Antibiotics, Vol. 9, Pages 504: Aminoglycosides: From Antibiotics to Building Blocks for the Synthesis and Development of Gene Delivery Vehicles Antibiotics doi: 10.3390/antibiotics9080504 Authors: Maria Cristina Bellucci Alessandro Volonterio Aminoglycosides are a class of naturally occurring and semi synthetic antibiotics that have been used for a long time in fighting bacterial infections. Due to acquired antibiotic resistance and inherent toxicity, aminoglycosides have experienced...
Tue Aug 11, 2020 03:00
Antibiotics, Vol. 9, Pages 503: Development of an NGS-Based Workflow for Improved Monitoring of Circulating Plasmids in Support of Risk Assessment of Antimicrobial Resistance Gene Dissemination Antibiotics doi: 10.3390/antibiotics9080503 Authors: Bas Berbers Pieter-Jan Ceyssens Pierre Bogaerts Kevin Vanneste Nancy H. C. Roosens Kathleen Marchal Sigrid C. J. De Keersmaecker Antimicrobial resistance (AMR) is one of the most prominent public health threats. AMR genes localized...
Tue Aug 11, 2020 03:00
Antioxidants, Vol. 9, Pages 736: Systemic Insulin Resistance and Metabolic Perturbations in Chow Fed Inducible Nitric Oxide Synthase Knockout Male Mice: Partial Reversal by Nitrite Supplementation Antioxidants doi: 10.3390/antiox9080736 Authors: Hobby Aggarwal Priya Pathak Pragati Singh Jiaur R. Gayen Kumaravelu Jagavelu Madhu Dikshit iNOS, an important mediator of inflammation, has emerged as an important metabolic regulator. There are conflicting observations on the...
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Antioxidants, Vol. 9, Pages 735: Effect of Adding Curcumin on the Properties of Linseed Oil Organogels Used as Fat Replacers in Pâtés Antioxidants doi: 10.3390/antiox9080735 Authors: Ramírez-Carrasco Paredes-Toledo Romero-Hasler Soto-Bustamante Díaz-Calderón Robert Giménez Beeswax-based organogels were formulated with linseed oil and curcumin according to a statistical design to increase the oxidative stability of spreadable meat products (pâté)...
Tue Aug 11, 2020 03:00
Antioxidants, Vol. 9, Pages 733: Comparative Study of the Antioxidant and Anti-Inflammatory Effects of Leaf Extracts from Four Different Morus alba Genotypes in High Fat Diet-Induced Obesity in Mice Antioxidants doi: 10.3390/antiox9080733 Authors: Francisco Javier Leyva-Jiménez Antonio Jesús Ruiz-Malagón José Alberto Molina-Tijeras Patricia Diez-Echave Teresa Vezza Laura Hidalgo-García Jesús Lozano-Sánchez David Arráez-Román José Luis Cenis Antonio Abel Lozano-Pérez...
Tue Aug 11, 2020 03:00
Antioxidants, Vol. 9, Pages 734: Effect of Roux-en-Y Bariatric Bypass Surgery on Subclinical Atherosclerosis and Oxidative Stress Markers in Leukocytes of Obese Patients: A One-Year Follow-Up Study Antioxidants doi: 10.3390/antiox9080734 Authors: Zaida Abad-Jiménez Sandra López-Domènech Segundo Ángel Gómez-Abril Dolores Periañez-Gómez Aranzazu M. de Marañón Celia Bañuls Carlos Morillas Víctor M. Víctor Milagros Rocha Little is known about the mechanisms underlying...
Tue Aug 11, 2020 03:00
Antioxidants, Vol. 9, Pages 731: Integrated Hypoxia Signaling and Oxidative Stress in Developmental Neurotoxicity of Benzo[a]Pyrene in Zebrafish Embryos Antioxidants doi: 10.3390/antiox9080731 Authors: Yi-Chen Lin Chang-Yi Wu Chin-Hwa Hu Tun-Wen Pai Yet-Ran Chen Wen-Der Wang Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon formed by the incomplete combustion of organic matter. Environmental B[a]P contamination poses a serious health risk to many organisms because...
Tue Aug 11, 2020 03:00
Antioxidants, Vol. 9, Pages 732: Comparison of In Vitro and In Vivo Antioxidant Activities of Six Flavonoids with Similar Structures Antioxidants doi: 10.3390/antiox9080732 Authors: Yixiu Zeng Jiajia Song Meimei Zhang Hongwei Wang Yu Zhang Huayi Suo The in vitro and in vivo antioxidant activities of six flavonoids with similar structures, including epicatechin (EC), epigallocatechin (EGC), procyanidin B2 (P), quercetin (Q), taxifolin (T), and rutin (R) were compared. The...
