Abstract Purpose Immunonutritional status is a known prognostic correlate in the context of gastric cancer (GC). In the present study, we investigated the prognostic relevance of a lipid profile-based immunonutritional score in patients with GC. Methods Data pertaining to 224 patients with stage II and III GC who underwent curative gastrectomy were retrospectively...
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Author: Godier, Anne MD, PhD; Martin, Anne-Celine MD, PhD Page: 1445-1447
Author: Verma, Subodh MD, PhD; Bhatt, Deepak L. MD, MPH Page: 1448-1450
Author: Eikelboom, John W. MBBS; Connolly, Stuart J. MD; Bosch, Jacqueline PhD; Shestakovska, Olga MSc; Aboyans, Victor MD; Alings, Marco MD; Anand, Sonia S. MD; Avezum, Alvaro MD, PhD; Berkowitz, Scott D. MD; Bhatt, Deepak L. MD; Cook-Bruns, Nancy MD; Felix, Camilo MD; Fox, Keith A.A. MBChB; Hart, Robert G. MD; Maggioni, Aldo P. MD; Moayyedi, Paul MD; O'Donnell, Martin MB; Ryden, Lars MD; Verhamme, Peter MD; Widimsky, Petr MD; Zhu, Jun MD; Yusuf, Salim...
Author: Roe, Matthew T. MD, MHS; Strickler, John MD Page: 1460-1462
Author: Nassif, Michael E. MD; Windsor, Sheryl L. BS; Tang, Fengming MS; Khariton, Yevgeniy MD; Husain, Mansoor MD; Inzucchi, Silvio E. MD; Mc-Guire, Darren K. MD; Pitt, Bertram MD; Scirica, Benjamin M. MD; Austin, Bethany MD; Drazner, Mark H. MD, MSc; Fong, Michael W. MD; Givertz, Michael M. MD; Gordon, Robert A. MD, PharmD; Jermyn, Rita MD; Katz, Stuart D. MD; Lamba, Sumant MD; Lanfear, David E. MD, MS; LaRue, Shane J. MD; Lindenfeld, JoAnn MD; Malone,...
Author: Nademanee, Koonlawee MD; Haissaguerre, Michel MD; Hocini, Meleze MD; Nogami, Akihiko MD; Cheniti, Ghassen MD; Duchateau, Josselin MD; Behr, Elijah R. MD; Saba, Magdi MD; Bokan, Ryan BS; Lou, Qing PhD; Amnueypol, Montawatt MD; Coronel, Ruben MD, PhD; Khongphatthanayothin, Apichai MD; Veerakul, Gumpanart MD Page: 1477-1490
Author: Chelko, Stephen P. PhD; Asimaki, Angeliki PhD; Lowenthal, Justin BS; Bueno-Beti, Carlos PhD; Bedja, Djahida PhD; Scalco, Arianna MS; Amat-Alarcon, Nuria MS; Andersen, Peter PhD; Judge, Daniel P. MD; Tung, Leslie PhD; Saffitz, Jeffrey E. MD, PhD Page: 1491-1505
Author: Weissgerber, Tracey L. PhD; Winham, Stacey J. PhD; Heinzen, Ethan P.; Milin-Lazovic, Jelena S. MD; Garcia-Valencia, Oscar MD; Bukumiric, Zoran MD, PhD; Savic, Marko D. MPH; Garovic, Vesna D. MD, PhD; Milic, Natasa M. MD, PhD Page: 1506-1518
Author: Narang, Nikhil MD; Kim, Gene H. MD; Uriel, Nir MD, MSc Page: 1519-1523
Author: Fujisawa, Takeshi BSc, PhD; Tura-Ceide, Olga BSc, PhD; Hunter, Amanda MBChB; Mitchell, Andrew MBChB; Vesey, Alex MBChB; Medine, Claire BSc, PhD; Gallogly, Susan BSc, PhD; Hadoke, Patrick W.F. BSc, PhD; Keith, Charlotte BSc; Sproul, Anne MI BIOL; Roddie, Huw MBChB, PhD; McQuaker, Grant DM; Wilmut, Ian BSc, PhD; Mills, Nicholas L. MBChB, PhD ,,*; Brittan, Mairi BSc, PhD ,* Page: ...
