Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.9b05131 (Source: Journal of Agricultural and Food Chemistry)
Mon Oct 07, 2019 06:00
In this study, we silenced the expression of PD-L1 in DCs and PD-1 in T cells by siRNA-loaded chitosan-dextran sulfate nanoparticles (NPs) and evaluated the DC phenotypic and functional characteristics and T cells functions following tumor antigen recognition on DCs, ex vivo. Our results showed that synthesized NPs had good physicochemical characteristics (size of 77.5 nm and zeta potential of 14.3) that was associated with efficient cellular uptake and target gene silencing. Moreover, PD-L1 silencing...
Sun Oct 06, 2019 00:00
CONCLUSIONS: Rapid analyses of automatically acquired Halcyon™ exit images could detect mid-treatment changes with high sensitivity, though appropriate thresholds will need to be set. This study presents the first steps toward developing effortless image evaluation for all aspects of every patient's treatment. PMID: 31587477 [PubMed - as supplied by publisher] (Source: Clinical Prostate Cancer)
Sun Oct 06, 2019 00:00
The palliative care unit is an emotionally challenging place where patients and their families may feel at loss. Art can allow the expression of complex feelings. We aimed to examine how cancer patients hospit... (Source: BMC Palliative Care)
Mon Oct 07, 2019 02:00
Authors: Chauhan R, Trivedi V Abstract Cancer is a leading cause of death worldwide and a major burden on developing and less developed countries of the world with limited resources for prevention and effective treatment of cancer. Although cancer is multifactorial in origin, various epidemiological and experimental studies suggest that chronic inflammation has an important role in all stages of cancer, from initiation to progression and even survival of the patient. Inflammatory products...
Mon Oct 07, 2019 19:21
Authors: Rao YL, Ganaraja B, Joy T, Pai MM, Ullal SD, Murlimanju BV Abstract Alzheimer's disease (AD) is a neurodegenerative disorder, which is commonly seen in older individuals. This is characterized by cognitive dysfunction, which leads to dementia. Pharmacological treatments for AD are mainly targeted on its symptoms like memory loss and cognitive impairment. The pathophysiology involved in AD is intra-neuronal accumulation of hyper-phosphorylated tau protein as neurofibrillary tangle...
Mon Oct 07, 2019 19:19
Authors: Shukla V, Adiga D, Jishnu PV, Varghese VK, Satyamoorthy K, Kabekkodu SP Abstract Epithelial to mesenchymal transition (EMT) is a multistep biological process in which epithelial cells acquire characteristics of mesenchymal cells. Inappropriate activation of EMT contributes to the acquisition of pro-metastatic characteristics and cancer progression. EMT process involves the downregulation of epithelial markers (EpCAM, CDH1) and upregulation of mesenchymal markers (VIM, CDH2) and...
Mon Oct 07, 2019 19:19
Publication date: Available online 6 October 2019Source: Journal of Thermal BiologyAuthor(s): Kuo-Chi Liu, Po-Jen ChengAbstractControl of the therapeutic temperature is essential in performing magnetic fluid hyperthermia. Thus, reliable predictions of the power dissipation are required to determine the correct dosage of magnetic particles to be injected into the cancerous tissue prior to treatment. To meet this requirement, the present study evaluates the power dissipation requirement for two magnetic...
Mon Oct 07, 2019 18:39
Chem. Soc. Rev., 2019, Advance Article DOI: 10.1039/C9CS00271E, Review ArticleQian Chen, Muchao Chen, Zhuang Liu Cancer immunotherapy by educating or stimulating patients ’ own immune systems to attack cancer cells has demonstrated promising therapeutic responses in the clinic. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chemical Society Reviews)
Mon Oct 07, 2019 18:08
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC05604A, CommunicationBiswajit Roy, Moumita Kundu, Amit Kumar Singh, Tara Singha, Sayantan Bhattacharya, Prasanta Kumar Datta, Mahitosh Mandal, Singh N. D. Pradeep In this work, we depleted Glutathione (GSH) by releasing SO2 with internal stimulus GSH itself, and also selectively marked the cancer cell followed by release of anticancer drug using other... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun....
Mon Oct 07, 2019 18:08
Conclusions: PEG stabilized, COSAN-functionalised AuNPs could be synthesized, radiolabelled and evaluated in vivo using PET. The low tumour accumulation in the animal model assayed points to the need of tuning the size and geometry of the gold core for future studies. (Source: Molecules)
Mon Oct 07, 2019 00:00
This study was aimed at identifying phytochemicals that can inhibit H. pylori and possibly serve as adjuvant treatments. Here, in silico molecular docking and drug-like properties analyses were performed to identify potential inhibitors of urease, shikimate kinase and aspartate-semialdehyde dehydrogenase. These three enzymes are targets of the treatment of H. pylori. Susceptibility and synergistic testing were performed on the selected phytochemicals and the positive control antibiotic, amoxicillin....
