IJERPH, Vol. 17, Pages 6046: Runner’s Perceptions of Reasons to Quit Running: Influence of Gender, Age and Running-Related Characteristics International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17176046 Authors: Daphne Menheere Mark Janssen Mathias Funk Erik van der Spek Carine Lallemand Steven Vos Physical inactivity has become a major public health concern and, consequently, the awareness of striving for a healthy lifestyle has increased....
Thu Aug 20, 2020 03:00
IJERPH, Vol. 17, Pages 6047: Interpopulation Similarity of Sex and Age-Related Body Composition Variations Among Older Adults International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17176047 Authors: Elisabetta Marini Roberto Buffa Luis Alberto Gobbo Guillermo Salinas-Escudero Silvia Stagi Carmen García-Peña Sergio Sánchez-García María Fernanda Carrillo-Vega The aim of the study was to analyze sex and age-related body composition variations...
Thu Aug 20, 2020 03:00
IJERPH, Vol. 17, Pages 6045: A Multi-Site Study of Traumatic Brain Injury in Mexico and Colombia: Longitudinal Mediational and Cross-Lagged Models of Family Dynamics, Coping, and Health-Related Quality of Life International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17176045 Authors: Annahir N. Cariello Paul B. Perrin Yaneth Rodríguez-Agudelo Silvia Leonor Olivera Plaza Maria Cristina Quijano-Martinez Juan Carlos Arango-Lasprilla Latin America...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 6013: Change the Laminin, Change the Cardiomyocyte: Improve Untreatable Heart Failure International Journal of Molecular Sciences doi: 10.3390/ijms21176013 Authors: Camila Hochman-Mendez Ernesto Curty Doris A. Taylor No effective medical treatment exists for heart failure with preserved ejection fraction (HFpEF), accounting for approximately half of all heart failure cases. The elevated passive myocardial stiffness in HFpEF is attributed to a combination of...
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IJMS, Vol. 21, Pages 6012: G-Protein-Coupled Receptor (GPCR) Signaling in the Carotid Body: Roles in Hypoxia and Cardiovascular and Respiratory Disease International Journal of Molecular Sciences doi: 10.3390/ijms21176012 Authors: Hayyaf S. Aldossary Abdulaziz A. Alzahrani Demitris Nathanael Eyas A. Alhuthail Clare J. Ray Nikolaos Batis Prem Kumar Andrew M. Coney Andrew P. Holmes The carotid body (CB) is an important organ located at the carotid bifurcation that...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 6011: Adenovirus-Mediated FasL Minigene Transfer Endows Transduced Cells with Killer Potential International Journal of Molecular Sciences doi: 10.3390/ijms21176011 Authors: Madalina Dumitrescu Violeta Georgeta Trusca Lorand Savu Ioana Georgeta Stancu Attila Cristian Ratiu Maya Simionescu Anca Violeta Gafencu Fas ligand (First apoptosis signal ligand, FasL, also known as CD95L) is the common executioner of apoptosis within the tumor necrosis factor...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5992: The Anti-ADAMTS-5 Nanobody® M6495 Protects Cartilage Degradation Ex Vivo International Journal of Molecular Sciences doi: 10.3390/ijms21175992 Authors: Anne Sofie Siebuhr Daniela Werkmann Anne-C. Bay-Jensen Christian S. Thudium Morten Asser Karsdal Benedikte Serruys Christoph Ladel Martin Michaelis Sven Lindemann Osteoarthritis (OA) is associated with cartilage breakdown, brought about by ADAMTS-5 mediated aggrecan degradation followed...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 6003: Characterization of the Role of SPL9 in Drought Stress Tolerance in Medicago sativa International Journal of Molecular Sciences doi: 10.3390/ijms21176003 Authors: Alexandria Hanly Jim Karagiannis Qing Shi Mimmie Lu Lining Tian Abdelali Hannoufa Extreme environmental conditions, such as drought, are expected to increase in frequency and severity due to climate change, leading to substantial deficiencies in crop yield and quality. Medicago sativa...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 6009: Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies International Journal of Molecular Sciences doi: 10.3390/ijms21176009 Authors: Valerio Gelfo Donatella Romaniello Martina Mazzeschi Michela Sgarzi Giada Grilli Alessandra Morselli Beatrice Manzan Karim Rihawi Mattia Lauriola IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-inflammatory activity. Beyond its biological...