Author: Elghazaly, Hussein BSc; Hajiev, Saur BSc; Singh, Parminder BSc Page: e738-e739
Author: Kato, Eri T. MD, MPH, PhD; Sabatine, Marc S. MD, MPH; Wiviott, Stephen D. MD Page: e740-e741
Author: Simpson, Timothy F. MD, PharmD; Salazar, James W. MD, MAS; Tseng, Zian H. MD, MAS Page: e742-e743
Author: Timal, Rohit J. MD; Jukema, J. Wouter MD, PhD Page: e744-e745
Author: Nolan, Jerry P. MB ChB, FRCA, FRCP, FFICM, FRCEM, Chair; Berg, Robert A. MD, FAHA, FAAP, FCCM; Andersen, Lars W. MD, MPH, PhD, DMSc; Bhanji, Farhan MD, MSc (Ed), FRCPC, FAHA; Chan, Paul S. MD, MS; Donnino, Michael W. MD; Lim, Swee Han MBBS; Ma, Matthew Huei-Ming MD, PhD; Nadkarni, Vinay M. MD, MS, FAHA; Starks, Monique A. MD, MHS; Perkins, Gavin D. MB ChB, MD, FRCP, FFICM, FMedSci; Morley, Peter T. MB BS, FRACP, FANZCA, FCICM, AFRACMA, FERC, FAHA;...
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Within the forensic science community, there is a continued push to develop novel tools to aid in criminal investigations. microRNA (miRNA) analysis has been the focus of many researcher’s attention in the biomedical field since their discovery in 1993, however the forensic application of miRNA analysis has only been suggested within the last ten years and has been gaining considerable traction recently. The primary focus of the forensic application of miRNA analysis has been on Body Fluid Identification...
In response to foreign RNA cellular antiviral mechanisms stimulate high expression of Interferon-induced proteins with tetratricopeptide repeats (IFITs). Two members of the IFIT protein family: IFIT1 and IFIT5 are capable of binding the very terminal 5’ end of mRNA. In eukaryotes these mRNA termini contain a cap structure (m7GpppN, cap 0) that is often subjected to further modifications. Here, we performed a thorough examination of IFIT1 and IFIT5 binding to a wide spectrum of differently capped...
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The aim of this work was to describe optimised dosing regimens of ceftolozane/tazobactam for critically ill patients receiving continuous venovenous hemodiafiltration (CVVHDF). We conducted a prospective observational pharmacokinetic study in adult critically ill patients with clinical indications for ceftolozane/tazobactam and CVVHDF. Unbound drug concentrations were measured from serial pre-filter blood, post-filter blood and ultrafiltrate samples by a chromatographic assay. Population pharmacokinetic...
The antifungal susceptibility tests used in clinical laboratories have several limitations. We developed a new test, SensiFONG, based on the detection of chitin levels after exposure to antifungal drugs. The optimal culture conditions were 30°C for 6 h for yeast strains, and 26°C for 16 h for molds. The strains were exposed to a range of echinocandin or azole concentrations. Chitin was stained with Calcofluor White. The percentage of fungal cells with high chitin levels was determined with an automatic...
Siderophore-antibiotic conjugates have increased in vitro activity in low iron environments where bacteria express siderophores and associated transporters. The host immune hypoferremic response reduces iron availability to bacteria, however, patients with iron overload or deficiency may have altered ability to restrict iron which may affect the efficacy of siderophore-antibiotic conjugates. In vivo models of infection with iron overload and deficiency are needed to perform this assessment.The standard...
