A new Northwestern University study finds that despite human's close genetic relationship to apes, the human gut microbiome is more similar to that of Old World monkeys like baboons than to that of apes like chimpanzees.
09:43
From microscopic algae to elephants, life has devised countless ways to thrive in every environment on the planet. But while biologists have tended to focus on the many varied forms that species have evolved, the age of Big Data offers an unprecedented view of some surprisingly common features shared by all creatures great and small.
Mon Oct 07, 2019 22:00
EPFL scientists have discovered that predatory bacteria like the cholera pathogen can steal up to 150 genes in one go from their neighbors. The study sheds light on one of the most fundamental mechanisms of horizontal gene transfer.
Mon Oct 07, 2019 19:40
An international group of researchers has proven that a molecule called TCMDC-135051 can selectively inhibit a protein that is essential to the lifecycle of Plasmodium falciparum, one of the parasites that causes malaria.
Mon Oct 07, 2019 19:38
Antibiotics are still the most important weapon for combating bacterial infections. But medical science is running out of ammunition because of more and more frequently occurring resistances. Scientists from the Technical University of Munich and the Max Planck Institute of Molecular Physiology have now elucidated the structure of the proteolytic complex ClpX-ClpP. This is a key to the development of innovative antibiotics that target the degradation process of defective proteins in bacteria.
Mon Oct 07, 2019 16:11
A new method to control the timing of gene deletion in the malaria parasite has been developed by researchers at the Crick, which could lead to better vaccines.
Mon Oct 07, 2019 15:27
Circadian clocks must be flexible and they must be able to adapt to varying environmental conditions. Otherwise, it would be impossible for living beings to change their patterns of activity when the days get shorter again as is happening now. After all, Drosophila, also known as the common fruit fly, no longer needs a long siesta in autumn to protect itself from excessive heat and predators as in the middle of summer. At the same time, the fly must shift its evening activity peak a few hours forward...
Mon Oct 07, 2019 15:24
Antibiotic resistance is spreading fast all over the world. When infectious bacteria mutate in a certain way and then multiply, they can become resistant to even the most powerful drugs. But research has revealed a worrying alternative way that antibiotic resistance can spread: an organism that passes on its resistance on to other living bacteria.
Mon Oct 07, 2019 14:09
Cells, Vol. 8, Pages 1212: Silencing Lysine-Specific Histone Demethylase 1 (LSD1) Causes Increased HP1-Positive Chromatin, Stimulation of DNA Repair Processes, and Dysregulation of Proliferation by Chk1 Phosphorylation in Human Endothelial Cells Cells doi: 10.3390/cells8101212 Authors: Wojtala Dąbek Rybaczek Śliwińska Świderska Słapek El-Osta Balcerczyk : The methylation of histone lysine residues modifies chromatin conformation and regulates the expression...
Mon Oct 07, 2019 03:00
Cells, Vol. 8, Pages 1210: Depletion of Bone Marrow-Derived Fibrocytes Attenuates TAA-Induced Liver Fibrosis in Mice Cells doi: 10.3390/cells8101210 Authors: Felix Hempel Martin Roderfeld Rajkumar Savai Akylbek Sydykov Karuna Irungbam Ralph Schermuly Robert Voswinckel Kernt Köhler Yury Churin Ladislau Kiss Jens Bier Jörn Pons-Kühnemann Elke Roeb Bone marrow-derived fibrocytes (FC) represent a unique cell type, sharing features of both mesenchymal and...
Mon Oct 07, 2019 03:00
Cells, Vol. 8, Pages 1211: Increased Regeneration Following Stress-Induced Lung Injury in Bleomycin-Treated Chimeric Mice with CD44 Knockout Mesenchymal Cells Cells doi: 10.3390/cells8101211 Authors: Dmytro Petukhov Mark Richter-Dayan Zvi Fridlender Raphael Breuer Shulamit B. Wallach-Dayan CD44, an adhesion-molecule promoting cell-migration, is shown here to increase in stress conditions following bleomycin-induced apoptosis in alveolar epithelial cells (AECs), a main target...
Mon Oct 07, 2019 03:00
Cells, Vol. 8, Pages 1209: The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis Cells doi: 10.3390/cells8101209 Authors: Kara M. de la Harpe Pierre P.D. Kondiah Yahya E. Choonara Thashree Marimuthu Lisa C. du Toit Viness Pillay Understanding cell–nanoparticle interactions is critical to developing effective nanosized drug delivery systems. Nanoparticles have already advanced the treatment of several challenging conditions...
Mon Oct 07, 2019 03:00
Abstract In patients with locally advanced human papillomavirus (HPV)-unrelated head and neck squamous-cell carcinoma (HNSCC), cisplatin and radiation therapy (CisRT) resulted in a local–regional recurrence (LRR) rate of 35%, progression-free survival (PFS) of 49%, and overall survival (OS) of 60%. We, and others, showed that nab-paclitaxel is an active agent in metastatic and locally advanced HNSCC. The aim of this report was to assess the efficacy of nab-paclitaxel-based induction...
03:00
Αντί να σπαταλάς τεράστια ποσά ενέργειας ελπίζοντας να αλλάξεις τους πάντες και τα πάντα, άρχισε να αλλάζεις τον εαυτό σου. Την επόμενη φορά που θα νιώσεις ότι έχει κολλήσει σε ένα οικείο σου μοτίβο, ρώτα τον εαυτό σου: «Πώς τα κατάφερα και ξαναζώ την ίδια εμπειρία;» Η αλλαγή δεν είναι εύκολη. Ο Jim Rohn, ένας από τους μέντορές μου, που οι ιδέες του έγιναν καταλύτες για πολλές από τις δικές μου αλλαγές, έκανε μια απλή αλλά σοφή παρατήρηση: δύο είναι οι βασικοί λόγοι που οδηγούν τους ανθρώπους...