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 6010: A Translational Paradigm to Study the Effects of Uncontrollable Stress in Humans International Journal of Molecular Sciences doi: 10.3390/ijms21176010 Authors: Laura E. Meine Katja Schüler Gal Richter-Levin Vanessa Scholz Michele Wessa Theories on the aetiology of depression in humans are intimately linked to animal research on stressor controllability effects. However, explicit translations of established animal designs are lacking. In two consecutive...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 6000: Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity International Journal of Molecular Sciences doi: 10.3390/ijms21176000 Authors: Wakako Sakaguchi Nobuhisa Kubota Tomoko Shimizu Juri Saruta Shinya Fuchida Akira Kawata Yuko Yamamoto Masahiro Sugimoto Mayumi Yakeishi Keiichi Tsukinoki The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor, angiotensin-converting enzyme 2 (ACE2), transmembrane protease serine...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 6007: Differential Labeling of Glycoproteins with Alkynyl Fucose Analogs International Journal of Molecular Sciences doi: 10.3390/ijms21176007 Authors: Chenyu Ma Hideyuki Takeuchi Huilin Hao Chizuko Yonekawa Kazuki Nakajima Masamichi Nagae Tetsuya Okajima Robert S. Haltiwanger Yasuhiko Kizuka Fucosylated glycans critically regulate the physiological functions of proteins and cells. Alterations in levels of fucosylated glycans are associated...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 6008: Garlic Substrate Induces Cucumber Growth Development and Decreases Fusarium Wilt through Regulation of Soil Microbial Community Structure and Diversity in Replanted Disturbed Soil International Journal of Molecular Sciences doi: 10.3390/ijms21176008 Authors: Ahmad Ali Muhammad Imran Ghani Ding Haiyan Muhammad Iqbal Zhihui Cheng Zucong Cai Garlic substrate could influence plant growth through affecting soil microbiome structure. The relationship...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 6005: Role of CGRP in Neuroimmune Interaction via NF-κB Signaling Genes in Glial Cells of Trigeminal Ganglia International Journal of Molecular Sciences doi: 10.3390/ijms21176005 Authors: Shaista Afroz Rieko Arakaki Takuma Iwasa Arief Waskitho Masamitsu Oshima Yoshizo Matsuka Activation of the trigeminal system causes the release of various neuropeptides, cytokines, and other immune mediators. Calcitonin gene-related peptide (CGRP), which is a potent...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 6004: Inflammatory Cytokine-Producing Cells and Inflammation Markers in the Synovium of Osteoarthritis Patients Evidenced in Human Herpesvirus 7 Infection International Journal of Molecular Sciences doi: 10.3390/ijms21176004 Authors: Valerija Groma Mihails Tarasovs Sandra Skuja Sofija Semenistaja Zaiga Nora-Krukle Simons Svirskis Modra Murovska A direct association between joint inflammation and the progression of osteoarthritis (OA) has been proposed,...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 6002: Are Myths and Preconceptions Preventing us from Applying Ionic Liquid Forms of Antiviral Medicines to the Current Health Crisis? International Journal of Molecular Sciences doi: 10.3390/ijms21176002 Authors: Julia L. Shamshina Robin D. Rogers At the moment, there are no U.S. Food and Drug Administration (U.S. FDA)-approved drugs for the treatment of COVID-19, although several antiviral drugs are available for repurposing. Many of these drugs suffer from...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 6001: Learning from Monocyte-Macrophage Fusion and Multinucleation: Potential Therapeutic Targets for Osteoporosis and Rheumatoid Arthritis International Journal of Molecular Sciences doi: 10.3390/ijms21176001 Authors: Laura Gambari Francesco Grassi Livia Roseti Brunella Grigolo Giovanna Desando Excessive bone resorption by osteoclasts (OCs) covers an essential role in developing bone diseases, such as osteoporosis (OP) and rheumatoid arthritis (RA)....
