sets split equality problem. The multiple-sets split equality problem is a unified form of the...
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In “Inferior Alveolar Nerve Block Using the Anterior Technique to Anesthetize Buccal Nerve and Improve Anesthesia Success Rates for Third Molar Extraction: A Randomized Controlled Trial and Magnetic Resonance Imaging Evaluation” by Tsukimoto et al, published in issue 77/10 of JOMS, the incorrect f igure 3 was included. The corrected version of the figure appears here. (Source: Journal of Oral and Maxillofacial Surgery)
Mon Oct 07, 2019 00:00
Medication-related osteonecrosis of the jaw in its advanced stages requires surgical treatment to resolve the pathology and to achieve good long-term results. After complete removal of the necrotic bone and infected soft tissue, it is essential to cover the exposed bone using well-vascularized soft tissue such as local, regional, and microvascular free flaps. The purpose of this study was to evaluate the technical usefulness of the modified submental island flap (SIF) for covering large bone and...
Sat Sep 14, 2019 00:00
Numerous incisions around the ear have been described, and many have been used in oral and maxillofacial surgery for procedures involving the temporomandibular joint (TMJ), condylar neck, and parotid gland, as well as for rhytidectomy.1-5 Although the traditional preauricular and endaural incisions will frequently provide an excellent outcome, they will heal with a visible scar.1,4 The incision we have described aims to refine the incision to further improve this esthetic outcome. Additionally, surgical...
Wed Sep 11, 2019 00:00
In the present report, we have traced the history of education and training of oral and maxillofacial surgeons as it has evolved from the mid-19th century to the present. We have considered the effects of the discovery of ether anesthesia, the separation of medicine and dentistry, and other milestones such as antisepsis (Lister), antibiotics (Fleming), and surgical progress during wartime. The main emphasis, however, was on the background, development, and implementation of current dual-degree oral...
Tue Sep 10, 2019 00:00
Planta MedDOI: 10.1055/a-1013-0382In Europe, especially in German-speaking countries, administration of mistletoe extracts is the most common and popular complementary and alternative therapy approach reported in oncology. Mistletoe therapy is applied to children with cancer for curative and palliative therapeutic regimes with increasing frequency, but at the same time, there are only a few studies on the effectiveness of this therapy. Therefore, we have investigated the response of various pediatric...
Mon Oct 07, 2019 02:00
Planta MedDOI: 10.1055/a-1014-3303 Commiphora gileadensis, locally known as becham, is a plant used in traditional Arabian medicine for treating headache, constipation, stomach, joint pain, and inflammatory disorders. Several studies have reported its antibacterial properties; however, no study has demonstrated its antiviral activity. This study aimed to evaluate the antiviral activity of C. gileadensis as well as to isolate its active compound and investigate its mode of action. This...
Mon Oct 07, 2019 02:00
Source: Yahoo News - BusinessA transgender woman in Michigan, Aimee Stephens was fired by the funeral home where she worked when she said she wanted to dress as a woman.
Mon Oct 07, 2019 18:06
Source: Yahoo News - BusinessActivists with the Extinction Rebellion movement blocked major roads across major European cities Monday, kicking off a wide-ranging series of protests demanding much more urgent action against climate change. In Berlin, around 1,000 people blocked the Grosser Stern, a traffic circle in the middle of the German capital's Tiergarten park dominated by the landmark Victory Column. At Monday lunchtime, another 300 people blocked Berlin's central...
Mon Oct 07, 2019 17:23
Source: Google News - HealthThe Cambridges and Sussexes have joined forces to lend their voices to a powerful new mental health PSA. As part of a new initiative with Britain’s National Health Service, the Fab Four provided narration for the short film alongside a number of TV personalities, actors and sports stars, including Gillian Anderson, Glenn Close, and...
Mon Oct 07, 2019 17:23
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Remarkable Boron Delivery Of iRGD-Modified Polymeric Nanoparticles For Boron Neutron Capture Therapy
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Oncogenesis, Published online: 07 October 2019; doi:10.1038/s41389-019-0168-5Rev-erbα inhibits proliferation by reducing glycolytic flux and pentose phosphate pathway in human gastric cancer cells
Mon Oct 07, 2019 03:00
Oncogenesis, Published online: 07 October 2019; doi:10.1038/s41389-019-0166-7c-Myc transactivates GP73 and promotes metastasis of hepatocellular carcinoma cells through GP73-mediated MMP-7 trafficking in a mildly hypoxic microenvironment
Mon Oct 07, 2019 03:00
Oncogenesis, Published online: 07 October 2019; doi:10.1038/s41389-019-0169-4Loss of CYLD accelerates melanoma development and progression in the Tg(Grm1) melanoma mouse model
Mon Oct 07, 2019 03:00
How vascular systems and their respiratory pigments evolved is still debated. To unravel blood evolution in Bilaterians, we studied the marine Annelid Platynereis dumerilii. Platynereis exhibits a closed vascular system filled with extracellular hemoglobin. An exhaustive screen in Platynereis genome reveals a family of 17 globins. Seven extracellular globins are produced by specialized hemogenic cells lining the vessels of the segmental appendages of the worm, serving as gills. Extracellular globins...