Tue Aug 11, 2020 03:00
Atmosphere, Vol. 11, Pages 849: Regional and Urban-Scale Environmental Influences of Oceanic DMS Emissions over Coastal China Seas Atmosphere doi: 10.3390/atmos11080849 Authors: Shanshan Li Yan Zhang Junri Zhao Golam Sarwar Shengqian Zhou Ying Chen Guipeng Yang Alfonso Saiz-Lopez Marine biogenic dimethyl sulfide (DMS) is an important natural source of sulfur in the atmosphere, which may play an important role in air quality. In this study, the WRF-CMAQ model is employed...
Tue Aug 11, 2020 03:00
Atmosphere, Vol. 11, Pages 839: Dendrochronological Reconstruction of June Drought (PDSI) from 1731–2016 for the Western Mongolian Plateau Atmosphere doi: 10.3390/atmos11080839 Authors: Liang Shi Guangxin Li Hongyan Liu Jeffery P. Dech Mei Zhou Pengwu Zhao Zhong Ren Droughts are a recurrent phenomenon in the semiarid forest-steppe ecotone of Mongolia with negative consequences for tree growth and agricultural management. In order to better cope with the uncertainty...
Tue Aug 11, 2020 03:00
Bioengineering, Vol. 7, Pages 93: Effects of Lasers and Their Delivery Characteristics on Machined and Micro-Roughened Titanium Dental Implant Surfaces Bioengineering doi: 10.3390/bioengineering7030093 Authors: Thomas Fenelon Mahmoud M. Bakr Laurence J. Walsh Roy George The aim of the study was to investigate the effects of neodymium: yttrium aluminium garnet (Nd:YAG) (1064 nm) and erbium: yttrium aluminium garnet (Er:YAG) (2940 nm) laser energy on titanium when delivered with...
Tue Aug 11, 2020 03:00
Biomedicines, Vol. 8, Pages 284: Neuroprotection: Targeting Multiple Pathways by Naturally Occurring Phytochemicals Biomedicines doi: 10.3390/biomedicines8080284 Authors: Andleeb Khan Sadaf Jahan Zuha Imtiyaz Saeed Alshahrani Hafiz Antar Makeen Bader Mohammed Alshehri Ajay Kumar Azher Arafah Muneeb U. Rehman With the increase in the expectancy of the life span of humans, neurodegenerative diseases (NDs) have imposed a considerable burden on the family, society,...
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Biomedicines, Vol. 8, Pages 283: Use of Oral Anticoagulation and Diabetes Do Not Inhibit the Angiogenic Potential of Hypoxia Preconditioned Blood-Derived Secretomes Biomedicines doi: 10.3390/biomedicines8080283 Authors: Philipp Moog Maryna Jensch Jessica Hughes Burak Salgin Ulf Dornseifer Hans-Günther Machens Arndt F. Schilling Ektoras Hadjipanayi Patients suffering from tissue ischemia, who would greatly benefit from angiogenesis-promoting therapies such as hypoxia...
Tue Aug 11, 2020 03:00
Biomedicines, Vol. 8, Pages 282: Genistein Combined Polysaccharide (GCP) Can Inhibit Intracrine Androgen Synthesis in Prostate Cancer Cells Biomedicines doi: 10.3390/biomedicines8080282 Authors: Neelu Batra Anhao Sam Tibebe Woldemariam George Talbott Ralph W. de Vere White Paramita M. Ghosh Nilesh W. Gaikwad Simeon O. Kotchoni Ruth L. Vinall Our group and others have previously shown that genistein combined polysaccharide (GCP), an aglycone isoflavone-rich extract...
Tue Aug 11, 2020 03:00
Biomedicines, Vol. 8, Pages 281: Targeting Mutant KRAS in Pancreatic Cancer: Futile or Promising? Biomedicines doi: 10.3390/biomedicines8080281 Authors: Friederike Inga Nollmann Dietrich Alexander Ruess Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal cancers with a dismal prognosis for the patient. This is due to limited diagnostic options for the early detection of the disease as well as its rather aggressive nature. Despite major advances in oncologic research in...