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5999: Microbiota-Associated Therapy for Non-Alcoholic Steatohepatitis-Induced Liver Cancer: A Review International Journal of Molecular Sciences doi: 10.3390/ijms21175999 Authors: Yi-Hsun Chen Wei-Kai Wu Ming-Shiang Wu Even though advancement in medicine has contributed to the control of many diseases to date, cancer therapy continues to pose several challenges. Hepatocellular carcinoma (HCC) etiology is multifactorial. Recently, non-alcoholic fatty liver disease...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 6006: A Novel Urease Inhibitor of Ruminal Microbiota Screened through Molecular Docking International Journal of Molecular Sciences doi: 10.3390/ijms21176006 Authors: Zhenyu Zhang Ming Li Xiaoyin Zhang Nan Zheng Shengguo Zhao Jiaqi Wang Inhibition of the urease activity of ruminal microbiota is not only beneficial for increasing dietary and endogenic urea-N utilization efficiency in ruminants but also might be applicable for the preservation of nitrogen...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5997: Convalescent Immunity to Guinea Pig Cytomegalovirus Induces Limited Cross Strain Protection against Re-Infection but High-Level Protection against Congenital Disease International Journal of Molecular Sciences doi: 10.3390/ijms21175997 Authors: K. Yeon Choi Nadia S. El-Hamdi Alistair McGregor The guinea pig is the only small animal model for congenital cytomegalovirus (cCMV) but requires guinea pig cytomegalovirus (GPCMV). Current GPCMV research utilizes...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5996: P2X7 Receptors Amplify CNS Damage in Neurodegenerative Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21175996 Authors: Peter Illes ATP is a (co)transmitter and signaling molecule in the CNS. It acts at a multitude of ligand-gated cationic channels termed P2X to induce rapid depolarization of the cell membrane. Within this receptor-channel family, the P2X7 receptor (R) allows the transmembrane fluxes of Na+, Ca2+, and K+, but also allows...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5995: Characterization of the Relationship between the Chaperone and Lipid-Binding Functions of the 70-kDa Heat-Shock Protein, HspA1A International Journal of Molecular Sciences doi: 10.3390/ijms21175995 Authors: Larissa Smulders Amanda J. Daniels Caroline B. Plescia Devon Berger Robert V. Stahelin Nikolas Nikolaidis HspA1A, a molecular chaperone, translocates to the plasma membrane (PM) of stressed and cancer cells. This translocation results in HspA1A’s...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5998: Ecto-Nucleotide Triphosphate Diphosphohydrolase-2 (NTPDase2) Deletion Increases Acetaminophen-Induced Hepatotoxicity International Journal of Molecular Sciences doi: 10.3390/ijms21175998 Authors: Linda Feldbrügge Katrin Splith Ines Kämmerer Sandra Richter Anna Riddermann Santiago Andres Ortiz Galindo Felix Krenzien Tobias Müller Eva Csizmadia Johann Pratschke Simon C. Robson Moritz Schmelzle Ecto-nucleotidase triphosphate diphosphohydrolase-2...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5994: Phage Display to Augment Biomaterial Function International Journal of Molecular Sciences doi: 10.3390/ijms21175994 Authors: Thomas A. Davidson Samantha J. McGoldrick David H. Kohn Biomaterial design relies on controlling interactions between materials and their biological environments to modulate the functions of proteins, cells, and tissues. Phage display is a powerful tool that can be used to discover peptide sequences with high affinity for a desired...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5993: Ionizing Radiation-Induced Epigenetic Modifications and Their Relevance to Radiation Protection International Journal of Molecular Sciences doi: 10.3390/ijms21175993 Authors: Mauro Belli Maria Antonella Tabocchini The present system of radiation protection assumes that exposure at low doses and/or low dose-rates leads to health risks linearly related to the dose. They are evaluated by a combination of epidemiological data and radiobiological models. The...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5990: Peripheral Cytokine Levels Differ by HPV Status and Change Treatment-Dependently in Patients with Head and Neck Squamous Cell Carcinoma International Journal of Molecular Sciences doi: 10.3390/ijms21175990 Authors: Daphne Mytilineos Jasmin Ezić Adrian von Witzleben Joannis Mytilineos Ramin Lotfi Daniel Fürst Chrysanthi Tsamadou Marie-Nicole Theodoraki Angelika Oster Gunnar Völkel Hans A. Kestler Cornelia Brunner Patrick J. Schuler...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5991: Melatonin Suppresses the Kainate Receptor-Mediated Excitation on Gonadotropin-Releasing Hormone Neurons in Female and Male Prepubertal Mice International Journal of Molecular Sciences doi: 10.3390/ijms21175991 Authors: Santosh Rijal Dong Hyu Cho Seon-Ah Park Seon Hui Jang István M. Ábrahám Seong Kyu Han Melatonin, a pineal gland secretion, is an amphiphilic neurohormone involved in the biological and physiologic regulation of bodily functions....
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5989: Estrogen Induces Selective Transcription of Caveolin1 Variants in Human Breast Cancer through Estrogen Responsive Element-Dependent Mechanisms International Journal of Molecular Sciences doi: 10.3390/ijms21175989 Authors: Antonella Romano Antonia Feola Antonio Porcellini Vincenzo Gigantino Maurizio Di Bonito Annabella Di Mauro Rocco Caggiano Raffaella Faraonio Candida Zuchegna The estrogen receptor (ER) signaling regulates numerous physiological...