We report our clinical experience treating a critically ill patient with polymicrobial infections due to multi-drug resistant Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa in a 56 year-old woman who received healthcare in India and was also colonized by Candida auris. A precision medicine approach using whole genome sequencing revealed a multiplicity of mobile elements associated with NDM-1, NDM-5, and OXA-181 and, supplemented by susceptibility testing, guided the selection...
Millions of women are exposed simultaneously to antiretroviral drugs (ARVs) and progestin-based hormonal contraceptives. Yet, the reciprocal modulation by ARVs and progestins of their intracellular functions is relatively unexplored. We investigated the effects of tenofovir disoproxil fumarate (TDF) and dapivirine (DPV), alone and in the presence of select steroids and progestins, on cell viability, steroid-regulated immunomodulatory gene expression, activation of steroid receptors and anti-HIV-1...
While resistance to antibacterial drugs is increasing globally, it is unevenly distributed. The number of cases that are truly difficult to treat remain below the number required to drive an adequate market for needed new therapies. Without a sufficient market, companies pursuing these drugs risk financial failure. Here, I explore, at least briefly, the current situation and the financial risks to companies. I provide potential solutions to the failed market.
Ceftolozane-tazobactam (C/T), a novel fifth-generation cephalosporin/β-lactamase inhibitor combination active against multidrug-resistant (MDR) Pseudomonas aeruginosa, is currently FDA-approved to treat complicated intra-abdominal and urinary tract infections at label dosage (1g/0.5g/8h intravenously), and also nosocomial and ventilator-associated pneumonia at high dose (2 g/1g/8h)....
Upregulated expression of efflux pumps, lpxC target mutations, LpxC protein overexpression, and mutations in fabG were previously shown to mediate single step resistance to the LpxC inhibitor CHIR-090 in P. aeruginosa. Single step selection experiments using three recently described LpxC inhibitors (compounds 2, 3 and 4, Figure 1) and mutant characterization showed that these mechanisms affect susceptibility to additional novel LpxC inhibitors. Serial passaging of P. aeruginosa wild-type and efflux...
Cefiderocol is a siderophore-cephalosporin conjugate with greater in vitro potency in iron-depleted conditions. During infection, iron is scarce in host tissue, however, it is not known whether iron overload in the host, such as in cases of hereditary hemochromatosis, alters the efficacy of cefiderocol. We compared cefiderocol efficacy between iron overloaded and standard murine thigh infection models.Female CD-1 mice rendered neutropenic received two weeks of iron dextran 100 mg/kg/d intraperitoneally...
Hepatitis B virus (HBV) is a major human pathogen killing an estimated 887,000 humans per year. Therefore, potentially curative therapies are of high need. Following infection, HBV deposits a covalently closed circular (ccc) DNA in the nucleus of infected cells that serves as transcription template and is not affected by current therapies. HBV core protein allosteric modulators (CpAMs) prevent correct capsid assembly but may also affect early stages of HBV infection. In this study, we aimed to determine...
Ceftriaxone (CRO) is widely used as the first-line treatment for gonococcal infections. However, CRO-resistant Neisseria gonorrhoeae strains carrying mosaic penA-60.001 have emerged and disseminated worldwide recently. To meet the urgent need to detect these strains, we report here a loop-mediated isothermal (LAMP) assay system that targets N. gonorrhoeae penA-60.001. This assay system can differentiate N. gonorrhoeae carrying mosaic penA-60.001 from strains carrying other penA alleles.
Understanding the mechanism(s) underpinning drug resistance could lead to novel treatments to reverse the increased tolerance of a pathogen. In this study paromomycin (PMM) resistance (PMM-R) was induced in three Nepalese clinical strains of L. donovani, with different inherent susceptibility to antimony drugs (Sb), by step-wise exposure of promastigotes to PMM. Exposure to PMM resulted in the production of mixed populations of parasites even though a single cloned population was used at the start...
