Related ArticlesRisk of Post-Operative, Pre-Radiotherapy Contralateral Neck Recurrence in Patients Treated with Surgery Followed by Adjuvant Radiotherapy for Human Papilloma Virus-Associated Tonsil Cancer. Br J Radiol. 2019 Oct 10;:20190466 Authors: Gershowitz J, Chao HH, Doucette A, Lukens JN, Swisher-McClure S, Weinstein GS, O'Malley BW, Chalian AA, Rassekh CH, Newman JG, Cohen RB, Bauml JM, Aggarwal C, Lin A Abstract OBJECTIVES: One approach to reduce...
Fri Oct 11, 2019 14:54
Related ArticlesTherapeutic efficacy, Prognostic variables and Clinical Outcome of 177Lu-PSMA-617 PRLT in Progressive mCRPC following multiple lines of treatment: prognostic implications of high FDG uptake on dual tracer PET-CT vis-à-vis Gleason Score in such cohort. Br J Radiol. 2019 Oct 10;:20190380 Authors: Suman S, Parghane RV, Joshi A, Prabhash K, Bakshi G, Talole S, Banerjee S, Basu S Abstract OBJECTIVES: To evaluatethe therapeutic response, progression...
Fri Oct 11, 2019 14:54
Related ArticlesDistinct roles of PIK3CA in the enrichment and maintenance of cancer stem cells in head and neck squamous cell carcinoma. Mol Oncol. 2019 Oct 10;: Authors: Chen X, Cao Y, Sedhom W, Lu L, Liu Y, Wang H, Oka M, Bornstein S, Said S, Song J, Lu SL Abstract Recurrence and metastasis are the major causes of mortality in head and neck squamous cell carcinoma (HNSCC). It is suggested that cancer stem cells (CSCs) play pivotal roles in recurrence...
Fri Oct 11, 2019 14:54
Related ArticlesMalignant pheochromocytoma and paraganglioma: management options. Curr Opin Oncol. 2019 Oct 09;: Authors: Corssmit EPM, Snel M, Kapiteijn E Abstract PURPOSE OF REVIEW: Although the majority of pheochromocytoma and paraganglioma are benign, 15-17% develop metastatic disease, being present at the initial diagnosis in about 11-31% of cases. The natural course of metastasized disease is highly heterogeneous, with an overall 5-year survival...
Fri Oct 11, 2019 14:54
Related ArticlesECLIM-SEHOP, a new platform to set up and develop international academic clinical trials for childhood cancer and blood disorders in Spain. Clin Transl Oncol. 2019 Oct 09;: Authors: Bautista F, Cañete A, Ramírez-Villar GL, Fernández JM, Fuster JL, Diaz de Heredia C, Astigarraga I, García-Ariza M, Rives S, Dapena JL, Márquez C, Molinés A, Bermúdez MDM, Gallego S, Andrés MDM, Verdu-Amoros J, Hernández C, López M, Catalá A, Lassaletta Á, Cruz O, Ramírez M,...
Fri Oct 11, 2019 13:09
Related ArticlesImmunotherapy Against Gliomas: is the Breakthrough Near? Drugs. 2019 Oct 09;: Authors: Lukas RV, Wainwright DA, Horbinski CM, Iwamoto FM, Sonabend AM Abstract Immunotherapeutic approaches have been, and continue to be, aggressively investigated in the treatment of infiltrating gliomas. While the results of late-phase clinical studies have been disappointing in this disease space thus far, the success of immunotherapies in other malignancies...
Fri Oct 11, 2019 13:09
Related ArticlesDruggable Molecular Targets for the Treatment of Triple Negative Breast Cancer. J Breast Cancer. 2019 Sep;22(3):341-361 Authors: Nakhjavani M, Hardingham JE, Palethorpe HM, Price TJ, Townsend AR Abstract Breast cancer (BC) is still the most common cancer among women worldwide. Amongst the subtypes of BC, triple negative breast cancer (TNBC) is characterized by deficient expression of estrogen, progesterone, and human epidermal growth...