Mon Oct 07, 2019 03:00
We present ABM-IRM, an agent-based modeling approach to insect resistance management. ABM-IRM is one of the agent-based models that we have developed to simulate the insect resistance of Asian Corn Borer (ACB) to BT corn. The model was implemented using NetLogo, an agent-based programming environment (Wilensky, 1999). We created our model using simple rules to find emergent patterns (Wilensky and Rand, 2015) based on refuge types and pyramid BT events that may aid in controlling the resistance of...
Mon Oct 07, 2019 03:00
Changes in gene regulation at multiple levels may comprise an important share of the molecular changes underlying adaptive evolution in nature. However, few studies have assayed within- and between-population variation in gene regulatory traits at a transcriptomic scale, and therefore inferences about the characteristics of adaptive regulatory changes have been elusive. Here, we assess quantitative trait differentiation in gene expression levels and alternative splicing (intron usage) between three...
Mon Oct 07, 2019 03:00
Sex appears to be the most successful reproductive strategy in eukaryotes despite its many costs. While a complete explanation for sex's success remains elusive, several evolutionary benefits of sex have been identified, such as, the purging of deleterious mutations, the accumulation of beneficial mutations, and an advantage in biotic interactions. It is predicted that, by forgoing these benefits, asexual lineages are evolutionary dead-ends due to genetic deterioration and/or an inability to adapt...
Mon Oct 07, 2019 03:00
Mathematical models provide insights for the design and optimization of strategies to control disease epidemics and evolution of pesticide resistance in crops. Here, we present a simple mathematical model to investigate the population dynamics of non-Bt resistant and Bt resistant cornborers in a field with refuge. In the presence of refuge, it is expected that the population of Bt resistant pests will decline due to the dilution effect (non-Bt resistant cornborers mate with Bt resistant pests). We...
Mon Oct 07, 2019 03:00
The widespread algal and plant (Archaeplastida) plastid originated >1 billion years ago, therefore relatively little can be learned about plastid integration during the initial stages of primary endosymbiosis by studying these highly derived species. Here we focused on a unique model for endosymbiosis research, the photosynthetic amoeba Paulinella micropora KR01 (Rhizaria) that underwent a more recent independent primary endosymbiosis about 124 Mya. A total of 149 Gbp of PacBio and 19 Gbp of Illumina...
Mon Oct 07, 2019 03:00
Biological communities are thought to have been evolving in trait spaces that are not only multi-dimensional, but also distorted in a sense that mutational covariance matrices among traits depend on the parental phenotypes of mutants. Such a distortion may affect diversifying evolution as well as directional evolution. In adaptive dynamics theory, diversifying evolution through ecological interaction is called evolutionary branching. This study analytically develops conditions for evolutionary branching...
Mon Oct 07, 2019 03:00
Agricultural insect pests frequently exhibit geographic variation in levels of insecticide resistance, which are often presumed to be due to the intensity of insecticide use for pest management. However, regional differences in the evolution of resistance to novel insecticides suggests that other factors are influencing rates of adaptation. We examined LC50 bioassay data spanning 15 years and six insecticides (abamectin, imidacloprid, spinosad, cyantraniliprole, chlorantraniliprole, and metaflumizone)...
Mon Oct 07, 2019 03:00
Amino acid propensities at a site change in the course of protein evolution. This may happen for two reasons. Changes may be triggered by substitutions at epistatically interacting sites elsewhere in the genome; alternatively, they may arise due to environmental changes that are external to the genome. Here, we design a framework for distinguishing between these alternatives. Using analytical modelling and simulations, we show that they cause opposite dynamics of the fitness of the allele currently...