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Abstract In many parts of the world, groundwater is considered as one of the main sources of urban and rural drinking water. Over the past three decades, the qualitative and quantitative characteristics of aquifers have been negatively affected by different factors such as excessive use of chemical fertilizers in agriculture, indiscreet, and over-exploitation use of groundwater. Therefore, finding the effective method for mapping the water quality index (WQI) is important for locating...
Abstract Atrazine (ATR) is a common herbicide used worldwide. It is a potent endocrine disruptor that causes hormonal imbalance. We investigated the modulatory role predisposed by glycyrrhizic acid (GA) against the hazardous effects caused by the ATR in the rabbit spleen. Sixty rabbits were assigned into 4 groups. The first group is the negative control; the ATR group received 1/10 of the oral LD 50 ATR; the GA group received 50 mg/kg body weight daily intraproteinally; and group...
Abstract Fluoxetine (FLX) is one of the main antidepressants used worldwide. After human use, FLX enters the aquatic ecosystems, where it has commonly detected in the high ng/L concentration range. Several investigations have shown that exposure to different concentrations of FLX caused different adverse effects towards a number of aquatic species. However, the information on the onset and the relationship between molecular and behavioral FLX-induced effects remains scant. The...
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J Neurol Surg BDOI: 10.1055/s-0039-1700513 Introduction Neurosurgical anatomy is traditionally taught via anatomic and operative atlases; however, these resources present the skull base using views that emphasize three-dimensional (3D) relationships rather than operative perspectives, and are frequently written above a typical resident's understanding. Our objective is to describe, step-by-step, a retrosigmoid approach dissection, in a way that is educationally valuable for trainees at...
J Neurol Surg BDOI: 10.1055/s-0039-3399518 Background The mastoid emissary veins (MEVs) pass through the mastoid emissary canal-mastoid foramen (MEC-MF) in the mastoid region of the skull. MEVs can give rise to complications during surgical procedures. The purpose of our study was to investigate the morphological and morphometric characteristics of MECs of patients with clinical chronic otitis media (COM) using high-resolution computed tomography (HRCT). Methods Patients diagnosed...
J Neurol Surg BDOI: 10.1055/s-0039-1698823We present a case of a medium-sized foramen magnum meningioma that was resected through a midline suboccipital subtonsillar approach with C1 laminectomy in prone (Concorde) position. The patient is a 77-year-old woman with a 6-month history of intermittent vertigo, moderate gait instability, and slight decline of memory.On magnetic resonance imaging (MRI) an extra-axial intradural lesion was discovered that originated from the right epicondylar region just...
J Neurol Surg BDOI: 10.1055/s-0039-1700893 Objectives To describe a far lateral approach for microsurgical clipping of a ruptured posterior inferior cerebellar artery (PICA) aneurysm involving the hypoglossal nerve, with emphasis on the microsurgical anatomy, and technique. Design A far lateral craniotomy is performed in the lateral decubitus position and the transverse and sigmoid sinuses were exposed. After opening the dura, sutures are placed to allow gentle mobilization...
J Neurol Surg BDOI: 10.1055/s-0039-3399492This operative video highlights a rare case of a neuroenteric cyst at the ventral craniocervical junction. The case involved a 30-year-old man who initially presented 13 years earlier with acute onset of headache and visual changes. At that time, he was found to have a small, enhancing ventral intradural extramedullary mass at the rostral aspect of C1 thought to be a meningioma. The lesion was managed conservatively, and surveillance imaging tracked its slow...
J Neurol Surg BDOI: 10.1055/s-0039-1698820Craniovertebral junction chordomas can represent a surgical challenge, especially when intradural extension and contact with neurovascular structures is involved. To date, there is still controversy on the choice of optimal surgical corridor for such lesions, with endoscopic endonasal, far lateral and anterolateral corridors being those most commonly used. In this operative video, we present a case of craniovertebral junction chordoma with significant bone...
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