Tue Aug 11, 2020 03:00
Biomolecules, Vol. 10, Pages 1173: Computational Identification and Characterization of New microRNAs in Human Platelets Stored in a Blood Bank Biomolecules doi: 10.3390/biom10081173 Authors: Jersey Heitor da Silva Maués Caroline de Fátima Aquino Moreira-Nunes Rommel Mário Rodriguez Burbano Platelet concentrate (PC) transfusions are widely used to save the lives of patients who experience acute blood loss. MicroRNAs (miRNAs) comprise a class of molecules with a biological role...
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Biomolecules, Vol. 10, Pages 1172: Multi-Scale Understanding of NMDA Receptor Function in Schizophrenia Biomolecules doi: 10.3390/biom10081172 Authors: Jo Soo Hyun Takafumi Inoue Akiko Hayashi-Takagi Schizophrenia is a chronic and disabling psychiatric disorder characterized by disturbances of thought, cognition, and behavior. Despite massive research efforts to date, the etiology and pathophysiology of schizophrenia remain largely unknown. The difficulty of brain research is largely...
Tue Aug 11, 2020 03:00
Biomolecules, Vol. 10, Pages 1171: Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab Biomolecules doi: 10.3390/biom10081171 Authors: Mahir Karakas Dominik Jarczak Martin Becker Kevin Roedl Marylyn M. Addo Frauke Hein Andreas Bergmann Jens Zimmermann Tim-Philipp Simon Gernot Marx Marc Lütgehetmann Axel Nierhaus Stefan Kluge Recently, the stabilization of the endothelium...
Tue Aug 11, 2020 03:00
Biomolecules, Vol. 10, Pages 1170: Interplay between Cell-Surface Receptors and Extracellular Matrix in Skin Biomolecules doi: 10.3390/biom10081170 Authors: Svenja Kleiser Alexander Nyström Skin consists of the epidermis and dermis, which are connected by a specialized basement membrane—the epidermal basement membrane. Both the epidermal basement membrane and the underlying interstitial extracellular matrix (ECM) created by dermal fibroblasts contain distinct network-forming...
Tue Aug 11, 2020 03:00
Biomolecules, Vol. 10, Pages 1169: Advanced Hydrogels as Wound Dressings Biomolecules doi: 10.3390/biom10081169 Authors: Shima Tavakoli Agnes S. Klar Skin is the largest organ of the human body, protecting it against the external environment. Despite high self-regeneration potential, severe skin defects will not heal spontaneously and need to be covered by skin substitutes. Tremendous progress has been made in the field of skin tissue engineering, in recent years, to develop new skin...
Tue Aug 11, 2020 03:00
Biosensors, Vol. 10, Pages 97: A New Possibility for Fermentation Monitoring by Electrical Driven Sensing of Ultraviolet Light and Glucose Biosensors doi: 10.3390/bios10080097 Authors: Cleber A. Amorim Kate C. Blanco Ivani M. Costa Estácio P. de Araújo Adryelle do Nascimento Arantes Jonas Contiero Adenilson J. Chiquito Industrial fermentation generates products through microbial growth associated with the consumption of substrates. The efficiency of industrial production...
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Biosensors, Vol. 10, Pages 96: Bioelectric Sensors: On the Road for the 4.0 Diagnostics and Biomedtech Revolution Biosensors doi: 10.3390/bios10080096 Authors: Spyridon Kintzios Bioelectric sensors lie, by definition, on the interface between biological elements and electronic circuits, irrespective of scale, manufacturing method, and working principle [...]
Tue Aug 11, 2020 03:00
Brain Sciences, Vol. 10, Pages 542: Reduced Attentional Control in Older Adults Leads to Deficits in Flexible Prioritization of Visual Working Memory Brain Sciences doi: 10.3390/brainsci10080542 Authors: Sarah E. Henderson Holly A. Lockhart Emily E. Davis Stephen M. Emrich Karen L. Campbell Visual working memory (VWM) resources have been shown to be flexibly distributed according to item priority. This flexible allocation of resources may depend on attentional control, an...
Tue Aug 11, 2020 03:00
Brain Sciences, Vol. 10, Pages 543: Behavioral Deficits in Juvenile Onset Huntington’s Disease Brain Sciences doi: 10.3390/brainsci10080543 Authors: Kathleen E. Langbehn Ashley M. Cochran Ellen van der Plas Amy L. Conrad Eric Epping Erin Martin Patricia Espe-Pfeifer Peg Nopoulos Reports of behavioral disturbance in Juvenile-Onset Huntington’s Disease (JOHD) have been based primarily on qualitative caregiver reports or retrospective medical record reviews....
