In the recently published ‘Recycled Sustainable 3D Printing Materials for Marine Environments,’ the authors—involved in the Bio-Shelters Project—venture into the realm of sustainability and recycling in 3D printing, but they also heavily explore the ever-growing science of materials during a three-phase project made up of not only designers and architects but also experts in materials and marine ecology. Full data-driven design: reef prototype, early testing and site-specific model For this project,...
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Nature Reviews Drug Discovery, Published online: 07 October 2019; doi:10.1038/d41573-019-00173-xIn 2009, Merck & Co.’s PD1-blocking antibody pembrolizumab was in development limbo. A decade on, the immuno-oncology drug is Merck’s crown jewel, with more than 20 approvals in 15 tumour types and revenues that are expected to reach US$10 billion this year. For Roger Perlmutter — an immunologist, president of Merck Research Laboratories and executive vice-president of Merck & Co. — this success...
Mon Oct 07, 2019 03:00
The proportion of those aged 65 and older prescribed antidepressants has more than doubled over two decades, from 4.2% in the 90s to 10.7% in twenty years later. However, the prevalence of depression among the age group has dropped since the 90s from 7.9% to 6.8%.
Mon Oct 07, 2019 23:18
Complete collections, DRM-free, unlimited use
Mon Oct 07, 2019 20:14
Germline mutations of the APC gene, which encodes a multidomain protein of 2843 amino acid residues, cause familial adenomatous polyposis (FAP). Three FAP clinical variants are correlated with the location of APC mutations: (1) classic FAP with profuse polyposis (>1000 adenomas), associated with mutations from codon 1250 to 1424; (2) attenuated FAP (<100 adenomas), associated with mutations at APC extremities (before codon 157 and after codon 1595); (3) classic FAP with intermediate colonic...
Mon Oct 07, 2019 18:00
Knowles et al in a paper published in EMJ have sought to examine the effect of emergency department (ED) closures on patient outcomes1. This is both welcome and timely, given the current debate on the viability of a number of EDs. Of necessity this is an opportunistic observational study as the ‘intervention’ population are persons within the catchment area of five EDs in England closed in the period 2009 to 2011. The outcome measure was mortality.As part of the rationale for the paper the authors...
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BackgroundIn England the demand for emergency care is increasing, while there is also a staffing shortage. This has implications for quality of care and patient safety. One solution may be to concentrate resources on fewer sites by closing or downgrading emergency departments (EDs). Our aim was to quantify the impact of such reorganisation on population mortality.MethodsWe undertook a controlled interrupted time series analysis to detect the impact of closing or downgrading five EDs, which occurred...
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Οκτώβριος πλέον, αλλα πολλοί είναι αυτοί που αναρωτιούνται πότε πέφτουν τα επόμενα τριήμερα για το 2019.
09:35
Η ασπιρίνη μπορεί να μειώσει τις βλάβες που προκαλεί στη λειτουργία των πνευμόνων η έκθεση στην ατμοσφαιρική ρύπανση.
Mon Oct 07, 2019 22:00
Η απώλεια βάρους είναι ένα ζήτημα που απασχολεί πολλούς είτε πρόκειται για λίγα ή για περισσότερα περιττά κιλά.
Mon Oct 07, 2019 21:00
Η λύση έχει όνομα
Mon Oct 07, 2019 19:00
Πολλοί πιστεύουν ότι η σεξουαλική ζωή ατονεί μετά τα 40, ειδικά όταν έχουν πίσω τους πολλά χρόνια σχέσης με τον ίδιο άνθρωπο.
Mon Oct 07, 2019 19:00
Εάν έχετε κάποιο αυτοάνοσο νόσημα όπως κοιλιοκάκη, νόσο του Crohn ή ρευματοειδή αρθρίτιδα, η κατανάλωση συγκεκριμένων τροφών και η αποχή από κάποιες άλλες, μπορεί…
Mon Oct 07, 2019 16:00
Ξεκινάνε μεν τα πρωτοβρόχια όμως δεν θα αρνηθούμε ένα ωραίο παγωτό.
Mon Oct 07, 2019 15:00
Ραγδαία επιδείνωση θα παρουσιάσει ο καιρός από σήμερα, Δευτέρα. Βροχές και καταιγίδες θα επηρεάσουν σχεδόν το σύνολο της χώρας και θα συνεχιστούν τουλάχιστον έως τις βραδινές ώρες της Τρίτης, ενώ σε…
Mon Oct 07, 2019 14:20
Τα θερμοκήπια μας δίνουν τη δυνατότητα να βρίσκουμε όλα τα φρέσκα φρούτα και λαχανικά σχεδόν όλες τις εποχές του χρόνου.
Mon Oct 07, 2019 14:00
Ήταν τόσο μεγάλο το ηλεκτρικό φορτίο που διαπέρασε τον άτυχο άνδρα, που άρπαξαν φωτιά τα παπούτσια του.
Mon Oct 07, 2019 13:05
Οι επαγγελματικές απαιτήσεις, οι οικογενειακές υποχρεώσεις, το άγχος της καθημερινότητας, αυξάνουν το στρες με ό,τι αυτό συνεπάγεται για την υγεία.
Mon Oct 07, 2019 13:00
Το πορτοκάλι είναι από τα πιο ωφέλιμα φρούτα για τον ανθρώπινο οργανισμό.
Mon Oct 07, 2019 12:00
Την δυνατότητα διεκδίκησης αναδρομικών από 7.350 ως και 30.000 ευρώ για παράνομες μειώσεις σε κύριες και επικουρικές συντάξεις τα προηγούμενα έτη και το 2019…
Mon Oct 07, 2019 11:30
Συναγερμός έχει σημάνει στην Ελληνική Αστυνομία μετά τις καταγγελίες ξυλοδαρμού ανήλικων παιδιών στα Μελίσσια.
Mon Oct 07, 2019 10:36
Οι παρεμβάσεις για τη στοχευμένη διεξαγωγή προληπτικών προγραμμάτων εκπαίδευσης των πολιτών και προγραμμάτων προσυμπτωματικού ελέγχου, ξεκινούν σύντομα με βάση τον σχεδιασμό της νέας διοίκησης…
Mon Oct 07, 2019 10:29
Η διασφάλιση της πρόσβασης των ασθενών σε κάθε απαραίτητο φάρμακο με το χαμηλότερο δυνατό κόστος, βρίσκεται στο επίκεντρο της σχεδιαζόμενης από το υπουργείο Υγείας…
Mon Oct 07, 2019 10:15
Η γρίπη εκδηλώνεται με ξαφνικό πυρετό, πονόλαιμο, ρίγη και μυϊκούς πόνους.
Mon Oct 07, 2019 10:00
Purpose of review To review pediatric hereditary angioedema for otolaryngologists, with emphasis on articles within the past 12–18 months. Recent findings Biologic therapies are accepted for adult hereditary angioedema (HAE), but have been studied less for pediatric HAE. Recent literature supports expanded use of biologic agents in pediatrics as acute treatment and prophylaxis. Available agents include plasma-derived C1 esterase inhibitors (C1-INH) (Berinert, Haegarda, Cinryze), recombinant...
Fri Oct 04, 2019 03:00
Purpose of review To review the latest literature on otitis media diagnosis, guidelines, treatment, and pathophysiology. Recent findings Although otitis media remains one of the most common reasons for outpatient visits, antibiotic prescriptions, and surgery in the United States, little progress has been made in terms of developing novel treatments for the prevention and resolution of this condition, indicating the urgent need to continue investigations into the pathophysiology of this disorder....
Fri Oct 04, 2019 03:00
Objective: Information on cochlear MRI signal change following vestibular schwannoma (VS) surgery by the retrolabyrinthine approach (RLA) is nonexisting, and information using the translabyrinthine approach (TLA) is scarce. We aimed to evaluate cochlear MRI fluid signal in patients with a unilateral VS, before and after surgery by the RLA or the TLA, that can have clinical importance for subsequent cochlear implantation feasibility. Study Design: Retrospective cohort study. Setting: University...
Fri Oct 04, 2019 03:00
Background: The general aim of this study is to describe a new modification to the posterior tibial artery flap (PTAF) and its clinical application in head and neck reconstruction and to investigate the distribution of septocutaneous perforators (SP) of the posterior tibial artery (PTA). The specific aim of this study is to evaluate the effectiveness of this new modification to the PTAF and describe the flap survival rate and donor site morbidity. Methods: From November 2017 to August 2018,...
Fri Oct 04, 2019 03:00
Summary: Replacement of the autologous bone flap after decompressive craniectomy can be complicated by significant osteolysis or infection with large defects over scarred dura. Demineralized bone matrix (DBM) is an alternative to autologous reconstruction, effective when reconstructing large defects using a resorbable mesh bilaminate technique in primary cranioplasty, but this technique has not been studied for revision cranioplasty and the setting of scarred dura. Retrospective review was performed...
Fri Oct 04, 2019 03:00
Background: Male-to-female (MtF) transgender patients desire to be identified and treated as female, not only with partners but also in public and social settings. Facial Feminization Surgery (FFS) entails a combination of highly visible changes in facial features which may affect social “first impressions.” No study to date has evaluated the impact of FFS on how MtF patients are gender-typed. To study the effectiveness of FFS, we investigated preoperative/postoperative gender-typing using facial...
Fri Oct 04, 2019 03:00
Background: Objective assessment of the unilateral cleft lip nasal deformity and the longitudinal changes with treatment is critical to optimizing cleft care. We used 3D images to evaluate nasal base morphology. Methods: Consecutive patients undergoing cleft lip repair and foundation-based rhinoplasty were included (N=102). 3D images pre-op, post-op, and at 5 years of age were assessed and compared to age-matched controls. Images were normalized to standard horizontal, cranio-caudal, and...
Fri Oct 04, 2019 03:00
Perineal reconstruction historically has been guided by the vertical rectus abdominus myocutaneous flap. In oncologic patients, due to prior surgical intervention this donor site is often unavailable, the pelvis has been radiated, and defects can be deep or irregularly contoured. Using plastic surgery principles of perforators, geometrically defined local tissue rearrangement, and flap inset our senior surgeons have developed a modification of the gracilis flap to include a second soft tissue arm...
Fri Oct 04, 2019 03:00
Background: Nonvascular bone grafts >4 cm have a 50% non- union rate in spine surgery. Vascular bone flaps are one potential solution, however their utility in spine surgery has not been fully elucidated. We hypothesized that the addition of a free fibula flap (FFF) after oncologic vertebrectomy would safely potentiate bone union. Methods: We performed a retrospective analysis, including all patients who received an oncologic vertebrectomy for a primary bone tumor at our institution during...
Fri Oct 04, 2019 03:00
Purpose: De-novo or rare transmitted mutations in the SMAD6 gene affect non-syndromic midline synostosis (NSC) in 7% of patients. This study aimed to determine the neurocognitive sequelae of SMAD6 NSC. Methods: NSC patients >6 years of age, with SMAD6 mutations and non-SMAD6 NSC controls, were recruited. All patients completed a double-blinded neurodevelopmental battery (Wechsler Fundamentals, Wechsler Abbreviated Scale of Intelligence, Beery-Buktenica Developmental test), and parents/guardians...
Fri Oct 04, 2019 03:00
Background: Approximately 1/2000 babies are born with craniosynostosis and primary open repair is typically performed before one year of age. Historically the procedure has been associated with nearly 100% transfusion rates. To decrease the rates of transfusion, our center has developed a novel multi-modal blood conservation protocol. Methods: We performed our standard of care to children aged one year or younger undergoing primary repair of craniosynostosis between 2008 and 2014. In 2014...
Fri Oct 04, 2019 03:00
Purpose: This study investigates the psychometric properties of patient-reported outcomes (PROs) instruments for assessing outcomes in post-surgical traumatic digit amputation patients. We hypothesize the MHQ(Michigan Hand Outcomes Questionnaire) and DASH(Disabilities of the Arm, Shoulder, and Hand Questionnaire) are the most valid and reliable instruments. Methods: We studied traumatic digit amputation patients as part of the Finger Replantation ANd amputation CHallenges in assessing Impairment,...
Fri Oct 04, 2019 03:00
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