Fri Oct 11, 2019 13:09
Related ArticlesAn update on treatment options for pancreatic adenocarcinoma. Ther Adv Med Oncol. 2019;11:1758835919875568 Authors: Lambert A, Schwarz L, Borbath I, Henry A, Van Laethem JL, Malka D, Ducreux M, Conroy T Abstract Pancreatic cancer is one of the most lethal solid organ tumors. Due to the rising incidence, late diagnosis, and limited treatment options, it is expected to be the second leading cause of cancer deaths in high income countries...
Fri Oct 11, 2019 13:09
Related ArticlesOrthopedia Homeobox (OTP) in Pulmonary Neuroendocrine Tumors: The Diagnostic Value and Possible Molecular Interactions. Cancers (Basel). 2019 Oct 08;11(10): Authors: Moonen L, Derks J, Dingemans AM, Speel EJ Abstract Generally, patients with stage I-IIIa (TNM) pulmonary carcinoid disease have a favourable prognosis after curative resection. Yet, distant recurrence of disease after curative surgery occurs in approximately 1-6% of patients...
Fri Oct 11, 2019 13:09
Related ArticlesThe impact of hyperglycemia on survival in glioblastoma: A systematic review and meta-analysis. Clin Neurol Neurosurg. 2018 07;170:165-169 Authors: Lu VM, Goyal A, Vaughan LS, McDonald KL Abstract In the management of glioblastoma (GBM), there is a considerable predisposition to hyperglycemia due to significant integration of corticosteroid therapy to treat predictable clinical sequelae following diagnosis and treatment. The aim of this...
Fri Oct 11, 2019 13:09
Related ArticlesmiR-200c suppresses stemness and increases cellular sensitivity to trastuzumab in HER2+ breast cancer. J Cell Mol Med. 2019 Oct 10;: Authors: Tang H, Song C, Ye F, Gao G, Ou X, Zhang L, Xie X, Xie X Abstract Resistance to trastuzumab remains a major obstacle in HER2-overexpressing breast cancer treatment. miR-200c is important for many functions in cancer stem cells (CSCs), including tumour recurrence, metastasis and resistance. We hypothesized...
Fri Oct 11, 2019 15:03
Related ArticlesCorrigendum: PAM50 Subtypes in Baseline and Residual Tumors Following Neoadjuvant Trastuzumab-Based Chemotherapy in HER2-Positive Breast Cancer: A Consecutive-Series From a Single Institution. Front Oncol. 2019;9:967 Authors: Pernas S, Petit A, Climent F, Paré L, Perez-Martin J, Ventura L, Bergamino M, Galván P, Falo C, Morilla I, Fernandez-Ortega A, Stradella A, Rey M, Garcia-Tejedor A, Gil-Gil M, Prat A Abstract [This corrects the article...
Fri Oct 11, 2019 13:07
Related ArticlesMeasuring Tumor Extent Based on Subtypes Using Magnetic Resonance Imaging: Radiologic-Pathologic Discordance and High Positive Margin Rates in Breast Cancer. J Breast Cancer. 2019 Sep;22(3):453-463 Authors: Bae SJ, Ahn SG, Yoon CI, Yang BS, Lee HW, Son EJ, Jeong J Abstract Purpose: We evaluated the clinical value of breast magnetic resonance imaging (MRI) in patients who underwent breast-conserving surgery (BCS). The degree of correlation...
Fri Oct 11, 2019 13:07
Related ArticlesA Genome-Wide Association Study Identifies Five Novel Genetic Markers for Trastuzumab-Induced Cardiotoxicity in Japanese Population. Biol Pharm Bull. 2019 Oct 09;: Authors: Nakano MH, Udagawa C, Shimo A, Kojima Y, Yoshie R, Zaha H, Abe N, Motonari T, Unesoko M, Tamura K, Shimoi T, Yoshida M, Yoshida T, Sakamoto H, Kato K, Mushiroda T, Tsugawa K, Zembutsu H Abstract Trastuzumab has been administered to patients with HER2-positive cancer,...
Fri Oct 11, 2019 13:07
Related ArticlesCarotid body tumor contemporary management in a high-volume centre. J Cardiovasc Surg (Torino). 2019 Oct 04;: Authors: Mascia D, Esposito G, Ferrante A, Grandi A, Melissano G, Chiesa R Abstract BACKGROUND: The aim of this study is to report our results with carotid body tumour (CBT) surgical management. METHODS: Between 2010 and 2018, 100 CBTs (mean age: 48.0 years, range 21-80 years old) were treated in our centre. The patients...
Fri Oct 11, 2019 15:04
Related ArticlesCombining CDK4/6 inhibitors ribociclib and palbociclib with cytotoxic agents does not enhance cytotoxicity. PLoS One. 2019;14(10):e0223555 Authors: Jin D, Tran N, Thomas N, Tran DD Abstract Cyclin-dependent kinases 4 and 6 (CDK4/6) play critical roles in the G1 to S checkpoint of the cell cycle and have been shown to be overactive in several human cancers. Small-molecule inhibitors of CDK4/6 have demonstrated significant efficacy against...
Fri Oct 11, 2019 14:57
Related ArticlesMicroRNA-524-5p suppresses cell proliferation and promotes cell apoptosis in gastric cancer by regulating CASP3. Eur Rev Med Pharmacol Sci. 2019 Sep;23(18):7968-7977 Authors: Zhu CY, Meng FQ, Liu J Abstract OBJECTIVE: To investigate miR-524-5p expression in gastric cancer (GC) tissues and the regulatory mechanism of miR-524-5p on biological behaviors of GC cell lines, such as proliferation, cell apoptosis and cycle. MATERIALS...
Fri Oct 11, 2019 14:57
Related ArticlesAntitumor effects of seleno-short-chain chitosan (SSCC) against human gastric cancer BGC-823 cells. Cytotechnology. 2019 Oct 09;: Authors: Dong XD, Yu J, Meng FQ, Feng YY, Ji HY, Liu A Abstract Seleno-short-chain chitosan (SSCC) is a derivative of chitosan. In the present study, we sought to investigate the underlying antitumor mechanism of SSCC on human gastric cancer BGC-823 cells in vitro. MTT assay suggested that SSCC exhibited a...
Fri Oct 11, 2019 13:00
Related ArticlesInhibition of Colon Cancer Cell Growth by Imidazole Through Activation of Apoptotic Pathway. Med Sci Monit. 2019 Oct 10;25:7597-7604 Authors: Long Y, Wang D Abstract BACKGROUND This study aimed to investigate the inhibitory effect of imidazole on colon cancer cell proliferation and understand the mechanism involved. MATERIAL AND METHODS MTT assay and flow cytometry using Hoechst 33258 staining were used to assess cell proliferation and...
Fri Oct 11, 2019 13:00
Related Articles[Cellular senescence and age-related diseases]. Rinsho Ketsueki. 2019;60(9):1027-1032 Authors: Nakanishi M Abstract Cellular senescence is a state of durable cell cycle arrest after a defined number of cell divisions. The number of population doublings of normal cells in culture depends on the species but not on the types of cells used to establish the culture, showing a positive correlation with the life span of the animals. Therefore,...
Fri Oct 11, 2019 13:00
Related ArticlesSynergism between ATM and PARP1 inhibition involves DNA damage and abrogating the G2 DNA damage checkpoint. Mol Cancer Ther. 2019 Oct 09;: Authors: Mak JPY, Ma HT, Poon RYC Abstract PARP inhibitors have emerged as effective chemotherapeutic agents for BRCA1/BRCA2-deficient cancers. Another DNA damage response protein ATM is also increasingly being recognized as a target for synthetic lethality with PARP inhibitors. As ATM functions in...