Tue Aug 11, 2020 03:00
Brain Sciences, Vol. 10, Pages 541: Evaluation of Anti-Convulsive Properties of Aqueous Kava Extract on Zebrafish Using the PTZ-Induced Seizure Model Brain Sciences doi: 10.3390/brainsci10080541 Authors: Yogini Jaiswal Mohd. Farooq Shaikh Ilya Wang Yanning Yong Vanessa Lin Lin Lee Leonard Williams Kava roots have been extensively studied in clinical trials as potential candidate anti-anxiety drugs. However, anti-convulsive properties of various tissues of stems of Kava...
Tue Aug 11, 2020 03:00
Cancers, Vol. 12, Pages 2249: The Possible Role of Cancer Stem Cells in the Resistance to Kinase Inhibitors of Advanced Thyroid Cancer Cancers doi: 10.3390/cancers12082249 Authors: Fiorenza Gianì Veronica Vella Dario Tumino Pasqualino Malandrino Francesco Frasca Target therapy with various kinase inhibitors (KIs) has been extended to patients with advanced thyroid cancer, but only a subset of these compounds has displayed efficacy in clinical use. However, after an initial...
Tue Aug 11, 2020 03:00
Cancers, Vol. 12, Pages 2247: A Multi-Analyte Approach for Improved Sensitivity of Liquid Biopsies in Prostate Cancer Cancers doi: 10.3390/cancers12082247 Authors: Hofmann Sallinger Haudum Smolle Heitzer Moser Novy Gesson Kroneis Bauernhofer El-Heliebi Novel androgen receptor (AR) signaling inhibitors have improved the treatment of castration-resistant prostate cancer (CRPC). Nonetheless, the effect of these drugs is often time-limited and eventually...
Tue Aug 11, 2020 03:00
Cancers, Vol. 12, Pages 2244: Histopathologic Response Is a Positive Predictor of Overall Survival in Patients Undergoing Neoadjuvant/Perioperative Chemotherapy for Locally Advanced Gastric or Gastroesophageal Junction Cancers—Analysis from a Large Single Center Cohort in Germany Cancers doi: 10.3390/cancers12082244 Authors: Schirren Novotny Friess Reim There is conflicting evidence regarding the efficacy of neoadjuvant/perioperative chemotherapy (NCT) for gastro-esophageal...
Tue Aug 11, 2020 03:00
Cancers, Vol. 12, Pages 2246: Association of a Palliative Surgical Approach to Stage IV Pancreatic Neuroendocrine Neoplasms with Survival: A Systematic Review and Meta-Analysis Cancers doi: 10.3390/cancers12082246 Authors: Marina Tsoli Maria-Eleni Spei Göran Wallin Gregory Kaltsas Kosmas Daskalakis The role of primary tumor resection in patients with pancreatic neuroendocrine neoplasms (PanNENs) and unresectable distant metastases remains controversial. We aimed to evaluate...
Tue Aug 11, 2020 03:00
Cancers, Vol. 12, Pages 2248: Intrinsic Balance between ZEB Family Members Is Important for Melanocyte Homeostasis and Melanoma Progression Cancers doi: 10.3390/cancers12082248 Authors: Kenneth Bruneel Jeroen Verstappe Niels Vandamme Geert Berx It has become clear that cellular plasticity is a main driver of cancer therapy resistance. Consequently, there is a need to mechanistically identify the factors driving this process. The transcription factors of the zinc-finger E-box-binding...
Tue Aug 11, 2020 03:00
Cancers, Vol. 12, Pages 2243: Genomic Mapping Identifies Mutations in RYR2 and AHNAK as Associated with Favorable Outcome in Basal-Like Breast Tumors Expressing PD1/PD-L1 Cancers doi: 10.3390/cancers12082243 Authors: Francisco J. Cimas Arancha Manzano Mariona Baliu-Piqué Elena García-Gil Pedro Pérez-Segura Ádám Nagy Atanasio Pandiella Balázs Győrffy Alberto Ocana Treatment with anti-PD-L1 antibodies has shown efficacy in basal-like breast cancer. In this context,...