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IJMS, Vol. 21, Pages 5988: Diverse Roles for Hyaluronan and Hyaluronan Receptors in the Developing and Adult Nervous System International Journal of Molecular Sciences doi: 10.3390/ijms21175988 Authors: Alec Peters Larry S. Sherman Hyaluronic acid (HA) plays a vital role in the extracellular matrix of neural tissues. Originally thought to hydrate tissues and provide mechanical support, it is now clear that HA is also a complex signaling molecule that can regulate cell processes in...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5987: Molecular Evolutionary and Expression Pattern Analysis of AKR Genes Shed New Light on GalUR Functional Characteristics in Brassica rapa International Journal of Molecular Sciences doi: 10.3390/ijms21175987 Authors: Weike Duan Zhinan Huang Ying Li Xiaoming Song Xiaochuan Sun Cong Jin Yunpeng Wang Jizhong Wang The aldo-keto reductase (AKR) superfamily plays a major role in oxidation-reduction in plants. D-galacturonic acid reductase (GalUR),...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5985: Drosophila melanogaster Sperm under Simulated Microgravity and a Hypomagnetic Field: Motility and Cell Respiration International Journal of Molecular Sciences doi: 10.3390/ijms21175985 Authors: Irina V. Ogneva Maria A. Usik Maria V. Burtseva Nikolay S. Biryukov Yuliya S. Zhdankina Vladimir N. Sychev Oleg I. Orlov The role of the Earth’s gravitational and magnetic fields in the evolution and maintenance of normal processes of various...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5986: MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases International Journal of Molecular Sciences doi: 10.3390/ijms21175986 Authors: Mariano Catanesi Michele d’Angelo Maria Grazia Tupone Elisabetta Benedetti Antonio Giordano Vanessa Castelli Annamaria Cimini Neurodegenerative diseases are debilitating and currently incurable conditions causing severe cognitive and motor impairments, defined by the progressive...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5984: Transcriptional Changes Involved in Atrophying Muscles during Prolonged Fasting in Rats International Journal of Molecular Sciences doi: 10.3390/ijms21175984 Authors: Marianne Ibrahim Thierry Wasselin Etienne Challet Alain Van Dorsselaer Yvon Le Maho Thierry Raclot Fabrice Bertile Food deprivation resulting in muscle atrophy may be detrimental to health. To better understand how muscle mass is regulated during such a nutritional challenge,...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5981: Chemical and Genetic Zebrafish Models to Define Mechanisms of and Treatments for Dopaminergic Neurodegeneration International Journal of Molecular Sciences doi: 10.3390/ijms21175981 Authors: Ola Wasel Jennifer L. Freeman The zebrafish (Danio rerio) is routinely used in biological studies as a vertebrate model system that provides unique strengths allowing applications in studies of neurodevelopmental and neurodegenerative diseases. One specific advantage...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5982: Bile Acid Signaling in Neurodegenerative and Neurological Disorders International Journal of Molecular Sciences doi: 10.3390/ijms21175982 Authors: Stephanie M. Grant Sharon DeMorrow Bile acids are commonly known as digestive agents for lipids. The mechanisms of bile acids in the gastrointestinal track during normal physiological conditions as well as hepatic and cholestatic diseases have been well studied. Bile acids additionally serve as ligands for signaling...
Thu Aug 20, 2020 03:00
IJMS, Vol. 21, Pages 5983: Roles of Proteoglycans and Glycosaminoglycans in Cancer Development and Progression International Journal of Molecular Sciences doi: 10.3390/ijms21175983 Authors: Jinfen Wei Meiling Hu Kaitang Huang Shudai Lin Hongli Du The extracellular matrix (ECM) spatiotemporally controls cell fate; however, dysregulation of ECM remodeling can lead to tumorigenesis and cancer development by providing favorable conditions for tumor cells. Proteoglycans (PGs)...
Thu Aug 20, 2020 03:00
IJNS, Vol. 6, Pages 66: Family Attitudes Regarding Newborn Screening for Krabbe Disease: Results from a Survey of Leukodystrophy Registries International Journal of Neonatal Screening doi: 10.3390/ijns6030066 Authors: Karlita Blackwell Michael H. Gelb Anna Grantham Natasha Spencer Christin Webb Tara West Newborn screening (NBS) for Krabbe disease (KD) is currently underway in eight states in the USA, and there is continued discussion of whether to implement KD NBS in additional...
Thu Aug 20, 2020 03:00
JCM, Vol. 9, Pages 2700: The Prevalence and Impact of Polycystic Ovary Syndrome in Recurrent Miscarriage: A Retrospective Cohort Study and Meta-Analysis Journal of Clinical Medicine doi: 10.3390/jcm9092700 Authors: Daniel Mayrhofer Marlene Hager Katharina Walch Stefan Ghobrial Nina Rogenhofer Rodrig Marculescu Rudolf Seemann Johannes Ott Background: The use of different definitions and diagnostic approaches of polycystic ovary syndrome (PCOS) and recurrent miscarriage...
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JCM, Vol. 9, Pages 2699: DNA Methylation in Adipose Tissue and Metabolic Syndrome Journal of Clinical Medicine doi: 10.3390/jcm9092699 Authors: Sunil K. Panchal Lindsay Brown Epigenetics is the study of heritable phenotype changes that do not involve alterations in the DNA sequence with the processes including DNA methylation, histone modifications and RNA-associated silencing [...]
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