An examination of biopsy specimens found no suggestion of an oncogenic role of cutavirus in malignant melanoma.Emerging Infectious Diseases (Source: Medscape Today Headlines)
Mon Oct 07, 2019 10:27
CONCLUSIONS</strong> This study suggests that HIF-1alpha promotes ovarian cancer cell invasion through a MMP13 mechanism. It might be an effective strategy targeting HIF-1alpha - MMP13 to inhibit invasion and metastasis of ovarian cancer. PMID: 31587013 [PubMed - in process] (Source: Medical Science Monitor)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
04:56
To analyse the additional clinical value of protocol-driven and selective use of multidetector single-photon-emission tomography/computed tomography (SPECT/CT) in oncology patients undergoing whole-body bone scintigraphy (BS) and to analyse reporter confidence in diagnosis with and without SPECT/CT. (Source: Clinical Radiology)
Mon Oct 07, 2019 00:00
(Source: BMJ News)
03:15
Conclusion: Volunteers showed a sustained high commitment. No long-term safety alert was identified during the postvaccine follow-up. Participating in vaccine trials did not increase risky behaviors for HIV infection. Vaccine-induced seropositivity may persist for more than 23 years after receiving rgp160. (Source: AIDS)
03:08
Conclusions Our study suggests that ID-RFA performed using a short-length probe with settings of 80 °C, 7 W and 60 – 120 s is a safe and feasible palliative treatment for malignant hilar obstruction. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Endoscopy International Open)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account....
Mon Oct 07, 2019 00:00
Cryptogenic pyogenic liver abscess (PLA) could result due to compromised colonic mucosal barrier in patients with colorectal cancer (CRC). Association of PLA and CRC is unclear. Evidence is weak and limited to small sized studies. As a result, the need for colonoscopy in PLA patients is debatable. (Source: Digestive and Liver Disease)
Mon Oct 07, 2019 00:00
Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass and strength. The aim of the study was to investigate the impact of skeletal muscle mass on surgical site infection (SSI) in flap reconstruction for defects after oral cancer resection. The subjects were a non-randomized, retrospective cohort of 106 patients who underwent this procedure after preoperative abdominal-lumbar computed tomography (CT). Cross-sectional areas (cm2) of skeletal muscles in the L3 region...
Mon Oct 07, 2019 00:00
Nature Reviews Gastroenterology & Hepatology, Published online: 07 October 2019; doi:10.1038/s41575-019-0221-zScreening and early diagnosis of pancreatic cancer are at the focal point of attention from researchers, physicians and patients. A new systematic review and recommendation statement by the USPSTF attempt to summarize the current state of affairs. (Source: Nature Reviews Gastroenterology and Hepatology)
Mon Oct 07, 2019 00:00
Planta Med DOI: 10.1055/a-1013-0382In Europe, especially in German-speaking countries, administration of mistletoe extracts is the most common and popular complementary and alternative therapy approach reported in oncology. Mistletoe therapy is applied to children with cancer for curative and palliative therapeutic regimes with increasing frequency, but at the same time, there are only a few studies on the effectiveness of this therapy. Therefore, we have investigated the response of various pediatric...
Mon Oct 07, 2019 00:00
Basal cell carcinoma (BCC) recurrence and metastatic rates are known to be very low. The risk factors for these rare outcomes are subsequently not well-studied. (Source: Journal of the American Academy of Dermatology)
Mon Oct 07, 2019 00:00
Publication date: Available online 6 October 2019Source: Acta Pharmaceutica Sinica BAuthor(s): Kangkang Zhi, Jiacheng Wang, Haitian Zhao, Xin YangAbstractNatural products, as a gift of nature to humanity, have long been used as drugs or pharmacological actives to help people cure various diseases. Yet we still know comparatively little about their ability to be materials. In recent years, some small molecule natural products isolated from traditional Chinese medicines have been found to have new...
01:17
BACKGROUND Trigger-free anaesthesia is required for patients who are susceptible to malignant hyperthermia. Therefore, all trace of volatile anaesthetics should be removed from anaesthetic machines before induction of anaesthesia. Because the washout procedure is time consuming, activated charcoal filters have been introduced, but never tested under minimal flow conditions. OBJECTIVE To investigate performance of activated charcoal filters during long duration (24 h) simulated ventilation. DESIGN...
