Abstract Background The prognosis of penetrating traumatic brain injury (pTBI) is poor yet highly variable. Current computerized tomography (CT) severity scores are commonly not used for pTBI prognostication but may provide important clinical information in these cohorts. Methods All consecutive pTBI patients from two large neurotrauma databases (Helsinki...
Abstract Background The surgeons’ estimate of the extent of resection (EOR) shows little accuracy in previous literature. Considering the developments in surgical techniques of glioblastoma (GBM) treatment, we hypothesize an improvement in this estimation. This study aims to compare the EOR estimated by the neurosurgeon with the EOR determined using volumetric analysis on the post-operative MR scan. ...
Abstract Background The extent of resection (EOR) plays a fundamental role in the prognosis of patients with high-grade gliomas (HGG). One of the main challenges in achieving a complete resection is the distinction between tumor and normal brain. Nowadays, several technologies are employed to obtain a higher tumor removal rate and respect the normal tissue in glioma surgery and in the last decades, fluorescein sodium (FS) and intraoperative...
Abstract Objective As the understanding of pathophysiology behind Chiari malformation still is limited, the treatment of Chiari malformation type 1 remains rather empirical. This may result in suboptimal treatment strategy and outcome in many cases. In this review, we critically address whether the condition known today as Chiari malformation type I should rather be denoted Chiari syndrome. ...
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In response to concerns related to inefficiencies and conflicts of interest in the processes of pharmacy and therapeutics committees in the United States, we recommend the development of a multicenter formulary, in which several institutions or systems pool their resources and collectively consider each new drug that comes to market. Abstract What is known and objective While many countries have central agencies responsible for formulary development, within the United States, each...
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Abstract Purpose To integrate the available data published on patients with epidermolysis bullosa (EB) rehabilitated with dental implants, as well as to review the recommendations for EB patients receiving implants. Methods An electronic search was undertaken in February 2019 in five databases. ...
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Abstract Outside the wide range of potential benefits, the use of nanomaterials can endanger human health, mostly through skin contact and the risk of inhalation. This article presents the results of harmonized measurements with contextual information on the emission of nanoparticles during the manufacturing and application of nanotechnology products. The purpose of the research was to investigate the actual levels of exposure to nano-objects in real working conditions in chosen...
Abstract The p-n junction structure has been regarded as an effective strategy to improve the photocatalytic activity due to their effectively separation of photoelectron-holes. In the paper, the p-NiO nanoparticles/n-TiO2 nanosphere photocatalysts were successfully fabricated by the hydrothermal method. The structure and morphology of the photocatalysts with p-n junction were systematically characterized by XRD, XPS, SEM, TEM, and UV-vis. And the photocatalytic performance of...
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Zusammenfassung Ein 6 Monate alter weiblicher Säugling aus Bahrain litt an einer ausgeprägten Dermatomykose des gesamten Integuments. Die topische Behandlung mit Terbinafin über 2 Monate führte zu keinerlei Besserung. An der Dermatophytose erkrankte erwachsene Familienmitglieder und Kinder wurden im Heimatland ebenfalls ohne Erfolg topisch und auch systemisch – mit Voriconazol – antimykotisch behandelt. Die mykologische Diagnostik während eines Urlaubsaufenthaltes in Deutschland...
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IJMS, Vol. 20, Pages 5357: Genome-Wide Analysis of Cotton miRNAs During Whitefly Infestation Offers New Insights into Plant-Herbivore Interaction International Journal of Molecular Sciences doi: 10.3390/ijms20215357 Authors: Jianying Li J. Joe Hull Sijia Liang Qiongqiong Wang Luo Chen Qinghua Zhang Maojun Wang Shahid Mansoor Xianlong Zhang Shuangxia Jin Although the regulatory function of miRNAs and their targets have been characterized in model plants, a possible...
IJMS, Vol. 20, Pages 5358: Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP+-Induced Mitochondrial Dysfunction in Cultured Dopaminergic Neurons International Journal of Molecular Sciences doi: 10.3390/ijms20215358 Authors: Ichiro Kawahata Luc Bousset Ronald Melki Kohji Fukunaga α-Synuclein is an abundant neuronal protein that accumulates in insoluble inclusions in Parkinson′s disease and other synucleinopathies. Fatty acids partially...
IJMS, Vol. 20, Pages 5356: IGF-1 Inhibits Apoptosis of Porcine Primary Granulosa Cell by Targeting Degradation of BimEL International Journal of Molecular Sciences doi: 10.3390/ijms20215356 Authors: Ying Han Shumin Wang Yingzheng Wang Shenming Zeng Insulin-like growth factor-1 (IGF-1) is an intra-ovarian growth factor that plays important endocrine or paracrine roles during ovarian development. IGF-1 affects ovarian function and female fertility through reducing apoptosis of...
IJMS, Vol. 20, Pages 5355: Melatonin-Induced Transcriptome Variation of Rapeseed Seedlings under Salt Stress International Journal of Molecular Sciences doi: 10.3390/ijms20215355 Authors: Xiaoyu Tan Weihua Long Liu Zeng Xiaoyu Ding Yong Cheng Xuekun Zhang Xiling Zou Salt stress inhibits the production of all crop species, including rapeseed (Brassica napus L.), the second most widely planted oil crop species. Although melatonin was confirmed to alleviate salt stress...
IJMS, Vol. 20, Pages 5353: Progress in Tissue Culture and Genetic Transformation of Oil Palm: An Overview International Journal of Molecular Sciences doi: 10.3390/ijms20215353 Authors: Rajesh Yarra Longfei Jin Zhihao Zhao Hongxing Cao Oil palm (Elaeis guineensis, Jacq.) is a prominent vegetable-oil-yielding crop. Cultivating high-yielding oil palm with improved traits is a pre-requisite to meet the increasing demands of palm oil consumption. However, tissue culture and biotechnological...
IJMS, Vol. 20, Pages 5352: Multivalent Carbonic Anhydrases Inhibitors International Journal of Molecular Sciences doi: 10.3390/ijms20215352 Authors: Fabrizio Carta Pascal Dumy Claudiu T. Supuran Jean-Yves Winum Biomolecular recognition using a multivalent strategy has been successfully applied, this last decade on several biological targets, especially carbohydrate-processing enzymes, proteases, and phosphorylases. This strategy is based on the fact that multivalent interactions...
IJMS, Vol. 20, Pages 5354: Examination of Adsorption Orientation of Amyloidogenic Peptides Over Nano-Gold Colloidal Particle Surfaces International Journal of Molecular Sciences doi: 10.3390/ijms20215354 Authors: Kazushige Yokoyama Kieran Brown Peter Shevlin Jack Jenkins Elizabeth D’Ambrosio Nicole Ralbovsky Jessica Battaglia Ishan Deshmukh Akane Ichiki The adsorption of amyloidogenic peptides, amyloid beta 1–40 (Aβ1–40), alpha-synuclein...
IJMS, Vol. 20, Pages 5351: Structural Insights into AQP2 Targeting to Multivesicular Bodies International Journal of Molecular Sciences doi: 10.3390/ijms20215351 Authors: Jennifer Virginia Roche Veronika Nesverova Caroline Olsson Peter MT Deen Susanna Törnroth-Horsefield Vasopressin-dependent trafficking of AQP2 in the renal collecting duct is crucial for the regulation of water homeostasis. This process involves the targeting of AQP2 to the apical membrane during dehydration...
IJMS, Vol. 20, Pages 5350: The Impact of Dose Rate on DNA Double-Strand Break Formation and Repair in Human Lymphocytes Exposed to Fast Neutron Irradiation International Journal of Molecular Sciences doi: 10.3390/ijms20215350 Authors: Shankari Nair Monique Engelbrecht Xanthene Miles Roya Ndimba Randall Fisher Peter du Plessis Julie Bolcaen Jaime Nieto-Camero Evan de Kock Charlot Vandevoorde The lack of information on how biological systems respond to low-dose...
IJMS, Vol. 20, Pages 5349: The Influence of a Nanopatterned Scaffold that Mimics Abnormal Renal Mesangial Matrix on Mesangial Cell Behavior International Journal of Molecular Sciences doi: 10.3390/ijms20215349 Authors: Chia-Jung Chang Rin Minei Takeshi Sato Akiyoshi Taniguchi The alteration of mesangial matrix (MM) components in mesangium, such as type IV collagen (COL4) and type I collagen (COL1), is commonly found in progressive glomerular disease. Mesangial cells (MCs) responding...
IJMS, Vol. 20, Pages 5346: Functional Comparison of Human and Zebra Fish FKBP52 Confirms the Importance of the Proline-Rich Loop for Regulation of Steroid Hormone Receptor Activity International Journal of Molecular Sciences doi: 10.3390/ijms20215346 Authors: Diondra C. Harris Yenni A. Garcia Cheryl Storer Samaniego Veronica W. Rowlett Nina R. Ortiz Ashley N. Payan Tatsuya Maehigashi Marc B. Cox Previous studies demonstrated that the 52-kDa FK506-binding protein...