Fri Oct 11, 2019 13:00
Related ArticlesReplication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing. Int J Mol Sci. 2019 Oct 08;20(19): Authors: Billard P, Poncet DA Abstract Senescence is defined as a stress-induced durable cell cycle arrest. We herein revisit the origin of two of these stresses, namely mitochondrial metabolic compromise, associated with reactive oxygen species (ROS) production, and replicative senescence, activated by...
Fri Oct 11, 2019 13:00
Related ArticlesThe methyl-triclosan induced caspase-dependent mitochondrial apoptosis in HepG2 cells mediated through oxidative stress. Ecotoxicol Environ Saf. 2019 Oct 30;182:109391 Authors: Li X, An J, Li H, Qiu X, Wei Y, Shang Y Abstract Methyl-triclosan (MTCS) is a dominant transformation product of triclosan (TCS), which has been widely used as an effective antimicrobial ingredient with increasing concentrations in the environment. MTCS shows...
Fri Oct 11, 2019 13:00
Related ArticlesZw10 is a spindle assembly checkpoint protein that regulates meiotic maturation in mouse oocytes. Histochem Cell Biol. 2019 Sep;152(3):207-215 Authors: Park Y, Kim JS, Oh JS Abstract Faithful chromosome segregation during the cell cycle is ensured by the spindle assembly checkpoint (SAC). Although SAC activity is highly conserved and most organisms share common SAC components, additional proteins that regulate SAC activity to ensure...
Fri Oct 11, 2019 13:00
Related ArticlesComparison of Coding Transcriptomes in Fibroblasts Irradiated With Low and High LET Proton Beams and Cobalt-60 Photons. Int J Radiat Oncol Biol Phys. 2019 04 01;103(5):1203-1211 Authors: Nielsen S, Bassler N, Grzanka L, Laursen L, Swakon J, Olko P, Andreassen CN, Alsner J, Singers Sørensen B Abstract PURPOSE: To identify differential cellular responses after proton and photon irradiation by comparing transcriptomes of primary fibroblasts...
Fri Oct 11, 2019 13:00
Related Articles18β-Glycyrrhetinic-acid-mediated unfolded protein response induces autophagy and apoptosis in hepatocellular carcinoma. Sci Rep. 2018 06 19;8(1):9365 Authors: Chen J, Zhang ZQ, Song J, Liu QM, Wang C, Huang Z, Chu L, Liang HF, Zhang BX, Chen XP Abstract 18β-Glycyrrhetinic acid (GA) is the active ingredient of the traditional Chinese medicine, Glycyrrhrzae Radix et Rhizoma. Here, we explored the effects of GA on hepatocellular carcinoma...
Fri Oct 11, 2019 13:00
Related ArticlesUniversal response in the RKO colon cancer cell line to distinct antimitotic therapies. Sci Rep. 2018 06 12;8(1):8979 Authors: Lorz A, Botesteanu DA, Levy D Abstract Both classic and newer antimitotics commonly induce a prolonged mitotic arrest in cell culture. During arrest, cells predominantly undergo one of two fates: cell death by apoptosis, or mitotic slippage and survival. To refine this binary description, a quantitative understanding...
Fri Oct 11, 2019 13:00
Related ArticlesmiR-212-3p reduced proliferation, and promoted apoptosis of fibroblast-like synoviocytes via down-regulating SOX5 in rheumatoid arthritis. Eur Rev Med Pharmacol Sci. 2018 01;22(2):461-471 Authors: Liu Y, Zhang XL, Li XF, Tang YC, Zhao X Abstract OBJECTIVE: Several microRNAs have been reported to contribute the progression of rheumatoid arthritis (RA) due to the ectopic expression of miRNAs in fibroblast-like synoviocytes (FLS). However,...
Fri Oct 11, 2019 13:00
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου