Abstract In this study, an extended calculation method for the determination of the water profiles in oil‐treated skin is proposed, which is based on the calculation of the ratio between the Raman band intensities of water (3350–3550 cm‐1) and keratin Amide I at 1650 cm‐1. The proposed method is compared with the conventional method based on the ratio of the Raman band intensities of water (3350–3550 cm‐1) and keratin at 2930 cm‐1. The conventional method creates artifacts in the depth‐profiles...
Fri Oct 11, 2019 11:49
ABSTRACT Multispectral imaging combines the spectral resolution of spectroscopy with the spatial resolution of imaging and is therefore very useful for biomedical applications. Currently, histological diagnostics use mainly stainings with standard dyes (e.g. haematoxylin + eosin, HE) to identify tumors. This method is not applicable in vivo and provides low amounts of chemical information. Biomolecules absorb near infrared light (800 nm ‐ 1700 nm, NIR) at different wavelengths, which could be used...
Fri Oct 11, 2019 11:44
Abstract Stroke is a significant cause of morbidity and long‐term disability globally. Detection of injured neuron is a prerequisite for defining the degree of focal ischemic brain injury, which can be used to guide further therapy. Here, we demonstrate the capability of two‐photon microscopy (TPM) to label‐freely identify injured neurons on unstained thin section and fresh tissue of rat cerebral ischemia‐reperfusion model, revealing definite diagnostic features compared with conventional staining...
Fri Oct 11, 2019 11:38
Abstract A novel bacteriochlorin bearing two spermine units (BCS) was synthesized from 3,13‐dibromo‐8,8,18,18‐tetramethylbacteriochlorin (BC‐Br 3,13 ). The synthesis involved the Suzuki coupling of BC‐Br 3,13 to obtain a bacteriochlorin–dibenzaldehyde (BCA), which was subjected to reductive amination with spermine. The resulting bacteriochlorin BCS presents a strong near‐infrared absorption band at 747 nm, emits fluoresce at 750 nm with fluorescence quantum yield of 0.14, and generates singlet...
Fri Oct 11, 2019 11:34
Vibrational optical coherence elastography (OCE) is a promising tool for extracting the mechanical property of soft tissue. Purpose of this study is focusing on settling the optimal frequency range for vibrational OCE with evenly distributed stress filed. A finite element model of 2% agar phantom was built with a vibration stimulation frequency range from 200 Hz to 3,000 Hz. Practical experiments were carried out for cross‐validation with the same frequencies and sample. Lateral and horizontal stress...
Fri Oct 11, 2019 11:15
Abstract Critical biomarkers of disease are increasingly being detected by point‐of‐care assays. Chemiluminescence (CL) and electrochemiluminescence (ECL) are often used in such assays due to their convenience and that they do not require light sources or other components that could complicate or add cost to the system. Reports of these assays often include readers built on a cellphone platform or constructed from low‐cost components. However, the impact the optical design has on the limit of detection...
Thu Oct 10, 2019 20:48
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