Tue Aug 11, 2020 03:00
Cancers, Vol. 12, Pages 2245: Novel Somatic Genetic Variants as Predictors of Resistance to EGFR-Targeted Therapies in Metastatic Colorectal Cancer Patients Cancers doi: 10.3390/cancers12082245 Authors: Pau Riera Benjamín Rodríguez-Santiago Adriana Lasa Lidia Gonzalez-Quereda Berta Martín Juliana Salazar Ana Sebio Anna C. Virgili Jordi Minguillón Cristina Camps Jordi Surrallés David Páez Background: About 40% of RAS/BRAF wild-type metastatic colorectal...
Tue Aug 11, 2020 03:00
Cancers, Vol. 12, Pages 2242: High Throughput Molecular Characterization of Normal Karyotype Acute Myeloid Leukemia in the Context of the Prospective Trial 02/06 of the Northern Italy Leukemia Group (NILG) Cancers doi: 10.3390/cancers12082242 Authors: Silvia Salmoiraghi Roberta Cavagna Pamela Zanghì Chiara Pavoni Anna Michelato Ksenija Buklijas Lara Elidi Tamara Intermesoli Federico Lussana Elena Oldani Chiara Caprioli Paola Stefanoni Giacomo Gianfaldoni...
Tue Aug 11, 2020 03:00
Cancers, Vol. 12, Pages 2241: Laryngeal Compartmentalization Does Not Affect the Prognosis of T3-T4 Laryngeal Cancer Treated by Upfront Total Laryngectomy Cancers doi: 10.3390/cancers12082241 Authors: Filippo Marchi Francesco Missale Claudio Sampieri Marta Filauro Andrea Iandelli Giampiero Parrinello Fabiola Incandela Ludwig E. Smeele Michiel W. M. van den Brekel Francesca Del Bon Piero Nicolai Cesare Piazza Giorgio Peretti A picture is emerging in...
Tue Aug 11, 2020 03:00
Cells, Vol. 9, Pages 1886: The State of Art of Regenerative Therapy in Cardiovascular Ischemic Disease: Biology, Signaling Pathways, and Epigenetics of Endothelial Progenitor Cells Cells doi: 10.3390/cells9081886 Authors: Perrotta Perna Komici Nigro Mollica D’Agnano De Luca Guerra Ischemic heart disease is currently a major cause of mortality and morbidity worldwide. Nevertheless, the actual therapeutic scenario does not target myocardial cell regeneration...
Tue Aug 11, 2020 03:00
Cells, Vol. 9, Pages 1885: Ischemic Stroke Risk Associated with Mitochondrial Haplogroup F in the Asian Population Cells doi: 10.3390/cells9081885 Authors: Meng-Han Tsai Chung-Wen Kuo Tsu-Kung Lin Chen-Jui Ho Pei-Wen Wang Jiin-Haur Chuang Chia-Wei Liou Mitochondrial dysfunction is involved in the pathogenesis of atherosclerosis, the primary risk factor for ischemic stroke. This study aims to explore the role of mitochondrial genomic variations in ischemic stroke, and...
Tue Aug 11, 2020 03:00
Cells, Vol. 9, Pages 1881: Biology and Physics of Heterochromatin-Like Domains/Complexes Cells doi: 10.3390/cells9081881 Authors: Singh Belyakin Laktionov The hallmarks of constitutive heterochromatin, HP1 and H3K9me2/3, assemble heterochromatin-like domains/complexes outside canonical constitutively heterochromatic territories where they regulate chromatin template-dependent processes. Domains are more than 100 kb in size; complexes less than 100 kb. They are present in the...
Tue Aug 11, 2020 03:00
Cells, Vol. 9, Pages 1883: Role of Brain Derived Extracellular Vesicles in Decoding Sex Differences Associated with Nicotine Self-Administration Cells doi: 10.3390/cells9081883 Authors: Sneh Koul Victoria L. Schaal Subhash Chand Steven T. Pittenger Neetha Nanoth Vellichirammal Vikas Kumar Chittibabu Guda Rick A. Bevins Sowmya V. Yelamanchili Gurudutt Pendyala Smoking remains a significant health and economic concern in the United States. Furthermore, the emerging...
Tue Aug 11, 2020 03:00
Cells, Vol. 9, Pages 1884: Structural and Mechanical Aberrations of the Nuclear Lamina in Disease Cells doi: 10.3390/cells9081884 Authors: Stiekema van Zandvoort Ramaekers Broers The nuclear lamins are the major components of the nuclear lamina in the nuclear envelope. Lamins are involved in numerous functions, including a role in providing structural support to the cell and the mechanosensing of the cell. Mutations in the genes encoding for lamins lead to the rare diseases...
Tue Aug 11, 2020 03:0
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