08:02
MINNEAPOLIS (CBSNewYork/AP) — Gleyber Torres got New York going with a second-inning home run, scored on each of his two doubles and made a pair of sparkling defensive plays, fueling the Yankees to a 5-1 victory over Minnesota on Monday night to finish yet another sweep of the Twins and advance to the AL Championship Series. Didi Gregorius hit two RBI singles for the Yankees and Cameron Maybin homered for the Yankees, who stretched their postseason winning streak over the Twins to 13 straight games....
08:59
Scientists at the University of Southern California say that their successful creation of cells that produce testosterone could aid in the development of new drugs.
09:40
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03586
Mon Oct 07, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03617
Mon Oct 07, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b03322
Mon Oct 07, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02874
Mon Oct 07, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b04283
Mon Oct 07, 2019 07:00
Analytical ChemistryDOI: 10.1021/acs.analchem.9b02839
Mon Oct 07, 2019 07:00
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Rectal locations are very rare, and minimally invasive surgery is a good choice for the treatment o... (Source: World Journal of Surgical Oncology)
Sun Oct 06, 2019 02:00
ConclusionTSEBT improved disease symptoms and significantly improved emotional domains of patients ’ quality of life in patients with MF or SS. In addition, our results indicate that maintenance or adjuvant therapy after TSEBT may improve the PFS. (Source: Strahlentherapie und Onkologie)
Mon Oct 07, 2019 00:00
The regulator approved the new drug application (NDA) for PF708, which was submitted under the 505(b)(2) regulatory pathway with Eli Lilly and Company’s Forteo as the reference medicine. The post Pfenex’ Forteo biosimilar PF708 secures FDA approval for osteoporosis appeared first on Pharmaceutical Business review.
03:10
The approval is supported by data from the Phase III GRECO trial and the Phase I AMES trial, which achieved their primary objective of usability and pharmacokinetic (PK) The post Fasenra approved in the US for self-administration in a new pre-filled auto-injector, the Fasenra Pen appeared first on Pharmaceutical Business review.
Mon Oct 07, 2019 15:05
Johnson & Johnson (J&J) will use the investment to advance research and development and delivery programmes to eliminate both diseases by 2030. The company will appoint a team The post Johnson & Johnson to invest $500m to end HIV and tuberculosis appeared first on Pharmaceutical Business review.
Mon Oct 07, 2019 13:04
Viaskin Peanut is the Company’s lead product candidate designed to potentially reduce the risk of life-threatening allergic reactions due to accidental exposure to peanuts. A non-invasive, once-daily, epicutaneous The post DBV Technologies announces FDA acceptance of BLA filing for Viaskin Peanut to treat peanut allergy appeared first on Pharmaceutical Business review.
Mon Oct 07, 2019 13:04
A study that gathered data for at least 8 years has shown that deep brain stimulation can have a robust, sustained effect in people with severe depression.
Mon Oct 07, 2019 19:00
Researchers revisit two surveys that looked at narcissism in a group of students and then 23 years later. It finds that narcissism declines over the years.
Mon Oct 07, 2019 10:00
Our findings suggest that a clinical benefit with durvalumab can be attained without compromising PROs. This result is of note because the previous standard of care was observation alone, with no presumed detriment to PROs.
01:30
In The Lancet Oncology, Rina Hui and colleagues report the patient-reported outcomes (PROs) data of the PACIFIC study.1 The PACIFIC study2,3 set a new standard of care in patients with stage III non-small-cell lung cancer, finding a significant benefit in survival with adjuvant durvalumab after chemoradiotherapy compared with placebo. Evaluation of health-related quality of life (HRQOL), showed that the addition of durvalumab was not detrimental to HRQOL; for example, physical functioning (mean change...
01:30
SACRAMENTO, Calif. (October 7, 2019) - What do gunowners and non-owners think about gun safety conversations that take place between health care providers and their patients in the exam room? A survey found little difference when a patient -- or someone in the patient's home -- is at increased risk for firearm-related harm.
Mon Oct 07, 2019 10:00
SACRAMENTO, Calif. (October 7, 2019) - Research from scholars at the UC Davis Violence Prevention Research Program and the University of California Firearm Violence Research Center published this week are informing the national dialogue on reducing injury and death from gun violence.
Mon Oct 07, 2019 10:00
SACRAMENTO, Calif. (October 7, 2019) - UC Davis Health researchers announced promising findings from interim results of HOPE-2 clinical trial for Duchenne muscular dystrophy.
Mon Oct 07, 2019 10:00
SACRAMENTO, Calif. (October 7, 2019) - The Sacramento Regional Transit District (SacRT) and UC Davis Health have officially announced a new name for the 39th Street light rail station: the 39th Street/UC Davis Health Station.
Mon Oct 07, 2019 10:00
Porcelain gallbladder is characterized by calcification of the gallbladder wall, possibly associated chronic inflammation from cholelithiasis. It is unknown whether porcelain gallbladder is associated with higher rates of hypercalcemia and/or hyperparathyroidism compared to cholelithiasis without porcelain gallbladder.
Mon Oct 07, 2019 03:00
Major venous injury (MVI) affecting the lower extremity can result in subsequent amputation. The contribution of intraoperative resuscitation efforts on the need for amputation is not well defined. We hypothesized that intraoperative large volume crystalloid resuscitation (LVCR) increases the risk of amputation after MVI, while massive transfusion (MT) does not.
Mon Oct 07, 2019 03:00
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