01:11
CONCLUSION Our data indicate that red cell transfusion alone does not create an immunological response in otherwise healthy surgical patients. Our findings do not generally contradict the transfusion-related immunomodulation phenomenon, which has, however, primarily been observed in patients with an already weakened or procedure-deteriorated immune system, such as from malignant disease, significant comorbidity, extensive abdominal/thoracic surgery and cardiopulmonary bypass. TRIAL REGISTRATION...
01:11
Effect Of Surgical Safety Checklists On Gastric Cancer Outcomes: A Single-Center Retrospective Study
(Source: Cancer Management and Research)
01:05
(Source: Cancer Management and Research)
00:54
British Journal of Cancer, Published online: 08 October 2019; doi:10.1038/s41416-019-0598-zMetformin use and risk of gastric adenocarcinoma in a Swedish population-based cohort study (Source: British Journal of Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
00:00
Cancer Gene Therapy, Published online: 08 October 2019; doi:10.1038/s41417-019-0140-8CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma (Source: Cancer Gene Therapy)
00:00
Trichosanthis semen, the seeds of Trichosanthes kirilowii Maxim. or Trichosanthes rosthornii Harms, has long been used in Korean medicine to loosen bowels and relieve chronic constipation. Although the fruits and... (Source: Chinese Medicine)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Mon Oct 07, 2019 02:00
This study estimated genital warts prevalence, genital-warts-related healthcare resource use and costs, and self-reported human-papillomavirus-related psychosocial impact among male and female patients aged 18... (Source: Infectious Agents and Cancer)
Mon Oct 07, 2019 02:00
CyclinD1 is crucial for cell cycling and can regulate the expression of Dicer, a crucial regulator of microRNA maturation. However, little is known on how CyclinD1 regulates Dicer and miRNA expression, and the... (Source: Journal of Experimental and Clinical Cancer Research)
Mon Oct 07, 2019 02:00
Oncogene, Published online: 07 October 2019; doi:10.1038/s41388-019-1044-7A drug library screen identifies Carbenoxolone as novel FOXO inhibitor that overcomes FOXO3-mediated chemoprotection in high-stage neuroblastoma (Source: Oncogene)
Mon Oct 07, 2019 00:00
Oncogene, Published online: 07 October 2019; doi:10.1038/s41388-019-1034-9RNA-binding motif protein 10 induces apoptosis and suppresses proliferation by activating p53 (Source: Oncogene)
Mon Oct 07, 2019 00:00
Oncogene, Published online: 07 October 2019; doi:10.1038/s41388-019-1043-8Bmi1 drives hepatocarcinogenesis by repressing the TGFβ2/SMAD signalling axis (Source: Oncogene)
Mon Oct 07, 2019 00:00
Oncogene, Published online: 07 October 2019; doi:10.1038/s41388-019-1045-6MHC class I dysfunction of glioma stem cells escapes from CTL-mediated immune response via activation of Wnt/β-catenin signaling pathway (Source: Oncogene)
Mon Oct 07, 2019 00:00
Authors: Shinya Hasegawa Shin Sugiyama Kawashima Takahashi Iwasaki Kashio Nakatomi Saito The efficacy of radiosurgery for neurofibromatosis type 2 (NF2)-associated vestibular schwannoma (VS) remains debatable. We retrospectively analyzed radiosurgical outcomes for NF2-associated VS compared to sporadic VS using our database of 422 consecutive VS patients. Twenty-five patients with 30 NF2-associated VSs with a mean follow-up of 121 months were identified....
Mon Oct 07, 2019 00:00
Authors: Dünker Jendrossek Radiotherapy (RT) is part of standard cancer treatment. Innovations in treatment planning and increased precision in dose delivery have significantly improved the therapeutic gain of radiotherapy but are reaching their limits due to biologic constraints. Thus, a better understanding of the complex local and systemic responses to RT and of the biological mechanisms causing treatment success or failure is required if we aim to define novel targets for biological...
Mon Oct 07, 2019 00:00
ConclusionTSEBT improved disease symptoms and significantly improved emotional domains of patients ’ quality of life in patients with MF or SS. In addition, our results indicate that maintenance or adjuvant therapy after TSEBT may improve the PFS. (Source: Strahlentherapie und Onkologie)
Mon Oct 07, 2019 00:00
Oncogene, Published online: 07 October 2019; doi:10.1038/s41388-019-1013-1Oncogenic HOXB8 is driven by MYC-regulated super-enhancer and potentiates colorectal cancer invasiveness via BACH1 (Source: Oncogene)
Mon Oct 07, 2019 00:00
Oncogene, Published online: 07 October 2019; doi:10.1038/s41388-019-1047-4Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant (Source: Oncogene)
Mon Oct 07, 2019 00:00
On ‐chip exosome isolation using immunoaffinity capture improves recovery from small sample volumes compared to ultracentrifugation. However, tetraspanins are not specific to cancer exosomes and some cancers secrete exosomes with low expression of tetraspanins. Here, a microfluidic‐device conjugate d with proteins against phosphatidylserine (PS), shown to be expressed on the outer surface of cancer‐associated exosome, is used to isolate cancer‐associated exosomes. AbstractExtracellular vesicles (EVs)...
Mon Oct 07, 2019 00:00
Recent research shows that potentially cancerous, somatic mutations can reside in normal cells. Pineda et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201907178) report on a unique management technique by hair follicle stem cells to evade tumorigenesis. (Source: Journal of Cell Biology)
Mon Oct 07, 2019 00:00
Mutations associated with tumor development in certain tissues can be nontumorigenic in others, yet the mechanisms underlying these different outcomes remains poorly understood. To address this, we targeted an activating Hras mutation to hair follicle stem cells and discovered that Hras mutant cells outcompete wild-type neighbors yet are integrated into clinically normal skin hair follicles. In contrast, targeting the Hras mutation to the upper noncycling region of the skin epithelium leads to benign...
Mon Oct 07, 2019 00:00
Metastasis is a major cause of cancer-related death. Membrane type 1–matrix metalloproteinase (MT1-MMP) is a critical protease for local invasion and metastasis. MT1-MMP is synthesized in the endoplasmic reticulum (ER) and transported in vesicles to invadopodia, specialized subdomains of the plasma membrane, through secretory and endocytic recycling pathways. The molecular mechanism underlying intracellular transport of MT1-MMP has been extensively studied, but is not fully understood. We show that...
Mon Oct 07, 2019 00:00
AbstractTumor subclass detection and diagnosis is inevitable requirement for personalized medical treatment and refinement of the effects that the somatic cells show towards other clinical conditions. The genome of these somatic cells exhibits mutations and genetic variations of the breast cancer cells and helps in understanding the characteristic behavior of the cancer cells. But their analysis is limited to clustering and there is requirement to analyze what else can be done with the data for identifying...
Mon Oct 07, 2019 00:00
The accurate regulation of phosphorylation at the kinetochore is essential for establishing chromosome bi-orientation. Phosphorylation of kinetochore proteins by the Aurora B kinase destabilizes improper kinetochore–microtubule attachments, whereas the phosphatase PP2A has a counteracting role. Imbalanced phosphoregulation leads to error-prone chromosome segregation and aneuploidy, a hallmark of cancer cells. However, little is known about the molecular events that control the balance of phosphorylation...
Mon Oct 07, 2019 00:00
99mTc-MIBI scintimammography and digital mammography in the diagnosis of multicentric breast cancer.
CONCLUSION: Scintimammography was significantly much better by all statistical parameters than DM in the detection of multicentric breast cancer. High positive predictive value of scintimammography (84.8%) advocates it as a tool for surgery and radiotherapy planning. PMID: 31587026 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)
Mon Oct 07, 2019 22:03
CONCLUSION: The pre-treatment tumor SUVmax could be utilized as an independent imaging biomarker of the tumor aggressiveness and poor prognosis. Risk stratification based on this index could play a pivotal role in alteration of treatment planning, such as neoadjuvant chemotherapy (precision oncology). PMID: 31587025 [PubMed - as supplied by publisher] (Source: Hellenic Journal of Nuclear Medicine)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on...
Mon Oct 07, 2019 22:03
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