Mon Oct 07, 2019 00:00
Authors: Sijongesonke Peter Blessing Atim Aderibigbe Malaria and cancer are chronic diseases. The challenge with drugs available for the treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent organometallic which have been hybridized with other compounds resulting in compounds with enhanced biological activity such as antimalarial and anticancer. Drugs such as ferroquine were developed from ferrocene and chloroquine. It was tested in the 1990s as an antimalarial...
Mon Oct 07, 2019 00:00
Purpose of review Central sleep apnoea (CSA) is highly prevalent in patients with heart failure and substantially impairs survival. If optimal cardiac treatment fails, alternative therapeutical options, including positive airway pressure (PAP) therapies, drugs or application of oxygen and carbon dioxide are considered to suppress CSA which interfere with the complex underlying pathophysiology. Most recently, unilateral phrenic nerve stimulation (PNS) has been studied in these patients. Therefore,...
Mon Oct 07, 2019 15:11
Nature Reviews Urology, Published online: 07 October 2019; doi:10.1038/s41585-019-0237-8A number of targetable molecular alterations and resistance mechanisms have been identified in metastatic castration-resistant prostate cancer (mCRPC). As our understanding of the genomic landscape of mCRPC increases, biomarker-driven clinical trials investigating targeted therapies will enable an increasingly personalized approach to its treatment. (Source: Nature Reviews Urology)
Mon Oct 07, 2019 00:00
Chronic inflammation and gut microbiota dysbiosis, in particular the bloom of genotoxin-producing E. coli strains, are risk factors for the development of colorectal cancer. Here, we sought to determine whether precision editing of gut microbiota metabolism and composition could decrease the risk for tumor development in mouse models of colitis-associated colorectal cancer (CAC). Expansion of experimentally introduced E. coli strains in the azoxymethane/dextran sulfate sodium colitis model was driven...
Mon Oct 07, 2019 00:00
Tumor-associated macrophages (TAMs) play critical roles in tumor progression but are also capable of contributing to antitumor immunity. Recent studies have revealed an unprecedented heterogeneity among TAMs in both human cancer and experimental models. Nevertheless, we still understand little about the contribution of different TAM subsets to tumor progression. Here, we demonstrate that CD163-expressing TAMs specifically maintain immune suppression in an experimental model of melanoma that is resistant...
Mon Oct 07, 2019 00:00
Nature, Published online: 07 October 2019; doi:10.1038/d41586-019-02963-0William Kaelin, Peter Ratcliffe and Gregg Semenza share the award for discoveries that are crucial for understanding diseases such as cancer. (Source: Nature AOP)
Mon Oct 07, 2019 00:00
Vol. 216, No. 3, March 4, 2019. 10.1084/jem.20180765. The authors regret that in their original paper, the Masson’s image of the control group in Fig. 7 J was incorrect as a result of an error... (Source: The Journal of Experimental Medicine)
Mon Oct 07, 2019 00:00
Prostate Cancer and Prostatic Diseases, Published online: 07 October 2019; doi:10.1038/s41391-019-0175-9United States trends in active surveillance or watchful waiting across patient socioeconomic status from 2010 to 2015 (Source: Prostate Cancer and Prostatic Diseases)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Mon Oct 07, 2019 00:00
AbstractFocal or non-focal/extensive extraprostatic extension of prostate carcinoma is an important pathologic prognostic parameter to be reported after radical prostatectomy. Currently, there is no agreement on how to measure and what are the best cutoff points to be used in practice. We hypothesized that digital microscopy would potentially provide more objective measurements of extraprostatic extension, thus better defining its clinical significance. To further our knowledge on digital prostate...
Mon Oct 07, 2019 00:00
Squamous cell carcinoma (SCC) of the head and neck is the sixth most common cancer worldwide. It is preceded by early asymptomatic lesions which, if identified early enough and removed, would prevent malignant transformation or avoid delaying diagnosis to advanced stages. Our aim was to evaluate the feasibility of a screening programme for SCC of the head and neck in a group of high-risk patients, and to investigate their addiction profile. Patients admitted to an inpatient alcohol addiction centre...
Sun Oct 06, 2019 00:00
Our images showed an advanced transverse colon cancer highly indicative of an invasion to the duodenum and pancreas. For en bloc tumor resection, surgeons should make a deliberate operative plan. AbstractOur images showed an advanced transverse colon cancer highly indicative of an invasion to the duodenum and pancreas. For en bloc tumor resection, surgeons should make a deliberate operative plan. (Source: Clinical Case Reports)
Sun Oct 06, 2019 00:00
(Source: Cancer Management and Research)
Mon Oct 07, 2019 03:31
(Source: Cancer Management and Research)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Mon Oct 07, 2019 03:26
(Source: OncoTargets and Therapy)
Mon Oct 07, 2019 03:19
(Source: OncoTargets and Therapy)
Mon Oct 07, 2019 03:13
(Source: OncoTargets and Therapy)
Mon Oct 07, 2019 03:04
AbstractThere is little consensus in the literature about the administration of crizotinib in patients with end ‐stage renal disease undergoing hemodialysis. A 69‐year‐old male patient, who was receiving regular hemodialysis due to end‐stage renal disease, visited the hospital with symptoms of repeated abdominal pain. There was no suspicious finding of cancer within the thorax. After biopsy, the abdom inal lymph nodes were identified as adenocarcinoma originating from the lung following computed...
Mon Oct 07, 2019 00:00
British Journal of Cancer, Published online: 07 October 2019; doi:10.1038/s41416-019-0595-2Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages (Source: British Journal of Cancer)
Mon Oct 07, 2019 00:00
Thoracic Cancer, EarlyView. (Source: Thoracic Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Mon Oct 07, 2019 00:00
British Journal of Cancer, Published online: 07 October 2019; doi:10.1038/s41416-019-0585-4Identification of a biomarker panel for improvement of prostate cancer diagnosis by volatile metabolic profiling of urine (Source: British Journal of Cancer)
Mon Oct 07, 2019 00:00
(Source: Cancer Management and Research)
Sun Oct 06, 2019 22:29
LINC01133 responds to mesenchymal stem/stromal cell ‐regulated miR‐199a/214‐FOXP2 pathway and upregulates the expression of the pluripotency master regulator KLF4 to drive cancer‐stem‐cell‐like phenotypic traits. AbstractThe fibrotic tumor microenvironment is a critical player in the pathogenesis of triple ‐negative breast cancers (TNBCs), with the presence of fibroblastic infiltrates particularly correlating with tumors that are clinically advanced. On this front, we previously demonstrated that...
Sun Oct 06, 2019 00:00
Adipose stem cells (ASCs) play a critical role in the tumor microenvironment of many different tumors through complex signaling networks. Common pathways activated by ASCs in multiple tumor types are highlighted in this review. AbstractIt is well established that the tumor microenvironment plays an important role in cancer development and progression. The tumor microenvironment is composed of neoplastic cells, endothelial cells, pericytes, adipocytes, fibroblasts and other connective tissue cells,...
Sun Oct 06, 2019 00:00
Factors that can impact the outcome of combination therapy include dose, frequency and order of administration, affecting not only the tumor burden but also metabolic competition, microbiota and the balance between cytotoxic and regulatory immunity. AbstractThe concept of immunoediting, a process whereby the immune system eliminates immunogenic cancer cell clones, allowing the remaining cells to progress and form a tumor, has evolved with growing appreciation of the importance of cancer ecology on...
Sun Oct 06, 2019 00:00
Publication date: Available online 5 October 2019Source: Veterinary ParasitologyAuthor(s): Alicia Rojas, Gad BanethAbstractSpirocerca lupi is a parasitic and carcinogenic nematode of canids distributed in tropical and subtropical regions around the world. The excretion-secretion proteins (PES) of S. lupi have been suggested to play a role in the pathogenesis of its infection. We aimed to identify the PES of different stages of S. lupi and search for proteins that would be useful for diagnostic, therapeutic...
Mon Oct 07, 2019 06:05
We report the minimally-invasive treatment of dentigerous cysts in two young patients using a modified Hawley plate to avoid traumatic injury to anatomical structures, with up to four years ’ follow up. (Source: The British Journal of Oral and Maxillofacial Surgery)
Mon Oct 07, 2019 00:00
The purpose of this retrospective cohort study was to identify the independent risk factors for long-term skeletal relapse following mandibular advancement with bilateral sagittal split osteotomy. Univariate and multivariate linear regression analyses were performed including nine common risk factors for relapse as independent variables and horizontal/vertical long-term ( ≥2 years) skeletal relapse as dependent variables. Ninety-six patients were analyzed; 66 were female (68.8%) and the average age...
Mon Oct 07, 2019 00:00
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