'Zombie deer' may be spreading deadly disease to humans — but officials say there’s no way of knowing yet The IndependentState wildlife officials trying to keep 'zombie deer' out of Nevada FOX5 Las Vegas'It's not a matter of if, it's a matter of when'; Nevada fights to keep 'zombie deer' out of state St George NewsNevada wildlife officials warn hunters about 'zombie' deer CNNStates Warn of Deer With Chronic Wasting Disease NewsmaxView full coverage on Google News
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Oxford, UK, and Cambridge, MA, US, 7 October 2019 – Summit Therapeutics plc (NASDAQ: SMMT, AIM: SUMM) today announced the presentation of new data that explain the link between two key findings in the Company’s Phase 2 clinical...
Mon Oct 07, 2019 08:10
Zinc transporter-8 (ZnT8) primarily functions as a zinc-sequestrating transporter in the insulin-secretory granules (ISGs) of pancreatic β cells. Loss-of-function mutations in ZnT8 are associated with protection against type-2 diabetes (T2D), but the protective mechanism is unclear. Here, we developed an in-cell ZnT8 assay to track endogenous ZnT8 responses to metabolic and inflammatory stresses applied to human insulinoma EndoC-βH1 cells. Unexpectedly, high glucose and free fatty acids (FFA) did...
Mon Oct 07, 2019 23:40
A heterobimetallic Mn/Fe cofactor is present in the R2 subunit of class Ic ribonucleotide reductases (R2c) and in R2-like ligand-binding oxidases (R2lox). Although the protein-derived metal ligands are the same in both groups of proteins, the connectivity of the two metal ions and the chemistry each cofactor performs are different: in R2c, a one-electron oxidant, the Mn/Fe dimer is linked by two oxygen bridges (μ-oxo/μ-hydroxo), whereas in R2lox, a two-electron oxidant, it is linked by a single oxygen...
Mon Oct 07, 2019 22:33
Streptococcus pneumoniae is an opportunistic respiratory pathogen that can spread to other body sites, including the ears, brain and blood. The ability of this bacterium to breakdown, import and metabolize a wide range of glycans is key to its virulence. Intriguingly, S. pneumoniae can utilize several plant oligosaccharides for growth in vitro, including raffinose-family oligosaccharides (RFOs, which are α-(1→6)-galactosyl extensions of sucrose). An RFO utilization locus has been identified in the...
Mon Oct 07, 2019 19:30
Hypoxia-inducible gene domain 1 (HIGD1) proteins are small integral membrane proteins, conserved from bacteria to humans, that associate with oxidative phosphorylation supercomplexes. Using yeast as a model organism, we have previously shown that its two HIGD1 proteins, Rcf1 and Rcf2, are required for the generation and maintenance of a normal membrane potential (Δψ) across the inner mitochondrial membrane (IMM). We have postulated that the lower Δψ observed in the absence of the HIGD1 proteins may...
Mon Oct 07, 2019 17:33
Regulation of human trophoblast syncytialization by histone demethylase LSD1 [Developmental Biology]
A successful pregnancy is critically dependent upon proper placental development and function. During human placentation, villous cytotrophoblast progenitors (CTBs) differentiate to form syncytiotrophoblasts (SynTBs), which provide the exchange surface between the mother and the fetus and secrete hormones to ensure proper progression of pregnancy. However, epigenetic mechanisms that regulate SynTB differentiation from CTB progenitors are incompletely understood. Here, we show that lysine-specific...
Mon Oct 07, 2019 17:33
ArfGAP with SH3 domain, ankyrin repeat, and PH domain 1 (ASAP1) is a multidomain GTPase-activating protein (GAP) for ADP-ribosylation factor (ARF)-type GTPases. ASAP1 affects integrin adhesions, the actin cytoskeleton, and invasion and metastasis of cancer cells. ASAP1’s cellular function depends on its highly regulated and robust ARF GAP activity, requiring both the PH and the ARF GAP domains of ASAP1, and is modulated by phosphatidylinositol 4,5-bisphosphate (PIP2). The mechanistic basis of PIP2-stimulated...
Mon Oct 07, 2019 08:30
We report the minimally-invasive treatment of dentigerous cysts in two young patients using a modified Hawley plate to avoid traumatic injury to anatomical structures, with up to four years ’ follow up. (Source: The British Journal of Oral and Maxillofacial Surgery)
Mon Oct 07, 2019 00:00
A 48-year-old woman presented to neurosurgery with proptosis of the left globe and worsening pain and swelling in the left temporal region. Her visual acuity was unaffected. A computed tomogram (CT) of her head showed a large expansile lesion that involved the left frontal, parietal, temporal, and sphenoid bones (Fig. 1 and Supplemental Fig. S1). It impinged on the orbit, causing proptosis and crowding of the orbital contents. A diagnosis of intraosseous meningioma was suspected. (Source: The British...
Sun Oct 06, 2019 00:00
Squamous cell carcinoma (SCC) of the head and neck is the sixth most common cancer worldwide. It is preceded by early asymptomatic lesions which, if identified early enough and removed, would prevent malignant transformation or avoid delaying diagnosis to advanced stages. Our aim was to evaluate the feasibility of a screening programme for SCC of the head and neck in a group of high-risk patients, and to investigate their addiction profile. Patients admitted to an inpatient alcohol addiction centre...
Sun Oct 06, 2019 00:00
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Abstract Economic models are increasingly being used by health economists to assess the value of health technologies and inform healthcare decision making. However, most published economic models represent a kind of black box, with known inputs and outputs but undisclosed internal calculations and assumptions. This lack of transparency makes the evaluation of the model results challenging, complicates comparisons between models, and limits the reproducibility of the models. Here,...
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Mon Oct 07, 2019 03:00
Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics
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