IJMS, Vol. 20, Pages 5348: Immunomodulatory Protein from Nectria haematococca Induces Apoptosis in Lung Cancer Cells via the P53 Pathway International Journal of Molecular Sciences doi: 10.3390/ijms20215348 Authors: Jing-Jing Wang Yan Wang Lizhen Hou Fengjiao Xin Bei Fan Cong Lu Lijing Zhang Fengzhong Wang Shuying Li Our previous research has shown that a fungal immunomodulatory protein from Nectria haematococca (FIP-nha) possesses a wide spectrum of anti-tumor...
IJMS, Vol. 20, Pages 5347: PD-L1/PD-1 Axis in Glioblastoma Multiforme International Journal of Molecular Sciences doi: 10.3390/ijms20215347 Authors: Jakub Litak Marek Mazurek Cezary Grochowski Piotr Kamieniak Jacek Roliński Glioblastoma (GBM) is the most popular primary central nervous system cancer and has an extremely expansive course. Aggressive tumor growth correlates with short median overall survival (OS) oscillating between 14 and 17 months. The survival rate of patients...
IJMS, Vol. 20, Pages 5345: First Report of a Patient with MPS Type VII, Due to Novel Mutations in GUSB, Who Underwent Enzyme Replacement and Then Hematopoietic Stem Cell Transplantation International Journal of Molecular Sciences doi: 10.3390/ijms20215345 Authors: Patricia Dubot Frédérique Sabourdy Geneviève Plat Charlotte Jubert Claude Cancès Pierre Broué Guy Touati Thierry Levade We report the case of a boy who was diagnosed with mucopolysaccharidosis (MPS) VII...
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Abstract Purpose To investigate the impact of blood-brain barrier (BBB) alterations induced by an experimental tumor and radiotherapy on MRI signal intensity (SI) in deep cerebellar nuclei (DCN) and the presence of gadolinium after repeated administration of a linear gadolinium-based contrast agent in rats. Methods Eighteen Fischer rats were...
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Abstract Background Many data suggest that patients with low rectal adenocarcinoma who achieved ypT0N0 status have improved survival and disease-free survival (DFS) compared to all other stages however only few data are available regarding the specific prognosis factors of this subgroup. This study aimed to evaluate predictive factors for disease free survival after complete pathological response (CPR) in cases of low rectal adenocarcinoma....
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Abstract Background The expression of microRNAs (miRNAs) is a promising prognostic and diagnostic tool in hepatocellular carcinoma (HCC). Here we performed small RNA sequencing (sRNA-seq) of tissue, serum and serum exosomes to investigate changes in miRNA expression between the different sample types and correlated the expression with clinical parameters. We also performed gene expression arrays on tumor and normal tissue. ...
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Abstract Cigarette smoke (CS) contains many free radicals and toxic chemicals. Nuclear erythroid-related factor-2 (Nrf2) is a transcriptional regulator of several phase II antioxidant genes, including glutamate-cysteine ligase (GCL). In this study, it was hypothesized that Crocin may mediate antioxidant signaling pathway to protect human lung epithelial cells against CS-mediated toxicity and oxidative stress via inducing glutathione (GSH) biosynthesis and activation of Nrf2 pathway....
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Abstract The prostate-specific antigen (PSA) blood test is the accepted biomarker of tumor recurrence. PSA levels in serum correlate with disease progression, though its diagnostic accuracy is questionable. As a result, significant progress has been made in developing modified PSA tests such as PSA velocity, PSA density, 4Kscore, PSA glycoprofiling, Prostate Health Index, and the STHLM3 test. PSA, a serine protease, is secreted from the epithelial cells of the prostate. PSA has...
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Abstract Background Microtubule dynamics is crucial for neuronal function and survival. The disrupted function of microtubule dynamics would lead to neurodegenerative and neurodevelopmental disorders. Tubulin-specific chaperone D (TBCD) is one of five tubulin co-chaperones acted in assembly and disassembly dynamics of microtubule. The biallelic pathogenic variants of TBCD gene were reported to be associated with severe degenerative...
Abstract Objective Hemicrania continua and paroxysmal hemicrania are considered different headaches belonging to a group of trigeminal autonomic cephalalgias. However, they share many clinical features. Both headaches also show complete response to indomethacin, which is a mandatory criterion for their diagnosis. Are they really different headaches? To answer this question, we compared the pain characteristics and autonomic features...
Abstract Background Foreign accent syndrome (FAS) is arare syndrome associated with altered speech rhythm and prosody, which listeners perceive as foreign; cerebrovascular accidents, tumors and multiple sclerosis are reported as possible causes of FAS. The pathophysiology of FAS is not yet understood. Case presentation A 68-year-old Italian...
The article “Basal ganglia calcifications (Fahr’s syndrome): related conditions and clinical features, written by Giulia Donzuso, Giovanni Mostile, Alessandra Nicoletti, and Mario Zappia”, was originally published electronically on the publisher’s internet portal (currently SpringerLink).
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