Mon Oct 07, 2019 03:00
Because of their replication mode and segmented dsRNA genome, homologous recombination is assumed to be rare in the rotaviruses. We analyzed 23,627 complete rotavirus genome sequences available in the NCBI Virus Variation database and found numerous instances of homologous recombination, some of which prevailed across multiple sequenced isolates. In one case, recombination may have generated a novel rotavirus VP1 lineage. We also found strong evidence for intergenotypic recombination in which more...
Mon Oct 07, 2019 03:00
Chromosomal inversions are among the primary drivers of genome structure evolution in a wide range of natural populations. While there is an impressive array of theory and empirical analyses that has identified conditions under which inversions can be positively selected, comparatively little data is available on the fitness impacts of these genome structural rearrangements themselves. Because inversion breakpoints can interrupt functional elements and alter chromatin domains, each rearrangement...
Mon Oct 07, 2019 03:00
Phylogenomic datasets have become common and fundamental to understanding the phylogenetic relationships of recalcitrant groups across the Tree of Life. At the same time, working with large genomic or transcriptomic datasets requires special attention to the processes that generate gene tree discordance, such as data processing and orthology inference, incomplete lineage sorting, hybridization, model violation, and uninformative gene trees. Methods to estimate species trees from phylogenomic datasets...
Mon Oct 07, 2019 03:00
The DAN gene family (DAN, Differential screening-selected gene Aberrant in Neuroblastoma) is a group of genes that is expressed during development and plays fundamental roles in limb bud formation and digitation, kidney formation and morphogenesis and left-right axis specification. During adulthood the expression of these genes are associated to diseases, including cancer. Although most of the attention to this group of genes has been dedicated to understanding its role in physiology and development,...
Mon Oct 07, 2019 03:00
Aim: We evaluated traditional biogeographic boundaries of coastal marine regions in SW Atlantic using DNA sequence data from common, rocky-shore inhabiting, marine mites of the genera Agauopsis and Rhombognathus, family Halacaridae. Methods: We investigated geographic population genetic structure using CO1 gene sequences, estimated divergence times using a multigene dataset and absolute time-calibrated molecular clock analyses, and performed environmental niche modeling (ENM) of common marine mite...
Mon Oct 07, 2019 03:00
Recent increases in understanding the ecological and evolutionary roles of microbial communities has underscored their importance for their hosts' biology. Yet, little is known about gut microbiota dynamics during early stages of ecological diversification and speciation. We studied the gut microbiota of extremely young adaptive radiations of Nicaraguan crater lake cichlid fish (Amphilophus cf. citrinellus) to test the hypothesis that parallel evolution in trophic ecology is associated with parallel...
Mon Oct 07, 2019 03:00
The movement of a population through space can have profound impacts on its evolution, as observed theoretically, experimentally,and clinically. Furthermore, it has been observed that mutants emerging at the spreading front develop higher frequencies in the population than their counterparts further from the front. Here we use fundamental arguments from population genetics regarding expected time scales of beneficial mutant establishment and fixation in a population undergoing range expansion to...
Mon Oct 07, 2019 03:00
Oncogene, Published online: 07 October 2019; doi:10.1038/s41388-019-1034-9RNA-binding motif protein 10 induces apoptosis and suppresses proliferation by activating p53 (Source: Oncogene)
Mon Oct 07, 2019 00:00
Oncogene, Published online: 07 October 2019; doi:10.1038/s41388-019-1047-4Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant (Source: Oncogene)
Mon Oct 07, 2019 00:00
Oncogene, Published online: 07 October 2019; doi:10.1038/s41388-019-1045-6MHC class I dysfunction of glioma stem cells escapes from CTL-mediated immune response via activation of Wnt/β-catenin signaling pathway (Source: Oncogene)
Mon Oct 07, 2019 00:00
Oncogene, Published online: 07 October 2019; doi:10.1038/s41388-019-1044-7A drug library screen identifies Carbenoxolone as novel FOXO inhibitor that overcomes FOXO3-mediated chemoprotection in high-stage neuroblastoma (Source: Oncogene)
Mon Oct 07, 2019 00:00
Oncogene, Published online: 07 October 2019; doi:10.1038/s41388-019-1013-1Oncogenic HOXB8 is driven by MYC-regulated super-enhancer and potentiates colorectal cancer invasiveness via BACH1 (Source: Oncogene)
Mon Oct 07, 2019 00:00
Oncogene, Published online: 07 October 2019; doi:10.1038/s41388-019-1043-8Bmi1 drives hepatocarcinogenesis by repressing the TGFβ2/SMAD signalling axis (Source: Oncogene)
Mon Oct 07, 2019 00:00
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