Purpose of review Prolyl-hydroxylase inhibitors are a novel class of orally administered drugs that are under development for the treatment of anemia in patients with chronic kidney disease. This review discusses the biology of these drugs and their target – hypoxia-inducible factor and potential advantages and disadvantages of these therapies. Finally, we will discuss current trials in patients with both chronic kidney disease and end-stage renal disease. Recent findings Recent smaller studies...
06:41
Conclusions Endovascular stent placement was effective for management of SVCS, with good technical and clinical success rates and provided prompt relief from symptoms.Resumo Contexto O tratamento da s índrome da veia cava superior (SVCS) visa aliviar, rapidamente, os sintomas desconfortáveis. Os resultados das abordagens convencionais nem sempre são tão rápidos quanto os do tratamento endovascular com colocação de stent. Objetivos Relatar a experiência de um Serviço de Cirurgia Vascular e Endovascular...
06:12
(Source: Patient Preference and Adherence)
03:59
(Source: Frontiers in Genetics)
00:00
Genetics in Medicine, Published online: 08 October 2019; doi:10.1038/s41436-019-0671-2Correction: Breast cancer in neurofibromatosis 1: survival and risk of contralateral breast cancer in a five country cohort study (Source: Genetics in Medicine)
00:00
This Teachable Moment describes a man in his 70s with a medical history of noninvasive bladder cancer who presented to his primary care clinic with significant weight loss and was subsequently found to have previously undiagnosed acquired immunodeficiency syndrome. (Source: JAMA Internal Medicine)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm...
Mon Oct 07, 2019 02:00
Pharmacogenomics,Volume 20, Issue 15, Page 1085-1092, October 2019. (Source: Future Medicine: Pharmacogenomics)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Mon Oct 07, 2019 00:00
Cell division and tissue growth must be coordinated with development. Defects in these processes are the basis for a number of diseases, including developmental malformations and cancer. We have conducted an unbiased RNAi screen for genes that are required for growth in the Drosophila wing, using GAL4-inducible short hairpin RNA (shRNA) fly strains made by the Drosophila RNAi Screening Center. shRNA expression down the center of the larval wing disc using dpp-GAL4, and the central region of the adult...
Mon Oct 07, 2019 00:00
Prostate Cancer and Prostatic Diseases, Published online: 07 October 2019; doi:10.1038/s41391-019-0177-7The association between inflammatory bowel disease and prostate cancer risk: a meta-analysis (Source: Prostate Cancer and Prostatic Diseases)
Mon Oct 07, 2019 00:00
The enzyme telomerase ensures the integrity of linear chromosomes by maintaining telomere length. As a hallmark of cancer, cell immortalization and unlimited proliferation is gained by reactivation of telomerase. However, a significant fraction of cancer cells instead uses alternative telomere lengthening mechanisms to ensure telomere function, collectively known as Alternative Lengthening of Telomeres (ALT). Although the budding yeast Naumovozyma castellii (Saccharomyces castellii) has a proficient...
Mon Oct 07, 2019 00:00
MDM2 regulates a variety of cellular processes through its dual protein:protein interaction and ubiquitin ligase activities. One major function of MDM2 is to bind and ubiquitinate P53, thereby regulating its proteasomal degradation. This function is in turn controlled by the cell fate determinant NUMB, which binds to and inhibits MDM2 via a short stretch of 11 amino acids, contained in its phosphotyrosine-binding (PTB) domain, encoded by exon 3 of the NUMB gene. The NUMB-MDM2-P53 circuitry is relevant...
Mon Oct 07, 2019 00:00
ConclusionThis study suggests that LSG is comparable to OSG in Western patients with respect to oncological quality and peri-operative morbidity. Two-year overall survival is predicted by the number of positive lymph nodes and not the operative access employed for resection. (Source: Surgical Endoscopy)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Mon Oct 07, 2019 00:00
ConclusionPatients undergoing attempted MIE requiring conversion to open surgery had significantly worse short-term outcomes including postoperative mortality. Patient factors and hospital experience contribute to conversion rates. These findings should inform surgeons and patients considering esophagectomy for cancer. (Source: Surgical Endoscopy)
Mon Oct 07, 2019 00:00
ConclusionMetformin inhibited autophagy and enhanced osimertinib sensitivity via inducing AMPK activation in a time ‐dependent manner. (Source: The Clinical Respiratory Journal)
Mon Oct 07, 2019 00:00
Biopsy instruments are being developed to enhance the diagnostic yield of endobronchial ultrasound (EBUS) sampling. Convex linear probe EBUS is a modality that has been refined and become the primary approach for tissue acquisition, particularly for target lesions in the mediastinum and pulmonary hila. Using this technology, EBUS guided transbronchial needle aspiration (TBNA) has been shown to have high sensitivity and specificity in diagnosing small cell and non-small cell lung carcinomatosis, whether...
Mon Oct 07, 2019 00:00
by Parmanand Malvi, Radoslav Janostiak, Arvindhan Nagarajan, Guoping Cai, Narendra Wajapeyee Metabolic alterations that are critical for cancer cell growth and metastasis are one of the key hallmarks of cancer. Here, we show that thymidine kinase 1 (TK1) is significantly overexpressed in tumor samples from lung adenocarcinoma (LUAD) patients relative to normal controls, and this TK1 overe xpression is associated with significantly reduced overall survival and cancer recurrence. Genetic knockdown...
Mon Oct 07, 2019 00:00
State officials stripped Stuart Copperman of his medical license almost 20 years ago. Armed with a new law, his former patients hope to file civil lawsuits.
09:30
FINDINGSResearchers from the UCLA Jonsson Comprehensive Cancer Center and other institutions in the U.S., Canada, the United Kingdom and Singapore, have identified 1,178 biomarkers in men ’s genomes — the complete set of genetic material inherited from one’s parents — that predict how an individual person’s prostate cancer will grow.The finding suggests that predicting how a person ’s cancer will evolve may lie in their inherited DNA.BACKGROUNDThe researchers focused in part on a biological process...
Mon Oct 07, 2019 17:00
Results from a phase III clinical trial comparing Keytruda (pembrolizumab) to standard chemotherapy shows the immunotherapy drug still has a long way to go as a viable treatment option for malignant pleural mesothelioma. Keytruda did not improve progression-free survival for mesothelioma patients who progressed after first-line chemotherapy. The disappointing results from the PROMISE-meso study were presented at the European Society of Medical Oncology (ESMO) annual meeting last week. It was...
Mon Oct 07, 2019 16:46
The longest running study of its kind on the "Housing First" model has found that it significantly reduces homelessness over the long term compared to treatment as usual, according to a study published in The Lancet Psychiatry by scientists at the Centre for Addiction and Mental Health (CAMH) and St. Michael's Hospital.
09:42
Abstract Purpose MR-guided radiotherapy (MRgRT) relies on the daily assignment of a relative electron density (RED) map to allow the fraction specific dose calculation. One approach to assign the RED map consists of segmenting the daily magnetic resonance image into five different density levels and assigning a RED bulk value to each level to generate a synthetic CT (sCT). The aim of this study is to evaluate the dose calculation accuracy...
03:00
Unfortunately, the denomination of the IEO was incorrectly published in the affiliation of this original
03:00
Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass and strength. The aim of the study was to investigate the impact of skeletal muscle mass on surgical site infection (SSI) in flap reconstruction for defects after oral cancer resection. The subjects were a non-randomized, retrospective cohort of 106 patients who underwent this procedure after preoperative abdominal-lumbar computed tomography (CT). Cross-sectional areas (cm2) of skeletal muscles in the L3 region...
Mon Oct 07, 2019 00:00
The purpose of this retrospective cohort study was to identify the independent risk factors for long-term skeletal relapse following mandibular advancement with bilateral sagittal split osteotomy. Univariate and multivariate linear regression analyses were performed including nine common risk factors for relapse as independent variables and horizontal/vertical long-term ( ≥2 years) skeletal relapse as dependent variables. Ninety-six patients were analyzed; 66 were female (68.8%) and the average age...
Mon Oct 07, 2019 00:00
This article reports the application of a novel open position splint integrated with a reference frame and registration markers for mandibular navigation surgery as a fourth strategy. (Source: International Journal of Oral and Maxillofacial Surgery)
Mon Oct 07, 2019 00:00
Surgical Infections, Ahead of Print.
Mon Oct 07, 2019 10:00
Surgical Infections, Ahead of Print.
Mon Oct 07, 2019 10:00
submitted by /u/appliedphilosophy [link] [comments]
05:42
I really want to discuss (please help me with this): (My) Philosophy, a subset of which is rationality Logic / informal logic / linguistics Statistics. For example in light of specific paradoxes such as "Raven Paradox" (and problems / paradoxes like that I want to discuss too) My theories about intelligence / my critique of cognitive theories My conceptual model, a subset of which are (maybe) different neural net architectures (I want to find out if I can give some new ideas) Find out if it can also...
03:02
Thyroid, Ahead of Print.
Mon Oct 07, 2019 10:00
Pharmacogenomics, Volume 20, Issue 15, Page 1071-1083, October 2019.
Mon Oct 07, 2019 14:02
Pharmacogenomics, Volume 20, Issue 15, Page 1063-1069, October 2019.
Mon Oct 07, 2019 14:02
Pharmacogenomics, Volume 20, Issue 15, Page 1103-1112, October 2019.
Mon Oct 07, 2019 14:02
Pharmacogenomics, Volume 20, Issue 15, Page 1061-1062, October 2019.
Mon Oct 07, 2019 14:02
Pharmacogenomics, Volume 20, Issue 15, Page 1093-1101, October 2019.
Mon Oct 07, 2019 14:02
Rejuvenation Research, Ahead of Print.
Mon Oct 07, 2019 10:00
Summary Many drugs have the potential to cause intracerebral haemorrhage. The mechanisms that underlie this association include elevation of blood pressure and increasing bleeding tendency. The consequences of intracerebral haemorrhage can be devastating for the individual, so careful risk assessment prior to drug initiation and close monitoring during treatment should be enacted when using medicines with an established association with haemorrhagic stroke.
Tue Oct 01, 2019 03:00
Protein chains contain only L-amino acids, with the exception of the achiral glycine, making the chains homochiral. This homochirality is a prerequisite for proper protein folding and, hence, normal cellular function. The importance of D-amino acids as a component of the bacterial cell wall and their roles in neurotransmission in higher eukaryotes is well established. However, the wider presence and the corresponding physiological roles of these specific amino acid stereoisomers have been appreciated...
Mon Oct 07, 2019 23:40
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου